Jay R. Lieberman, MD

Dr. Lieberman is professor and chair of the Department of Orthopaedic Surgery at the Keck School of Medicine of USC and the Director of the Institute of Orthopaedics at the Keck Medical Center of USC. Dr. Lieberman is internationally recognized for his expertise in primary and revision total hip and knee replacement and treatment of osteonecrosis (bone death) of the hip and knee. He is interested in improving outcomes and limiting complications after total hip and knee replacement. Dr. Lieberman wants to assess the influence of spirituality on the results of total joint replacement.
Dr. Lieberman is the Past President of both the American Association of Hip and Knee Surgeons and The Hip Society. He is also a member of The Knee Society, and The International Hip Society. He has been named multiple times to the Best Doctors in America list, Top Doctors and as a Southern California Super Doctor. He has co-edited three books for the American Academy of Orthopaedic Surgeons (AAOS) on surgical techniques related to total hip and knee arthroplasty and he has co-edited two editions of a popular text entitled “Surgery of the Hip”. He has published more than 300 manuscripts, book chapters and reviews. Dr. Lieberman has won numerous awards including the Frank Stinchfield Hip Society Award; the Orthopaedic Research Society’s Marshall Urist Award in recognition of his contribution to the field of tissue engineering; and the prestigious AAOS Elizabeth Winston Lanier Kappa Delta Award for his pioneering work related to the development of regional gene therapy to enhance bone repair. Dr. Lieberman received his medical degree from the Albany Medical College of Union University and completed his fellowship training in total joint replacement at The Hospital for Special Surgery in New York.

• The HIP Society: Frank Stinchfield Hip Society Award, 2011
• American Orthopaedic Association: ABC Traveling Fellowship, 2011
• Orthopaedic Research Society: Marshall R. Urist Award for Excellence in Tissue Regeneration Research, 2011
• American Academy of Orthopaedic Surgeons: Elizabeth Winston Lanier Kappa Delta Research Award, 2012
• Keck School of Medicine: Outstanding Required Student Project Mentor Award, 2015
• Los Angeles Magazine: Southern California Super Doctors, 2013
   – 2022
• Castle Connolly: America’s Top Doctors, 2016
   – 2017
• Castle Connolly: America’s Top Doctors, 2019
• Pasadena Magazine: Top Doctor, 2013
   – 2015
• Pasadena Magazine: Top Doctor, 2017
   – 2021

• Regional Gene Therapy to Enhance Bone Repair
  NIH · R01AR057076 · Apr 1, 2010 – Mar 31, 2022 · Role: Principal Investigator
• RANKL and BMPs in Prostate Cancer Induced Bone Lesions
  NIH · R01CA103039 · Sep 1, 2003 – Jun 30, 2009 · Role: Principal Investigator
• Regional Gene Therapy to Enhance Bone Repair
  NIH · R01AR046789 · Apr 1, 2001 – Jan 31, 2005 · Role: Principal Investigator
• RECOMBINANT BMP AND BONE FORMATION
  NIH · K11AR001931 · Sep 30, 1994 – Aug 31, 1999 · Role: Principal Investigator

• Jay Lieberman Named Professor and Chair of Department of Orthopaedic Surgery (06/11/2012)

• Recognizing and treating serious allergic reactions (anaphylaxis) in infants and toddlers: a plain language review. Expert Rev Clin Immunol. 2026 Jul 30; 1.. View in PubMed
• Perioperative Dexamethasone Is Associated With a Reduced Risk of Periprosthetic Joint Infection Following Aseptic Revision Total Hip and Knee Arthroplasty. Arthroplast Today. 2026 Aug; 40:102100.. View in PubMed
• Predictive Factors for Manipulations Under Anesthesia After Total Knee Arthroplasty: An Analysis of 15,139 Cases. J Am Acad Orthop Surg. 2026 Jul 23.. View in PubMed
• Nontraumatic Osteonecrosis of the Femoral Head: An Update. J Bone Joint Surg Am. 2026 Jul 20.. View in PubMed
• The Impact of Standardized Letter of Recommendation Origin on Orthopedic Surgery Residency Match Outcomes. J Surg Educ. 2026 Jul 20; 83(9):104077.. View in PubMed
• Dexamethasone is Associated with a Dose-Dependent Reduction in Venous Thromboembolic Complications following Total Knee and Hip Arthroplasty. J Arthroplasty. 2026 Jul 16.. View in PubMed
• Combination ex vivo regional gene therapy with sonic hedgehog and bone morphogenetic protein-2 does not enhance bone healing in critical size defects. Connect Tissue Res. 2026 Jul 12; 1.. View in PubMed
• Inflammatory Bowel Disease and Periprosthetic Joint Infection Following Total Joint Arthroplasty: Crohn’s Disease and Ulcerative Colitis Associated With Varying Risk. Arthroplast Today. 2026 Aug; 40:102077.. View in PubMed
• Risk of Total Hip Arthroplasty After Sacroiliac Joint Fusion Surgery: A Nationwide Study. Global Spine J. 2026 Jul 02; 21925682261463491.. View in PubMed
• Reassessing Total Joint Arthroplasty Case Volumes in the United States: Accounting for Ultralow-Volume Surgeons. J Arthroplasty. 2026 Jun 27.. View in PubMed
• Neutrophil-Lymphocyte Ratio Trajectories Predict Mortality and Medical Complications in Hip Fracture Patients Undergoing Hemiarthroplasty. J Arthroplasty. 2026 Jun 19.. View in PubMed
• Epinephrine Underuse for Anaphylaxis in Infants and Toddlers: A Practical Review for Pediatricians. Paediatr Drugs. 2026 Jul; 28(4):373-385.. View in PubMed
• Transfusions Are Associated With an Elevated Risk of Venous Thromboembolism and Periprosthetic Joint Infection Following Revision Total Knee Arthroplasty. J Arthroplasty. 2026 Jun 17.. View in PubMed
• Factor XI and XIa Inhibitors for Venous Thromboembolism Prophylaxis After Total Knee Arthroplasty: A Review From Mechanism to Phase III Trials. J Arthroplasty. 2026 Jun 09.. View in PubMed
• Emerging Concepts in Periprosthetic Joint Infection Research: RNA, DNA, and Protein Sequencing Tools for the Characterization and Diagnosis of Periprosthetic Joint Infection. J Arthroplasty. 2026 May 14.. View in PubMed
• From Practice Guidelines to Shared Decision-Making: Care in Context. J Allergy Clin Immunol Pract. 2026 May 09.. View in PubMed
• Advanced Practice Providers in Total Joint Arthroplasty: A National Assessment Demonstrates Increasing Prevalence and Unique Practice Characteristics. J Arthroplasty. 2026 May 07.. View in PubMed
• Perioperative Dexamethasone in Periprosthetic Joint Infection Surgery: Diabetes-Stratified Results From a Propensity Score-Matched Retrospective Cohort Study. Anesth Analg. 2026 Apr 27.. View in PubMed
• Age-Related Microbiologic Trends in Periprosthetic Joint Infection of the Knee: Increased Rates of Atypical Pathogens With Increasing Age. Arthroplast Today. 2026 Jun; 39:102021.. View in PubMed
• Technology Assistance Mitigates the Volume-Dependent Risk of Hip Dislocation Following Total Hip Arthroplasty. J Bone Joint Surg Am. 2026 Apr 20.. View in PubMed
• Delayed Administration of Apixaban and Rivaroxaban is Associated with Reduced Rates of Postoperative Bleeding Without Increasing Thromboembolic Risk Following Elective Total Hip Arthroplasty. J Arthroplasty. 2026 Apr 17.. View in PubMed
• Assessing the diagnostic accuracy of synovial fluid send-out laboratory panels for suspected knee periprosthetic joint infection. Bone Joint J. 2026 Apr 01; 108.. View in PubMed
• Increased Opioid Consumption Following Total Knee Arthroplasty Is Associated With an Increased Risk of Manipulation Under Anesthesia. J Arthroplasty. 2026 07; 41(S1):S357-S362.e2.. View in PubMed
• Total Lymphocyte Count Fails as a Predictor of Acute Periprosthetic Joint Infection for Total Hip or Knee Arthroplasty. J Arthroplasty. 2026 07; 41(S1):S342-S349.e2.. View in PubMed
• An Increase in the Treatment of High-Risk Total Joint Arthroplasty Patients Who Have Medicare at Teaching Hospitals. J Arthroplasty. 2026 Mar 26.. View in PubMed
• Aspirin Is Associated With Improved Thromboprophylaxis Versus Low-Molecular-Weight Heparin Following Revision Knee Arthroplasty for Periprosthetic Joint Infection. J Arthroplasty. 2026 Mar 03.. View in PubMed
• The Limited Utility of Synovial C-Reactive Protein in the Diagnosis of Knee and Hip Periprosthetic Joint Infection: Proposed New Diagnostic Cutoffs. J Arthroplasty. 2026 Feb 21.. View in PubMed
• The Osteoimmunologic Basis of Biologic and Bioengineered Scaffolds in Fracture Healing. Bioengineering (Basel). 2026 Feb 14; 13(2).. View in PubMed
• Postoperative Clopidogrel Thromboprophylaxis in TJA: Increased Risk of Transfusion but Similar Venous Thromboembolic Risk Compared with Aspirin. J Bone Joint Surg Am. 2026 May 20; 108(10):729-737.. View in PubMed
• GLP-1 receptor agonist utilization is associated with a low risk of Anesthesia-related complications prior to total joint arthroplasty. Eur J Orthop Surg Traumatol. 2025 Dec 06; 36(1):37.. View in PubMed
• Dual-Antiplatelet Therapy Is Not Associated With Greater Odds of Postoperative Bleeding Following Elective Total Joint Arthroplasty. J Am Acad Orthop Surg. 2026 May 15; 34(10):e1480-e1487.. View in PubMed
• Delayed Administration of Apixaban, but Not Rivaroxaban, Reduces Transfusion Risk Without Increasing Thromboembolic Rates Following Revision Total Hip Arthroplasty. J Arthroplasty. 2025 Nov 27.. View in PubMed
• Characteristics of Adult Reconstructive Hip and Knee Fellowship Graduates Pursuing Private Practice versus Academic Careers. J Arthroplasty. 2026 04; 41(4):990-997.. View in PubMed
• Modern Approaches and Emerging Biological Therapies to Treat Fracture Nonunion. Pharmaceutics. 2025 Nov 11; 17(11).. View in PubMed
• Preoperative Hemoglobin as a Continuous Predictor of Postoperative Complications Following Elective Total Hip Arthroplasty. J Arthroplasty. 2026 08; 41(8):2424-2431.e6.. View in PubMed
• Response to the Letter to the Editor Commenting on “Low-Level Evidence Used to Substantiate Insurance Coverage Policies for Knee and Hip Arthroplasty”. J Arthroplasty. 2025 Nov; 40(11):e77-e78.. View in PubMed
• 2025 ICM: Two-Stage. J Arthroplasty. 2025 Dec; 41(1S1):S385-S398.. View in PubMed
• Emerging Concepts in Periprosthetic Joint Infection Research: Infection Recurrence and Microbe Persistence. J Arthroplasty. 2026 06; 41(6):1813-1821.. View in PubMed
• Allogeneic gene therapy with BMP-2-transduced mesenchymal stem cells combined with immunosuppression enhances bone healing. Mol Ther. 2026 Feb 04; 34(2):950-963.. View in PubMed
• Spin and reporting bias in the use of platelet-rich plasma for the treatment of knee osteoarthritis. Eur J Orthop Surg Traumatol. 2025 Aug 12; 35(1):348.. View in PubMed
• Novel Technologies in Periprosthetic Joint Infection: Emerging Diagnostics. J Arthroplasty. 2026 02; 41(2):551-559.. View in PubMed
• Erratum to ‘The Limited Utility of Hemoglobin A1c as a Predictor for Periprosthetic Joint Infection Following Total Joint Arthroplasty: A Continuous Variable Analysis’ [The Journal of Arthroplasty 40 (2025) 1836-1844]. J Arthroplasty. 2025 Oct; 40(10):2771.. View in PubMed
• Total Hip Arthroplasty Among Superobese Patients: Proceed With Caution. Arthroplast Today. 2025 Aug; 34:101770.. View in PubMed
• High-dose romosozumab promoted bone regeneration of critical-size ulnar defect filled with demineralized bone matrix in nonhuman primates. J Orthop Translat. 2025 Sep; 54:1-7.. View in PubMed
• Novel Technologies in Periprosthetic Joint Infections: Emerging Therapeutics. J Arthroplasty. 2026 02; 41(2):560-568.. View in PubMed
• Epinephrine Nasal Spray Improves Allergic Symptoms in Patients Undergoing Oral Food Challenge, Phase 3 Trial. J Allergy Clin Immunol Pract. 2025 Oct; 13(10):2787-2794.. View in PubMed
• Defining Benchmarks for Case Minimums During Accreditation Council for Graduate Medical Education-Accredited Total Joint Arthroplasty Fellowship Training. J Arthroplasty. 2026 02; 41(2):364-369.e1.. View in PubMed
• Whole-Exome Sequencing of Total Joint Arthroplasty Patients Who Have Known Pulmonary Embolism: A Pilot Study. J Arthroplasty. 2026 01; 41(1):193-200.e4.. View in PubMed
• Low-Level Evidence Used to Substantiate Insurance Coverage Policies for Knee and Hip Arthroplasty. J Arthroplasty. 2025 Sep; 40(9S1):S142-S151.. View in PubMed
• Medicare Reimbursement for Primary Hip and Knee Arthroplasty Is Disproportionately Decreasing Relative to Other High-Volume Inpatient Procedures: Leader of the Pack. J Arthroplasty. 2025 Sep; 40(9S1):S105-S109.. View in PubMed
• Rivaroxaban Utilization Without Perioperative Tranexamic Acid Is Associated With an Increased Risk of Bleeding Complications Following Total Joint Arthroplasty. J Arthroplasty. 2025 10; 40(10):2586-2592.e3.. View in PubMed
• Increased Incidence of Spin and Reporting Bias on the Use of Hyaluronic Acid for the Treatment of Knee Osteoarthritis: An Evaluation of Systematic Reviews and Meta-Analyses. J Arthroplasty. 2025 Sep; 40(9S1):S581-S587.. View in PubMed
• Effect of BMI on the risk of postoperative complications following total hip arthroplasty. Bone Joint J. 2025 May 01; 107.. View in PubMed
• 10 ways to improve your management of food allergy. Ann Allergy Asthma Immunol. 2025 May; 134(5):616-618.. View in PubMed
• Emerging Concepts in Periprosthetic Joint Infection Research: Intracellular Organisms. J Arthroplasty. 2026 01; 41(1):176-185.. View in PubMed
• Barriers and Solutions to Optimal Food Allergy Prevention, Diagnostic, and Management Strategies. J Allergy Clin Immunol Pract. 2025 Aug; 13(8):1928-1934.. View in PubMed
• Medicare Reimbursement for Primary and Revision Total Hip and Knee Arthroplasty: An Updated Analysis From 2000 to 2024. J Arthroplasty. 2025 Sep; 40(9S1):S100-S104.e1.. View in PubMed
• Dexamethasone Is Associated With Lower Rates of Pulmonary Complications Following Cemented Femoral Fixation During Primary Total Hip Arthroplasty. J Arthroplasty. 2025 Aug; 40(8S1):S159-S165.e1.. View in PubMed
• Imaging near titanium total hip arthroplasty at 0.55 T compared with 3 T. Magn Reson Med. 2025 07; 94(1):242-250.. View in PubMed
• Shared Decision-Making in Food Protein-Induced Enterocolitis Syndrome. J Allergy Clin Immunol Pract. 2025 06; 13(6):1310-1316.. View in PubMed
• Preoperative Anemia as a Predictor of Periprosthetic Joint Infection Following Total Knee Arthroplasty: A Continuous Variable Analysis. J Arthroplasty. 2025 Jul; 40(7S1):S169-S175.e5.. View in PubMed
• Efficacy and Safety of Epicutaneous Immunotherapy in Peanut-Allergic Toddlers: Open-Label Extension to EPITOPE. J Allergy Clin Immunol Pract. 2025 May; 13(5):1176-1187.e7.. View in PubMed
• Albumin as a Predictor of Periprosthetic Joint Infection Following Total Joint Arthroplasty: Identifying a New Data-Driven Threshold Utilizing a Continuous Variable Analysis. J Arthroplasty. 2025 08; 40(8):2117-2125.e4.. View in PubMed
• Regional Gene Therapy for Bone Tissue Engineering: A Current Concepts Review. Bioengineering (Basel). 2025 Jan 27; 12(2).. View in PubMed
• Integrated phase I pharmacokinetics and pharmacodynamics of epinephrine administered through sublingual film, autoinjector, or manual injection. Ann Allergy Asthma Immunol. 2025 05; 134(5):580-586.. View in PubMed
• The Limited Utility of Hemoglobin A1c as a Predictor for Periprosthetic Joint Infection Following Total Joint Arthroplasty: A Continuous Variable Analysis. J Arthroplasty. 2025 07; 40(7):1836-1844.e5.. View in PubMed
• Emerging Concepts in Periprosthetic Joint Infection Research: The Human Microbiome. J Arthroplasty. 2025 07; 40(7):1821-1826.. View in PubMed
• Proposed mechanism of cardiovascular responses for bolus injection of epinephrine from epinephrine autoinjectors. J Allergy Clin Immunol Pract. 2025 Apr; 13(4):944-946.e1.. View in PubMed
• Ex Vivo Regional Gene Therapy Compared to Recombinant BMP-2 for the Treatment of Critical-Size Bone Defects: An In Vivo Single-Cell RNA-Sequencing Study. Bioengineering (Basel). 2025 Jan 01; 12(1).. View in PubMed
• Risk Factors for Venous Thromboembolism Following Total Knee Arthroplasty: An Analysis of 3,052 Pulmonary Emboli. J Am Acad Orthop Surg. 2025 Apr 01; 33(7):e380-e390.. View in PubMed
• Medicaid Insurance Is Associated With Increased Readmissions and Mortality After Surgery for Periprosthetic Joint Infection. J Am Acad Orthop Surg. 2025 Apr 01; 33(7):e391-e400.. View in PubMed
• Complete Blood Cell Count-Based Ratios Identify Total Joint Arthroplasty Patients Likely to Benefit from Perioperative Dexamethasone. J Bone Joint Surg Am. 2025 Jan 15; 107(2):163-173.. View in PubMed
• Alarmingly High Rates of Deep Vein Thrombosis and Pulmonary Embolism Following Closed Reduction for Dislocated Total Hip Arthroplasty. J Arthroplasty. 2025 Jun; 40(6):1629-1635.e4.. View in PubMed
• Safety and Efficacy of Aspirin Compared to Enoxaparin Following Total Hip and Total Knee Arthroplasty Among Patients Who Have a History of Venous Thromboembolic Disease. J Arthroplasty. 2025 Jun; 40(6):1484-1491.e4.. View in PubMed
• Tranexamic Acid Is Safe in Arthroplasty Patients Who Have a History of Venous Thromboembolism: An Analysis Accounting for Surgeon Selection Bias. J Arthroplasty. 2025 Jun; 40(6):1492-1499.e1.. View in PubMed
• Are Activity Restrictions Necessary After Total Hip Arthroplasty: A Systematic Review. Arthroplast Today. 2024 Dec; 30:101576.. View in PubMed
• Dual-Mobility Articulations in Primary Total Hip Arthroplasty: Mid-Term Outcomes From the American Joint Replacement Registry. J Arthroplasty. 2025 05; 40(5):1252-1257.e3.. View in PubMed
• Perioperative Tranexamic Acid Should Be Considered for Total Joint Arthroplasty Patients Receiving Apixaban for Thromboprophylaxis. Arthroplast Today. 2024 Dec; 30:101548.. View in PubMed
• Low-Volume Surgeons Operating at High-Volume Hospitals Have Low Rates of Periprosthetic Joint Infection After Hip and Knee Arthroplasty. J Arthroplasty. 2025 05; 40(5):1317-1325.e4.. View in PubMed
• Sex Diversity in the Emerging United States Arthroplasty Workforce Is Limited. J Arthroplasty. 2025 May; 40(5):1347-1352.. View in PubMed
• Medicare Advantage Is Associated With Higher Mortality After Antibiotic Spacer Placement for Periprosthetic Joint Infection. J Arthroplasty. 2025 04; 40(4):854-859.e6.. View in PubMed
• Pharmacokinetic and Pharmacodynamic Profile of Epinephrine Nasal Spray Versus Intramuscular Epinephrine Autoinjector in Healthy Adults. J Allergy Clin Immunol Pract. 2024 Dec; 12(12):3274-3282.e2.. View in PubMed
• Body Mass Index and the Risk of Postoperative Complications After Total Knee Arthroplasty. J Am Acad Orthop Surg. 2025 Jan 01; 33(1):e36-e45.. View in PubMed
• Evaluating the 2023 Standardized Letter of Recommendation Form in Applications to Orthopaedic Surgery Residency. J Am Acad Orthop Surg. 2025 Jan 01; 33(1):e11-e23.. View in PubMed
• Perceptions, realities, and alternatives in rescue epinephrine. Ann Allergy Asthma Immunol. 2024 Dec; 133(6):623-625.. View in PubMed
• Risk Factors for Femoral Head Collapse in Osteonecrosis. J Arthroplasty. 2025 Mar; 40(3):559-565.. View in PubMed
• Correction: Limited potential of AAV-mediated gene therapy in transducing human mesenchymal stem cells for bone repair applications. Gene Ther. 2024 Sep; 31(9-10):527.. View in PubMed
• Reply to the Letter to the Editor: Risk Factors Associated with Thromboembolic Complications Following Total Hip Arthroplasty: An Analysis of 1,129 Pulmonary Emboli. J Am Acad Orthop Surg. 2025 Feb 15; 33(4):e257-e258.. View in PubMed
• Is It Realistic to Think Venous Thromboembolism is a Never Event in Total Joint Arthroplasty. J Arthroplasty. 2024 10; 39(10):2403-2404.. View in PubMed
• Perioperative Dexamethasone in Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized, Placebo-Controlled Trials. Anesth Analg. 2024 09 01; 139(3):479-489.. View in PubMed
• Awareness and Application of United States Food Allergy Prevention Guidelines Among Pediatricians and Other Clinicians. J Pediatr. 2024 12; 275:114218.. View in PubMed
• Glucagon-Like Peptide Receptor-1 Agonists Used for Medically-Supervised Weight Loss in Patients With Hip and Knee Osteoarthritis: Critical Considerations for the Arthroplasty Surgeon. Arthroplast Today. 2024 Jun; 27:101327.. View in PubMed
• Super-Obesity is Associated With an Increased Risk of Complications Following Primary Total Knee Arthroplasty. J Arthroplasty. 2024 12; 39(12):2986-2991.e1.. View in PubMed
• The Association Between Surgeon Volume and Dislocation After Total Hip Arthroplasty: A Nationwide Evaluation of 5,106 Orthopaedic Surgeons. J Am Acad Orthop Surg. 2025 Jan 01; 33(1):23-33.. View in PubMed
• Preoperative Laboratory Values Predicting Periprosthetic Joint Infection in Morbidly Obese Patients Undergoing Total Hip or Knee Arthroplasty. J Bone Joint Surg Am. 2024 Jul 17; 106(14):1317-1327.. View in PubMed
• Perioperative Dexamethasone is Associated With a Decreased Risk of Pulmonary Embolism and Deep Vein Thrombosis Following Total Joint Arthroplasty: An Analysis of 70,000 High-Risk Patients. J Arthroplasty. 2024 10; 39(10):2446-2451.e1.. View in PubMed
• In vivo effects of cell seeding technique in an ex vivo regional gene therapy model for bone regeneration. J Biomed Mater Res A. 2024 10; 112(10):1688-1698.. View in PubMed
• Risk Factors Associated with Thromboembolic Complications After total Hip Arthroplasty: An Analysis of 1,129 Pulmonary Emboli. J Am Acad Orthop Surg. 2024 Jul 15; 32(14):e706-e715.. View in PubMed
• Practice Management Strategies Among Current Members of the American Association of Hip and Knee Surgeons. J Arthroplasty. 2024 09; 39(9 Suppl 2):S39-S44.e5.. View in PubMed
• Pharmacoequity and Biologics in the Allergy Clinic: Providing the Right Care, at the Right Time, Every Time, to Everyone. J Allergy Clin Immunol Pract. 2024 05; 12(5):1170-1180.. View in PubMed

• Heckmann, Nathanael