Keck School Faculty

Gianluca Lazzi

Gianluca Lazzi

Provost Professor of Ophthalmology, Electrical Engineering, Clinical Entrepreneurship and Biomedical Engineering
Fred H. Cole Professorship in Engineering
Director, Institute for Technology and Medical Systems (ITEMS)
Director for Bioengineering Mentorship
Stevens Hall Institute Health Sciences Campus Los Angeles


AIMBE: Fellow, "Contributions to Bioelectromagnetics and Design of Bioelectrical Implantable Devices", 2015

R&D Magazine: R&D 100 Award and Editor's Choice Award, 2009

North Carolina State University: ALCOA Foundation Distinguished Engineering Research Achievement Award, 2009

IEEE: Fellow, "Contributions to Bioelectromagnetics and Implantable Devices", 2008

IEEE GLOBECOM: Best Paper Award, 2008

IEEE Trans.: IEEE H.A. Wheeler Award for best paper published, 2006

IEEE Trans.: IEEE H.A. Wheeler Award for the best paper published, 2005

North Carolina State University: Featured Achiever, College of Engineering, 2003

North Carolina State University: Alumni Outstanding Teacher Award, 2003

North Carolina State University: ALCOA Foundation Engineering Research Achievement Award, 2003

North Carolina State University: Outstanding Teacher Award, 2003

The Whitaker Foundation Biomedical Engineering Grant: Young Investigator Award, 2001

National Science Foundation: Career Award, 2001

Bioelectromagnetics Society: Curtis Carl Johnson Memorial Award, 1996

International Union of Radio Science: Young Investigator Award, 1996

Electrical Stimulation Induced Current Distribution in Peripheral Nerves Varies Significantly with the Extent of Nerve Damage: A Computational Study Utilizing Convolutional Neural Network and Realistic Nerve Models Int J Neural Syst. 2023 Apr; 33(4):2350022. . View in PubMed

Impact of Retinal Degeneration on Response of ON and OFF Cone Bipolar Cells to Electrical Stimulation IEEE Trans Neural Syst Rehabil Eng. 2023; 31:2424-2437. . View in PubMed

Computational optimization of delivery parameters to guide the development of targeted Nasal spray Sci Rep. 2023 03 12; 13(1):4099. . View in PubMed

The Influence of Electrode Properties on Induced Voltage Gradient Along the Rat Optic Nerve IEEE J Electromagn RF Microw Med Biol. 2022 Sep; 6(3):321-330. . View in PubMed

Selective Activation of Retinal Ganglion Cell Subtypes Through Targeted Electrical Stimulation Parameters IEEE Trans Neural Syst Rehabil Eng. 2022; 30:350-359. . View in PubMed

Publisher Correction: Color and cellular selectivity of retinal ganglion cell subtypes through frequency modulation of electrical stimulation Sci Rep. 2021 Jun 14; 11(1):12855. . View in PubMed

Electrode Spacing and Current Distribution in Electrical Stimulation of Peripheral Nerve: A Computational Modeling Study using Realistic Nerve Models Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:4416-4419. . View in PubMed

A Computational Model Simulates Light-Evoked Responses in the Retinal Cone Pathway Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:4482-4486. . View in PubMed

On the Design of an Efficient Inductive Wireless Power Transfer for Passive Neurostimulation Systems Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:7497-7501. . View in PubMed

Modeling ON Cone Bipolar Cells for Electrical Stimulation Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:6547-6550. . View in PubMed

Model-based comparison of current flow in rod bipolar cells of healthy and early-stage degenerated retina Exp Eye Res. 2021 06; 207:108554. . View in PubMed

Color and cellular selectivity of retinal ganglion cell subtypes through frequency modulation of electrical stimulation Sci Rep. 2021 03 04; 11(1):5177. . View in PubMed

Mechanisms underlying activation of retinal bipolar cells through targeted electrical stimulation: a computational study J Neural Eng. 2021 12 15; 18(6). . View in PubMed

Stimulus waveform design for decreasing charge and increasing stimulation selectivity in retinal prostheses Healthc Technol Lett. 2020 Jun; 7(3):66-71. . View in PubMed

Simulation-Based Optimization of Figure-of-Eight Coil Designs and Orientations for Magnetic Stimulation of Peripheral Nerve IEEE Trans Neural Syst Rehabil Eng. 2020 12; 28(12):2901-2913. . View in PubMed

Targeted Stimulation of Retinal Ganglion Cells in Epiretinal Prostheses: A Multiscale Computational Study IEEE Trans Neural Syst Rehabil Eng. 2020 11; 28(11):2548-2556. . View in PubMed

Responsiveness of Retinal Ganglion Cells Through Frequency Modulation of Electrical Stimulation: A Computational Modeling Study Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:3393-3398. . View in PubMed

Admittance Method for Estimating Local Field Potentials Generated in a Multi-Scale Neuron Model of the Hippocampus Front Comput Neurosci. 2020; 14:72. . View in PubMed

ROOTS: An Algorithm to Generate Biologically Realistic Cortical Axons and an Application to Electroceutical Modeling Front Comput Neurosci. 2020; 14:13. . View in PubMed

Selective stimulation of rat sciatic nerve using an array of mm-size magnetic coils: a simulation study Healthc Technol Lett. 2019 Jun; 6(3):70-75. . View in PubMed

Reduced Heat Generation During Magnetic Stimulation of Rat Sciatic Nerve Using Current Waveform Truncation IEEE Trans Neural Syst Rehabil Eng. 2019 05; 27(5):937-946. . View in PubMed

The Promise of Mobile Technologies for the Health Care System in the Developing World: A Systematic Review IEEE Rev Biomed Eng. 2019; 12:100-122. . View in PubMed

Model-Based Analysis of Electrode Placement and Pulse Amplitude for Hippocampal Stimulation IEEE Trans Biomed Eng. 2018 10; 65(10):2278-2289. . View in PubMed

Increasing Electrical Stimulation Efficacy in Degenerated Retina: Stimulus Waveform Design in a Multiscale Computational Model IEEE Trans Neural Syst Rehabil Eng. 2018 06; 26(6):1111-1120. . View in PubMed

A large-scale detailed neuronal model of electrical stimulation of the dentate gyrus and perforant path as a platform for electrode design and optimization Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug; 2016:2794-2797. . View in PubMed

Virtual electrode design for increasing spatial resolution in retinal prosthesis Healthc Technol Lett. 2016 Jun; 3(2):93-7. . View in PubMed

In Vivo Magnetic Stimulation of Rat Sciatic Nerve With Centimeter- and Millimeter-Scale Solenoid Coils IEEE Trans Neural Syst Rehabil Eng. 2016 11; 24(11):1138-1147. . View in PubMed

On the computation of a retina resistivity profile for applications in multi-scale modeling of electrical stimulation and absorption Phys Med Biol. 2016 06 21; 61(12):4491-505. . View in PubMed

A µm-Scale Computational Model of Magnetic Neural Stimulation in Multifascicular Peripheral Nerves IEEE Trans Biomed Eng. 2015 Dec; 62(12):2837-49. . View in PubMed

A 3-D admittance-level computational model of a rat hippocampus for improving prosthetic design Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:2295-8. . View in PubMed

Ferrite core non-linearity in coils for magnetic neurostimulation Healthc Technol Lett. 2014 Oct; 1(4):87-91. . View in PubMed

Magnetic stimulation of mammalian peripheral nerves in vivo: an alternative to functional electrical stimulation Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:2573-6. . View in PubMed

A multi-scale computational model for the study of retinal prosthetic stimulation Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:6100-3. . View in PubMed

Multi-coil approach to reduce electromagnetic energy absorption for wirelessly powered implants Healthc Technol Lett. 2014 Jan; 1(1):21-5. . View in PubMed

A µm-resolution heterogeneous tissue model for the magnetic stimulation of multifascicular sciatic nerve Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:5679-82. . View in PubMed

Grand challenges in interfacing engineering with life sciences and medicine IEEE Trans Biomed Eng. 2013 Mar; 60(3):589-98. . View in PubMed

On the design of efficient multi-coil telemetry system for biomedical implants IEEE Trans Biomed Circuits Syst. 2013 Feb; 7(1):11-23. . View in PubMed

Preservation of retinotopic map in retinal degeneration Exp Eye Res. 2012 May; 98:88-96. . View in PubMed

Modeling and percept of transcorneal electrical stimulation in humans IEEE Trans Biomed Eng. 2011 Jul; 58(7):1932-9. . View in PubMed

Modeling cellular lysis in skeletal muscle due to electric shock IEEE Trans Biomed Eng. 2011 May; 58(5):1286-93. . View in PubMed

Spatial characterization of electric potentials generated by pulsed microelectrode arrays Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:6243-6. . View in PubMed

On the thermal elevation of a 60-electrode epiretinal prosthesis for the blind IEEE Trans Biomed Circuits Syst. 2008 Dec; 2(4):289-300. . View in PubMed

Thermal effects of bioimplants IEEE Eng Med Biol Mag. 2005 Sep-Oct; 24(5):75-81. . View in PubMed

Thermal elevation in the human eye and head due to the operation of a retinal prosthesis IEEE Trans Biomed Eng. 2004 Aug; 51(8):1469-77. . View in PubMed

Two-dimensional SPICE-linked multiresolution impedance method for low-frequency electromagnetic interactions IEEE Trans Biomed Eng. 2003 Jul; 50(7):881-9. . View in PubMed

Retinal prosthesis for the blind Surv Ophthalmol. 2002 Jul-Aug; 47(4):335-56. . View in PubMed

Currents induced in anatomic models of the human for uniform and nonuniform power frequency magnetic fields Bioelectromagnetics. 2001 Feb; 22(2):112-21. . View in PubMed

Comparison of numerical and experimental methods for determination of SAR and radiation patterns of handheld wireless telephones Bioelectromagnetics. 1999; Suppl 4:93-101. . View in PubMed

Over the past 25 years, Gianluca Lazzi, PhD, has focused his research on biomedical electromagnetics, with particular interest to the application to wireless and biomedical devices. In the early stages of his career, he focused on understanding the interaction between electromagnetic fields and biological tissue, with particular interest in the potential hazards to the human body due to devices radiating or inducing electromagnetic fields in tissue. Lazzi's research contributed to define the computational methods that could be reliably used to assess the Specific Absorption Rate of power, or SAR, induced by wireless devices in the human body: this work directly impacted the acceptance of computational methods to demonstrate that wireless devices previously fulfilled IEEE safety standards prior to being marketed.

The computational and experimental methods that Lazzi and his team developed progressively shifted to be used for medical device applications, and in particular an artificial retina to restore partial vision to the blind and hippocampal prosthesis. Lazzi has also been recognized for multiscale computational methods to calculate the electromagnetic distribution in neural tissue for optimization of neurostimulators, human body models for the safety assessment of wireless biomedical devices, implantable microantennas for high-data rate wireless biomedical devices, novel coils for wireless telemetry systems, methods for the minimization of the temperature increase in the human body due to implantable devices, and methods to optimize electrode shape and size for neurosimulators. For nearly 20 years, Lazzi and his team have been part of a team dedicated to the development a retinal prosthesis to restore partial vision to the blind, in collaboration with the company Second Sight Medical Products, Inc. He also been part of an NSF supported Engineering Research Center (ERC) on Biomimetic Devices led by the University of Southern California. Lazzi's contributions in the field of implantable devices have been recognized with the election as AIMBE Fellow for “contributions to bioelectromagnetics and design of bioelectrical implantable devices,” election as a IEEE Fellow for “contributions to Bioelectromagnetics and implantable devices,” the IEEE Wheeler Best paper Award for a manuscript on the invention of microwave microantennas for implantable devices, and a R&D100 Award in 2009 for one of the 100 most significant inventions of 2009 (artificial retina). His team recently presented research on neuroprosthetics and multiscale modeling at the IEEE Grand Challenges in Life Science Symposium at the National Academies: parts of this inspired a position paper on the future grand challenges in life science published in IEEE Trans. on Biomedical Engineering, jointly prepared by all the presenters.
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