Keck School Faculty

Guy A. Young, MD
Guy A. Young, MD
Professor of Pediatrics (Clinical Scholar)
CHL Mail Stop 54 Off Campus Los Angeles
Following medical school, I completed my residency in pediatrics at Schneider Children's Hospital-Long Island Jewish Medical Center which is part of the Albert Einstein College of Medicine. I then completed a fellowship in pediatric hematology/oncology at Children's National Medical Center in Washington, DC which is part of the George Washington University School of Medicine. I then began my research career at the Children's Hospital of Orange County under the mentorship of Dr. Diane Nugent. There, I became interested in improving the treatment for patients with hemophilia and inhibitors and for children with blood clots. I received my first independent grants there inculding a grant from the FDA to study a new anticoagulant in children. In addition, I became interested in thromboelastography. In 2007, I moved the Children's Hospital Los Angeles where I am continuing to perform research in the same areas as I had started in Orange County.

National Hemophilia Foundation: Physician of the Year, 2013

Laboratory assay measurement of modified clotting factor concentrates: a review of the literature and recommendations for practice J Thromb Haemost. 2019 Apr; 17(4):567-573. . View in PubMed

Anticoagulation Therapies in Children Pediatr Clin North Am. 2017 12; 64(6):1257-1269. . View in PubMed

Anticoagulation in children: Making the most of little patients and little evidence Blood Cells Mol Dis. 2017 09; 67:48-53. . View in PubMed

Nonacog beta pegol (N9-GP) in haemophilia B: A multinational phase III safety and efficacy extension trial (paradigm™4) Thromb Res. 2016 May; 141:69-76. . View in PubMed

Evaluation of algorithms for the treatment of problem bleeding episodes in patients with hemophilia having inhibitors Clin Appl Thromb Hemost. 2015 Jan; 21(1):10-8. . View in PubMed

Thrombin generation and whole blood viscoelastic assays in the management of hemophilia: current state of art and future perspectives Blood. 2013 Mar 14; 121(11):1944-50. . View in PubMed

PRO-PACT: retrospective observational study on the prophylactic use of recombinant factor VIIa in hemophilia patients with inhibitors Thromb Res. 2012 Dec; 130(6):864-70. . View in PubMed

Dosing and effectiveness of recombinant activated factor VII (rFVIIA) in congenital haemophilia with inhibitors by bleed type and location: the experience of the Haemophilia and Thrombosis Research Society (HTRS) Registry (2004-2008) Haemophilia. 2012 Nov; 18(6):990-6. . View in PubMed

From boy to man: recommendations for the transition process in haemophilia Haemophilia. 2012 Jul; 18 Suppl 5:27-32. . View in PubMed

Patient/caregiver-reported recombinant factor VIIa (rFVIIa) dosing: home treatment of acute bleeds in the Dosing Observational Study in Hemophilia (DOSE) Haemophilia. 2012 May; 18(3):392-9. . View in PubMed

New challenges in hemophilia: long-term outcomes and complications Hematology Am Soc Hematol Educ Program. 2012; 2012:362-8. . View in PubMed

Old and new antithrombotic drugs in neonates and infants Semin Fetal Neonatal Med. 2011 Dec; 16(6):349-54. . View in PubMed

FondaKIDS: a prospective pharmacokinetic and safety study of fondaparinux in children between 1 and 18 years of age Pediatr Blood Cancer. 2011 Dec 01; 57(6):1049-54. . View in PubMed

When should prophylaxis therapy in inhibitor patients be considered? Haemophilia. 2011 Sep; 17(5):e849-57.. View in PubMed

Argatroban therapy in pediatric patients requiring nonheparin anticoagulation: an open-label, safety, efficacy, and pharmacokinetic study Pediatr Blood Cancer. 2011 Jul 01; 56(7):1103-9. . View in PubMed

New anticoagulants in children: a review of recent studies and a look to the future Thromb Res. 2011 Feb; 127(2):70-4. . View in PubMed

Transitioning issues in adolescent to young adult hemophilia patients with inhibitors: an approach for a growing population Blood Coagul Fibrinolysis. 2010 Sep; 21 Suppl 1:S7-10. . View in PubMed

Comparison of kaolin and tissue factor activated thromboelastography in haemophilia Haemophilia. 2010 May; 16(3):518-24. . View in PubMed

Off-label use of rFVIIa in children with excessive bleeding: a consecutive study of 153 off-label uses in 139 children Pediatr Blood Cancer. 2009 Aug; 53(2):179-83. . View in PubMed

Evaluation of thromboelastography for monitoring recombinant activated factor VII ex vivo in haemophilia A and B patients with inhibitors: a multicentre trial Blood Coagul Fibrinolysis. 2008 Jun; 19(4):276-82. . View in PubMed

Single 270 microg kg(-1)-dose rFVIIa vsstandard 90 microg kg(-1)-dose rFVIIa and APCC for home treatment of joint bleeds in haemophilia patients with inhibitors: a randomized comparison. Haemophilia. 2008 Mar; 14(2):287-94. . View in PubMed

New anticoagulants in children Hematology Am Soc Hematol Educ Program. 2008; 245-50. . View in PubMed

Recombinant activated factor VII effectively reverses the anticoagulant effects of heparin, enoxaparin, fondaparinux, argatroban, and bivalirudin ex vivo as measured using thromboelastography Blood Coagul Fibrinolysis. 2007 Sep; 18(6):547-53. . View in PubMed

Pilot dose-finding and safety study of bivalirudin in infants <6 months of age with thrombosis J Thromb Haemost. 2007 Aug; 5(8):1654-9. . View in PubMed

Safety and efficacy of enzyme replacement therapy in combination with hematopoietic stem cell transplantation in Hurler syndrome Genet Med. 2005 Feb; 7(2):143-6. . View in PubMed

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