Keck School Faculty

Jian Yu

Jian Yu

Visiting Professor of Medicine
1450 Biggy Street Health Sciences Campus Los Angeles


University of Pittsburgh: Innovator Award, 2011

American Cancer Society: Research Scholar Award, 2010

University of Pittsburgh Cancer Institute: Junior Scholar Award, 2008

The Alliance for Cancer Gene Therapy : Young Investigator Award, 2005

The Hillman Foundation: The Hillman Fellow of Innovative Cancer Research, 2004

The Flight Attendant Medical Research Institute: Young Clinical Scientist Award, 2003

Johns Hopkins University School of Medicine: Michael A. Shanoff Research Excellence Award, 2001

mTOR inhibition suppresses Myc-driven polyposis by inducing immunogenic cell death Oncogene. 2023 May 03. . View in PubMed

Targeting Myc-driven stress addiction in colorectal cancer Drug Resist Updat. 2023 Apr 20; 69:100963. . View in PubMed

Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer Mol Biomed. 2022 Mar 21; 3(1):10. . View in PubMed

Interferon b drives intestinal regeneration after radiation Sci Adv. 2021 Oct 08; 7(41):eabi5253. . View in PubMed

eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis Elife. 2020 Nov 02; 9. . View in PubMed

MLH1 Deficiency Induces Cetuximab Resistance in Colon Cancer via Her-2/PI3K/AKT Signaling Adv Sci (Weinh). 2020 Jul; 7(13):2000112. . View in PubMed

Targeting p53-dependent stem cell loss for intestinal chemoprotection Sci Transl Med. 2018 Feb 07; 10(427). . View in PubMed

Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice J Clin Invest. 2016 Nov 01; 126(11):4076-4087. . View in PubMed

mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation Oncogene. 2016 Jan 14; 35(2):148-57. . View in PubMed

PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome Cell Stem Cell. 2008 Jun 05; 2(6):576-83. . View in PubMed

PUMA mediates the apoptotic response to p53 in colorectal cancer cells Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1931-6. . View in PubMed

PUMA induces the rapid apoptosis of colorectal cancer cells Mol Cell. 2001 Mar; 7(3):673-82. . View in PubMed

My research explores mechanistic coupling of intestinal stem cell injury with regeneration, focusing on cancer driver-dependent regulation of cell death, stress adaptation, and immunologic outcomes. Our long-term goal is to identify novel targets and agents for colon cancer prevention and treatment through stem cell and niche normalization and epithelial barrier longevity. I have been active in teaching and mentoring students, postdoctoral fellows, and junior faculty.


-Google Scholar, 143 papers, over 25,000 citations, h-index 70 (2023)
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