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Hidekazu Tsukamoto, PhD

Professor of Pathology

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Phone +1 323 442 5107
Email [email protected]
CTSI Profile

Research Funding

  • "CYP1B1+PRRX1+NR4A2+ hepatic stellate cells in alcohol-associated hepatitis"
    NIH · R01AA031670 · Aug 20, 2024 – Jun 30, 2029 · Role: Principal Investigator
  • Hepatocyte-derived extracellular vesicles in alcoholic liver disease
    NIH · R01AA028134 · Jul 1, 2020 – Mar 31, 2025 · Role: Co-Principal Investigator
  • Immunosuppressive mechanisms responsible for development of non-viral liver cancer and control of its response to immune checkpoint inhibitors
    NIH · U01AA027681 · Sep 25, 2018 – Aug 31, 2023 · Role: Co-Principal Investigator
  • BLR&D Research Career Scientist Award Application
    NIH · IK6BX004205 · Apr 1, 2018 – Mar 31, 2030 · Role: Principal Investigator
  • Molecular Mechanisms of Stellate Cell Activation in Liver Fibrosis
    NIH · I01BX001991 · Oct 1, 2013 – Sep 30, 2026 · Role: Principal Investigator
  • The dynamics and mechanisms of autophagy in ethanol – induced liver pathogenesis
    NIH · R01AA021751 · Aug 15, 2013 – Jul 31, 2019 · Role: Co-Principal Investigator
  • International Symposium of ALPD and Cirrhosis
    NIH · R13AA020691 · Aug 5, 2011 – Jul 31, 2021 · Role: Principal Investigator
  • Epigenetic Regulation of Alcoholic Liver Fibrosis
    NIH · U01AA018663 · Sep 1, 2010 – Aug 31, 2021 · Role: Principal Investigator
  • 15th International Symposium on Cells of the Hepatic Sinusoid
    NIH · R13AA019890 · Jul 1, 2010 – Jun 30, 2011 · Role: Principal Investigator
  • TLR4 and TGF-beta interactions in HCC induced by HCV and alcohol
    NIH · RC2AA019392 · Sep 30, 2009 – Aug 31, 2012 · Role: Principal Investigator
  • Epigenetic mechanism of HSC transdifferentiation in alcoholic liver fibrosis
    NIH · R21AA016682 · Sep 30, 2006 – Aug 31, 2009 · Role: Principal Investigator
  • Iron Signaling/Monocytes/Alcoholic Hepatitis Patients
    NIH · R21AA015162 · Sep 10, 2004 – Aug 31, 2007 · Role: Principal Investigator
  • Integrative Liver Cell Core
    NIH · R24AA012885 · Jun 1, 2001 – May 31, 2026 · Role: Principal Investigator
  • NON-PARENCHYMAL LIVER CELL CORE
    NIH · R01AA012885 · Jun 1, 2001 – May 31, 2006 · Role: Principal Investigator
  • Training Program in Alcoholic Liver&Pancreatic Diseases
    NIH · T32AA007578 · May 1, 2000 – Apr 30, 2011 · Role: Principal Investigator
  • Southern California Research Center for ALPD and Cirrhosis
    NIH · P50AA011999 · Dec 31, 1998 – Apr 30, 2029 · Role: Principal Investigator
  • PATHOGENESIS OF ALCOHOL LIVER INJURY
    NIH · R37AA006603 · Sep 1, 1991 – Nov 30, 2004 · Role: Principal Investigator
  • PATHOGENESIS OF ALCOHOL LIVER INJURY
    NIH · R01AA006603 · Jun 1, 1984 – Nov 30, 1998 · Role: Principal Investigator

Publications

  • Characterizing Kupffer Cell Production of CD5 Antigen-Like and Its Function on Regulating Migration of Natural Killer T Cells. Am J Pathol. 2025 10; 195(10):1839-1853.. View in PubMed
  • Retraction: C-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair. Hepatology. 2025 06 01; 81(6):E181.. View in PubMed
  • Activation of intestinal endogenous retroviruses by alcohol exacerbates liver disease. J Clin Invest. 2025 Jul 01; 135(13).. View in PubMed
  • Retraction Notice to: LIN28 and histone H3K4 methylase induce TLR4 to generate tumor-initiating stem-like cells. iScience. 2025 Mar 21; 28(3):112032.. View in PubMed
  • Retraction Notice to: Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal. iScience. 2024 Dec 20; 27(12):111489.. View in PubMed
  • Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells. J Clin Invest. 2024 10 01; 134(19).. View in PubMed
  • Author Correction: NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells. Exp Mol Med. 2024 Oct; 56(10):2323.. View in PubMed
  • NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells. Exp Mol Med. 2024 02; 56(2):461-477.. View in PubMed
  • The mitochondrial biliverdin exporter ABCB10 in hepatocytes mitigates neutrophilic inflammation in alcoholic hepatitis. Redox Biol. 2024 04; 70:103052.. View in PubMed
  • Protocol for generation of humanized HCC mouse model and cancer-driver mutations using CRISPR-Cas9. STAR Protoc. 2023 12 15; 4(4):102389.. View in PubMed

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