Houda Alachkar

Associate Professor of Clinical Pharmacy

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Publications

  • Differences in the mutational landscape of clonal hematopoiesis of indeterminate potential among Races and between Male and Female patients with cancer Exp Hematol. 2024 Jul 03; 104271. . View in PubMed
  • The DNA methylation landscape across the TCR loci in patients with acute myeloid leukemia Int Immunopharmacol. 2024 Jun 24; 138:112376. . View in PubMed
  • A rigorous benchmarking of alignment-based HLA typing algorithms for RNA-seq data bioRxiv. 2024 Jan 16. . View in PubMed
  • Deletion of CD36 exhibits limited impact on normal hematopoiesis and the leukemia microenvironment Cell Mol Biol Lett. 2023 May 24; 28(1):45. . View in PubMed
  • Genomics and transcriptomic alterations of the glutamate receptors in acute myeloid leukemia Clin Transl Sci. 2023 10; 16(10):1828-1841. . View in PubMed
  • Profiling the epigenetic landscape of the antigen receptor repertoire: the missing epi-immunogenomics data Nat Methods. 2023 04; 20(4):477-481. . View in PubMed
  • Features of the TCR repertoire associate with patients’ clinical and molecular characteristics in acute myeloid leukemia Front Immunol. 2023; 14:1236514. . View in PubMed
  • Response to ‘comment on rigorous benchmarking of T cell receptor repertoire profiling methods for cancer RNA sequencing’ by Davydov AN. ; Bolotin D. A. ; Poslavsky S. V. and Chudakov D. M. Brief Bioinform. 2023 09 22; 24(6). . View in PubMed
  • Rigorous benchmarking of T-cell receptor repertoire profiling methods for cancer RNA sequencing Brief Bioinform. 2023 07 20; 24(4). . View in PubMed
  • Asparaginase toxicity in Hispanic adult and pediatric patients with acute lymphoblastic leukemia: current understanding Expert Opin Drug Metab Toxicol. 2023 Jan-Jun; 19(6):357-366. . View in PubMed
  • Prediction of Peptide and TCR CDR3 Loops in Formation of Class I MHC-Peptide-TCR Complexes Using Molecular Models with Solvation Methods Mol Biol. 2023; 2673:273-287. . View in PubMed
  • Hispanic ethnicity and the rs4880 variant in SOD2 are associated with elevated liver enzymes and bilirubin levels in children receiving asparaginase-containing chemotherapy for acute lymphoblastic leukemia Biomed Pharmacother. 2022 Jun; 150:113000. . View in PubMed
  • CD99 in malignant hematopoiesis Exp Hematol. 2022 02; 106:40-46. . View in PubMed
  • pyTCR: A comprehensive and scalable solution for TCR-Seq data analysis to facilitate reproducibility and rigor of immunogenomics research Front Immunol. 2022; 13:954078. . View in PubMed
  • Strategies targeting FLT3 beyond the kinase inhibitors Pharmacol Ther. 2021 09; 225:107844. . View in PubMed
  • Profiling of T Cell Repertoire in SARS-CoV-2-Infected COVID-19 Patients Between Mild Disease and Pneumonia J Clin Immunol. 2021 08; 41(6):1131-1145. . View in PubMed
  • Deregulation of apolipoprotein C2 gene in cancer: A potential metabolic vulnerability Clin Transl Med. 2021 06; 11(6):e406. . View in PubMed
  • Diversity in immunogenomics: the value and the challenge Nat Methods. 2021 06; 18(6):588-591. . View in PubMed
  • Ancestral diversity is limited in published T cell receptor sequencing studies Immunity. 2021 10 12; 54(10):2177-2179. . View in PubMed
  • OTS167 blocks FLT3 translation and synergizes with FLT3 inhibitors in FLT3 mutant acute myeloid leukemia Blood Cancer J. 2021 03 03; 11(3):48. . View in PubMed
  • Anti-CD99 scFv-ELP nanoworms for the treatment of acute myeloid leukemia Nanomedicine. 2020 10; 29:102236. . View in PubMed
  • Apolipoprotein C2 – CD36 Promotes Leukemia Growth and Presents a Targetable Axis in Acute Myeloid Leukemia Blood Cancer Discov. 2020 09; 1(2):198-213. . View in PubMed
  • Deciphering the TCR Repertoire to Solve the COVID-19 Mystery Trends Pharmacol Sci. 2020 08; 41(8):518-530. . View in PubMed
  • Clinical and preclinical characterization of CD99 isoforms in acute myeloid leukemia Haematologica. 2020 04; 105(4):999-1012. . View in PubMed
  • Anti-FLT3 nanoparticles for acute myeloid leukemia: Preclinical pharmacology and pharmacokinetics J Control Release. 2020 08 10; 324:317-329. . View in PubMed
  • Human Granulocyte-Macrophage Colony-Stimulating Factor Fused to Elastin-Like Polypeptides Assembles Biologically-Active Nanoparticles Bioconjug Chem. 2020 05 20; 31(5):1551-1561. . View in PubMed
  • The mitochondrial transcription machinery genes are upregulated in acute myeloid leukemia and associated with poor clinical outcome Metabol Open. 2019 Jun; 2:100009. . View in PubMed
  • Characterization of upregulated adhesion GPCRs in acute myeloid leukemia Transl Res. 2019 10; 212:26-35. . View in PubMed
  • CD97 expression is associated with poor overall survival in acute myeloid leukemiaExp Hematol. 2019 07; 75:64-73. e4. . View in PubMed
  • Clinical and laboratory features of seventy-eight UK patients with Good’s syndrome (thymoma and hypogammaglobulinaemia) Clin Exp Immunol. 2019 01; 195(1):132-138. . View in PubMed
  • The era of immunogenomics/immunopharmacogenomics J Hum Genet. 2018 Jul; 63(8):865-875. . View in PubMed
  • The United Kingdom Primary Immune Deficiency (UKPID) registry 2012 to 2017 Clin Exp Immunol. 2018 06; 192(3):284-291. . View in PubMed
  • Midostaurin reduces Regulatory T cells markers in Acute Myeloid Leukemia Sci Rep. 2018 12 03; 8(1):17544. . View in PubMed
  • Characterization of Mutations in the Mitochondrial Encoded Electron Transport Chain Complexes in Acute Myeloid Leukemia Sci Rep. 2018 09 05; 8(1):13301. . View in PubMed
  • Upregulation of the EMT marker vimentin is associated with poor clinical outcome in acute myeloid leukemia J Transl Med. 2018 06 20; 16(1):170. . View in PubMed
  • Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia Pharmacogenomics J. 2017 06; 17(3):274-279. . View in PubMed
  • Quantitative characterization of T-cell repertoire and biomarkers in kidney transplant rejection BMC Nephrol. 2016 11 21; 17(1):181. . View in PubMed
  • SUV420H1 enhances the phosphorylation and transcription of ERK1 in cancer cells Oncotarget. 2015 Dec 22; 6(41):43162-71. . View in PubMed
  • T-LAK cell-originated protein kinase presents a novel therapeutic target in FLT3-ITD mutated acute myeloid leukemia Oncotarget. 2015 Oct 20; 6(32):33410-25. . View in PubMed
  • Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia Leukemia. 2015 Oct; 29(10):1981-92. . View in PubMed
  • Targeting Suppressor of Variegation 3-9 Homologue 2 (SUV39H2) in Acute Lymphoblastic Leukemia (ALL) Transl Oncol. 2015 Oct; 8(5):368-375. . View in PubMed
  • Quantitative characterization of T-cell repertoire in allogeneic hematopoietic stem cell transplant recipients Bone Marrow Transplant. 2015 Sep; 50(9):1227-34. . View in PubMed
  • Deep-sequencing of the T-cell receptor repertoire in patients with haplo-cord and matched-donor transplants Chimerism. 2015 Jul 03; 6(3):47-9. . View in PubMed
  • WHSC1 promotes oncogenesis through regulation of NIMA-related kinase-7 in squamous cell carcinoma of the head and neck Mol Cancer Res. 2015 Feb; 13(2):293-304. . View in PubMed
  • Spectrum and management of complement immunodeficiencies (excluding hereditary angioedema) across Europe J Clin Immunol. 2015 Feb; 35(2):199-205. . View in PubMed
  • Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia Oncotarget. 2014 Dec 15; 5(23):12371-82. . View in PubMed
  • TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis Sci Transl Med. 2014 Oct 22; 6(259):259ra145. . View in PubMed
  • SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome J Clin Invest. 2014 Apr; 124(4):1512-24. . View in PubMed
  • The United Kingdom Primary Immune Deficiency (UKPID) Registry: report of the first 4 years’ activity 2008-2012 Clin Exp Immunol. 2014 Jan; 175(1):68-78. . View in PubMed
  • A UK national audit of hereditary and acquired angioedema Clin Exp Immunol. 2014 Jan; 175(1):59-67. . View in PubMed
  • Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia J Hematol Oncol. 2013 Mar 16; 6:21. . View in PubMed
  • Lenalidomide-mediated enhanced translation of C/EBPa-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia Blood. 2013 Jan 03; 121(1):159-69. . View in PubMed
  • Determination of cellular uptake and intracellular levels of Cenersen (Aezea(®), EL625), a p53 antisense oligonucleotide in acute myeloid leukemia cells J Pharm Biomed Anal. 2012 Dec; 71:228-32. . View in PubMed
  • Nicotinic a5 receptor subunit mRNA expression is associated with distant 5′ upstream polymorphisms Eur J Hum Genet. 2011 Jan; 19(1):76-83. . View in PubMed
  • Allelic mRNA expression of sortilin-1 (SORL1) mRNA in Alzheimer’s autopsy brain tissues Neurosci Lett. 2008 Dec 19; 448(1):120-4. . View in PubMed
  • Skin penetration and lag times of neat and aqueous diethyl phthalate, 1,2-dichloroethane and naphthalene Cutan Ocul Toxicol. 2007; 26(2):147-60. . View in PubMed