Keck School Faculty

Gabriel Zada, MD
Gabriel Zada, MD
Associate Professor of Neurological Surgery (Clinical Scholar)
Neurological Surgery
GNH 3300 Health Sciences Campus Los Angeles
Dr. Zada is a board certified neurosurgeon and nationally recognized expert in brain and pituitary tumor surgery as well as a variety of endoscopic and minimally invasive neurosurgical techniques. He is an Assistant Professor of Neurosurgery at the Keck School of Medicine of USC with associate appointments in the Departments of Otolaryngology and Internal Medicine. He is the Co-Director of the Keck USC Pituitary Center, Co-Director of the USC Radiosurgery Center, and Director of the USC Endoscopic Skull Base Surgery Program. He has a keen clinical and academic interest in brain and skull base tumor surgery, and has published over 100 peer-reviewed articles on various neurosurgical topics, mostly relating to brain and pituitary tumors as well as endoscopic skull base surgery. He authored and edited the textbook entitled “The Atlas of Sellar and Parasellar Lesions”. He directs a comprehensive neuro-endoscopic program including endoscopic skull base/pituitary surgery, exoscopic channel (BrainPath) surgery, and intraventricular neuro-endoscopy. He co-directs the USC Radiosurgery Center and performs both Gamma Knife and CyberKnife Radiosurgery.

Management of Pituitary Adenomas Invading the Cavernous Sinus Neurosurg Clin N Am. 2019 Oct; 30(4):445-455. . View in PubMed

Costs and training results of an objectively validated cadaveric perfusion-based internal carotid artery injury simulation during endoscopic skull base surgery Int Forum Allergy Rhinol. 2019 Mar 18. . View in PubMed

Clinical utility of routine postoperative morning cortisol monitoring in detecting new hypothalamic-pituitary-adrenal axis insufficiency following endoscopic transsphenoidal surgery for sellar lesions J Neurosurg. 2019 Mar 01; 1-5. . View in PubMed

Long-Term Tumor Control Rates Following Gamma Knife Radiosurgery for Acoustic Neuroma World Neurosurg. 2019 Feb; 122:366-371. . View in PubMed

Multicenter Investigation of Channel-Based Subcortical Trans-Sulcal Exoscopic Resection of Metastatic Brain Tumors: A Retrospective Case Series Oper Neurosurg (Hagerstown). 2019 Feb 01; 16(2):159-166. . View in PubMed

Combination ipilimumab and radiosurgery for brain metastases: tumor, edema, and adverse radiation effects J Neurosurg. 2018 Dec 01; 129(6):1397-1406. . View in PubMed

Long-Term Tumor Control Rates Following Gamma Knife Radiosurgery for Acoustic Neuroma World Neurosurg. 2018 Nov 14. . View in PubMed

Identification and repair of intraoperative cerebrospinal fluid leaks in endonasal transsphenoidal pituitary surgery: surgical experience in a series of 1002 patients J Neurosurg. 2018 Aug; 129(2):425-429. . View in PubMed

Complications associated with microscopic and endoscopic transsphenoidal pituitary surgery: experience of 1153 consecutive cases treated at a single tertiary care pituitary center J Neurosurg. 2018 Jun 01; 1-8. . View in PubMed

Long-term surgical outcomes following transsphenoidal surgery in patients with Rathke's cleft cysts J Neurosurg. 2018 May 18; 1-7. . View in PubMed

Complications associated with microscopic and endoscopic transsphenoidal pituitary surgery: experience of 1153 consecutive cases treated at a single tertiary care pituitary center J Neurosurg. 2018 May 01; 1-8. . View in PubMed

Long-term surgical outcomes following transsphenoidal surgery in patients with Rathke's cleft cysts J Neurosurg. 2018 May 01; 1-7. . View in PubMed

Multicenter Investigation of Channel-Based Subcortical Trans-Sulcal Exoscopic Resection of Metastatic Brain Tumors: A Retrospective Case Series Oper Neurosurg (Hagerstown). 2018 Apr 18. . View in PubMed

"IDEAL", the operating microscope, and the parachute Acta Neurochir (Wien). 2018 Feb; 160(2):367-368. . View in PubMed

Cavernous Sinus Hemangioma: Rare Vascular Tumor of Cavernous Sinus World Neurosurg. 2018 Feb; 110:432-433. . View in PubMed

Combination ipilimumab and radiosurgery for brain metastases: tumor, edema, and adverse radiation effects J Neurosurg. 2018 Jan 05; 1-10. . View in PubMed

"IDEAL", the operating microscope, and the parachute Acta Neurochir (Wien). 2018 02; 160(2):367-368. . View in PubMed

In Reply to "Neurosurgery Elective for Preclinical Medical Students: 6-Year Follow-up" World Neurosurg. 2018 02; 110:506. . View in PubMed

Development of a Perfusion-Based Cadaveric Simulation Model Integrated into Neurosurgical Training: Feasibility Based On Reconstitution of Vascular and Cerebrospinal Fluid Systems Oper Neurosurg (Hagerstown). 2018 Jan 01; 14(1):72-80. . View in PubMed

Endoscopic Endonasal Transsphenoidal Drainage of a Spontaneous Candida glabrata Pituitary Abscess World Neurosurg. 2018 Jan; 109:467-470. . View in PubMed

Complications Associated With Transsphenoidal Pituitary Surgery: Review of the Literature Neurosurgery. 2018 09 01; 65(CN_suppl_1):69-73. . View in PubMed

Extended endoscopic endonasal approach for resection of tuberculum sellae meningioma Neurosurg Focus. 2017 Oct; 43(VideoSuppl2):V2. . View in PubMed

Introduction: surgical management of skull base meningiomas Neurosurg Focus. 2017 Oct; 43(VideoSuppl2):Intro. . View in PubMed

Identification and repair of intraoperative cerebrospinal fluid leaks in endonasal transsphenoidal pituitary surgery: surgical experience in a series of 1002 patients J Neurosurg. 2017 Sep 29; 1-5. . View in PubMed

Endoscopic-Assisted Median Aperture Approach for Resection of Fourth Ventricular Tumor and Confirmation of Patency of Cerebral Aqueduct Using an Adjustable-Angle Endoscope: Technical Case Report Oper Neurosurg (Hagerstown). 2017 Apr 01; 13(2):293-296. . View in PubMed

Management of aggressive growth hormone secreting pituitary adenomas Pituitary. 2017 Feb; 20(1):169-178. . View in PubMed

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Posttreatment Follow-up Evaluation of Patients With Nonfunctioning Pituitary Adenomas Neurosurgery. 2016 Oct; 79(4):E541-3. . View in PubMed

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Primary Management of Patients With Nonfunctioning Pituitary Adenomas Neurosurgery. 2016 Oct; 79(4):E533-5. . View in PubMed

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for Pretreatment Endocrine Evaluation of Patients With Nonfunctioning Pituitary Adenomas Neurosurgery. 2016 Oct; 79(4):E527-9. . View in PubMed

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Surgical Techniques and Technologies for the Management of Patients With Nonfunctioning Pituitary Adenomas Neurosurgery. 2016 Oct; 79(4):E536-8. . View in PubMed

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for the Management of Patients With Residual or Recurrent Nonfunctioning Pituitary Adenomas Neurosurgery. 2016 Oct; 79(4):E539-40. . View in PubMed

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Preoperative Imaging Assessment of Patients With Suspected Nonfunctioning Pituitary Adenomas Neurosurgery. 2016 Oct; 79(4):E524-6. . View in PubMed

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Pretreatment Ophthalmology Evaluation in Patients With Suspected Nonfunctioning Pituitary Adenomas Neurosurgery. 2016 Oct; 79(4):E530-2. . View in PubMed

Meningiomas: An Update on Diagnostic and Therapeutic Approaches Neurosurg Clin N Am. 2016 Apr; 27(2):xiii. . View in PubMed

Endoscopic Endonasal and Keyhole Surgery for the Management of Skull Base Meningiomas Neurosurg Clin N Am. 2016 Apr; 27(2):207-14. . View in PubMed

Gene expression in prolactinomas: a systematic review Pituitary. 2016 Feb; 19(1):93-104. . View in PubMed

Giant, calcified colloid cyst of the lateral ventricle J Clin Neurosci. 2016 Feb; 24:6-9. . View in PubMed

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for the Management of Patients With Residual or Recurrent Nonfunctioning Pituitary Adenomas Neurosurgery. 2016 10; 79(4):E539-40. . View in PubMed

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Surgical Techniques and Technologies for the Management of Patients With Nonfunctioning Pituitary Adenomas Neurosurgery. 2016 10; 79(4):E536-8. . View in PubMed

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Pretreatment Ophthalmology Evaluation in Patients With Suspected Nonfunctioning Pituitary Adenomas Neurosurgery. 2016 10; 79(4):E530-2. . View in PubMed

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Preoperative Imaging Assessment of Patients With Suspected Nonfunctioning Pituitary Adenomas Neurosurgery. 2016 10; 79(4):E524-6. . View in PubMed

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Posttreatment Follow-up Evaluation of Patients With Nonfunctioning Pituitary Adenomas Neurosurgery. 2016 10; 79(4):E541-3. . View in PubMed

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Primary Management of Patients With Nonfunctioning Pituitary Adenomas Neurosurgery. 2016 10; 79(4):E533-5. . View in PubMed

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for Pretreatment Endocrine Evaluation of Patients With Nonfunctioning Pituitary Adenomas Neurosurgery. 2016 10; 79(4):E527-9. . View in PubMed

Endoscopic Endonasal Approaches to the Craniovertebral Junction: A Systematic Review of the Literature J Neurol Surg B Skull Base. 2015 Dec; 76(6):480-8. . View in PubMed

Cerebrospinal fluid reconstitution via a perfusion-based cadaveric model: feasibility study demonstrating surgical simulation of neuroendoscopic procedures J Neurosurg. 2015 Nov; 123(5):1316-21. . View in PubMed

Intracranial bacterial infections of oral origin J Clin Neurosci. 2015 May; 22(5):800-6. . View in PubMed

Demographic factors, outcomes, and patient access to transsphenoidal surgery for Cushing's disease: analysis of the Nationwide Inpatient Sample from 2002 to 2010 Neurosurg Focus. 2015 Feb; 38(2):E2. . View in PubMed

Introduction: Cushing's disease: a century of evolving diagnostics and therapeutics for an often elusive entity Neurosurg Focus. 2015 Feb; 38(2):E1. . View in PubMed

Ectopic ACTH-secreting pituitary adenoma of the sphenoid sinus: case report of endoscopic endonasal resection and systematic review of the literature Neurosurg Focus. 2015 Feb; 38(2):E10. . View in PubMed

Gene and protein expression in pituitary corticotroph adenomas: a systematic review of the literature Neurosurg Focus. 2015 Feb; 38(2):E17. . View in PubMed

Making the diagnosis of cyclic Cushing's syndrome: a position statement from the topic editors Neurosurg Focus. 2015 Feb; 38(2):E8. . View in PubMed

Imaging of central neurocytomas Neurosurg Clin N Am. 2015 Jan; 26(1):11-9. . View in PubMed

Endoscopic endonasal surgery for nonadenomatous sellar/parasellar lesions World Neurosurg. 2014 Dec; 82(6 Suppl):S138-46. . View in PubMed

Intracranial fusarium fungal abscess in an immunocompetent patient: case report and review of the literature J Neurol Surg Rep. 2014 Dec; 75(2):e241-5. . View in PubMed

A Perfusion-based Human Cadaveric Model for Management of Carotid Artery Injury during Endoscopic Endonasal Skull Base Surgery J Neurol Surg B Skull Base. 2014 Oct; 75(5):309-13. . View in PubMed

Endoscopic-assisted resection of intracranial epidermoid tumors World Neurosurg. 2014 Sep-Oct; 82(3-4):450-4. . View in PubMed

Diffusion restriction in a non-enhancing metastatic brain tumor treated with bevacizumab - recurrent tumor or atypical necrosis? Clin Imaging. 2014 Sep-Oct; 38(5):724-6.. View in PubMed

A systematic review of inhaled intranasal therapy for central nervous system neoplasms: an emerging therapeutic option J Neurooncol. 2014 Feb; 116(3):437-46. . View in PubMed

Endoscopic extended transsphenoidal resection of craniopharyngiomas: nuances of neurosurgical technique Neurosurg Focus. 2014; 37(4):E10. . View in PubMed

Editorial: The endoscopic keyhole supraorbital approach Neurosurg Focus. 2014; 37(4):E21. . View in PubMed

Editorial: Vascularized flap reconstruction for CSF leaks during endoscopic skull base surgery Neurosurg Focus. 2014; 37(4):E5. . View in PubMed

Introduction: Endoscopic endonasal skull base surgery Neurosurg Focus. 2014; 37(4):Introduction. . View in PubMed

Concurrent intracranial and spinal subdural hematoma in a teenage athlete: a case report of this rare entity Case Rep Radiol. 2014; 2014:143408. . View in PubMed

A pilot genome-scale profiling of DNA methylation in sporadic pituitary macroadenomas: association with tumor invasion and histopathological subtype PLoS One. 2014; 9(4):e96178. . View in PubMed

Endoscopic endonasal transsphenoidal surgery: implementation of an operative and perioperative checklist Neurosurg Focus. 2014; 37(4):E1. . View in PubMed

A review of epigenetic and gene expression alterations associated with intracranial meningiomas Neurosurg Focus. 2013 Dec; 35(6):E5. . View in PubMed

Intraventricular and skull base neuroendoscopy in 2012: a global survey of usage patterns and the role of intraoperative neuronavigation World Neurosurg. 2013 Dec; 80(6):709-16. . View in PubMed

A proposed grading system for standardizing tumor consistency of intracranial meningiomas Neurosurg Focus. 2013 Dec; 35(6):E1. . View in PubMed

Genomic and transcriptome analysis revealing an oncogenic functional module in meningiomas Neurosurg Focus. 2013 Dec; 35(6):E3. . View in PubMed

Leptomeningeal carcinomatosis in sinonasal undifferentiated carcinoma Head Neck. 2013 Nov; 35(11):E343-5. . View in PubMed

Minimally invasive posterior atlantoaxial fusion: a cadaveric and clinical feasibility study World Neurosurg. 2013 Sep-Oct; 80(3-4):414-21. . View in PubMed

Inversion-mediated gene fusions involving NAB2-STAT6 in an unusual malignant meningioma Br J Cancer. 2013 Aug 20; 109(4):1051-5. . View in PubMed

Diagnosis and surgical management of traumatic cerebrospinal fluid oculorrhea: case report and systematic review of the literature J Neurol Surg Rep. 2013 Jun; 74(1):57-66. . View in PubMed

Delayed cavernous carotid artery pseudoaneurysm caused by absorbable plate following transsphenoidal surgery: case report and review of the literature J Neurol Surg Rep. 2013 Jun; 74(1):10-6. . View in PubMed

"Through the looking glass": optical physics, issues, and the evolution of neuroendoscopy World Neurosurg. 2013 Feb; 79(2 Suppl):S3-13. . View in PubMed

DNA methylation in the malignant transformation of meningiomas PLoS One. 2013; 8(1):e54114. . View in PubMed

Diagnosis and Multimodality Management of Cushing's Disease: A Practical Review Int J Endocrinol. 2013; 2013:893781. . View in PubMed

Introduction: quality process improvement and the neurosurgeon Neurosurg Focus. 2012 Nov; 33(5):Introduction. . View in PubMed

Endoscopic surgery for pituitary tumors Neurosurg Clin N Am. 2012 Oct; 23(4):555-69. . View in PubMed

Extent of resection and early postoperative outcomes following removal of cystic vestibular schwannomas: surgical experience over a decade and review of the literature Neurosurg Focus. 2012 Sep; 33(3):E13. . View in PubMed

Cerebral vasospasm after transsphenoidal resection of pituitary macroadenomas: report of 3 cases and review of the literature Neurosurgery. 2012 Sep; 71(1 Suppl Operative):173-80; discussion 180-1. . View in PubMed

Imaging of the pituitary and parasellar region Semin Neurol. 2012 Sep; 32(4):320-31. . View in PubMed

Indocyanine green fluorescence endoscopy for visual differentiation of pituitary tumor from surrounding structures J Neurosurg. 2012 May; 116(5):935-41. . View in PubMed

Incidence trends in the anatomic location of primary malignant brain tumors in the United States: 1992-2006 World Neurosurg. 2012 Mar-Apr; 77(3-4):518-24. . View in PubMed

"Through the looking glass": optical physics, issues, and the evolution of neuroendoscopy World Neurosurg. 2012 Jan; 77(1):92-102. . View in PubMed

Cerebral aneurysms with intrasellar extension: a systematic review of clinical, anatomical, and treatment characteristics J Neurosurg. 2012 Jan; 116(1):164-78. . View in PubMed

Molecular genetics of meningiomas: a systematic review of the current literature and potential basis for future treatment paradigms Neurosurg Focus. 2011 May; 30(5):E7. . View in PubMed

Atypical pituitary adenomas: incidence, clinical characteristics, and implications J Neurosurg. 2011 Feb; 114(2):336-44. . View in PubMed

Defining the "edge of the envelope": patient selection in treating complex sellar-based neoplasms via transsphenoidal versus open craniotomy J Neurosurg. 2011 Feb; 114(2):286-300. . View in PubMed

Midline filum of the sellar dura: a useful landmark during endoscopic transsphenoidal pituitary surgery Neurosurgery. 2010 Dec; 67(2 Suppl Operative):391-4. . View in PubMed

Cushing's disease and idiopathic intracranial hypertension: case report and review of underlying pathophysiological mechanisms J Clin Endocrinol Metab. 2010 Nov; 95(11):4850-4. . View in PubMed

A novel method for administering intrathecal chemotherapy in patients with leptomeningeal metastases and shunted hydrocephalus: case report Neurosurgery. 2010 Sep; 67(3 Suppl Operative):onsE306-7; discussion onsE307. . View in PubMed

Long term outcome following repeat transsphenoidal surgery for recurrent endocrine-inactive pituitary adenomas Pituitary. 2010 Sep; 13(3):223-9. . View in PubMed

Long-term outcomes and patterns of tumor progression after gamma knife radiosurgery for benign meningiomas Neurosurgery. 2010 Aug; 67(2):322-8; discussion 328-9. . View in PubMed

Early decreased tumor volume following fractionated Gamma Knife Radiosurgery for metastatic melanoma and the role of "adaptive radiosurgery": case report Neurosurgery. 2010 Aug; 67(2):E512-3. . View in PubMed

Cerebral vasospasm and concurrent left ventricular outflow tract obstruction: requirement for modification of hyperdynamic therapy regimen Neurocrit Care. 2010 Apr; 12(2):265-8. . View in PubMed

Intraoperative conversion from endoscopic to microscopic approach for the management of sellar pathology: incidence and rationale in a contemporary series World Neurosurg. 2010 Apr; 73(4):334-7. . View in PubMed

Craniopharyngioma and other cystic epithelial lesions of the sellar region: a review of clinical, imaging, and histopathological relationships Neurosurg Focus. 2010 Apr; 28(4):E4. . View in PubMed

Intraoperative neurophysiological monitoring during spine surgery: a review Neurosurg Focus. 2009 Oct; 27(4):E6. . View in PubMed

Delayed toxicity from gamma knife radiosurgery to lesions in and adjacent to the brainstem J Clin Neurosci. 2009 Sep; 16(9):1139-47. . View in PubMed

Anaplastic intraventricular oligodendroglioma: case report and review of the literature Surg Neurol. 2009 Jun; 71(6):693-700. . View in PubMed

Endovascular management of spinal dural arteriovenous fistulasA review. Neurosurg Focus. 2009 May; 26(5):E15. . View in PubMed

Fenestrated aneurysm clips in the surgical management of anterior communicating artery aneurysms: operative techniques and strategyClinical article. Neurosurg Focus. 2009 May; 26(5):E7. . View in PubMed

A review of selective hypothermia in the management of traumatic brain injury Neurosurg Focus. 2008 Oct; 25(4):E9. . View in PubMed

Internal carotid artery aneurysms occurring at the origin of fetal variant posterior cerebral arteries: surgical and endovascular experience Neurosurgery. 2008 Jul; 63(1 Suppl 1):ONS55-61; discussion ONS61-2. . View in PubMed

Long-term recurrence and mortality after surgery and adjuvant radiotherapy for nonfunctional pituitary adenomas J Neurosurg. 2008 Apr; 108(4):736-45. . View in PubMed

Indications for routine repeat head computed tomography (CT) stratified by severity of traumatic brain injury J Trauma. 2007 Jun; 62(6):1339-44; discussion 1344-5. . View in PubMed

Motor cortex stimulation: mild transient benefit in a primate model of Parkinson disease J Neurosurg. 2007 Apr; 106(4):695-700. . View in PubMed

A review of ocular manifestations in intracranial hypotension Neurosurg Focus. 2007; 23(5):E8. . View in PubMed

Changes in transcranial motor evoked potentials during intramedullary spinal cord tumor resection correlate with postoperative motor function Neurosurgery. 2005 May; 56(5):982-93; discussion 982-93. . View in PubMed

Incidence of venous thromboembolism in patients undergoing craniotomy and motor mapping for glioma without intraoperative mechanical prophylaxis to the contralateral leg J Neurosurg. 2003 Oct; 99(4):680-4. . View in PubMed

Endonasal transsphenoidal approach for pituitary adenomas and other sellar lesions: an assessment of efficacy, safety, and patient impressions J Neurosurg. 2003 Feb; 98(2):350-8. . View in PubMed

A novel role for p75NTR in subplate growth cone complexity and visual thalamocortical innervation J Neurosci. 2002 May 01; 22(9):3580-93. . View in PubMed

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