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Gary Craig Kanel, MD

Clinical Professor of Pathology (Part-Time)

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Email gckanel@aol.com
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Publications

  • Innate and adaptive immune cell interaction drives inflammasome activation and hepatocyte apoptosis in murine liver injury from immune checkpoint inhibitors. Cell Death Dis. 2024 02 14; 15(2):140.. View in PubMed
  • Hepatic damage caused by long-term high cholesterol intake induces a dysfunctional restorative macrophage population in experimental NASH. Front Immunol. 2022; 13:968366.. View in PubMed
  • Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis. Hepatology. 2021 12; 74(6):3127-3145.. View in PubMed
  • A Case of Benign Hepatic Cyst with Supra-elevated Cyst Fluid Tumor Markers. Dig Dis Sci. 2021 11; 66(11):4063-4067.. View in PubMed
  • IgG:IgM Ratios of Liver Plasma Cells Reveal Similar Phenotypes of Primary Biliary Cholangitis With and Without Features of Autoimmune Hepatitis. Clin Gastroenterol Hepatol. 2021 02; 19(2):397-399.. View in PubMed
  • Niacin-Induced Anicteric Microvesicular Steatotic Acute Liver Failure. Hepatol Commun. 2018 Nov; 2(11):1293-1298.. View in PubMed
  • Prediction of histologic alcoholic hepatitis based on clinical presentation limits the need for liver biopsy. Hepatol Commun. 2017 12; 1(10):1070-1084.. View in PubMed
  • Hepatic angiosarcoma with clinical and histological features of Kasabach-Merritt syndrome. World J Gastroenterol. 2017 Apr 07; 23(13):2443-2447.. View in PubMed
  • Detection of Occult Hepatitis C Virus Infection in Patients Who Achieved a Sustained Virologic Response to Direct-Acting Antiviral Agents for Recurrent Infection After Liver Transplantation. Gastroenterology. 2017 02; 152(3):550-553.e8.. View in PubMed
  • Alcoholic foamy degeneration and alcoholic fatty liver with jaundice: Often overlooked causes of jaundice and hepatic decompensation that can mimic alcoholic hepatitis. Clin Liver Dis (Hoboken). 2015 Dec; 6(6):145-148.. View in PubMed
  • GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN. Oncogene. 2014 Oct 16; 33(42):4997-5005.. View in PubMed
  • Targeted deletion of ER chaperone GRP94 in the liver results in injury, repopulation of GRP94-positive hepatocytes, and spontaneous hepatocellular carcinoma development in aged mice. Neoplasia. 2014 Aug; 16(8):617-26.. View in PubMed
  • Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis. Hepatology. 2014 Mar; 59(3):947-57.. View in PubMed
  • Isolated arterioportal fistula presenting with variceal hemorrhage. World J Gastroenterol. 2013 May 07; 19(17):2714-7.. View in PubMed
  • Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats. Gastroenterology. 2012 Apr; 142(4):918-927.e6.. View in PubMed
  • Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2. Gastroenterology. 2010 Dec; 139(6):2170-82.. View in PubMed
  • The critical role of AKT2 in hepatic steatosis induced by PTEN loss. Am J Pathol. 2010 May; 176(5):2302-8.. View in PubMed
  • Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns. Hum Mol Genet. 2009 Dec 15; 18(24):4808-17.. View in PubMed
  • Phlegmonous gastritis in a patient with myeloid sarcoma: a case report. Appl Immunohistochem Mol Morphol. 2009 Oct; 17(5):458-62.. View in PubMed
  • S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model. Hepatology. 2009 Aug; 50(2):462-71.. View in PubMed
  • Bone marrow progenitor cells repair rat hepatic sinusoidal endothelial cells after liver injury. Gastroenterology. 2009 Aug; 137(2):704-12.. View in PubMed
  • Prolonged cholestasis associated with benazepril therapy. Am J Gastroenterol. 2009 Jan; 104(1):245-6.. View in PubMed
  • Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis. Am J Pathol. 2008 Oct; 173(4):993-1001.. View in PubMed
  • Lack of increases in methylation at three CpG-rich genomic loci in non-mitotic adult tissues during aging. BMC Med Genet. 2007 Jul 31; 8:50.. View in PubMed
  • Occult hepatic opportunistic infection (OI) and highly active antiretroviral therapy (HAART) induced immune reconstitution: an important cause of jaundice in a patient with AIDS. AIDS Res Hum Retroviruses. 2006 Oct; 22(10):1052-3.. View in PubMed
  • Interobserver agreement in hepatitis C grading and staging and in the Banff grading schema for acute cellular rejection: the “hepatitis C 3” multi-institutional trial experience. Arch Pathol Lab Med. 2006 Aug; 130(8):1157-62.. View in PubMed
  • More advanced hepatic fibrosis in hispanics with chronic hepatitis C infection: role of patient demographics, hepatic necroinflammation, and steatosis. Am J Gastroenterol. 2006 Aug; 101(8):1817-23.. View in PubMed
  • Do type and duration of antiretroviral therapy attenuate liver fibrosis in HIV-hepatitis C virus-coinfected patients? Clin Infect Dis. 2006 Jan 15; 42(2):262-70.. View in PubMed
  • Isolated hepatic metastasis from a gastrointestinal stromal tumor (GIST) 17 years after initial resection: need for long-term surveillance. J Clin Gastroenterol. 2005 Nov-Dec; 39(10):925.. View in PubMed
  • Severe cholestatic liver injury days after initiating antiretroviral therapy in a patient with AIDS: drug toxicity or immune reconstitution inflammatory syndrome? Dig Dis Sci. 2005 Oct; 50(10):1813-7.. View in PubMed
  • Gastrointestinal stromal tumors: clinical profile, pathogenesis, treatment strategies and prognosis. J Gastroenterol Hepatol. 2005 Jun; 20(6):818-24.. View in PubMed
  • Proposal for a histological scoring and grading system for non-alcoholic fatty liver disease. Liver Int. 2005 Apr; 25(2):294-304.. View in PubMed
  • Colchicine treatment of alcoholic cirrhosis: a randomized, placebo-controlled clinical trial of patient survival. Gastroenterology. 2005 Apr; 128(4):882-90.. View in PubMed
  • Tracheobronchomalacia and noninvasive ventilation revisited. Chest. 2004 Oct; 126(4):1390-2.. View in PubMed
  • Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis. Alcohol Clin Exp Res. 2004 Jan; 28(1):173-81.. View in PubMed
  • Decreased hepatic nitric oxide production contributes to the development of rat sinusoidal obstruction syndrome. Hepatology. 2003 Oct; 38(4):900-8.. View in PubMed
  • Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition. Gastroenterology. 2003 Sep; 125(3):882-90.. View in PubMed
  • Tracheobronchomalacia and tracheal hemorrhage in patients with Duchenne muscular dystrophy receiving long-term ventilation with uncuffed tracheostomies. Chest. 2003 Apr; 123(4):1307-11.. View in PubMed
  • Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A. FASEB J. 2002 Aug; 16(10):1292-4.. View in PubMed
  • Live-donor liver transplantation: the USC experience. Acta Chir Belg. 2001 Sep-Oct; 101(5):220-3.. View in PubMed
  • Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5560-5.. View in PubMed
  • Acute hepatitis induced by bupropion. Dig Dis Sci. 2000 Sep; 45(9):1872-3.. View in PubMed
  • Support of sinusoidal endothelial cell glutathione prevents hepatic veno-occlusive disease in the rat. Hepatology. 2000 Feb; 31(2):428-34.. View in PubMed
  • A novel, simple method of functional spleen volume calculation by liver-spleen scan. J Nucl Med. 1999 Oct; 40(10):1745-55.. View in PubMed
  • Coccidioidomycosis prostatitis associated with prostate cancer. BJU Int. 1999 Aug; 84(3):372-3.. View in PubMed
  • Characterization of a reproducible rat model of hepatic veno-occlusive disease. Hepatology. 1999 Jun; 29(6):1779-91.. View in PubMed
  • Differential effect of thioacetamide on hepatic methionine adenosyltransferase expression in the rat. Hepatology. 1999 May; 29(5):1471-8.. View in PubMed
  • Functional measurement of nonfibrotic hepatic mass in cirrhotic patients. Am J Gastroenterol. 1997 Nov; 92(11):2054-8.. View in PubMed
  • Peritoneal mucinous carcinomatosis. A possible explanation for an unusual laparoscopic appearance. Dig Dis Sci. 1997 Jun; 42(6):1270-3.. View in PubMed
  • Low albumin gradient ascites complicating severe pseudomembranous colitis. Gastroenterology. 1997 Mar; 112(3):991-4.. View in PubMed
  • Duodenal and hepatic toxoplasmosis in a patient with HIV infection: review of the literature. Am J Gastroenterol. 1996 Sep; 91(9):1838-40.. View in PubMed
  • Diagnostic features of tuberculous peritonitis in the absence and presence of chronic liver disease: a case control study. Am J Med. 1996 Feb; 100(2):179-85.. View in PubMed
  • The liver-spleen scan as a quantitative liver function test: correlation with liver severity at peritoneoscopy. Hepatology. 1995 Oct; 22(4 Pt 1):1113-21.. View in PubMed
  • Perfused Kupffer cell mass. Correlation with histology and severity of chronic liver disease. Dig Dis Sci. 1995 Mar; 40(3):552-60.. View in PubMed
  • Fatal intrathoracic hemorrhage in a patient with von Recklinghausen’s disease. Respiration. 1995; 62(2):104-6.. View in PubMed
  • Clinical significance of concomitant hepatitis C infection in patients with alcoholic liver disease. Hepatology. 1994 Mar; 19(3):554-7.. View in PubMed
  • Hepatic lesions resembling alcoholic liver disease. Pathology (Phila). 1994; 3(1):77-104.. View in PubMed
  • Ultrasonographic diagnosis of acute alcoholic hepatitis ‘pseudoparallel channel sign’ of intrahepatic artery dilatation. Gastroenterology. 1993 Nov; 105(5):1477-82.. View in PubMed
  • Control of ventilation, respiratory muscle strength, and granulomatous involvement of skeletal muscle in patients with sarcoidosis. Chest. 1993 Feb; 103(2):396-402.. View in PubMed
  • Hepatocellular carcinoma coexisting with hepatic adenoma. Incidental discovery after long-term oral contraceptive use. West J Med. 1991 Oct; 155(4):416-8.. View in PubMed
  • Portal vein thrombosis complicating endoscopic variceal sclerotherapy. Convincing further evidence. Dig Dis Sci. 1991 Aug; 36(8):1164-7.. View in PubMed
  • Acetaminophen, isoniazid, and hepatic toxicity. Ann Intern Med. 1991 Mar 01; 114(5):431.. View in PubMed
  • Fatty infiltration of the liver: quantification with phase-contrast MR imaging at 1.5 T vs biopsy. AJR Am J Roentgenol. 1991 Feb; 156(2):307-12.. View in PubMed
  • A rodent model of cirrhosis, ascites, and bacterial peritonitis. Gastroenterology. 1991 Feb; 100(2):489-93.. View in PubMed
  • Peliosis hepatis in a patient with human immunodeficiency virus infection. AJR Am J Roentgenol. 1991 Jan; 156(1):91-2.. View in PubMed
  • Failure of colchicine to improve short-term survival in patients with alcoholic hepatitis. Gastroenterology. 1990 Sep; 99(3):811-8.. View in PubMed
  • Cocaine-induced liver cell injury: comparison of morphological features in man and in experimental models. Hepatology. 1990 Apr; 11(4):646-51.. View in PubMed
  • Twenty isoniazid-associated deaths in one state. Am Rev Respir Dis. 1989 Sep; 140(3):700-5.. View in PubMed
  • Fibrinous pericarditis in alcoholic liver disease. J Clin Gastroenterol. 1989 Feb; 11(1):53-5.. View in PubMed
  • Risk lesions in cirrhosis and development of hepatocellular carcinoma: an autopsy study. Biomed Pharmacother. 1989; 43(2):127-33.. View in PubMed
  • Hepatotoxicity of cocaine. NIDA Res Monogr. 1988; 88:250-75.. View in PubMed
  • In vivo acoustic attenuation in liver: correlations with blood tests and histology. Ultrasound Med Biol. 1988; 14(5):405-13.. View in PubMed
  • Effects of sodium tetradecyl sulfate endoscopic variceal sclerotherapy on the esophagus. A prospective clinical and histopathologic study. J Clin Gastroenterol. 1987 Dec; 9(6):635-43.. View in PubMed
  • Atypical diffuse angiosarcoma of the liver. West J Med. 1987 Apr; 146(4):482-5.. View in PubMed
  • FM sonography in diffuse liver disease: prospective assessment and blinded analysis. Radiology. 1986 Nov; 161(2):451-4.. View in PubMed
  • Noninvasive evaluation of hepatic fibrosis using frequency demodulation of ultrasound signals. Dig Dis Sci. 1986 Oct; 31(10):1046-55.. View in PubMed
  • Frequency-demodulated US: evaluation in the liver. Work in progress. Radiology. 1986 Jul; 160(1):59-64.. View in PubMed
  • Osteomyelitis associated with pressure ulcers. Arch Phys Med Rehabil. 1986 May; 67(5):314-8.. View in PubMed
  • Hepatorenal syndrome without avid sodium retention. Hepatology. 1986 Mar-Apr; 6(2):248-51.. View in PubMed
  • Delta agent superinfection. Rapidly progressive liver disease in a hepatitis B virus carrier. Arch Pathol Lab Med. 1985 May; 109(5):395-7.. View in PubMed
  • Tubular dysfunction in the deeply jaundiced patient with hepatorenal syndrome. Hepatology. 1985 Mar-Apr; 5(2):321-6.. View in PubMed
  • Fulminant hepatic and renal failure complicating Wilson’s disease. Liver. 1984 Dec; 4(6):341-7.. View in PubMed
  • Chronic delta infection and liver biopsy changes in chronic active hepatitis B. Ann Intern Med. 1984 Jul; 101(1):51-4.. View in PubMed
  • Phencyclidine-induced malignant hyperthermia causing submassive liver necrosis. Am J Med. 1984 Jul; 77(1):167-72.. View in PubMed
  • Sex and strain differences in response to cocaine. Biochem Pharmacol. 1984 Apr 15; 33(8):1299-307.. View in PubMed
  • Glomerular tubular reflux–a morphologic renal lesion associated with the hepatorenal syndrome. Hepatology. 1984 Mar-Apr; 4(2):242-6.. View in PubMed
  • Prevalence of delta-antibody among chronic hepatitis B virus infected patients in the Los Angeles area: its correlation with liver biopsy diagnosis. Gastroenterology. 1983 Jul; 85(1):160-2.. View in PubMed
  • High-density lipoprotein cholesterol and liver disease. Hepatology. 1983 May-Jun; 3(3):343-8.. View in PubMed
  • Portasystemic shunts in primary biliary cirrhosis: survival is the same as in patients with Laennec’s cirrhosis and postnecrotic cirrhosis. Dig Dis Sci. 1982 Jun; 27(6):507-12.. View in PubMed
  • Double-blind, controlled trial of propylthiouracil in patients with severe acute alcoholic hepatitis. Gastroenterology. 1982 May; 82(5 Pt 1):925-31.. View in PubMed
  • Globular hepatic amyloid–an unusual morphologic presentation. Hepatology. 1981 Nov-Dec; 1(6):647-52.. View in PubMed
  • Liver damage from narcotics in mice. Toxicol Appl Pharmacol. 1981 Apr; 58(2):157-70.. View in PubMed
  • A distinctive perivenular hepatic lesion associated with heart failure. Am J Clin Pathol. 1980 Feb; 73(2):235-9.. View in PubMed
  • Enzyme changes and morphometric analysis of bile ducts in experimental bile duct obstruction. Clin Chim Acta. 1979 Dec 03; 99(2):113-9.. View in PubMed
  • Heart failure and the liver. Gastroenterology. 1978 Aug; 75(2):350.. View in PubMed
  • “Naturally-occurring” anti-K1: possible association with mycobacterium infection. Transfusion. 1978 Jul-Aug; 18(4):472-3.. View in PubMed
  • Survival in patients with postnecrotic cirrhosis and Laennec’s cirrhosis undergoing therapeutic portacaval shunt. Gastroenterology. 1977 Oct; 73(4 Pt 1):679-83.. View in PubMed

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