Giorgio Casaburi

Dr. Giorgio Casaburi is a bioinformatics scientist and translational genomics researcher specializing in artificial intelligence, multi-omics data integration, and precision medicine. His work focuses on developing clinically actionable molecular diagnostics and computational platforms that translate complex biological data into real-world healthcare applications.

Dr. Casaburi has over 15 years of experience leading genomics, transcriptomics, methylomics, metagenomics, and machine learning initiatives across academia, biotechnology, and regulated diagnostics environments. His research spans cancer biology, microbiome science, biomarker discovery, translational AI, and predictive modeling for therapeutic response and disease stratification.

He has led the development and validation of multiple AI-driven diagnostic and bioinformatics platforms, including CLIA-oriented molecular workflows and clinical decision-support systems. His work integrates next-generation sequencing, cloud-scale bioinformatics infrastructure, and machine learning approaches to accelerate translational research and precision oncology applications.

Prior to joining USC, Dr. Casaburi held leadership roles in biotechnology and molecular diagnostics organizations, including SOLVD Health, Exagen, Prescient Metabiomics, and Evolve Biosystems. He has authored more than 70 peer-reviewed publications, contributed to multiple patents in diagnostics and AI-enabled healthcare technologies, and has presented research at major international scientific conferences.

At USC, his academic interests include translational genomics, AI-driven biomedical research, computational oncology, and the application of machine learning to molecular diagnostics and precision medicine.

• Randomized, placebo-controlled trial reveals the impact of dose and timing of Bifidobacterium infantis probiotic supplementation on breastfed infants’ gut microbiome. mSphere. 2026 Jan 27; 11(1):e0051825.. View in PubMed
• Gut mucosa-associated microbiota signatures in healthy individuals and patients at different stages of liver disease: a pilot study. Gut Pathog. 2025 Dec 08; 17(1):99.. View in PubMed
• Establishing Best Practices for Clinical GWAS: Tackling Imputation and Data Quality Challenges. Int J Mol Sci. 2025 Jul 03; 26(13).. View in PubMed
• Metabolic model of necrotizing enterocolitis in the premature newborn gut resulting from enteric dysbiosis. Front Pediatr. 2022; 10:893059.. View in PubMed
• Bifidobacterium infantis treatment promotes weight gain in Bangladeshi infants with severe acute malnutrition. Sci Transl Med. 2022 04 13; 14(640):eabk1107.. View in PubMed
• Bifidobacterium longum Subspecies infantis Strain EVC001 Decreases Neonatal Murine Necrotizing Enterocolitis. Nutrients. 2022 Jan 24; 14(3).. View in PubMed
• Microbiome composition indicate dysbiosis and lower richness in tumor breast tissues compared to healthy adjacent paired tissue, within the same women. BMC Cancer. 2022 Jan 03; 22(1):30.. View in PubMed
• Multidisciplinary In-Depth Investigation in a Young Athlete Suffering from Syncope Caused by Myocardial Bridge. Diagnostics (Basel). 2021 Nov 19; 11(11).. View in PubMed
• Author Correction: Metagenomic insights of the infant microbiome community structure and function across multiple sites in the United States. Sci Rep. 2021 May 20; 11(1):11050.. View in PubMed
• Early probiotic supplementation with B. infantis in breastfed infants leads to persistent colonization at 1 year. Pediatr Res. 2022 02; 91(3):627-636.. View in PubMed
• Impact of Probiotic B. infantis EVC001 Feeding in Premature Infants on the Gut Microbiome, Nosocomially Acquired Antibiotic Resistance, and Enteric Inflammation. Front Pediatr. 2021; 9:618009.. View in PubMed
• Metagenomic insights of the infant microbiome community structure and function across multiple sites in the United States. Sci Rep. 2021 01 21; 11(1):1472.. View in PubMed
• Comparative Genome Analysis of Bifidobacterium longum subsp. infantis Strains Reveals Variation in Human Milk Oligosaccharide Utilization Genes among Commercial Probiotics. Nutrients. 2020 Oct 23; 12(11).. View in PubMed
• Digital Proxy of a Bio-Reactor (DIYBOT) combines sensor data and data analytics to improve greywater treatment and wastewater management systems. Sci Rep. 2020 05 15; 10(1):8015.. View in PubMed
• Integrating the Ecosystem Services Framework to Define Dysbiosis of the Breastfed Infant Gut: The Role of B. infantis and Human Milk Oligosaccharides. Front Nutr. 2020; 7:33.. View in PubMed
• Colonization Resistance in the Infant Gut: The Role of B. infantis in Reducing pH and Preventing Pathogen Growth. High Throughput. 2020 Mar 27; 9(2).. View in PubMed
• A common microbial signature is present in the lower airways of interstitial lung diseases including sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2018; 35(4):354-362.. View in PubMed
• Colonization by B. infantis EVC001 modulates enteric inflammation in exclusively breastfed infants. Pediatr Res. 2019 12; 86(6):749-757.. View in PubMed
• Early-life gut microbiome modulation reduces the abundance of antibiotic-resistant bacteria. Antimicrob Resist Infect Control. 2019; 8:131.. View in PubMed
• GenCoF: a graphical user interface to rapidly remove human genome contaminants from metagenomic datasets. Bioinformatics. 2019 07 01; 35(13):2318-2319.. View in PubMed
• Genomic evidence of the illumination response mechanism and evolutionary history of magnetotactic bacteria within the Rhodospirillaceae family. BMC Genomics. 2019 May 22; 20(1):407.. View in PubMed
• Symbiotic organs shaped by distinct modes of genome evolution in cephalopods. Proc Natl Acad Sci U S A. 2019 02 19; 116(8):3030-3035.. View in PubMed
• Reduced colonic mucin degradation in breastfed infants colonized by Bifidobacterium longum subsp. infantis EVC001. FEBS Open Bio. 2018 Oct; 8(10):1649-1657.. View in PubMed
• Oropharyngeal microbiome evaluation highlights Neisseria abundance in active celiac patients. Sci Rep. 2018 07 23; 8(1):11047.. View in PubMed
• Comparative Metagenomics Provides Insight Into the Ecosystem Functioning of the Shark Bay Stromatolites, Western Australia. Front Microbiol. 2018; 9:1359.. View in PubMed
• Elevated Fecal pH Indicates a Profound Change in the Breastfed Infant Gut Microbiome Due to Reduction of Bifidobacterium over the Past Century. mSphere. 2018 Mar-Apr; 3(2).. View in PubMed
• A year in the life of a thrombolite: comparative metatranscriptomics reveals dynamic metabolic changes over diel and seasonal cycles. Environ Microbiol. 2018 02; 20(2):842-861.. View in PubMed
• Persistence of Supplemented Bifidobacterium longum subsp. infantis EVC001 in Breastfed Infants. mSphere. 2017 Nov-Dec; 2(6).. View in PubMed
• A Study of the Microbial Spatial Heterogeneity of Bahamian Thrombolites Using Molecular, Biochemical, and Stable Isotope Analyses. Astrobiology. 2017 May; 17(5):413-430.. View in PubMed
• Transcriptomic changes in an animal-bacterial symbiosis under modeled microgravity conditions. Sci Rep. 2017 04 10; 7:46318.. View in PubMed
• The Cause of Death of a Child in the 18th Century Solved by Bone Microbiome Typing Using Laser Microdissection and Next Generation Sequencing. Int J Mol Sci. 2017 Jan 06; 18(1).. View in PubMed
• Corrigendum: No Change in the Mucosal Gut Microbiome is Associated with Celiac Disease-Specific Microbiome Alteration in Adult Patients. Am J Gastroenterol. 2017 01; 112(1):193.. View in PubMed
• No Change in the Mucosal Gut Mycobioma Is Associated with Celiac Disease-Specific Microbiome Alteration in Adult Patients. Am J Gastroenterol. 2016 11; 111(11):1659-1661.. View in PubMed
• Characterization of Microbial Mat Microbiomes in the Modern Thrombolite Ecosystem of Lake Clifton, Western Australia Using Shotgun Metagenomics. Front Microbiol. 2016; 7:1064.. View in PubMed
• Metagenomics Reveals Dysbiosis and a Potentially Pathogenic N. flavescens Strain in Duodenum of Adult Celiac Patients. Am J Gastroenterol. 2016 Jun; 111(6):879-90.. View in PubMed
• Characterization of the stromatolite microbiome from Little Darby Island, The Bahamas using predictive and whole shotgun metagenomic analysis. Environ Microbiol. 2016 05; 18(5):1452-69.. View in PubMed
• Comparative metagenomic analysis of human gut microbiome composition using two different bioinformatic pipelines. Biomed Res Int. 2014; 2014:325340.. View in PubMed
• The personal human oral microbiome obscures the effects of treatment on periodontal disease. PLoS One. 2014; 9(1):e86708.. View in PubMed
• An altered gut microbiome profile in a child affected by Crohn’s disease normalized after nutritional therapy. Am J Gastroenterol. 2013 May; 108(5):851-2.. View in PubMed

• Haiman, Christopher
• Goran, Michael
• Klausner, Jeffrey
• Peters, Anne
• Thomas, Paul
• Thompson, Paul