Keck School Faculty

James Amatruda, MD, PhD
James Amatruda, MD, PhD
Professor of Pediatrics and Medicine
Pediatrics
Childrens Hospital Los Angeles CHLA Mail Stop 57 Los Angeles
James F. Amatruda, MD, PhD is Endowed Chair of Sarcoma Research in the Children’s Center for Cancer and Blood Diseases and the Division of Hematology, Oncology and Blood and Marrow Transplantation at Children’s Hospital Los Angeles; and Professor of Pediatrics and Medicine at the Keck School of Medicine of the University of Southern California. He received his Bachelor’s degree in Biochemical Sciences from Harvard University and his MD,PhD from Washington University School of Medicine. He did internship and residency training in Internal Medicine at the Brigham and Women’s Hospital in Boston, MA, followed by fellowship training in Medical Oncology at Dana-Farber/Partners Cancer Care in Boston, MA. He was a Postdoctoral Fellow in the laboratory of Dr. Leonard Zon at Boston Children’s Hospital, Harvard Medical School. From 2005-2019, Dr. Amatruda was on the faculty of UT Southwestern Medical Center in Dallas, TX.

Dr. Amatruda is a physician-scientist with a primary research and clinical focus on solid tumors of childhood including sarcomas, germ cell tumors and Wilms tumor. His lab has developed zebrafish models of genetic subtypes of pediatric solid tumors to better define their biology and to use that knowledge to identify and validate novel approaches for improved therapies. He has had long-standing leadership positions in the Children’s Oncology Group; serving as Chair for the Germ Cell Tumor Biology Committee and the Rare Tumors Biology Committee. He also serves as a member of the COG Solid Malignancies Integrated Translational Science Center Steering Committee, and on the Scientific Advisory Boards of the William Guy Forbeck Foundation, the Osteosarcoma Institute, the Pablove Foundation, Curing Kids Cancer and the 1 Million 4 Anna Foundation.

Serum MicroRNA-371a-3p Levels Predict Viable Germ Cell Tumor in Chemotherapy-naïve Patients Undergoing Retroperitoneal Lymph Node Dissection Eur Urol. 2019 Nov 04. . View in PubMed

Genetics of testicular germ cell tumors Curr Opin Urol. 2019 Jul; 29(4):344-349. . View in PubMed

Detection of Relapse by Tumor Markers Versus Imaging in Children and Adolescents With Nongerminomatous Malignant Germ Cell Tumors: A Report From the Children's Oncology Group J Clin Oncol. 2019 Feb 10; 37(5):396-402. . View in PubMed

pouC Regulates Expression of bmp4 During Atrioventricular Canal Formation in Zebrafish Dev Dyn. 2019 02; 248(2):173-188. . View in PubMed

Differences in DNA methylation profiles by histologic subtype of paediatric germ cell tumours: a report from the Children's Oncology Group Br J Cancer. 2018 10; 119(7):864-872. . View in PubMed

Is carboplatin-based chemotherapy as effective as cisplatin-based chemotherapy in the treatment of advanced-stage dysgerminoma in children, adolescents and young adults? Gynecol Oncol. 2018 08; 150(2):253-260.. View in PubMed

Practice Patterns and Impact of Postchemotherapy Retroperitoneal Lymph Node Dissection on Testicular Cancer Outcomes Eur Urol Oncol. 2018 08; 1(3):242-251. . View in PubMed

Comparison of carboplatin versus cisplatin in the treatment of paediatric extracranial malignant germ cell tumours: A report of the Malignant Germ Cell International Consortium Eur J Cancer. 2018 07; 98:30-37. . View in PubMed

EGF Receptor and mTORC1 Are Novel Therapeutic Targets in Nonseminomatous Germ Cell Tumors Mol Cancer Ther. 2018 05; 17(5):1079-1089. . View in PubMed

Gonadal dysgenesis is associated with worse outcomes in patients with ovarian nondysgerminomatous tumors: A report of the Children's Oncology Group AGCT 0132 study Pediatr Blood Cancer. 2018 04; 65(4). . View in PubMed

Adolescents and Young Adults With a "Rare" Cancer: Getting Past Semantics to Optimal Care for Patients With Germ Cell Tumors Oncologist. 2018 02; 23(2):272. . View in PubMed

Differences at Presentation and Treatment of Testicular Cancer in Hispanic Men: Institutional and National Hospital-based Analyses Urology. 2018 02; 112:103-111. . View in PubMed

Family history of cancer in children and adolescents with germ cell tumours: a report from the Children's Oncology Group Br J Cancer. 2018 01; 118(1):121-126. . View in PubMed

Pediatric Germ Cell Tumors: A Developmental Perspective Adv Urol. 2018; 2018:9059382. . View in PubMed

Klinefelter syndrome in males with germ cell tumors: A report from the Children's Oncology Group Cancer. 2018 10 01; 124(19):3900-3908. . View in PubMed

Integrative Bayesian Analysis Identifies Rhabdomyosarcoma Disease Genes Cell Rep. 2018 07 03; 24(1):238-251. . View in PubMed

Mutations in microRNA processing genes in Wilms tumors derepress the IGF2 regulator PLAG1 Genes Dev. 2018 08 01; 32(15-16):996-1007. . View in PubMed

PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis Elife. 2018 06 05; 7. . View in PubMed

Retrotransposons Mimic Germ Plasm Determinants to Promote Transgenerational InheritanceCurr Biol. 2017 Oct 09; 27(19):3010-3016. e3. . View in PubMed

Reduced and Compressed Cisplatin-Based Chemotherapy in Children and Adolescents With Intermediate-Risk Extracranial Malignant Germ Cell Tumors: A Report From the Children's Oncology Group J Clin Oncol. 2017 Apr 10; 35(11):1203-1210. . View in PubMed

Variants in BAK1, SPRY4, and GAB2 are associated with pediatric germ cell tumors: A report from the children's oncology group Genes Chromosomes Cancer. 2017 07; 56(7):548-558. . View in PubMed

Testicular germ cell tumor genomics Curr Opin Urol. 2017 01; 27(1):41-47. . View in PubMed

Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation Nat Med. 2017 01; 23(1):79-90. . View in PubMed

Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1649-1654. . View in PubMed

Cancer. 2016 Jan 15; 122(2):230-7. . View in PubMed

Paediatric extracranial germ-cell tumours Lancet Oncol. 2016 04; 17(4):e149-e162. . View in PubMed

p53 genes function to restrain mobile elements Genes Dev. 2016 Jan 01; 30(1):64-77. . View in PubMed

Risk of second gonadal cancers in women and children with germ cell tumors Cancer. 2016 07 01; 122(13):2076-82. . View in PubMed

Zebrafish Germ Cell Tumors Adv Exp Med Biol. 2016; 916:479-94. . View in PubMed

Biochemical Analysis of Tankyrase Activity in Zebrafish In Vitro and In Vivo Methods Mol Biol. 2016; 1481:95-100. . View in PubMed

Zebrafish as a Model for the Study of Solid Malignancies Methods Mol Biol. 2016; 1451:121-42. . View in PubMed

Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis Oncotarget. 2016 10 18; 7(42):67919-67933. . View in PubMed

Pediatric and Adolescent Extracranial Germ Cell Tumors: The Road to Collaboration J Clin Oncol. 2015 Sep 20; 33(27):3018-28. . View in PubMed

Surveillance after initial surgery for Stage I pediatric and adolescent boys with malignant testicular germ cell tumors: Report from the Children's Oncology Group J Pediatr Surg. 2015 Jun; 50(6):1000-3. . View in PubMed

Revised risk classification for pediatric extracranial germ cell tumors based on 25 years of clinical trial data from the United Kingdom and United States J Clin Oncol. 2015 Jan 10; 33(2):195-201. . View in PubMed

Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours Nat Commun. 2014 Sep 05; 2:4802. . View in PubMed

Adolescents and young adults with a "rare" cancer: getting past semantics to optimal care for patients with germ cell tumors Oncologist. 2014 Jul; 19(7):689-92. . View in PubMed

The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response Cell. 2014 Apr 24; 157(3):565-79. . View in PubMed

Autophagy is essential for cardiac morphogenesis during vertebrate development Autophagy. 2014 Apr; 10(4):572-87. . View in PubMed

DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors BMC Cancer. 2013 Jun 27; 13:313. . View in PubMed

Children's Oncology Group's 2013 blueprint for research: rare tumors Pediatr Blood Cancer. 2013 Jun; 60(6):1016-21. . View in PubMed

A big catch for germ cell tumour research PLoS Genet. 2013 Apr; 9(4):e1003481. . View in PubMed

The development of highly potent inhibitors for porcupine J Med Chem. 2013 Mar 28; 56(6):2700-4. . View in PubMed

C/EBP transcription factors mediate epicardial activation during heart development and injury Science. 2012 Dec 21; 338(6114):1599-603. . View in PubMed

Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development Mol Cancer Res. 2012 Nov; 10(11):1451-61. . View in PubMed

Fetal and neonatal germ cell tumors Semin Fetal Neonatal Med. 2012 Aug; 17(4):222-230. . View in PubMed

Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine J Biol Chem. 2012 Jun 29; 287(27):23246-54. . View in PubMed

A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis Dis Model Mech. 2012 Jan; 5(1):95-106. . View in PubMed

Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms Dis Model Mech. 2012 Jan; 5(1):33-7. . View in PubMed

Mutation in the type IB bone morphogenetic protein receptor Alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish Proc Natl Acad Sci U S A. 2011 Aug 09; 108(32):13153-8. . View in PubMed

High-resolution array CGH identifies common mechanisms that drive embryonal rhabdomyosarcoma pathogenesis Genes Chromosomes Cancer. 2011 Jun; 50(6):397-408. . View in PubMed

Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling Sci Signal. 2011 Jan 25; 4(157):ra4. . View in PubMed

Zebrafish models of germ cell tumor Methods Cell Biol. 2011; 105:3-24. . View in PubMed

Analysis of cell proliferation, senescence, and cell death in zebrafish embryos Methods Cell Biol. 2011; 101:19-38. . View in PubMed

Breast cancer between faith and medicine: the Peres Maldonado ex-voto Med Humanit. 2010 Dec; 36(2):112-4. . View in PubMed

Trends in incidence and survival of pediatric and adolescent patients with germ cell tumors in the United States, 1975 to 2006 Cancer. 2010 Oct 15; 116(20):4882-91. . View in PubMed

Effect of vascular cadherin knockdown on zebrafish vasculature during development PLoS One. 2010 Jan 20; 5(1):e8807. . View in PubMed

Identification of a heritable model of testicular germ cell tumor in the zebrafish Zebrafish. 2009 Dec; 6(4):319-27. . View in PubMed

Structure-activity relationship studies of small-molecule inhibitors of Wnt response Bioorg Med Chem Lett. 2009 Jul 15; 19(14):3825-7. . View in PubMed

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer Nat Chem Biol. 2009 Feb; 5(2):100-7. . View in PubMed

p53 ancestry: gazing through an evolutionary lens Nat Rev Cancer. 2009 10; 9(10):758-62. . View in PubMed

Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3 Cell. 2008 May 30; 133(5):864-77. . View in PubMed

Genetic models of cancer in zebrafish Int Rev Cell Mol Biol. 2008; 271:1-34. . View in PubMed

Analysis of the cell cycle in zebrafish embryos Methods Cell Biol. 2004; 76:109-25. . View in PubMed

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