USC.edu
Are You a Patient?

Gutian Xiao

Professor of Molecular Microbiology and Immunology

Culture and Engagement Director

Image of Gutian Xiao
Is this your profile? Click to edit
Email Gutian.Xiao@med.usc.edu
CTSI Profile

Publications

  • NanoPDLIM2-Based Combination Therapy for Lung Cancer Treatment in Mouse Preclinical Studies. Bio Protoc. 2025 Sep 05; 15(17):e5437.. View in PubMed
  • Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2. Elife. 2024 Dec 24; 12.. View in PubMed
  • PDLIM2 is a novel E5 ubiquitin ligase enhancer that stabilizes ROC1 and recruits the ROC1-SCF ubiquitin ligase to ubiquitinate and degrade NF-κB RelA. Cell Biosci. 2024 Jul 30; 14(1):99.. View in PubMed
  • Critical and distinct roles of cell type-specific NF-κB2 in lung cancer. JCI Insight. 2024 02 22; 9(4).. View in PubMed
  • Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2. bioRxiv. 2024 Jan 09.. View in PubMed
  • Alveolar Macrophages Inherently Express Programmed Death-1 Ligand 1 for Optimal Protective Immunity and Tolerance. J Immunol. 2021 07 01; 207(1):110-114.. View in PubMed
  • Hydrogel-based electrodes for selective cervical vagus nerve stimulation. J Neural Eng. 2021 04 20; 18(5).. View in PubMed
  • PDLIM2 repression by ROS in alveolar macrophages promotes lung tumorigenesis. JCI Insight. 2021 03 08; 6(5).. View in PubMed
  • Methods to Detect NF-κB Activity in Tumor-Associated Macrophage (TAM) Populations. Methods Mol Biol. 2021; 2366:213-241.. View in PubMed
  • Dual but not single PD-1 or TIM-3 blockade enhances oncolytic virotherapy in refractory lung cancer. J Immunother Cancer. 2020 05; 8(1).. View in PubMed
  • Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance. Nat Commun. 2019 11 22; 10(1):5324.. View in PubMed
  • NF-κB RelA renders tumor-associated macrophages resistant to and capable of directly suppressing CD8+ T cells for tumor promotion. Oncoimmunology. 2018; 7(6):e1435250.. View in PubMed
  • Isolation of Murine Alveolar Type II Epithelial Cells. Bio Protoc. 2017 May 20; 7(10).. View in PubMed
  • Murine Bronchoalveolar Lavage. Bio Protoc. 2017 May 20; 7(10).. View in PubMed
  • Myeloid STAT3 Promotes Lung Tumorigenesis by Transforming Tumor Immunosurveillance into Tumor-Promoting Inflammation. Cancer Immunol Res. 2017 03; 5(3):257-268.. View in PubMed
  • Interleukin-6 Prevents the Initiation but Enhances the Progression of Lung Cancer. Cancer Res. 2015 Aug 15; 75(16):3209-15.. View in PubMed
  • Differential roles of STAT3 in the initiation and growth of lung cancer. Oncogene. 2015 Jul; 34(29):3804-3814.. View in PubMed
  • Systematic detection of noncanonical NF-κB activation. Methods Mol Biol. 2015; 1280:121-54.. View in PubMed
  • NF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination? Retrovirology. 2012 Sep 25; 9:78.. View in PubMed
  • PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease. Cell Biosci. 2012 Jun 25; 2(1):23.. View in PubMed
  • Angiopoietin-2, an angiogenic regulator, promotes initial growth and survival of breast cancer metastases to the lung through the integrin-linked kinase (ILK)-AKT-B cell lymphoma 2 (Bcl-2) pathway. J Biol Chem. 2011 Aug 19; 286(33):29249-29260.. View in PubMed
  • Human T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesis. Viruses. 2011 Jun; 3(6):714-49.. View in PubMed
  • The tumor suppressor gene WWOX links the canonical and noncanonical NF-κB pathways in HTLV-I Tax-mediated tumorigenesis. Blood. 2011 Feb 03; 117(5):1652-61.. View in PubMed
  • NF-κB and cancer: a paradigm of Yin-Yang. Am J Cancer Res. 2011; 1(2):192-221.. View in PubMed
  • Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer. J Biol Chem. 2010 Apr 16; 285(16):11786-92.. View in PubMed
  • DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target. Cancer Res. 2010 Mar 01; 70(5):1766-72.. View in PubMed
  • Human T-cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax. Neoplasia. 2009 Oct; 11(10):1036-41.. View in PubMed
  • PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation. Blood. 2009 Apr 30; 113(18):4370-80.. View in PubMed
  • SUMO1 modification of NF-kappaB2/p100 is essential for stimuli-induced p100 phosphorylation and processing. EMBO Rep. 2008 Sep; 9(9):885-90.. View in PubMed
  • Targeting autophagic regulation of NFkappaB in HTLV-I transformed cells by geldanamycin: implications for therapeutic interventions. Autophagy. 2007 Nov-Dec; 3(6):600-3.. View in PubMed
  • Hsp90 regulates processing of NF-kappa B2 p100 involving protection of NF-kappa B-inducing kinase (NIK) from autophagy-mediated degradation. Cell Res. 2007 Jun; 17(6):520-30.. View in PubMed
  • Autophagy and NF-kappaB: fight for fate. Cytokine Growth Factor Rev. 2007 Jun-Aug; 18(3-4):233-43.. View in PubMed
  • Endoproteolytic processing of C-terminally truncated NF-kappaB2 precursors at kappaB-containing promoters. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5324-9.. View in PubMed
  • Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IkappaB kinase (IKK). Cell Res. 2006 Nov; 16(11):895-901.. View in PubMed
  • Alternative pathways of NF-kappaB activation: a double-edged sword in health and disease. Cytokine Growth Factor Rev. 2006 Aug; 17(4):281-93.. View in PubMed
  • Stabilization of basally translated NF-kappaB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-kappaB2 p100. J Biol Chem. 2005 Dec 09; 280(49):40578-82.. View in PubMed
  • Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100. J Biol Chem. 2005 Mar 18; 280(11):9765-8.. View in PubMed
  • Regulation of NF-kappa B2 p100 processing by its cis-acting domain. J Biol Chem. 2005 Jan 07; 280(1):18-27.. View in PubMed
  • Tax deregulation of NF-kappaB2 p100 processing involves both beta-TrCP-dependent and -independent mechanisms. J Biol Chem. 2004 Oct 22; 279(43):44563-72.. View in PubMed
  • Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation. J Biol Chem. 2004 Jul 16; 279(29):30099-105.. View in PubMed

Similar People