Jeanmarie Bouteiller, PhD

Jean-Marie Bouteiller joined the University of Southern California with a Masters in Electrical Engineering and Computer Science (from University of Montpellier, FRANCE) to start a PhD in Computational Neuroscience with Prof. Michel Baudry. With this dual competency in Neuroscience and Engineering, he joined in 2002 the laboratory of Prof. Theodore W. Berger to start the development of a unique computational synaptic modeling platform that would take into account the multitude of mechanisms that comprise presynaptic terminal, cleft and postsynaptic spine. This platform has substantially grown throughout the years to include a large number of mechanisms and modulatory pathways as well as astrocytic modulation, while extending its hierarchical structure to span multiple biological scales, from biomolecular mechanisms to synapse, neuron and neuronal network.

• Impact of Aii Amacrine Cell Rewiring in a Pathoconnectome-Based Computational Model of Early Retinal Degeneration. bioRxiv. 2026 May 05.. View in PubMed
• Population-scale analysis of frequency-dependent calcium dynamics in retinal ganglion cells under electric field stimulation. Sci Rep. 2026 Apr 24; 16(1).. View in PubMed
• A spatially discretized convolutional neural mass model for studying meso-scale spatio-temporal transformations in the rat hippocampus. Res Sq. 2026 Apr 13.. View in PubMed
• Population-Scale Analysis of Frequency-Dependent Calcium Dynamics in Retinal Ganglion Cells Under Electric Field Stimulation. bioRxiv. 2026 Jan 25.. View in PubMed
• Maximizing theoretical and practical storage capacity in single-layer feedforward neural networks. Front Comput Neurosci. 2025; 19:1646810.. View in PubMed
• Dentate gyrus granule cell activation following extracellular electrical stimulation: a multi-scale computational model to guide hippocampal neurostimulation strategies. Front Comput Neurosci. 2025; 19:1638002.. View in PubMed
• Experimentally Constrained Mechanistic and Data-Driven Models for Simulating NMDA Receptor Dynamics. Biomedicines. 2025 Jul 08; 13(7).. View in PubMed
• Retention and characteristics associated with remote questionnaire completion in a general population cohort study: the project baseline health study. Front Digit Health. 2025; 7:1520132.. View in PubMed
• Toward Safety Protocols for Peripheral Nerve Stimulation (PNS): A Computational and Experimental Approach. Bioelectromagnetics. 2025 Jan; 46(1):e22533.. View in PubMed
• Hydroxypropyl-Beta Cyclodextrin Barrier Prevents Respiratory Viral Infections: A Preclinical Study. Int J Mol Sci. 2024 Feb 08; 25(4).. View in PubMed
• Machine learning enables non-Gaussian investigation of changes to peripheral nerves related to electrical stimulation. Sci Rep. 2024 02 02; 14(1):2795.. View in PubMed
• Editorial: Amplifying Efficiency and Accuracy in Dementia Drug Development. J Prev Alzheimers Dis. 2024; 11(5):1180-1182.. View in PubMed
• Impact of Retinal Degeneration on Response of ON and OFF Cone Bipolar Cells to Electrical Stimulation. IEEE Trans Neural Syst Rehabil Eng. 2023; 31:2424-2437.. View in PubMed
• Electrical Stimulation Induced Current Distribution in Peripheral Nerves Varies Significantly with the Extent of Nerve Damage: A Computational Study Utilizing Convolutional Neural Network and Realistic Nerve Models. Int J Neural Syst. 2023 Apr; 33(4):2350022.. View in PubMed
• Computational optimization of delivery parameters to guide the development of targeted Nasal spray. Sci Rep. 2023 03 12; 13(1):4099.. View in PubMed
• Hallmarks of neurodegenerative disease: A systems pharmacology perspective. CPT Pharmacometrics Syst Pharmacol. 2022 11; 11(11):1399-1429.. View in PubMed
• Electrical Stimulation Induced Current Distribution in Peripheral Nerves Varies Significantly with the Extent of Nerve Damage: A Computational Study Utilizing Convolutional Neural Network and Realistic Nerve Models. Int Work Conf Interp Nat Artif Comput. 2022 May-Jun; 13258:526-535.. View in PubMed
• Mechanisms underlying activation of retinal bipolar cells through targeted electrical stimulation: a computational study. J Neural Eng. 2021 12 15; 18(6).. View in PubMed
• Electrode Spacing and Current Distribution in Electrical Stimulation of Peripheral Nerve: A Computational Modeling Study using Realistic Nerve Models. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:4416-4419.. View in PubMed
• A Computational Model Simulates Light-Evoked Responses in the Retinal Cone Pathway. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:4482-4486.. View in PubMed
• Modeling ON Cone Bipolar Cells for Electrical Stimulation. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:6547-6550.. View in PubMed
• Bridging Hierarchies in Multi-Scale Models of Neural Systems: Look-Up Tables Enable Computationally Efficient Simulations of Non-linear Synaptic Dynamics. Front Comput Neurosci. 2021; 15:733155.. View in PubMed
• Recycled products are not always skin-friendly: Occupational dermatitis due to recycled plastic. Ann Dermatol Venereol. 2021 Sep; 148(3):191-192.. View in PubMed
• Topographic Organization of Correlation Along the Longitudinal and Transverse Axes in Rat Hippocampal CA3 Due to Excitatory Afferents. Front Comput Neurosci. 2020; 14:588881.. View in PubMed
• A Computational Model of the Cholinergic Modulation of CA1 Pyramidal Cell Activity. Front Comput Neurosci. 2020; 14:75.. View in PubMed
• Admittance Method for Estimating Local Field Potentials Generated in a Multi-Scale Neuron Model of the Hippocampus. Front Comput Neurosci. 2020; 14:72.. View in PubMed
• A Computational Model of Mitochondria Motility in Axons. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:2287-2290.. View in PubMed
• ROOTS: An Algorithm to Generate Biologically Realistic Cortical Axons and an Application to Electroceutical Modeling. Front Comput Neurosci. 2020; 14:13.. View in PubMed
• Pathogenic Processes Underlying Alzheimer’s Disease: Modeling the Effects of Amyloid Beta on Synaptic Transmission. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul; 2019:1956-1959.. View in PubMed
• Editorial: Influence of Inter- and Intra-Synaptic Factors on Information Processing in the Brain. Front Comput Neurosci. 2019; 13:32.. View in PubMed
• Axonal Anatomy Optimizes Spatial Encoding in the Rat Entorhinal-Dentate System: A Computational Study. IEEE Trans Biomed Eng. 2019 10; 66(10):2728-2739.. View in PubMed
• A Glutamatergic Spine Model to Enable Multi-Scale Modeling of Nonlinear Calcium Dynamics. Front Comput Neurosci. 2018; 12:58.. View in PubMed
• Cholinergic Modulation of CA1 Pyramidal Cells via M1 Muscarinic Receptor Activation: A Computational Study at Physiological and Supraphysiological Levels. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:1396-1399.. View in PubMed
• Graph-Based Models of Cortical Axons for the Prediction of Neuronal Response to Extracellular Electrical Stimulation. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:1380-1383.. View in PubMed
• Decoding Position to Analyze Spatial Information Encoding in a Large-Scale Neuronal Network Model of Rat Dentate Gyrus. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:6137-6140.. View in PubMed
• Model-Based Analysis of Electrode Placement and Pulse Amplitude for Hippocampal Stimulation. IEEE Trans Biomed Eng. 2018 10; 65(10):2278-2289.. View in PubMed
• Development of a Computational Approach/Model to Explore NMDA Receptors Functions. Methods Mol Biol. 2017; 1677:291-306.. View in PubMed
• A large-scale detailed neuronal model of electrical stimulation of the dentate gyrus and perforant path as a platform for electrode design and optimization. Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug; 2016:2794-2797.. View in PubMed
• Development of a detailed model of calcium dynamics at the postsynaptic spine of an excitatory synapse. Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug; 2016:6102-6105.. View in PubMed
• Impact of synaptic localization and subunit composition of ionotropic glutamate receptors on synaptic function: modeling and simulation studies. IEEE/ACM Trans Comput Biol Bioinform. 2017 Jul-Aug; 14(4):892-904.. View in PubMed
• Impact of synaptic localization and subunit composition of ionotropic glutamate receptors on synaptic function: modeling and simulation studies. IEEE/ACM Trans Comput Biol Bioinform. 2017 Jul-Aug; 14(4):892-904.. View in PubMed
• Modeling and simulation of organophosphate-induced neurotoxicity: Prediction and validation by experimental studies. Neurotoxicology. 2016 05; 54:140-152.. View in PubMed
• Synaptic Efficacy as a Function of Ionotropic Receptor Distribution: A Computational Study. PLoS One. 2015; 10(10):e0140333.. View in PubMed
• A fully parallel in time and space algorithm for simulating the electrical activity of a neural tissue. J Neurosci Methods. 2016 Jan 15; 257:17-25.. View in PubMed
• Volterra representation enables modeling of complex synaptic nonlinear dynamics in large-scale simulations. Front Comput Neurosci. 2015; 9:112.. View in PubMed
• libRoadRunner: a high performance SBML simulation and analysis library. Bioinformatics. 2015 Oct 15; 31(20):3315-21.. View in PubMed
• The volterra functional series is a viable alternative to kinetic models for synaptic modeling–calibration and benchmarking. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:3291-4.. View in PubMed
• A comparison between direct and indirect measurements of neurotransmitter vesicle release dynamics: a computational study. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:1155-8.. View in PubMed
• Insights on synaptic paired-pulse response using parametric and non-parametric models. Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:1041-4.. View in PubMed
• Influence of ionotropic receptors localization on glutamatergic synaptic response to paired-pulse stimulation protocol. Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:1037-40.. View in PubMed
• A programmable analog subthreshold biomimetic model for bi-directional communication with the brain. Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:787-90.. View in PubMed
• A computational model to investigate astrocytic glutamate uptake influence on synaptic transmission and neuronal spiking. Front Comput Neurosci. 2012; 6:70.. View in PubMed
• Influence of ionotropic receptor location on their dynamics at glutamatergic synapses. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:1374-7.. View in PubMed
• Modeling of the nervous system: from modulation of glutamatergic and gabaergic molecular dynamics to neuron spiking activity. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:6612-5.. View in PubMed
• Simulation of postsynaptic glutamate receptors reveals critical features of glutamatergic transmission. PLoS One. 2011; 6(12):e28380.. View in PubMed
• Integrated multiscale modeling of the nervous system: predicting changes in hippocampal network activity by a positive AMPA receptor modulator. IEEE Trans Biomed Eng. 2011 Oct; 58(10):3008-11.. View in PubMed
• Modeling of the nervous system: from molecular dynamics and synaptic modulation to neuron spiking activity. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:445-8.. View in PubMed
• Modeling neuron-glia interactions: from parametric model to neuromorphic hardware. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:3581-4.. View in PubMed
• Paired-pulse stimulation at glutamatergic synapses – pre- and postsynaptic components. Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:787-90.. View in PubMed
• Computational studies of NMDA receptors: differential effects of neuronal activity on efficacy of competitive and non-competitive antagonists. Open Access Bioinformatics. 2010; 2:113-125.. View in PubMed
• Modeling glutamatergic synapses: insights into mechanisms regulating synaptic efficacy. J Integr Neurosci. 2008 Jun; 7(2):185-97.. View in PubMed
• EONS: an online synaptic modeling platform. Conf Proc IEEE Eng Med Biol Soc. 2006; 2006:4155-8.. View in PubMed