Keck School Faculty

Partial Hepatectomy and Castration of HBV Transgenic Mice Methods Mol Biol. 2017; 1540:259-266. . View in PubMed

Suppression of Host Innate Immune Response by Hepatitis C Virus via Induction of Autophagic Degradation of TRAF6 J Virol. 2016 Dec 01; 90(23):10928-10935. . View in PubMed

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Autophagy. 2016; 12(1):1-222. . View in PubMed

Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission Immunity. 2016 05 17; 44(5):1204-14. . View in PubMed

Hepatitis C virus and autophagy Biol Chem. 2015 Nov; 396(11):1215-22. . View in PubMed

Autophagy, a double-edged sword in hepatocarcinogenesis Mol Cell Oncol. 2015 Oct-Dec; 2(4):e1004968. . View in PubMed

Autophagy inhibits oxidative stress and tumor suppressors to exert its dual effect on hepatocarcinogenesis Cell Death Differ. 2015 Jun; 22(6):1025-34. . View in PubMed

TNF-a Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism PLoS Pathog. 2015 May; 11(5):e1004937. . View in PubMed

Genetic and epigenetic alterations in hepatitis B virus-associated hepatocellular carcinoma Virol Sin. 2015 Apr; 30(2):85-91. . View in PubMed

Technical standards for hepatitis B virus X protein (HBx) research Hepatology. 2015 Apr; 61(4):1416-24. . View in PubMed

Oncogenic viruses and cancer Virol Sin. 2015 Apr; 30(2):83-4. . View in PubMed

HCV induces the expression of Rubicon and UVRAG to temporally regulate the maturation of autophagosomes and viral replication PLoS Pathog. 2015 Mar; 11(3):e1004764. . View in PubMed

Virus control goes epigenetic PLoS Pathog. 2014 Sep; 10(9):e1004370. . View in PubMed

Functions of autophagy in normal and diseased liver Autophagy. 2013 Aug; 9(8):1131-58. . View in PubMed

Transient activation of the PI3K-AKT pathway by hepatitis C virus to enhance viral entry J Biol Chem. 2012 Dec 07; 287(50):41922-30. . View in PubMed

Viral-load-dependent effects of liver injury and regeneration on hepatitis B virus replication in mice J Virol. 2012 Sep; 86(18):9599-605. . View in PubMed

Replication of hepatitis C virus RNA on autophagosomal membranes J Biol Chem. 2012 May 25; 287(22):18036-43. . View in PubMed

Effects of Lipofectamine 2000/siRNA complexes on autophagy in hepatoma cells Mol Biotechnol. 2012 May; 51(1):1-8. . View in PubMed

Guidelines for the use and interpretation of assays for monitoring autophagy Autophagy. 2012 Apr; 8(4):445-544. . View in PubMed

Enhancement of hepatitis B virus replication by androgen and its receptor in mice J Virol. 2012 Feb; 86(4):1904-10. . View in PubMed

Hepatitis C virus translation preferentially depends on active RNA replication PLoS One. 2012; 7(8):e43600. . View in PubMed

Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signaling PLoS One. 2012; 7(5):e36818. . View in PubMed

Autophagy required for hepatitis B virus replication in transgenic mice J Virol. 2011 Dec; 85(24):13453-6. . View in PubMed

IFN-a/ß and autophagy: tug-of-war between HCV and the host Autophagy. 2011 Nov; 7(11):1394-6. . View in PubMed

Inhibition of RIG-I-mediated signaling by Kaposi's sarcoma-associated herpesvirus-encoded deubiquitinase ORF64 J Virol. 2011 Oct; 85(20):10899-904. . View in PubMed

Krüppel-like factor 15 activates hepatitis B virus gene expression and replication Hepatology. 2011 Jul; 54(1):109-21. . View in PubMed

Effects of interferon-a/ß on HBV replication determined by viral load PLoS Pathog. 2011 Jul; 7(7):e1002159. . View in PubMed

Transgenic expression of entire hepatitis B virus in mice induces hepatocarcinogenesis independent of chronic liver injury PLoS One. 2011; 6(10):e26240. . View in PubMed

The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway PLoS One. 2011; 6(7):e22979. . View in PubMed

Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes J Immunol. 2010 Dec 01; 185(11):6985-98. . View in PubMed

Inhibition of cellular proteasome activities mediates HBX-independent hepatitis B virus replication in vivo J Virol. 2010 Sep; 84(18):9326-31. . View in PubMed

c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair Hepatology. 2010 Aug; 52(2):480-92. . View in PubMed

Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription Sci Transl Med. 2010 May 19; 2(32):32ra35. . View in PubMed

Autophagy by hepatitis B virus and for hepatitis B virus Autophagy. 2010 May; 6(4):548-9. . View in PubMed

The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4383-8. . View in PubMed

Autophagy in viral replication and pathogenesis Mol Cells. 2010 Jan; 29(1):1-7. . View in PubMed

Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1548-53. . View in PubMed

PKC delta signaling: a dual role in regulating hypoxic stress-induced autophagy and apoptosis Autophagy. 2009 Feb; 5(2):244-6. . View in PubMed

Ubiquitin-independent degradation of hepatitis C virus F protein J Virol. 2009 Jan; 83(2):612-21. . View in PubMed

Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response Hepatology. 2008 Oct; 48(4):1054-61. . View in PubMed

Beyond autophagy: the role of UVRAG in membrane trafficking Autophagy. 2008 Aug; 4(6):817-20. . View in PubMed

Perturbation of autophagic pathway by hepatitis C virus Autophagy. 2008 Aug; 4(6):830-1. . View in PubMed

Hepatitis C virus ARFP/F protein interacts with cellular MM-1 protein and enhances the gene trans-activation activity of c-Myc J Biomed Sci. 2008 Jul; 15(4):417-25. . View in PubMed

Enhancement of gene transactivation activity of androgen receptor by hepatitis B virus X protein Virology. 2007 Jul 05; 363(2):454-61. . View in PubMed

Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice Hepatology. 2007 Jan; 45(1):16-21. . View in PubMed

Redox modulation of the hepatitis C virus replication complex is calcium dependent Free Radic Biol Med. 2006 Nov 01; 41(9):1488-98. . View in PubMed

[Genetics of heteroplasmy in the mtDNA control region among the Chinese Han population] Fa Yi Xue Za Zhi. 2006 Jun; 22(3):198-203. . View in PubMed

Mechanisms of liver injuryIII. Oxidative stress in the pathogenesis of hepatitis C virus. Am J Physiol Gastrointest Liver Physiol. 2006 May; 290(5):G847-51. . View in PubMed

Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein Virology. 2005 Nov 10; 342(1):150-8. . View in PubMed

Regulation of hepatitis B virus core promoter by transcription factors HNF1 and HNF4 and the viral X protein J Virol. 2004 Jul; 78(13):6908-14. . View in PubMed

The C-terminal transmembrane domain of hepatitis C virus (HCV) RNA polymerase is essential for HCV replication in vivo J Virol. 2004 Apr; 78(7):3797-802. . View in PubMed

A heat inducible tyrosinase with distinct properties from Bacillus thuringiensis Lett Appl Microbiol. 2004; 39(5):407-12. . View in PubMed

Reactive oxygen species suppress hepatitis C virus RNA replication in human hepatoma cells Hepatology. 2004 Jan; 39(1):81-9. . View in PubMed

Endogenous polymerase assay for the analysis of hepatitis B virus in transgenic mice Methods Mol Med. 2004; 95:295-302. . View in PubMed

Phosphorylation analysis of hepatitis B virus core protein in mammalian cells Methods Mol Med. 2004; 95:227-33. . View in PubMed

[Horizontal gene transfer] Yi Chuan. 2003 Sep; 25(5):623-7. . View in PubMed

The absence of up-regulation of telomerase activity during regeneration after partial hepatectomy in hepatitis B virus X gene transgenic mice J Hepatol. 2003 Aug; 39(2):262-8. . View in PubMed

Regulation of hepatitis B virus replication by the ras-mitogen-activated protein kinase signaling pathway J Virol. 2003 Jul; 77(14):7707-12. . View in PubMed

Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4 J Biol Chem. 2003 Mar 14; 278(11):9353-60. . View in PubMed

Triple decoding of hepatitis C virus RNA by programmed translational frameshifting Mol Cell Biol. 2003 Mar; 23(5):1489-97. . View in PubMed

Hepatitis C virus f protein is a short-lived protein associated with the endoplasmic reticulum J Virol. 2003 Jan; 77(2):1578-83. . View in PubMed

Membrane topology of the hepatitis C virus NS2 protein J Biol Chem. 2002 Sep 06; 277(36):33228-34. . View in PubMed

Phosphorylation of hepatitis C virus core protein by protein kinase A and protein kinase C Virology. 2002 Aug 15; 300(1):20-30. . View in PubMed

Regulation of hepatocyte nuclear factor 1 activity by wild-type and mutant hepatitis B virus X proteins J Virol. 2002 Jun; 76(12):5875-81. . View in PubMed

Enhancement of hepatitis B virus replication by its X protein in transgenic mice J Virol. 2002 Mar; 76(5):2579-84. . View in PubMed

Post-translational modification of the hepatitis C virus core protein by tissue transglutaminase J Biol Chem. 2001 Dec 21; 276(51):47993-9. . View in PubMed

Differential regulation of hepatitis B virus gene expression by the Sp1 transcription factor J Virol. 2001 Sep; 75(18):8400-6. . View in PubMed

Transitional cell carcinoma in dialysis patients Eur Urol. 2000 Jan; 37(1):90-4. . View in PubMed

Activation of p53 tumor suppressor by hepatitis C virus core protein Virology. 1999 Nov 10; 264(1):134-41. . View in PubMed

Mechanism of suppression of hepatitis B virus precore RNA transcription by a frequent double mutation J Virol. 1999 Feb; 73(2):1239-44. . View in PubMed

Expression and Dimerization of Hepatitis C Virus Core Protein in Ecoli. Methods Mol Med. 1999; 19:325-30. . View in PubMed

Molecular biology of hepatitis B virus e antigen J Gastroenterol Hepatol. 1997 Oct; 12(9-10):S178-87. . View in PubMed

Effects of a frequent double-nucleotide basal core promoter mutation and its putative single-nucleotide precursor mutations on hepatitis B virus gene expression and replication J Gen Virol. 1997 Aug; 78 ( Pt 8):2055-65. . View in PubMed

Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor J Virol. 1997 Feb; 71(2):1301-9. . View in PubMed

Interaction of transcription factors RFX1 and MIBP1 with the gamma motif of the negative regulatory element of the hepatitis B virus core promoter Virology. 1997 Jan 20; 227(2):515-8. . View in PubMed

Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication J Virol. 1996 Sep; 70(9):5845-51. . View in PubMed

Interaction between hepatitis C virus core protein and E1 envelope protein J Virol. 1996 Aug; 70(8):5177-82. . View in PubMed

Characterization of nuclear localization of a hepatitis B virus precore protein derivative P22 Arch Virol. 1996; 141(3-4):425-38. . View in PubMed

Cell type-dependent regulation of the activity of the negative regulatory element of the hepatitis B virus core promoter Virology. 1995 Dec 01; 214(1):198-206. . View in PubMed

Differential subcellular localization of hepatitis C virus core gene products Virology. 1995 Nov 10; 213(2):455-61. . View in PubMed

Detection of Cellular Proteins and Viral Core Protein Interacting with the 5' Untranslated Region of Hepatitis C Virus RNA J Biomed Sci. 1995 Aug; 2(3):227-236. . View in PubMed

Phosphorylation and nuclear localization of the hepatitis B virus core protein: significance of serine in the three repeated SPRRR motifs J Virol. 1995 Feb; 69(2):1025-9. . View in PubMed

Key role of a CCAAT element in regulating hepatitis B virus surface protein expression Virology. 1995 Feb 01; 206(2):1155-8. . View in PubMed

Regulation of hepatitis B virus ENI enhancer activity by hepatocyte-enriched transcription factor HNF3 Virology. 1994 Nov 15; 205(1):127-32. . View in PubMed

Alteration of the subcellular localization of hepatitis B virus core protein by large but not small surface proteins Biochem Biophys Res Commun. 1994 Sep 15; 203(2):1348-54. . View in PubMed

Early detection of anti-HCc antibody in acute hepatitis C virus (HCV) by western blot (immunoblot) using a recombinant HCV core protein fragment J Clin Microbiol. 1994 Sep; 32(9):2235-41. . View in PubMed

Comparative studies of the core gene products of two different hepatitis C virus isolates: two alternative forms determined by a single amino acid substitution Virology. 1994 Feb 15; 199(1):124-31. . View in PubMed

Cell cycle regulation of nuclear localization of hepatitis B virus core protein Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6459-63. . View in PubMed

Hepatocyte-specific expression of the hepatitis B virus core promoter depends on both positive and negative regulation Mol Cell Biol. 1993 Jan; 13(1):443-8. . View in PubMed

Brefeldin A as a regulator of grp78 gene expression in mammalian cells J Biol Chem. 1992 Apr 05; 267(10):7128-33. . View in PubMed

Characterization of nuclear targeting signal of hepatitis delta antigen: nuclear transport as a protein complex J Virol. 1992 Feb; 66(2):914-21. . View in PubMed

Characterization of the hepatitis B virus EnhI enhancer and X promoter complex J Virol. 1991 Dec; 65(12):6686-92. . View in PubMed

Proteolytic conversion of hepatitis B virus e antigen precursor to end product occurs in a postendoplasmic reticulum compartment J Virol. 1991 Sep; 65(9):5080-3. . View in PubMed

Phosphorylation of hepatitis B virus precore and core proteins J Virol. 1991 May; 65(5):2327-31. . View in PubMed