Janice M. Liebler, MD

Professor of Clinical Medicine

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Overview

Dr. Liebler hails from Detroit, MI where she attended medical school at Wayne State University. After coming to the USC Keck School of Medicine in 1999, Dr. Liebler has established herself as a leading educator in lung transplantation and critical care medicine. She was formally the Associate Medical Director for Keck’s Lung Transplantation Program and is currently an attending physician for both LAC+USC Medical Center’s Medical Intensive Care Unit and Keck Hospital of USC Pulmonary and Critical Care Medicine division. In addition to lung transplantation, Dr. Liebler research interests also include lung injury and repair and cell-based treatment of lung diseases.

Awards

  • OHSU Foundation: Donor Research Grant, 1992-1999
  • American Lung Association of Oregon: Research Grant, 1989
  • Medical Research Foundation of Oregon: Research Grant, 1987
  • San Jacinto Lung Association: Training Research Grant, 1981

Publications

  • Validation of SeptiCyte RAPID to Discriminate Sepsis from Non-Infectious Systemic Inflammation J Clin Med. 2024 Feb 20; 13(5). . View in PubMed
  • Frequency of screening and SBT Technique Trial-North American Weaning Collaboration (FAST-NAWC): an update to the protocol and statistical analysis plan Trials. 2023 Oct 02; 24(1):626. . View in PubMed
  • Causes of Death Among Medical ICU Patients With Pneumonia Due to COVID-19 in a Safety-Net Hospital Crit Care Explor. 2023 Jul; 5(7):e0947. . View in PubMed
  • A retrospective analysis of rates of dermatology follow-up and new skin cancer diagnosis among solid organ transplant recipients during the COVID-19 pandemic JAAD Int. 2023 Mar; 10:53-54. . View in PubMed
  • Perceived Hospital Stress, Severe Acute Respiratory Syndrome Coronavirus 2 Activity, and Care Process Temporal Variance During the COVID-19 Pandemic Crit Care Med. 2023 04 01; 51(4):445-459. . View in PubMed
  • Angiopoietin-Like4 Is a Novel Marker of COVID-19 Severity Crit Care Explor. 2023 Jan; 5(1):e0827. . View in PubMed
  • Severe Acute Respiratory Infection-Preparedness: Protocol for a Multicenter Prospective Cohort Study of Viral Respiratory Infections Crit Care Explor. 2022 Oct; 4(10):e0773. . View in PubMed
  • Wellness and Coping of Physicians Who Worked in ICUs During the Pandemic: A Multicenter Cross-Sectional North American Survey Crit Care Med. 2022 12 01; 50(12):1689-1700. . View in PubMed
  • Variation in Early Management Practices in Moderate-to-Severe ARDS in the United States: The Severe ARDS: Generating Evidence Study Chest. 2021 10; 160(4):1304-1315. . View in PubMed
  • Evaluation of Time-Limited Trials Among Critically Ill Patients With Advanced Medical Illnesses and Reduction of Nonbeneficial ICU Treatments JAMA Intern Med. 2021 06 01; 181(6):786-794. . View in PubMed
  • Updated guidance on the management of COVID-19: from an American Thoracic Society/European Respiratory Society coordinated International Task Force (29 July 2020) Eur Respir Rev. 2020 Sep 30; 29(157). . View in PubMed
  • Super Obesity in the Medical Intensive Care Unit J Intensive Care Med. 2020 May; 35(5):478-484. . View in PubMed
  • Time-Limited Trials Among Critically Ill Patients With Advanced Medical Illnesses to Reduce Nonbeneficial Intensive Care Unit Treatments: Protocol for a Multicenter Quality Improvement Study JMIR Res Protoc. 2019 Nov 25; 8(11):e16301. . View in PubMed
  • Circulating angiotensin peptides levels in Acute Respiratory Distress Syndrome correlate with clinical outcomes: A pilot study PLoS One. 2019; 14(3):e0213096. . View in PubMed
  • Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis J Clin Invest. 2018 03 01; 128(3):970-984. . View in PubMed
  • Region-specific role for Pten in maintenance of epithelial phenotype and integrity Am J Physiol Lung Cell Mol Physiol. 2017 01 01; 312(1):L131-L142. . View in PubMed
  • Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung Am J Physiol Lung Cell Mol Physiol. 2016 Jan 15; 310(2):L114-20. . View in PubMed
  • Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance Am J Respir Cell Mol Biol. 2016 09; 55(3):395-406. . View in PubMed
  • Protocols and Hospital Mortality in Critically Ill Patients: The United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study Crit Care Med. 2015 Oct; 43(10):2076-84. . View in PubMed
  • Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. . View in PubMed
  • Interactions between ß-catenin and transforming growth factor-ß signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP) J Biol Chem. 2012 Mar 02; 287(10):7026-38. . View in PubMed
  • Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury Am J Physiol Lung Cell Mol Physiol. 2008 Aug; 295(2):L285-92. . View in PubMed
  • Rat aquaporin-5 43-kb 5′-flanking region differentially regulates expression in salivary gland and lung in vivo. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C111-20. . View in PubMed
  • Developmental pathways and specification of intrapulmonary stem cells Pediatr Res. 2006 Apr; 59(4 Pt 2):84R-93R. . View in PubMed
  • Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis Am J Pathol. 2005 May; 166(5):1321-32. . View in PubMed
  • Alveolar epithelial type I cells express beta2-adrenergic receptors and G-protein receptor kinase 2 J Histochem Cytochem. 2004 Jun; 52(6):759-67. . View in PubMed
  • Subunit-specific coordinate upregulation of sodium pump activity in alveolar epithelial cells by lentivirus-mediated gene transfer Hum Gene Ther. 2004 May; 15(5):457-68. . View in PubMed
  • Foxj1 is required for apical localization of ezrin in airway epithelial cells J Cell Sci. 2003 Dec 15; 116(Pt 24):4935-45. . View in PubMed
  • Modulation of ion conductance and active transport by TGF-beta 1 in alveolar epithelial cell monolayers Am J Physiol Lung Cell Mol Physiol. 2003 Dec; 285(6):L1192-200. . View in PubMed
  • Identification of three genes of known function expressed by alveolar epithelial type I cells Am J Respir Cell Mol Biol. 2003 Jul; 29(1):98-105. . View in PubMed
  • Na transport proteins are expressed by rat alveolar epithelial type I cells Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L599-608. . View in PubMed
  • Expression of basic fibroblast growth factor in nasal polyps Ann Otol Rhinol Laryngol. 1998 Oct; 107(10 Pt 1):891-7. . View in PubMed
  • Fibroproliferation and mast cells in the acute respiratory distress syndrome Thorax. 1998 Oct; 53(10):823-9. . View in PubMed
  • Ultrastructural immunolocalization of basic fibroblast growth factor in mast cell secretory granulesMorphological evidence for bfgf release through degranulation. J Histochem Cytochem. 1998 Oct; 46(10):1119-28. . View in PubMed
  • Synthesis of basic fibroblast growth factor by murine mast cellsRegulation by transforming growth factor beta, tumor necrosis factor alpha, and stem cell factor. Int Arch Allergy Immunol. 1998 Jan; 115(1):47-54. . View in PubMed
  • Altered immunohistochemical localization of basic fibroblast growth factor after bleomycin-induced lung injury Growth Factors. 1997; 14(1):25-38. . View in PubMed
  • Invasive line placement in critically ill patients: do hemostatic defects matter? Transfusion. 1996 Sep; 36(9):827-31.. View in PubMed
  • Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma Am J Pathol. 1995 Sep; 147(3):564-73. . View in PubMed
  • Gene expression of macrophage inflammatory protein-1 alpha from human blood monocytes and alveolar macrophages is inhibited by interleukin-4 Am J Respir Cell Mol Biol. 1993 Aug; 9(2):192-8. . View in PubMed
  • Respiratory complications in critically ill medical patients with acute upper gastrointestinal bleeding Crit Care Med. 1991 Sep; 19(9):1152-7. . View in PubMed
  • Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells J Appl Physiol (1985). 2005 Jan; 98(1):322-8. . View in PubMed