Georgina Gyarmati
Assistant Director of Confocal Microscopy Core
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Intravital imaging reveals glomerular capillary distension and endothelial and immune cell activation early in Alport syndrome JCI Insight. 2022 01 11; 7(1). . View in PubMed
The role of TRPC6 calcium channels and P2 purinergic receptors in podocyte mechanical and metabolic sensing Physiol Int. 2021 Dec 16. . View in PubMed
Serial intravital imaging captures dynamic and functional endothelial remodeling with single-cell resolution JCI Insight. 2021 05 24; 6(10). . View in PubMed
A new view of macula densa cell protein synthesis Am J Physiol Renal Physiol. 2021 12 01; 321(6):F689-F704. . View in PubMed
New Endothelial Mechanisms in Glomerular (Patho)biology and Proteinuria Development Captured by Intravital Multiphoton Imaging Front Med (Lausanne). 2021; 8:765356. . View in PubMed
A new view of macula densa cell microanatomy Am J Physiol Renal Physiol. 2021 03 01; 320(3):F492-F504. . View in PubMed
Renomedullary Interstitial Cell Endothelin A Receptors Regulate BP and Renal Function J Am Soc Nephrol. 2020 07; 31(7):1555-1568. . View in PubMed
Essential role and therapeutic targeting of the glomerular endothelial glycocalyx in lupus nephritis JCI Insight. 2020 10 02; 5(19). . View in PubMed
Novel fluorescence techniques to quantitate renal cell biology Methods Cell Biol. 2019; 154:85-107. . View in PubMed
Advances in Renal Cell Imaging Semin Nephrol. 2018 01; 38(1):52-62. . View in PubMed
The macula densa prorenin receptor is essential in renin release and blood pressure control Am J Physiol Renal Physiol. 2018 09 01; 315(3):F521-F534. . View in PubMed
Combined use of electron microscopy and intravital imaging captures morphological and functional features of podocyte detachment Pflugers Arch. 2017 Aug; 469(7-8):965-974. . View in PubMed
ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4 Circ Res. 2017 Apr 28; 120(9):1426-1439. . View in PubMed
Night shift work and stomach cancer risk in the MCC-Spain study Occup Environ Med. 2016 08; 73(8):520-7. . View in PubMed
[Utility of B-type natriuretic peptide in children] Orv Hetil. 2007 Feb 11; 148(6):265-70. . View in PubMed
[Quantification of right and left ventricular function with magnetic resonance imaging after Senning operation for complete transposition of the great arteries] Orv Hetil. 2006 Jan 29; 147(4):171-4. . View in PubMed
Dr. Gyarmati’s current research focuses on the characterization and human and preclinical therapeutic translation of a new vascular cell type that she discovered and named neuro-endothelial cell (NEC). This new line of research is consistent with her overall goal to develop new, highly effective, and mechanism-based therapeutic strategies for cardiovascular diseases by the discovery and targeting of novel cell and molecular targets.
Dr. Gyarmati’s main line of research as a postdoctoral fellow in the Peti-Peterdi laboratory identified new neuron-like structural and functional features of the macula densa, a niche of 20-25 MD cells in each nephron functioning as a ganglion-like mini-brain with somatosensory neuroepithelial and neuroendocrine functions. These results suggest that MD cells can sense, process, and communicate a variety of signals in the local and systemic environment to control key renal functions and provide renal sensory input to the central nervous system in a kidney-brain axis.
Dr. Gyarmati has made major contributions to the development of several applications of intravital imaging technology in the Multiphoton Microscopy Core of which she became Assistant Director in 2022. This state-of-the-art and high-power imaging technique allow to quantitatively visualize the most basic (patho)physiological parameters of several organs including the kidney, brain, liver, spleen, and skin.
