Keck School Faculty

James Amatruda
James Amatruda
Visiting Professor of Pediatrics
Pediatrics
Not Available Health Sciences Campus Los Angeles

Genetics of testicular germ cell tumors Curr Opin Urol. 2019 Jul; 29(4):344-349. . View in PubMed

Detection of Relapse by Tumor Markers Versus Imaging in Children and Adolescents With Nongerminomatous Malignant Germ Cell Tumors: A Report From the Children's Oncology Group J Clin Oncol. 2019 Feb 10; 37(5):396-402. . View in PubMed

pouC Regulates Expression of bmp4 During Atrioventricular Canal Formation in Zebrafish Dev Dyn. 2019 02; 248(2):173-188. . View in PubMed

Detection of Relapse by Tumor Markers Versus Imaging in Children and Adolescents With Nongerminomatous Malignant Germ Cell Tumors: A Report From the Children's Oncology Group J Clin Oncol. 2018 Dec 21; JCO1800790. . View in PubMed

Klinefelter syndrome in males with germ cell tumors: A report from the Children's Oncology Group Cancer. 2018 Oct 01; 124(19):3900-3908. . View in PubMed

Differences in DNA methylation profiles by histologic subtype of paediatric germ cell tumours: a report from the Children's Oncology Group Br J Cancer. 2018 Oct; 119(7):864-872. . View in PubMed

Practice Patterns and Impact of Postchemotherapy Retroperitoneal Lymph Node Dissection on Testicular Cancer Outcomes Eur Urol Oncol. 2018 Aug; 1(3):242-251. . View in PubMed

Integrative Bayesian Analysis Identifies Rhabdomyosarcoma Disease Genes Cell Rep. 2018 Jul 03; 24(1):238-251. . View in PubMed

Comparison of carboplatin versus cisplatin in the treatment of paediatric extracranial malignant germ cell tumours: A report of the Malignant Germ Cell International Consortium Eur J Cancer. 2018 Jul; 98:30-37. . View in PubMed

Gonadal dysgenesis is associated with worse outcomes in patients with ovarian nondysgerminomatous tumors: A report of the Children's Oncology Group AGCT 0132 study Pediatr Blood Cancer. 2018 Apr; 65(4). . View in PubMed

Adolescents and Young Adults With a "Rare" Cancer: Getting Past Semantics to Optimal Care for Patients With Germ Cell Tumors Oncologist. 2018 Feb; 23(2):272. . View in PubMed

Is carboplatin-based chemotherapy as effective as cisplatin-based chemotherapy in the treatment of advanced-stage dysgerminoma in children, adolescents and young adults? Gynecol Oncol. 2018 08; 150(2):253-260.. View in PubMed

Comparison of carboplatin versus cisplatin in the treatment of paediatric extracranial malignant germ cell tumours: A report of the Malignant Germ Cell International Consortium Eur J Cancer. 2018 07; 98:30-37. . View in PubMed

EGF Receptor and mTORC1 Are Novel Therapeutic Targets in Nonseminomatous Germ Cell Tumors Mol Cancer Ther. 2018 05; 17(5):1079-1089. . View in PubMed

Differences at Presentation and Treatment of Testicular Cancer in Hispanic Men: Institutional and National Hospital-based Analyses Urology. 2018 02; 112:103-111. . View in PubMed

Family history of cancer in children and adolescents with germ cell tumours: a report from the Children's Oncology Group Br J Cancer. 2018 01; 118(1):121-126. . View in PubMed

Pediatric Germ Cell Tumors: A Developmental Perspective Adv Urol. 2018; 2018:9059382. . View in PubMed

Mutations in microRNA processing genes in Wilms tumors derepress the IGF2 regulator PLAG1 Genes Dev. 2018 08 01; 32(15-16):996-1007. . View in PubMed

PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis Elife. 2018 06 05; 7. . View in PubMed

Retrotransposons Mimic Germ Plasm Determinants to Promote Transgenerational InheritanceCurr Biol. 2017 Oct 09; 27(19):3010-3016. e3. . View in PubMed

Reduced and Compressed Cisplatin-Based Chemotherapy in Children and Adolescents With Intermediate-Risk Extracranial Malignant Germ Cell Tumors: A Report From the Children's Oncology Group J Clin Oncol. 2017 Apr 10; 35(11):1203-1210. . View in PubMed

Variants in BAK1, SPRY4, and GAB2 are associated with pediatric germ cell tumors: A report from the children's oncology group Genes Chromosomes Cancer. 2017 07; 56(7):548-558. . View in PubMed

Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation Nat Med. 2017 01; 23(1):79-90. . View in PubMed

Testicular germ cell tumor genomics Curr Opin Urol. 2017 01; 27(1):41-47. . View in PubMed

Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1649-1654. . View in PubMed

Cancer. 2016 Jan 15; 122(2):230-7. . View in PubMed

Paediatric extracranial germ-cell tumours Lancet Oncol. 2016 04; 17(4):e149-e162. . View in PubMed

Risk of second gonadal cancers in women and children with germ cell tumors Cancer. 2016 07 01; 122(13):2076-82. . View in PubMed

Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis Oncotarget. 2016 10 18; 7(42):67919-67933. . View in PubMed

Zebrafish as a Model for the Study of Solid Malignancies Methods Mol Biol. 2016; 1451:121-42. . View in PubMed

Biochemical Analysis of Tankyrase Activity in Zebrafish In Vitro and In Vivo Methods Mol Biol. 2016; 1481:95-100. . View in PubMed

Zebrafish Germ Cell Tumors Adv Exp Med Biol. 2016; 916:479-94. . View in PubMed

p53 genes function to restrain mobile elements Genes Dev. 2016 Jan 01; 30(1):64-77. . View in PubMed

Pediatric and Adolescent Extracranial Germ Cell Tumors: The Road to Collaboration J Clin Oncol. 2015 Sep 20; 33(27):3018-28. . View in PubMed

Surveillance after initial surgery for Stage I pediatric and adolescent boys with malignant testicular germ cell tumors: Report from the Children's Oncology Group J Pediatr Surg. 2015 Jun; 50(6):1000-3. . View in PubMed

Revised risk classification for pediatric extracranial germ cell tumors based on 25 years of clinical trial data from the United Kingdom and United States J Clin Oncol. 2015 Jan 10; 33(2):195-201. . View in PubMed

Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours Nat Commun. 2014 Sep 05; 2:4802. . View in PubMed

Adolescents and young adults with a "rare" cancer: getting past semantics to optimal care for patients with germ cell tumors Oncologist. 2014 Jul; 19(7):689-92. . View in PubMed

The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response Cell. 2014 Apr 24; 157(3):565-79. . View in PubMed

Autophagy is essential for cardiac morphogenesis during vertebrate development Autophagy. 2014 Apr; 10(4):572-87. . View in PubMed

DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors BMC Cancer. 2013 Jun 27; 13:313. . View in PubMed

Children's Oncology Group's 2013 blueprint for research: rare tumors Pediatr Blood Cancer. 2013 Jun; 60(6):1016-21. . View in PubMed

A big catch for germ cell tumour research PLoS Genet. 2013 Apr; 9(4):e1003481. . View in PubMed

The development of highly potent inhibitors for porcupine J Med Chem. 2013 Mar 28; 56(6):2700-4. . View in PubMed

C/EBP transcription factors mediate epicardial activation during heart development and injury Science. 2012 Dec 21; 338(6114):1599-603. . View in PubMed

Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development Mol Cancer Res. 2012 Nov; 10(11):1451-61. . View in PubMed

Fetal and neonatal germ cell tumors Semin Fetal Neonatal Med. 2012 Aug; 17(4):222-230. . View in PubMed

Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine J Biol Chem. 2012 Jun 29; 287(27):23246-54. . View in PubMed

A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis Dis Model Mech. 2012 Jan; 5(1):95-106. . View in PubMed

Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms Dis Model Mech. 2012 Jan; 5(1):33-7. . View in PubMed

Mutation in the type IB bone morphogenetic protein receptor Alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish Proc Natl Acad Sci U S A. 2011 Aug 09; 108(32):13153-8. . View in PubMed

High-resolution array CGH identifies common mechanisms that drive embryonal rhabdomyosarcoma pathogenesis Genes Chromosomes Cancer. 2011 Jun; 50(6):397-408. . View in PubMed

Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling Sci Signal. 2011 Jan 25; 4(157):ra4. . View in PubMed

Analysis of cell proliferation, senescence, and cell death in zebrafish embryos Methods Cell Biol. 2011; 101:19-38. . View in PubMed

Zebrafish models of germ cell tumor Methods Cell Biol. 2011; 105:3-24. . View in PubMed

Breast cancer between faith and medicine: the Peres Maldonado ex-voto Med Humanit. 2010 Dec; 36(2):112-4. . View in PubMed

Trends in incidence and survival of pediatric and adolescent patients with germ cell tumors in the United States, 1975 to 2006 Cancer. 2010 Oct 15; 116(20):4882-91. . View in PubMed

Effect of vascular cadherin knockdown on zebrafish vasculature during development PLoS One. 2010 Jan 20; 5(1):e8807. . View in PubMed

Identification of a heritable model of testicular germ cell tumor in the zebrafish Zebrafish. 2009 Dec; 6(4):319-27. . View in PubMed

Structure-activity relationship studies of small-molecule inhibitors of Wnt response Bioorg Med Chem Lett. 2009 Jul 15; 19(14):3825-7. . View in PubMed

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer Nat Chem Biol. 2009 Feb; 5(2):100-7. . View in PubMed

p53 ancestry: gazing through an evolutionary lens Nat Rev Cancer. 2009 10; 9(10):758-62. . View in PubMed

Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3 Cell. 2008 May 30; 133(5):864-77. . View in PubMed

Genetic models of cancer in zebrafish Int Rev Cell Mol Biol. 2008; 271:1-34. . View in PubMed

Analysis of the cell cycle in zebrafish embryos Methods Cell Biol. 2004; 76:109-25. . View in PubMed

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