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Jessie Huang, PhD

Assistant Professor of Medicine

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Publications

  • Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice. Cell Stem Cell. 2023 09 07; 30(9):1217-1234.e7.. View in PubMed
  • Generation of human alveolar epithelial type I cells from pluripotent stem cells. bioRxiv. 2023 Jan 20.. View in PubMed
  • Culture impact on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cells. JCI Insight. 2023 01 10; 8(1).. View in PubMed
  • CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells. Sci Adv. 2022 07 15; 8(28):eabo6566.. View in PubMed
  • Correction: Recombinant Lloviu virus as a tool to study viral replication and host responses. PLoS Pathog. 2022 Jun; 18(6):e1010659.. View in PubMed
  • Generating 3D Spheres and 2D Air-Liquid Interface Cultures of Human Induced Pluripotent Stem Cell-Derived Type 2 Alveolar Epithelial Cells. J Vis Exp. 2022 04 15; (182).. View in PubMed
  • Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell-derived alveolar epithelium. JCI Insight. 2022 03 22; 7(6).. View in PubMed
  • Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection. Am J Physiol Lung Cell Mol Physiol. 2022 03 01; 322(3):L462-L478.. View in PubMed
  • The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters. bioRxiv. 2022 Feb 09.. View in PubMed
  • Recombinant Lloviu virus as a tool to study viral replication and host responses. PLoS Pathog. 2022 02; 18(2):e1010268.. View in PubMed
  • Reconstructed signaling and regulatory networks identify potential drugs for SARS-CoV-2 infection. bioRxiv. 2021 Dec 09.. View in PubMed
  • Heterogeneity in Human Induced Pluripotent Stem Cell-derived Alveolar Epithelial Type II Cells Revealed with ABCA3/SFTPC Reporters. Am J Respir Cell Mol Biol. 2021 10; 65(4):442-460.. View in PubMed
  • Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19. Proc Natl Acad Sci U S A. 2021 09 07; 118(36).. View in PubMed
  • SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes. Proc Natl Acad Sci U S A. 2021 04 20; 118(16).. View in PubMed
  • Mechanical stress determines the configuration of TGFβ activation in articular cartilage. Nat Commun. 2021 03 17; 12(1):1706.. View in PubMed
  • Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2021 Jan 07; 81(1):212.. View in PubMed
  • Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19. bioRxiv. 2020 Dec 07.. View in PubMed
  • SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. Cell Stem Cell. 2020 12 03; 27(6):962-973.e7.. View in PubMed
  • The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28485-28495.. View in PubMed
  • SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial derived cells and cardiomyocytes. bioRxiv. 2020 Nov 02.. View in PubMed
  • Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells. Cell Stem Cell. 2020 10 01; 27(4):663-678.e8.. View in PubMed
  • SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. bioRxiv. 2020 Aug 06.. View in PubMed
  • Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors. bioRxiv. 2020 Jun 04.. View in PubMed
  • YAP and TAZ regulate cell volume. J Cell Biol. 2019 10 07; 218(10):3472-3488.. View in PubMed
  • Defining an olfactory receptor function in airway smooth muscle cells. Sci Rep. 2016 12 01; 6:38231.. View in PubMed
  • An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma. J Allergy Clin Immunol. 2016 07; 138(1):294-297.e4.. View in PubMed
  • Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells. Oncotarget. 2015 Jan 01; 6(1):130-43.. View in PubMed
  • Positive end-expiratory pressure increments during anesthesia in normal lung result in hysteresis and greater numbers of smaller aerated airspaces. Anesthesiology. 2013 Dec; 119(6):1402-9.. View in PubMed

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