Jian Yu

My research explores mechanistic coupling of intestinal stem cell injury with regeneration, focusing on cancer driver-dependent regulation of cell death, stress adaptation, and immunologic outcomes. Our long-term goal is to identify novel targets and agents for colon cancer prevention and treatment through stem cell and niche normalization and epithelial barrier longevity. I have been active in teaching and mentoring students, postdoctoral fellows, and junior faculty.

Secondary appointment: Professor of Cancer Biology

Publications
-My NCBI
https://www.ncbi.nlm.nih.gov/myncbi/jian.yu.1/bibliography/public/
-Google Scholar
https://scholar.google.com/citations?user=yXODGQYAAAAJ&hl=en&authuser=1

• Johns Hopkins University School of Medicine: Michael A. Shanoff Research Excellence Award, 2001
• The Flight Attendant Medical Research Institute: Young Clinical Scientist Award, 2003
• The Hillman Foundation: The Hillman Fellow of Innovative Cancer Research, 2004
• The Alliance for Cancer Gene Therapy: Young Investigator Award, 2005
• University of Pittsburgh Cancer Institute: Junior Scholar Award, 2008
• American Cancer Society: Research Scholar Award, 2010
• University of Pittsburgh: Innovator Award, 2011

• Sichuan University, Chengdu, China — BS — 07/1991 — Chemistry
• Johns Hopkins University, Baltimore, USA — PhD — 05/2001 — Human Genetics and Molecular Biology
• The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins , Baltimore, USA — Fellowship, postdoctoral — 06/2002 — Oncology

• LR-IL-22 for Mitigation and Management of Radiation Injuries
  NIH/NIAID · U01 AI172885 · Dec 1, 2022 – Nov 30, 2027 · Role: Co-Investigator
• STING-dependent Intestinal Regeneration upon Radiation Injury
  NIH/NCI · R01CA260900 · Feb 9, 2022 – Jan 31, 2027 · Role: Principal Investigator
• STING-dependent Intestinal Regeneration upon Radiation Injury
  NIH · R01CA260900 · Feb 7, 2022 – Aug 31, 2027 · Role: Principal Investigator
• BET degraders for improving colorectal cancer therapy
  NIH/NCI · R01CA248112 · Apr 1, 2021 – Mar 31, 2026 · Role: Co-Investigator
• Targeting defective necroptosis in colorectal cancer
  NIH · R01CA247231 · Dec 1, 2019 – Mar 31, 2025 · Role: Co-Principal Investigator
• Targeting defective necroptosis in colorectal cancer
  NIH/NCI · R01CA247231 · Dec 1, 2019 – Nov 30, 2024 · Role: Co-Principle Investigator, MPI
• Translation addiction and targeting in colon cancer
  NIH/NCI · R01CA215481 · Jan 1, 2018 – Mar 31, 2023 · Role: Principle Investigator
• Translation addiction and targeting in colon cancer
  NIH · R01CA215481 · Jan 1, 2018 – Mar 31, 2023 · Role: Principal Investigator
• Intestinal Stem Cell Survival and Renewal Coordinately Regulated by PUMA and p21
  NIH · U01DK085570 · Sep 30, 2009 – Aug 31, 2015 · Role: Principal Investigator
• Role of PUMA in EGFR targeted therapy in HNSCC
  NIH · R01CA129829 · Aug 1, 2008 – May 31, 2014 · Role: Principal Investigator

• cell death
• stress adaptation
• intestinal stem cell
• colon cancer
• inflammation

• Lenz, Heinz-Josef
• Zhang, Lin
• Ulaner, Gary
• Chen, Dongshi
• Cohen, Pinchas
• Wang, Rongfu