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Jobin Varkey, PhD

Assistant Professor of Research Physiology and Neuroscience

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Phone +1 323 442 0106
Email jvarkey@usc.edu
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Awards

  • Department of Biotechnology, Government of India: DBT Ramalingaswami Fellowship, 2013-2016
  • Council of Scientific and Industrial Research, Government of India: Senior Research Fellowship, 2004-2007
  • Council of Scientific and Industrial Research, Government of India: Junior Research Fellowship, 2002-2004
  • Department of Biotechnology, Government of India: MS Scholarship, 1999-2001

Publications

  • TDP43 and huntingtin Exon-1 undergo a conformationally specific interaction that strongly alters the fibril formation of both proteins. J Biol Chem. 2024 Sep; 300(9):107660.. View in PubMed
  • Retraction Note: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2024 Apr; 30(4):1215.. View in PubMed
  • Fluorescent protein tagging promotes phase separation and alters the aggregation pathway of huntingtin exon-1. J Biol Chem. 2024 01; 300(1):105585.. View in PubMed
  • Molecular basis of Q-length selectivity for the MW1 antibody-huntingtin interaction. J Biol Chem. 2023 04; 299(4):104616.. View in PubMed
  • An Amphipathic Alpha-Helix Domain from Poliovirus 2C Protein Tubulate Lipid Vesicles. Viruses. 2020 12 18; 12(12).. View in PubMed
  • Structural Model of the Proline-Rich Domain of Huntingtin Exon-1 Fibrils. Biophys J. 2020 11 17; 119(10):2019-2028.. View in PubMed
  • Gene co-expression network analysis for identifying genetic markers in Parkinson’s disease – a three-way comparative approach. Genomics. 2019 07; 111(4):819-830.. View in PubMed
  • E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity. J Biol Chem. 2019 06 21; 294(25):9799-9812.. View in PubMed
  • Construction of Parkinson’s disease marker-based weighted protein-protein interaction network for prioritization of co-expressed genes. Gene. 2019 May 20; 697:67-77.. View in PubMed
  • Membranes as modulators of amyloid protein misfolding and target of toxicity. Biochim Biophys Acta Biomembr. 2018 Sep; 1860(9):1863-1875.. View in PubMed
  • Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2018 03; 24(3):326-337.. View in PubMed
  • Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR. J Magn Reson. 2017 07; 280:127-139.. View in PubMed
  • α-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils. J Biol Chem. 2016 Jan 29; 291(5):2310-8.. View in PubMed
  • Early sodium dodecyl sulfate induced collapse of α-synuclein correlates with its amyloid formation. ACS Chem Neurosci. 2015 Feb 18; 6(2):239-46.. View in PubMed
  • Nonaggregated α-synuclein influences SNARE-dependent vesicle docking via membrane binding. Biochemistry. 2014 Jun 24; 53(24):3889-96.. View in PubMed
  • Hydration dynamics as an intrinsic ruler for refining protein structure at lipid membrane interfaces. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):16838-43.. View in PubMed
  • α-Synuclein oligomers with broken helical conformation form lipoprotein nanoparticles. J Biol Chem. 2013 Jun 14; 288(24):17620-30.. View in PubMed
  • Rational design of potent domain antibody inhibitors of amyloid fibril assembly. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):19965-70.. View in PubMed
  • Remodeling of lipid vesicles into cylindrical micelles by α-synuclein in an extended α-helical conformation. J Biol Chem. 2012 Aug 24; 287(35):29301-11.. View in PubMed
  • Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation. J Am Chem Soc. 2012 Mar 28; 134(12):5468-71.. View in PubMed
  • Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins. J Biol Chem. 2010 Oct 15; 285(42):32486-93.. View in PubMed
  • Antibacterial activity of linear peptides spanning the carboxy-terminal beta-sheet domain of arthropod defensins. Peptides. 2006 Nov; 27(11):2614-23.. View in PubMed
  • Antibacterial activity of human neutrophil defensin HNP-1 analogs without cysteines. Antimicrob Agents Chemother. 2005 Nov; 49(11):4561-6.. View in PubMed

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