Keck School Faculty

John C. Wood, MD, PhD
John C. Wood, MD, PhD
Professor of Pediatrics and Radiology
Pediatrics
CHL Mail Stop 34 Off Campus Los Angeles
Dr. John Wood graduated in from UC. Davis (Electrical Engineering) in 1984 and received his MD/PhD (Bioengineering) from the University of Michigan in 1994. He performed his residency and fellowship in Pediatric Cardiology at Yale and joined Children’s Hospital Los Angeles/USC Keck School of Medicine in 1999. Dr. Wood is the director of cardiovascular MRI and specializes in the MRI assessment of congenital heart disease as well as noninvasive assessment of iron burden by MRI.

Dr. Wood has been studying the cardiovascular consequences of hemoglobinopathies for almost a decade. He is one of the pioneer’s of MRI-based cardiac and liver iron measurements but is also studying oral chelation strategies in animals and humans. He was the principle investigator for the NIH-sponsored Early Detection of Iron Cardiomyopathy Trial whose goal is to identify earlier markers of cardiac dysfunction. Dr. Wood also has funded projects examining pancreatic and pituitary iron burden by MRI and their functional correlates. Recently, Dr. Wood received a ARRA Challenge grant to study the role of iron overload and other factors in sickle cell vasculopathy and is exploring the links between abnormal red cell mechanics and vascular dynamics in the hemoglobinopathies.

: RSNA Scholar, 2001

: Alfred F. Towsley Award for Pediatrics, 1994

: Alpha Omega Alpha, 1993

: Medical Scientist Training Program Fellowship, 1986

: Tau Beta Pi (National Engineering Honor Society), 1982

Patients with sickle-cell disease exhibit greater functional connectivity and centrality in the locus coeruleus compared to anemic controls Neuroimage Clin. 2019; 21:101686. . View in PubMed

Assessment of Cardiac Iron Overload in Thalassemia With MRI on 30-T: High-Field T1, T2, and T2* Quantitative Parametric Mapping in Comparison to T2* on 1. 5-T. JACC Cardiovasc Imaging. 2018 Nov 08. . View in PubMed

Differences in Right Ventricular Physiologic Response to Chronic Volume Load in Patients with Repaired Pulmonary Atresia Intact Ventricular Septum/Critical Pulmonary Stenosis Versus Tetralogy of Fallot Pediatr Cardiol. 2018 Oct 23. . View in PubMed

Increased brain iron deposition in patients with sickle cell disease: an MRI quantitative susceptibility mapping study Blood. 2018 Oct 11; 132(15):1618-1621. . View in PubMed

Increased brain iron deposition in patients with sickle cell disease: an MRI quantitative susceptibility mapping study Blood. 2018 Jul 25. . View in PubMed

Diminished cerebral oxygen extraction and metabolic rate in sickle cell disease using T2 relaxation under spin tagging MRI Magn Reson Med. 2018 Jul; 80(1):294-303. . View in PubMed

ORCHESTRAL FULLY CONVOLUTIONAL NETWORKS FOR SMALL LESION SEGMENTATION IN BRAIN MRI Proc IEEE Int Symp Biomed Imaging. 2018 Apr; 2018:889-892. . View in PubMed

CEREBRAL BLOOD FLOW AND PREDICTORS OF WHITE MATTER LESIONS IN ADULTS WITH TETRALOGY OF FALLOT Proc IEEE Int Symp Biomed Imaging. 2018 Apr; 2018:1309-1312. . View in PubMed

Experimental Investigation of the Effect of Non-Newtonian Behavior of Blood Flow in the Fontan Circulation Eur J Mech B Fluids. 2018 Mar-Apr; 68:184-192. . View in PubMed

Intracranial 4D flow magnetic resonance imaging reveals altered haemodynamics in sickle cell disease Br J Haematol. 2018 02; 180(3):432-442. . View in PubMed

A novel cross-correlation methodology for assessing biophysical responses associated with pain J Pain Res. 2018; 11:2207-2219. . View in PubMed

Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain Am J Hematol. 2017 Nov; 92(11):1137-1145. . View in PubMed

Measuring Stroke Volume: Impedance Cardiography vs Phase-Contrast Magnetic Resonance Imaging Am J Crit Care. 2017 Sep; 26(5):408-415. . View in PubMed

Graph Lasso-Based Test for Evaluating Functional Brain Connectivity in Sickle Cell Disease Brain Connect. 2017 Sep; 7(7):443-453. . View in PubMed

Magn Reson Med. 2017 Jun; 77(6):2364-2371. . View in PubMed

Graph Lasso-Based Test for Evaluating Functional Brain Connectivity in Sickle Cell Disease Brain Connect. 2017 09; 7(7):443-453. . View in PubMed

How we manage iron overload in sickle cell patients Br J Haematol. 2017 06; 177(5):703-716. . View in PubMed

Magn Reson Med. 2017 06; 77(6):2364-2371. . View in PubMed

Contrasting resting-state fMRI abnormalities from sickle and non-sickle anemia PLoS One. 2017; 12(10):e0184860. . View in PubMed

Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease PLoS One. 2017; 12(5):e0178353. . View in PubMed

Hemoglobin and mean platelet volume predicts diffuse T1-MRI white matter volume decrease in sickle cell disease patients Neuroimage Clin. 2017; 15:239-246. . View in PubMed

Comparison between different software programs and post-processing techniques for the MRI quantification of liver iron concentration in thalassemia patients Radiol Med. 2016 Oct; 121(10):751-62. . View in PubMed

Determinants of resting cerebral blood flow in sickle cell disease Am J Hematol. 2016 Sep; 91(9):912-7. . View in PubMed

Elevated Low-Shear Blood Viscosity is Associated with Decreased Pulmonary Blood Flow in Children with Univentricular Heart Defects Pediatr Cardiol. 2016 Apr; 37(4):789-801. . View in PubMed

Determinants of resting cerebral blood flow in sickle cell disease Am J Hematol. 2016 09; 91(9):912-7. . View in PubMed

Management of iron overload in hemoglobinopathies: what is the appropriate target iron level? Ann N Y Acad Sci. 2016 03; 1368(1):95-106.. View in PubMed

Organ iron accumulation in chronically transfused children with sickle cell anaemia: baseline results from the TWiTCH trial Br J Haematol. 2016 Jan; 172(1):122-30. . View in PubMed

Liver iron concentration measurements by MRI in chronically transfused children with sickle cell anemia: baseline results from the TWiTCH trial Am J Hematol. 2015 Sep; 90(9):806-10. . View in PubMed

Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease Blood. 2015 Aug 06; 126(6):703-10. . View in PubMed

Autonomic responses to cold face stimulation in sickle cell disease: a time-varying model analysis Physiol Rep. 2015 Jul 14; 3(7). . View in PubMed

Liver MRI is more precise than liver biopsy for assessing total body iron balance: a comparison of MRI relaxometry with simulated liver biopsy results Magn Reson Imaging. 2015 Jul; 33(6):761-7. . View in PubMed

Estimating tissue iron burden: current status and future prospects Br J Haematol. 2015 Jul; 170(1):15-28. . View in PubMed

Effect of inversion recovery fat suppression on hepatic R2* quantitation in transfusional siderosis AJR Am J Roentgenol. 2015 Mar; 204(3):625-9. . View in PubMed

A significant proportion of thalassemia major patients have adrenal insufficiency detectable on provocative testing J Pediatr Hematol Oncol. 2015 Jan; 37(1):54-9. . View in PubMed

Guidelines for quantifying iron overload Hematology Am Soc Hematol Educ Program. 2014 Dec 05; 2014(1):210-5. . View in PubMed

Mechanisms of plasma non-transferrin bound iron generation: insights from comparing transfused diamond blackfan anaemia with sickle cell and thalassaemia patients Br J Haematol. 2014 Dec; 167(5):692-6. . View in PubMed

mRNA regulation of cardiac iron transporters and ferritin subunits in a mouse model of iron overload Exp Hematol. 2014 Dec; 42(12):1059-67. . View in PubMed

Characterization of transfusion-derived iron deposition in childhood cancer survivors Cancer Epidemiol Biomarkers Prev. 2014 Sep; 23(9):1913-9. . View in PubMed

Calibration of myocardial T2 and T1 against iron concentration J Cardiovasc Magn Reson. 2014 Aug 12; 16:62. . View in PubMed

Cardiac R2* values are independent of the image analysis approach employed Magn Reson Med. 2014 Aug; 72(2):485-91. . View in PubMed

Cardiac iron overload in sickle-cell disease Am J Hematol. 2014 Jul; 89(7):678-83. . View in PubMed

Dose titration of deferasirox iron chelation therapy by magnetic resonance imaging for chronic iron storage disease in three adult red bald-headed uakari (Cacajao calvus rubicundus) J Zoo Wildl Med. 2014 Jun; 45(2):339-49. . View in PubMed

Deformability analysis of sickle blood using ektacytometry Biorheology. 2014; 51(2-3):159-70. . View in PubMed

Fast approximation to pixelwise relaxivity maps: validation in iron overloaded subjects Magn Reson Imaging. 2013 Sep; 31(7):1074-80. . View in PubMed

Patients with sickle cell anemia on simple chronic transfusion protocol show sex differences for hemodynamic and hematologic responses to transfusion Transfusion. 2013 May; 53(5):1059-68. . View in PubMed

Exercise performance in thalassemia major: correlation with cardiac iron burden Am J Hematol. 2013 Mar; 88(3):193-7. . View in PubMed

Comparison of biventricular dimensions and function between pediatric sickle-cell disease and thalassemia major patients without cardiac iron Am J Hematol. 2013 Mar; 88(3):213-8. . View in PubMed

Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy Transfusion. 2013 Feb; 53(2):297-305. . View in PubMed

Ascorbate status modulates reticuloendothelial iron stores and response to deferasirox iron chelation in ascorbate-deficient rats Exp Hematol. 2012 Oct; 40(10):820-7. . View in PubMed

Pancreatic iron stores assessed by magnetic resonance imaging (MRI) in beta thalassemic patients Eur J Radiol. 2012 Jul; 81(7):1465-70. . View in PubMed

A phase 2 study of the safety, tolerability, and pharmacodynamics of FBS0701, a novel oral iron chelator, in transfusional iron overload Blood. 2012 Apr 05; 119(14):3263-8. . View in PubMed

Iron overload in non-transfusion-dependent thalassemia: a clinical perspective Blood Rev. 2012 Apr; 26 Suppl 1:S16-9. . View in PubMed

Electrocardiographic consequences of cardiac iron overload in thalassemia major Am J Hematol. 2012 Feb; 87(2):139-44. . View in PubMed

Inter-site validations of the Pixel-Wise method for cardiac T2* analysis in transfusion-dependent Thai thalassemia patients J Med Assoc Thai. 2012 Feb; 95 Suppl 2:S165-72. . View in PubMed

Pancreatic iron and glucose dysregulation in thalassemia major Am J Hematol. 2012 Feb; 87(2):155-60. . View in PubMed

Intersite validations of the pixel-wise method for liver R2* analysis in transfusion-dependent thalassemia patients: a more accessible and affordable diagnostic technology Hematol Oncol Stem Cell Ther. 2012; 5(2):91-5. . View in PubMed

Elevated liver iron concentration is a marker of increased morbidity in patients with ß thalassemia intermedia Haematologica. 2011 Nov; 96(11):1605-12. . View in PubMed

Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease Am J Respir Crit Care Med. 2011 Aug 15; 184(4):474-81. . View in PubMed

Iron overload in Brazilian thalassemic patients Einstein (Sao Paulo). 2011 Jun; 9(2):165-72. . View in PubMed

Comparison of the region-based and pixel-wise methods for cardiac T2* analysis in 50 transfusion-dependent Thai thalassemia patients J Comput Assist Tomogr. 2011 May-Jun; 35(3):375-81. . View in PubMed

On T2* magnetic resonance and cardiac iron Circulation. 2011 Apr 12; 123(14):1519-28. . View in PubMed

Iron chelation in thalassemia: time to reconsider our comfort zones Expert Rev Hematol. 2011 Feb; 4(1):17-26. . View in PubMed

Interdependence of cardiac iron and calcium in a murine model of iron overload Transl Res. 2011 Feb; 157(2):92-9. . View in PubMed

Impact of iron assessment by MRI Hematology Am Soc Hematol Educ Program. 2011; 2011:443-50. . View in PubMed

Pancreatic iron loading in chronically transfused sickle cell disease is lower than in thalassaemia major Br J Haematol. 2011 Jan; 152(2):229-33. . View in PubMed

Combining two orally active iron chelators for thalassemia Ann Hematol. 2010 Nov; 89(11):1177-8. . View in PubMed

Follow-up report on the 2-year cardiac data from a deferasirox monotherapy trial Am J Hematol. 2010 Oct; 85(10):818-9. . View in PubMed

Cardiovascular MRI in thalassemia major Ann N Y Acad Sci. 2010 Aug; 1202:173-9. . View in PubMed

Absence of cardiac siderosis despite hepatic iron overload in Italian patients with thalassemia intermedia: an MRI T2* study Ann Hematol. 2010 Jun; 89(6):585-9. . View in PubMed

Iron overload indices rise linearly with transfusion rate in patients with sickle cell disease Blood. 2010 Apr 08; 115(14):2980-1; author reply 2981-2. . View in PubMed

Magnetic resonance evaluation of hepatic and myocardial iron deposition in transfusion-independent thalassemia intermedia compared to regularly transfused thalassemia major patients Am J Hematol. 2010 Apr; 85(4):288-90. . View in PubMed

Absence of cardiac siderosis by MRI T2* despite transfusion burden, hepatic and serum iron overload in Lebanese patients with sickle cell disease Eur J Haematol. 2009 Dec 01; 83(6):565-71. . View in PubMed

History and current impact of cardiac magnetic resonance imaging on the management of iron overload Circulation. 2009 Nov 17; 120(20):1937-9. . View in PubMed

Pancreatic iron loading predicts cardiac iron loading in thalassemia major Blood. 2009 Nov 05; 114(19):4021-6. . View in PubMed

Patterns of hepatic iron distribution in patients with chronically transfused thalassemia and sickle cell disease Am J Hematol. 2009 Aug; 84(8):480-3. . View in PubMed

Nutritional deficiencies in iron overloaded patients with hemoglobinopathies Am J Hematol. 2009 Jun; 84(6):344-8. . View in PubMed

Cardiac complications in thalassemia major Hemoglobin. 2009; 33 Suppl 1:S81-6. . View in PubMed

Cardiac iron across different transfusion-dependent diseases Blood Rev. 2008 Dec; 22 Suppl 2:S14-21. . View in PubMed

Cardiac medications are not associated with clinically important preoperative electrolyte disturbances in children presenting for cardiac surgery Anesth Analg. 2008 Dec; 107(6):1840-7. . View in PubMed

Longitudinal analysis of heart and liver iron in thalassemia major Blood. 2008 Oct 01; 112(7):2973-8. . View in PubMed

Magnetic resonance detection of kidney iron deposition in sickle cell disease: a marker of chronic hemolysis J Magn Reson Imaging. 2008 Sep; 28(3):698-704. . View in PubMed

Influence of iron chelation on R1 and R2 calibration curves in gerbil liver and heart Magn Reson Med. 2008 Jul; 60(1):82-9. . View in PubMed

Onset of cardiac iron loading in pediatric patients with thalassemia major Haematologica. 2008 Jun; 93(6):917-20. . View in PubMed

Atrial dysfunction as a marker of iron cardiotoxicity in thalassemia major Haematologica. 2008 Feb; 93(2):311-2. . View in PubMed

Magnetic resonance imaging assessment of excess iron in thalassemia, sickle cell disease and other iron overload diseases Hemoglobin. 2008; 32(1-2):85-96. . View in PubMed

Diagnosis and management of transfusion iron overload: the role of imaging Am J Hematol. 2007 Dec; 82(12 Suppl):1132-5. . View in PubMed

Comparison of twice-daily vs once-daily deferasirox dosing in a gerbil model of iron cardiomyopathy Exp Hematol. 2007 Jul; 35(7):1069-73. . View in PubMed

Magnetic resonance imaging measurement of iron overload Curr Opin Hematol. 2007 May; 14(3):183-90. . View in PubMed

Antioxidant-mediated effects in a gerbil model of iron overload Acta Haematol. 2007; 118(4):193-9. . View in PubMed

Myelin deficiencies visualized in vivo: visually evoked potentials and T2-weighted magnetic resonance images of shiverer mutant and wild-type mice J Neurosci Res. 2006 Dec; 84(8):1716-26. . View in PubMed

Deferasirox and deferiprone remove cardiac iron in the iron-overloaded gerbil Transl Res. 2006 Nov; 148(5):272-80. . View in PubMed

MRI detects myocardial iron in the human heart Magn Reson Med. 2006 Sep; 56(3):681-6. . View in PubMed

Anatomical assessment of congenital heart disease J Cardiovasc Magn Reson. 2006; 8(4):595-606. . View in PubMed

Improved R2* measurements in myocardial iron overload J Magn Reson Imaging. 2006 Jan; 23(1):9-16. . View in PubMed

Mechanisms of tissue-iron relaxivity: nuclear magnetic resonance studies of human liver biopsy specimens Magn Reson Med. 2005 Nov; 54(5):1185-93. . View in PubMed

MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients Blood. 2005 Aug 15; 106(4):1460-5. . View in PubMed

Cardiac iron determines cardiac T2*, T2, and T1 in the gerbil model of iron cardiomyopathy Circulation. 2005 Jul 26; 112(4):535-43. . View in PubMed

MR imaging of newborns by using an MR-compatible incubator with integrated radiofrequency coils: initial experience Radiology. 2004 May; 231(2):594-601. . View in PubMed

Myocardial iron loading in transfusion-dependent thalassemia and sickle cell disease Blood. 2004 Mar 01; 103(5):1934-6. . View in PubMed

Mimicking liver iron overload using liposomal ferritin preparations Magn Reson Med. 2004 Mar; 51(3):607-11. . View in PubMed

Characterization of interpolation effects in cine anatomic and phase-velocity images J Magn Reson Imaging. 2003 Aug; 18(2):266-71. . View in PubMed

Cardiac abnormalities in children with sickle cell anemia Am J Hematol. 2002 Aug; 70(4):306-12. . View in PubMed

Homograft conduit failure in infants is not due to somatic outgrowth J Thorac Cardiovasc Surg. 2002 Jul; 124(1):88-96. . View in PubMed

Diagnosis of very long chain acyl-dehydrogenase deficiency from an infant's newborn screening card Pediatrics. 2001 Jul; 108(1):E19. . View in PubMed

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