Hualin Zhang, PhD

Professor of Clinical Radiation Oncology

Lead, Medical Physics Brachytherapy

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Overview

Hualin Zhang, Ph.D., DABR, FAAPM, is a professor in the Department of Radiation Oncology at the University of Southern California. Dr. Zhang completed his medical physics residency at the University of Kentucky in 2005. He got his Ph.D. from Lanzhou Institute of Physics of China.
Dr. Zhang’s research spans several innovative modalities, including spatially fractionated radiation therapy, MRI-guided low dose rate (LDR) and high dose rate (HDR) brachytherapy, and intraoperative radiation therapies using mesh and balloon-based systems.
Dr. Zhang has authored over 60 peer-reviewed articles and delivered more than 100 scientific presentations globally. He published the world’s first textbook on spatially fractionated radiation therapy in 2023, titled by “Spatially Fractionated, Microbeam, and Flash Radiation Therapy: A Physics and Multi-disciplinary Approach.”
Dr. Zhang has held numerous leadership roles, including co-Chair of the American Association of Physicists in Medicine (AAPM) Task Group on Intraoperative Mesh Brachytherapy (TG-222), co-Chair of AAPM Task Group on Spatially Fractionated Radiation Therapy (TG-440), and Chair of the Physics Working Group of the RSS GRID/Lattice, Microbeam, and Flash Radiotherapy Working Groups.
In 2018, Dr. Zhang was awarded as the outstanding teacher at Northwestern University Feinberg School of Medicine.
In 2024, Dr. Zhang was awarded as the Fellow of American Association of Physicists in Medicine (FAAPM).

Awards

  • American Association of Physicist in medicine: Fellow, 2024
  • Northwestern University Feinberg School of Medicine: Outstanding Teacher, 2017
     – 2018

Education and Training

  • University of Kentucky, Lexington, Kentucky — 2005 — Medical Physics Residency
  • University of Basse Normandie, Caen, France — 2000 — Physics
  • Lanzhou Institute of Physics, Chinese Academy of Space Technology, Lanzhou, China — Ph.D — 1995
  • Lanzhou University, Lanzhou, China — MSc — 1991 — Physics
  • Lanzhou University, Lanzhou, China — BSc — 1986 — Physics

Research Keywords

  • Brachytherapy
  • Spatially Fractionated Radiation Therapy
  • Radiobiology
  • Molecular Physics
  • Immunology

Publications

  • Electron spatially fractionated radiation therapy using a clinically biocompatible 3D-printed tungsten-filament GRID. J Appl Clin Med Phys. 2026 Apr; 27(4):e70567.. View in PubMed
  • Spatially fractionated radiation therapy: A powerful and low-toxicity technique for cancer treatment. J Radiosurg SBRT. 2026; 10(1-2):139-144.. View in PubMed
  • Initial experience of spatially fractionated lattice radiation therapy for palliative treatment of pediatric bulky tumors. Front Oncol. 2025; 15:1648847.. View in PubMed
  • Stereotactic core ablative radiation therapy for small hypoxic tumors: impact of dosimetric approaches and consequent optimization strategy in the context of spatially fractionated radiation therapy. Front Oncol. 2025; 15:1568959.. View in PubMed
  • The Radiosurgery Society Working Groups on GRID, LATTICE, Microbeam, and FLASH Radiotherapies: Advancements Symposium and Subsequent Progress Made. Pract Radiat Oncol. 2025 May-Jun; 15(3):300-307.. View in PubMed
  • Optimizing GRID and Lattice Spatially Fractionated Radiation Therapy: Innovative Strategies for Radioresistant and Bulky Tumor Management. Semin Radiat Oncol. 2024 07; 34(3):310-322.. View in PubMed
  • Which Modality of SFRT Should be Considered First for Bulky Tumor Radiation Therapy, GRID or LATTICE? Semin Radiat Oncol. 2024 07; 34(3):302-309. Zhang H , Wu X . View in PubMed
  • Dosimetric characterization for GRID collimator-based spatially fractionated radiation therapy: Dosimetric parameter acquisition and machine interchangeability investigation. J Appl Clin Med Phys. 2024 Aug; 25(8):e14410.. View in PubMed
  • Intraoperative radiation therapy with 50 kV x-rays: A multi-institutional review. J Appl Clin Med Phys. 2024 Mar; 25(3):e14272.. View in PubMed
  • Overview and Recommendations for Prospective Multi-institutional Spatially Fractionated Radiation Therapy Clinical Trials. Int J Radiat Oncol Biol Phys. 2024 07 01; 119(3):737-749.. View in PubMed