Keck School Faculty

Ho Sung Kim
Ho Sung Kim
Assistant Professor of Neurology
Neurology
SHN, 2025 Zonal Ave. Health Sciences Campus Los Angeles
My research spans an interdisciplinary cross-section of Medical Image Processing, Machine learning, and Neuroscience covering clinical neurology and neuropsychiatry. In the fields of medical image processing and analysis, I have studied on multicontrast image registration and segmentation, surface modeling of cortical/subcortical structures which are the prerequisite techniques to proceed the analysis of structural and functional brain imaging studies.
My projects that have been recently launched at USC-INI and USC-LONI include mainly three domains of the research field: 1) Prediction of neurodevelopmental outcome in neonates with various clinical conditions such as preterm birth, hypoxia-ischemia, and congenital heart disease: This project expands in line with my team's expertise in neurodevelopment, neuroimaging, computational imaging feature modeling and machine learning (particularly DEEP learning); 2) Neuroimaging data quality controls (image QC): My team dedicates its efforts to implementation of online-based LONI-QC system that allows the public to evaluate their own data as well as to automated QC feature that will ultimately predict the accuracy of brain image post-processing and the sensitivity in the subsequently biological/clinical analysis to given target pathophysiology, and 3) Prediction of brain age and accelerated aging due to neurodegeneration: combination of brain imaging data and covolutional neural network-based deep-learning can estimate the brain age for individual images. extending this model with a statistical hazard model, we aim to determine risk scores for aging subjects who potentially develop a neurodegenerative disease.
In other clinical/neuroscientific applications, my team has applied various advanced analytic frameworks, including cortical morphometry, voxel-based morphometry, deformation-based morphometry and structural network analysis, to the assessment of brain structure in healthy conditions as well as pathological conditions, which often present anatomical variations beyond the range of normal structures.
My team continues to expand aforementioned techniques to the analysis of BIG DATA of brain imaging data to better understand mechanisms involved in various diseases and disorders such as stroke, epilepsy, dementia, sleep disorders, as well as long-term deafness and sudden hearing loss.

Baxter Foundation: Donald E. and Delia B. Baxter Foundation Faculty Fellowship Award, 2017-2018

ISMRM 24th Annual Meeting & Exhibition: Young Investigator / Trainee Stipends Award, 2016

Canadian Institutes of Health Research: Banting Postdoctoral Fellowships, 2015-2017

Fonds de la recherche en sante/ Health Research Funds in Quebec (FRSQ): Post-doctoral fellowship, 2014-2016

Sleep: Sleep Research Society Abstract Excellence Award, 2013

10th Annual Meeting of Korean Sleep Research Society: Best Poster presentation award, 2013

American Epilepsy Society (AES 2011): Young Investigator Travel Award , 2011

International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2011): Student Travel Award, 2011

American Epilepsy Society (AES 2010): Young Investigator Travel Award , 2010

Fonds de la recherche en santé / Health Research Funds in Quebec (FRSQ) : Doctoral Training Awards , 2009-2010

McGill University: Fellowship for returning graduate students , 2007

Hanyang University: Excellent Student Scholarship , 1998-2000

The association between cardiac physiology, acquired brain injury, and postnatal brain growth in critical congenital heart diseaseJ Thorac Cardiovasc Surg. 2018 01; 155(1):291-300. e3. . View in PubMed

Medical Imaging with Deep Learning (MIDL 2018) Retrospective correction of motion artifact affected structural MRI images using deep learning of simulated motion. 2018; (accepted). . View in PubMed

Quantitative surface analysis of combined MRI and PET enhances detection of focal cortical dysplasias Neuroimage. 2018 02 01; 166:10-18. . View in PubMed

Surface-based morphometry reveals caudate subnuclear structural damage in patients with premotor Huntington disease Brain Imaging Behav. 2017 Oct; 11(5):1365-1372. . View in PubMed

Egocentric and allocentric visuospatial working memory in premotor Huntington's disease: A double dissociation with caudate and hippocampal volumes Neuropsychologia. 2017 Jul 01; 101:57-64. . View in PubMed

Microstructure of the Default Mode Network in Preterm Infants AJNR Am J Neuroradiol. 2017 Feb; 38(2):343-348. . View in PubMed

Surface–wise texture patch analysis of combined MRi andPET to detect MRI-negative focal cortical dysplasiasMed. Image. Comp. Comp. Assist. Interv. 2017; 10433:212-220. . View in PubMed

Early changes in brain structure correlate with language outcomes in children with neonatal encephalopathy Neuroimage Clin. 2017; 15:572-580. . View in PubMed

Semi-automated Robust Quantification of Lesions (SRQL) Toolbox Research Ideas and Outcomes. 2017; 3:e13395. . View in PubMed

Extensive migration of young neurons into the infant human frontal lobe Science. 2016 Oct 07; 354(6308). . View in PubMed

NEOCIVET: Towards accurate morphometry of neonatal gyrification and clinical applications in preterm newborns Neuroimage. 2016 Sep; 138:28-42. . View in PubMed

Hindbrain regional growth in preterm newborns and its impairment in relation to brain injury Hum Brain Mapp. 2016 Feb; 37(2):678-88. . View in PubMed

Morphological alterations in amygdalo-hippocampal substructures in narcolepsy patients with cataplexy Brain Imaging Behav. 2016 12; 10(4):984-994. . View in PubMed

Cortical Thinning and Altered Cortico-Cortical Structural Covariance of the Default Mode Network in Patients with Persistent Insomnia Symptoms Sleep. 2016 Jan 01; 39(1):161-71. . View in PubMed

Effects of long-term treatment on brain volume in patients with obstructive sleep apnea syndrome Hum Brain Mapp. 2016 Jan; 37(1):395-409. . View in PubMed

Pyruvate to Lactate Metabolic Changes during Neurodevelopment Measured Dynamically Using Hyperpolarized 13C Imaging in Juvenile Murine Brain Dev Neurosci. 2016; 38(1):34-40. . View in PubMed

Multi-template Mesiotemporal Lobe Segmentation: Effects of Surface and Volume Feature Modeling Neuroinformatics. 2016; in revision. . View in PubMed

Brain Injury in the Preterm and Term Neonate Current Radiology Reports. 2016; 4(39). . View in PubMed

A Surface Patch-Based Segmentation Method for Hippocampal Subfields Medical Image Computing and Computer-Assisted Intervention – MICCAI 2016. 2016; 9901. . View in PubMed

Accurate cortical tissue classification on MRI by modeling cortical folding patterns Hum Brain Mapp. 2015 Sep; 36(9):3563-74. . View in PubMed

NEOCIVET: Extraction of cortical surface and analysis of neonatal gyrification using a modified CIVET pipeline Medical Image Computing and Computer-Assisted Intervention. 2015; 9351:571-9. . View in PubMed

Automated detection of cortical dysplasia type II in MRI-negative epilepsy Neurology. 2014 Jul 01; 83(1):48-55. . View in PubMed

Hippocampal substructural vulnerability to sleep disturbance and cognitive impairment in patients with chronic primary insomnia: magnetic resonance imaging morphometry Sleep. 2014 Jul 01; 37(7):1189-98. . View in PubMed

Multivariate hippocampal subfield analysis of local MRI intensity and volume: application to temporal lobe epilepsy Med Image Comput Comput Assist Interv. 2014; 17(Pt 2):170-8. . View in PubMed

Patterns of subregional mesiotemporal disease progression in temporal lobe epilepsy Neurology. 2013 Nov 19; 81(21):1840-7. . View in PubMed

Disentangling hippocampal shape anomalies in epilepsy Front Neurol. 2013; 4:131. . View in PubMed

Surface-based multi-template automated hippocampal segmentation: application to temporal lobe epilepsy Med Image Anal. 2012 Oct; 16(7):1445-55. . View in PubMed

Spatial patterns of water diffusion along white matter tracts in temporal lobe epilepsy Neurology. 2012 Jul 31; 79(5):455-62. . View in PubMed

Automatic hippocampal segmentation in temporal lobe epilepsy: impact of developmental abnormalities Neuroimage. 2012 Feb 15; 59(4):3178-86. . View in PubMed

Mapping thalamocortical network pathology in temporal lobe epilepsy Neurology. 2012 Jan 10; 78(2):129-36. . View in PubMed

Increased temporolimbic cortical folding complexity in temporal lobe epilepsy Neurology. 2011 Jan 11; 76(2):138-44. . View in PubMed

Vertex-wise shape analysis of the hippocampus: disentangling positional differences from volume changes Med Image Comput Comput Assist Interv. 2011; 14(Pt 2):352-9. . View in PubMed

Robust surface-based multi-template automated algorithm to segment healthy and pathological hippocampi Med Image Comput Comput Assist Interv. 2011; 14(Pt 3):445-53. . View in PubMed

Multidimensional classification of hippocampal shape features discriminates Alzheimer's disease and mild cognitive impairment from normal aging Neuroimage. 2009 Oct 01; 47(4):1476-86. . View in PubMed

Longitudinal and cross-sectional analysis of atrophy in pharmacoresistant temporal lobe epilepsy Neurology. 2009 May 19; 72(20):1747-54. . View in PubMed

Temporal lobe epilepsy: differential pattern of damage in temporopolar cortex and white matter Hum Brain Mapp. 2008 Aug; 29(8):931-44. . View in PubMed

Basal temporal sulcal morphology in healthy controls and patients with temporal lobe epilepsy Neurology. 2008 May 27; 70(22 Pt 2):2159-65. . View in PubMed

Surface-based vector analysis using heat equation interpolation: a new approach to quantify local hippocampal volume changes Med Image Comput Comput Assist Interv. 2008; 11(Pt 1):1008-15. . View in PubMed

Clinical experience with zonisamide monotherapy and adjunctive therapy in children with epilepsy at a tertiary care referral center J Child Neurol. 2005 Mar; 20(3):212-9. . View in PubMed

Magnetoencephalography (MEG) and magnetic source imaging (MSI) Neurologist. 2004 May; 10(3):138-53. . View in PubMed

Multimodality neuroimaging evaluation improves the detection of subtle cortical dysplasia in seizure patients Neurol Res. 2003 Jan; 25(1):53-7. . View in PubMed

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