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James Jeffrey Cox

Clinical Instructor of Psychiatry and the Behavioral Sciences (Practitioner)

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Email [email protected]
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Publications

  • Nav1.5 in the dorsal root ganglion plays a crucial role in mechanical hypersensitivity. Brain. 2026 Jul 07; 149(7):2516-2532.. View in PubMed
  • Natural antisense transcript Nat9a suppresses Scn9a (NaV1.7) expression in parvalbumin-positive proprioceptive and inhibitory neurons. Sci Rep. 2026 Apr 16; 16(1).. View in PubMed
  • MDFIC2 is a PIEZO channel modulator that can alleviate mechanical allodynia associated with neuropathic pain. Proc Natl Acad Sci U S A. 2025 Nov 11; 122(45):e2512426122.. View in PubMed
  • Intrathecal administration of the Nav1.7 inhibitor PF-05089771 produces rapid and side-effect-free analgesia in mice. Pain. 2026 Mar 01; 167(3):589-605.. View in PubMed
  • Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine). J Gen Physiol. 2025 07 07; 157(4).. View in PubMed
  • Sodium channels Nav1.7, Nav1.8 and pain; two distinct mechanisms for Nav1.7 null analgesia. Neurobiol Pain. 2024 Jul-Dec; 16:100168.. View in PubMed
  • Novel therapies for cancer-induced bone pain. Neurobiol Pain. 2024 Jul-Dec; 16:100167.. View in PubMed
  • Analgesic targets identified in mouse sensory neuron somata and terminal pain translatomes. Cell Rep. 2024 08 27; 43(8):114614.. View in PubMed
  • Out of the dark: the emerging roles of lncRNAs in pain. Trends Genet. 2024 08; 40(8):694-705.. View in PubMed
  • Transcriptomic profiling reveals a pronociceptive role for angiotensin II in inflammatory bowel disease. Pain. 2024 Jul 01; 165(7):1592-1604.. View in PubMed
  • Genetic landscape of congenital insensitivity to pain and hereditary sensory and autonomic neuropathies. Brain. 2023 12 01; 146(12):4880-4890.. View in PubMed
  • Chemogenetic Silencing of NaV1.8-Positive Sensory Neurons Reverses Chronic Neuropathic and Bone Cancer Pain in FLEx PSAM4-GlyR Mice. eNeuro. 2023 09; 10(9).. View in PubMed
  • Molecular basis of FAAH-OUT-associated human pain insensitivity. Brain. 2023 09 01; 146(9):3851-3865.. View in PubMed
  • Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nat Commun. 2023 04 28; 14(1):2442.. View in PubMed
  • Genetic pain loss disorders. Nat Rev Dis Primers. 2022 06 16; 8(1):41.. View in PubMed
  • Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation. Eur J Pharmacol. 2022 Jun 15; 925:175013.. View in PubMed
  • The Tarantula Venom Peptide Eo1a Binds to the Domain II S3-S4 Extracellular Loop of Voltage-Gated Sodium Channel NaV1.8 to Enhance Activation. Front Pharmacol. 2021; 12:789570.. View in PubMed
  • Tools for analysis and conditional deletion of subsets of sensory neurons. Wellcome Open Res. 2021; 6:250.. View in PubMed
  • A central mechanism of analgesia in mice and humans lacking the sodium channel NaV1.7. Neuron. 2021 05 05; 109(9):1497-1512.e6.. View in PubMed
  • Sensory neuron-derived NaV1.7 contributes to dorsal horn neuron excitability. Sci Adv. 2020 02; 6(8):eaax4568.. View in PubMed
  • Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity. Br J Anaesth. 2019 Aug; 123(2):e249-e253.. View in PubMed
  • Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions. Wellcome Open Res. 2018; 3:78.. View in PubMed
  • Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy. Pain. 2018 03; 159(3):469-480.. View in PubMed
  • A novel human pain insensitivity disorder caused by a point mutation in ZFHX2. Brain. 2018 02 01; 141(2):365-376.. View in PubMed
  • Mapping protein interactions of sodium channel NaV1.7 using epitope-tagged gene-targeted mice. EMBO J. 2018 02 01; 37(3):427-445.. View in PubMed
  • The Genetics of Pain: Implications for Therapeutics. Annu Rev Pharmacol Toxicol. 2018 01 06; 58:123-142.. View in PubMed
  • Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7. Nat Commun. 2015 Dec 04; 6:8967.. View in PubMed
  • Regulation of Nav1.7: A Conserved SCN9A Natural Antisense Transcript Expressed in Dorsal Root Ganglia. PLoS One. 2015; 10(6):e0128830.. View in PubMed
  • Novel SCN9A mutations underlying extreme pain phenotypes: unexpected electrophysiological and clinical phenotype correlations. J Neurosci. 2015 May 20; 35(20):7674-81.. View in PubMed
  • Pain in Fabry disease: Plasma lipids sensitise nociceptors. Neurosci Lett. 2015 May 06; 594:161-2.. View in PubMed
  • Sodium channels and pain. Handb Exp Pharmacol. 2015; 227:39-56.. View in PubMed
  • Sodium channel genes in pain-related disorders: phenotype-genotype associations and recommendations for clinical use. Lancet Neurol. 2014 Nov; 13(11):1152-1160.. View in PubMed
  • Null mutation in SCN9A in which noxious stimuli can be detected in the absence of pain. Neurology. 2014 Oct 21; 83(17):1577-80.. View in PubMed
  • No pain, more gain. Nat Genet. 2013 Nov; 45(11):1271-2.. View in PubMed
  • Novel mutations mapping to the fourth sodium channel domain of Nav1.7 result in variable clinical manifestations of primary erythromelalgia. Neuromolecular Med. 2013 Jun; 15(2):265-78.. View in PubMed
  • Splice variants of Na(V)1.7 sodium channels have distinct β subunit-dependent biophysical properties. PLoS One. 2012; 7(7):e41750.. View in PubMed
  • TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells. Open Biol. 2012 May; 2(5):120068.. View in PubMed
  • The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis. Am J Hum Genet. 2011 May 13; 88(5):523-35.. View in PubMed
  • A SOX9 duplication and familial 46,XX developmental testicular disorder. N Engl J Med. 2011 Jan 06; 364(1):91-3.. View in PubMed
  • A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy. J Med Genet. 2011 Feb; 48(2):131-5.. View in PubMed
  • WDR62 is associated with the spindle pole and is mutated in human microcephaly. Nat Genet. 2010 Nov; 42(11):1010-4.. View in PubMed
  • Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations. Hum Mutat. 2010 Sep; 31(9):E1670-86.. View in PubMed
  • A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome. Neuron. 2010 Jun 10; 66(5):671-80.. View in PubMed
  • A new Nav1.7 sodium channel mutation I234T in a child with severe pain. Eur J Pain. 2010 Oct; 14(9):944-50.. View in PubMed
  • Pain perception is altered by a nucleotide polymorphism in SCN9A. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5148-53.. View in PubMed
  • INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse. Nat Genet. 2009 Sep; 41(9):1027-31.. View in PubMed
  • An SCN9A channelopathy causes congenital inability to experience pain. Nature. 2006 Dec 14; 444(7121):894-8.. View in PubMed
  • Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene. Diabetes. 2006 Dec; 55(12):3366-71.. View in PubMed
  • High schoolers work in health departments in President’s Youth Opportunity Program. Public Health Rep (1896). 1966 May; 81(5):478-480.. View in PubMed