Georgina Gyarmati, MD, PhD

Assistant Professor of Research Physiology and Neuroscience

Assistant Director of Confocal Microscopy Core

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Overview

Dr. Georgina Gyarmati is an assistant professor of research at the Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California. She received her MD degree from Semmelweis University Medical School, Budapest, Hungary, and her Master of Public Health degree from Johns Hopkins University, Baltimore, US. She completed her postdoctoral training in renal physiology at the University of Southern California. She joined the faculty of USC Keck School of Medicine in 2022.
Dr. Gyarmati’s current research focuses on the characterization and human and preclinical therapeutic translation of a new vascular cell type that she discovered and named neuro-endothelial cell (NEC). This new line of research is consistent with her overall goal to develop new, highly effective, and mechanism-based therapeutic strategies for cardiovascular diseases by the discovery and targeting of novel cell and molecular targets.
Dr. Gyarmati’s main line of research as a postdoctoral fellow in the Peti-Peterdi laboratory identified new neuron-like structural and functional features of the macula densa, a niche of 20-25 MD cells in each nephron functioning as a ganglion-like mini-brain with somatosensory neuroepithelial and neuroendocrine functions. These results suggest that MD cells can sense, process, and communicate a variety of signals in the local and systemic environment to control key renal functions and provide renal sensory input to the central nervous system in a kidney-brain axis.
Dr. Gyarmati has made major contributions to the development of several applications of intravital imaging technology in the Multiphoton Microscopy Core of which she became Assistant Director in 2022. This state-of-the-art and high-power imaging technique allow to quantitatively visualize the most basic (patho)physiological parameters of several organs including the kidney, brain, liver, spleen, and skin.

Education and Training

  • Johns Hopkins University, Baltimore, US — MPH — 2017 — Public Health
  • Semmelweis University, Budapest, Hungary — MD — 2003 — Medicine

Publications

  • Pyridoxine supplementation amelioratesSGPL1 R222Q variant sphingosine phosphate lyase insufficiency syndrome in mice. J Clin Invest. 2026 Sep 24.. View in PubMed
  • Renin cells orchestrate a neuro-endocrine microenvironment of the kidney arterial tree in health and disease. JCI Insight. 2026 Jul 16.. View in PubMed
  • The non-steroidal mineralocorticoid receptor blocker esaxerenone reduces glomerular hyperfiltration and albuminuria. Nephrol Dial Transplant. 2026 May 29; 41(6):1069-1081.. View in PubMed
  • Pyridoxine supplementation confers protection against SGPL1R222Q variant sphingosine phosphate lyase insufficiency syndrome. bioRxiv. 2026 May 14.. View in PubMed
  • Reversal of advanced diabetic kidney disease in mice treated with a monoclonal anti-VEGFR1 antibody. Kidney Int. 2026 Jul; 110(1):99-114.. View in PubMed
  • Renal PIEZO2 is an essential regulator of renin. Cell. 2026 Jan 08; 189(1):161-178.e22.. View in PubMed
  • Are Mother Glomeruli in Good or Bad Company? Am J Kidney Dis. 2026 Feb; 87(2):275-277. Gyarmati G . View in PubMed
  • Soluble urokinase receptor is a kidney-specific vasoconstrictor. EBioMedicine. 2025 Nov; 121:106012.. View in PubMed
  • Spatially patterned kidney assembloids recapitulate progenitor self-assembly and enable high-fidelity in vivo disease modeling. Cell Stem Cell. 2025 Oct 02; 32(10):1614-1633.e13.. View in PubMed
  • Macula densa cell angiogenic mechanisms and their therapeutic potential in kidney disease. Front Bioeng Biotechnol. 2025; 13:1606230.. View in PubMed