John C. Wood, MD, PhD

Professor of Pediatrics and Radiology

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Overview

Dr. John Wood graduated in from UC. Davis (Electrical Engineering) in 1984 and received his MD/PhD (Bioengineering) from the University of Michigan in 1994. He performed his residency and fellowship in Pediatric Cardiology at Yale and joined Children’s Hospital Los Angeles/USC Keck School of Medicine in 1999. Dr. Wood is the director of cardiovascular MRI and specializes in the MRI assessment of congenital heart disease as well as noninvasive assessment of iron burden by MRI.

Dr. Wood has been studying the cardiovascular consequences of hemoglobinopathies for almost a decade. He is one of the pioneer’s of MRI-based cardiac and liver iron measurements but is also studying oral chelation strategies in animals and humans. He was the principle investigator for the NIH-sponsored Early Detection of Iron Cardiomyopathy Trial whose goal is to identify earlier markers of cardiac dysfunction. Dr. Wood also has funded projects examining pancreatic and pituitary iron burden by MRI and their functional correlates. Recently, Dr. Wood received a ARRA Challenge grant to study the role of iron overload and other factors in sickle cell vasculopathy and is exploring the links between abnormal red cell mechanics and vascular dynamics in the hemoglobinopathies.

Awards

  • RSNA Scholar, 2001
  • Alfred F. Towsley Award for Pediatrics, 1994
  • Alpha Omega Alpha, 1993
  • Medical Scientist Training Program Fellowship, 1986
  • Tau Beta Pi (National Engineering Honor Society), 1982

Publications

  • Postacute Sequelae of SARS-CoV-2 in Children Pediatrics. 2024 Feb 07. . View in PubMed
  • Contrast-free dynamic susceptibility contrast using sinusoidal and bolus oxygenation challenges NMR Biomed. 2024 Jan 31; e5111. . View in PubMed
  • Cerebrovascular responses to a 90° tilt in healthy neonates Pediatr Res. 2024 Jan 27. . View in PubMed
  • Decreased erythrocyte aggregation in Glenn and Fontan: univentricular circulation as a rheologic disease model Pediatr Res. 2024 Jan 04. . View in PubMed
  • Improved cerebrovascular reactivity mapping using coherence weighted general linear model in the frequency domain Neuroimage. 2023 Dec 15; 284:120448. . View in PubMed
  • Cerebral hemodynamics and oxygenation in adult patients with sickle cell disease after stem cell transplantation Am J Hematol. 2023 Oct 19. . View in PubMed
  • Low-field 055 T MRI evaluation of the fetus. Pediatr Radiol. 2023 Jun; 53(7):1469-1475. . View in PubMed
  • Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design medRxiv. 2023 May 12. . View in PubMed
  • Early-Onset Late Gadolinium Enhancement is a Prognostic Factor for Duchenne Cardiomyopathy Pediatr Cardiol. 2023 Feb; 44(2):433-440. . View in PubMed
  • Venous Blood Oxygenation Measurements Using TRUST and T2-TRIR MRI During Hypoxic and Hypercapnic Gas Challenges J Magn Reson Imaging. 2023 12; 58(6):1903-1914. . View in PubMed
  • Cardiac complications in thalassemia throughout the lifespan: Victories and challenges Ann N Y Acad Sci. 2023 12; 1530(1):64-73. . View in PubMed
  • Brain BOLD and NIRS response to hyperoxic challenge in sickle cell disease and chronic anemias Magn Reson Imaging. 2023 07; 100:26-35. . View in PubMed
  • Quantification of Liver Iron Overload with MRI: Review and Guidelines from the ESGAR and SAR Radiology. 2023 04; 307(1):e221856. . View in PubMed
  • Imputation models and error analysis for phase contrast MR cerebral blood flow measurements Front Physiol. 2023; 14:1096297. . View in PubMed
  • Splenic iron decreases without change in volume or liver parameters during luspatercept therapy Blood. 2023 11 30; 142(22):1932-1934. . View in PubMed
  • Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design PLoS One. 2023; 18(6):e0286297. . View in PubMed
  • Anemia and brain hypoxia Blood. 2023 01 26; 141(4):327-328. . View in PubMed
  • Sinusoidal CO2 respiratory challenge for concurrent perfusion and cerebrovascular reactivity MRI Front Physiol. 2023; 14:1102983. . View in PubMed
  • Quantitative Susceptibility Mapping: Translating an Investigative Research Tool into High Volume Clinical Diagnostic Imaging Diagnostics (Basel). 2022 Nov 26; 12(12). . View in PubMed
  • Impact of COVID-19 Related Maternal Stress on Fetal Brain Development: A Multimodal MRI Study J Clin Med. 2022 Nov 09; 11(22). . View in PubMed
  • Impact of COVID-19 related maternal stress on fetal brain development: A Multimodal MRI study medRxiv. 2022 Oct 27. . View in PubMed
  • Impaired Neurovascular Function Underlies Poor Neurocognitive Outcomes and Is Associated with Nitric Oxide Bioavailability in Congenital Heart Disease Metabolites. 2022 Sep 19; 12(9). . View in PubMed
  • Third Trimester Fetal Heart Rates in Antibody-Mediated Complete Heart Block Predict Need for Neonatal Pacemaker Placement Pediatr Cardiol. 2022 Feb; 43(2):324-331. . View in PubMed
  • Early prediction of failure to progress in single ventricle palliation: A step toward personalizing care for severe congenital heart disease J Heart Lung Transplant. 2022 09; 41(9):1268-1276. . View in PubMed
  • Myocardial Iron Overload Causes Subclinical Myocardial Dysfunction in Sickle Cell Disease JACC Cardiovasc Imaging. 2022 08; 15(8):1510-1512. . View in PubMed
  • Effects of B1+ Heterogeneity on Spin Echo-Based Liver Iron Estimates J Magn Reson Imaging. 2022 05; 55(5):1419-1425. . View in PubMed
  • Chronic anemia: The effects on the connectivity of white matter Front Neurol. 2022; 13:894742. . View in PubMed
  • Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium Nat Commun. 2022 10 27; 13(1):6394. . View in PubMed
  • Assessment of functional shunting in patients with sickle cell disease Haematologica. 2022 11 01; 107(11):2708-2719. . View in PubMed
  • Early initiation of disease-modifying therapy can impede or prevent diffuse myocardial fibrosis in sickle cell anemia Blood. 2022 09 15; 140(11):1322-1324. . View in PubMed
  • Pulmonary hypertension in thalassemia: a call to action Blood. 2022 03 31; 139(13):1937-1938. . View in PubMed
  • Anemia Increases Oxygen Extraction Fraction in Deep Brain Structures but Not in the Cerebral Cortex Front Physiol. 2022; 13:896006. . View in PubMed
  • Intramyocardial Hemorrhage and the “Wave Front” of Reperfusion Injury Compromising Myocardial Salvage J Am Coll Cardiol. 2022 01 04; 79(1):35-48. . View in PubMed
  • Dynamic MR imaging of cerebral perfusion during bicycling exercise Neuroimage. 2022 04 15; 250:118961. . View in PubMed
  • Progression in Fontan conduit stenosis and hemodynamic impact during childhood and adolescenceJ Thorac Cardiovasc Surg. 2021 Aug; 162(2):372-380. e2. . View in PubMed
  • Acute respiratory infections in hospitalised infants with congenital heart disease Cardiol Young. 2021 Apr; 31(4):547-555. . View in PubMed
  • Algorithms for segmenting cerebral time-of-flight magnetic resonance angiograms from volunteers and anemic patients J Med Imaging (Bellingham). 2021 Mar; 8(2):024005. . View in PubMed
  • Perfusion MRI using endogenous deoxyhemoglobin as a contrast agent: Preliminary data Magn Reson Med. 2021 12; 86(6):3012-3021. . View in PubMed
  • Improving CPMG liver iron estimates with a T1 -corrected proton density estimator Magn Reson Med. 2021 12; 86(6):3348-3359. . View in PubMed
  • Calibration of T2 oximetry MRI for subjects with sickle cell disease Magn Reson Med. 2021 08; 86(2):1019-1028. . View in PubMed
  • Kidney iron deposition by R2* is associated with haemolysis and urinary iron Br J Haematol. 2021 05; 193(3):633-636. . View in PubMed
  • Tract-specific analysis and neurocognitive functioning in sickle cell patients without history of overt stroke Brain Behav. 2021 03; 11(3):e01978. . View in PubMed
  • Quantitative perfusion mapping with induced transient hypoxia using BOLD MRI Magn Reson Med. 2021 01; 85(1):168-181. . View in PubMed
  • Am J Hematol. 2021 01; 96(1):31-39. . View in PubMed
  • Cerebral oxygen saturation and cerebrovascular instability in newborn infants with congenital heart disease compared to healthy controls PLoS One. 2021; 16(5):e0251255. . View in PubMed
  • Impairment of Cerebrovascular Hemodynamics in Patients With Severe and Milder Forms of Sickle Cell Disease Front Physiol. 2021; 12:645205. . View in PubMed
  • Reduced global cerebral oxygen metabolic rate in sickle cell disease and chronic anemias Am J Hematol. 2021 08 01; 96(8):901-913. . View in PubMed
  • Loss of alpha-globin genes in human subjects is associated with improved nitric oxide-mediated vascular perfusion Am J Hematol. 2021 03 01; 96(3):277-281. . View in PubMed
  • Transient Hypoxia Model Revealed Cerebrovascular Impairment in Anemia Using BOLD MRI and Near-Infrared Spectroscopy J Magn Reson Imaging. 2020 11; 52(5):1400-1412. . View in PubMed
  • Lower white matter volume in beta-thalassemia associated with anemia and cognitive performance Am J Hematol. 2020 06; 95(6):E144-E146. . View in PubMed
  • Group delay method for MRI aortic pulse wave velocity measurements in clinical protocols with low temporal resolution: Validation in a heterogeneous cohort Magn Reson Imaging. 2020 06; 69:8-15. . View in PubMed
  • Fixing the MRI R2-iron calibration in liver Am J Hematol. 2020 05; 95(5):E120-E122. . View in PubMed
  • Cerebral oxygen metabolism in adults with sickle cell disease Am J Hematol. 2020 04; 95(4):401-412. . View in PubMed
  • Mental stress causes vasoconstriction in subjects with sickle cell disease and in normal controls Haematologica. 2020 01; 105(1):83-90. . View in PubMed
  • Progressive vasoconstriction with sequential thermal stimulation indicates vascular dysautonomia in sickle cell disease Blood. 2020 09 03; 136(10):1191-1200. . View in PubMed
  • Action of iron chelator on intramyocardial hemorrhage and cardiac remodeling following acute myocardial infarction Basic Res Cardiol. 2020 03 05; 115(3):24. . View in PubMed
  • MRI restoration using edge-guided adversarial learning IEEE Access. 2020; 8:83858-83870. . View in PubMed
  • Sickle cell trait: A sigh of relief? EClinicalMedicine. 2019 May-Jun; 11:7-8.. View in PubMed
  • Differences in Right Ventricular Physiologic Response to Chronic Volume Load in Patients with Repaired Pulmonary Atresia Intact Ventricular Septum/Critical Pulmonary Stenosis Versus Tetralogy of Fallot Pediatr Cardiol. 2019 Mar; 40(3):526-536. . View in PubMed
  • In vivo validation of T2- and susceptibility-based Sv O2 measurements with jugular vein catheterization under hypoxia and hypercapnia Magn Reson Med. 2019 12; 82(6):2188-2198. . View in PubMed
  • Anemia predicts lower white matter volume and cognitive performance in sickle and non-sickle cell anemia syndrome Am J Hematol. 2019 10; 94(10):1055-1065. . View in PubMed
  • Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents Free Radic Biol Med. 2019 09; 141:408-415. . View in PubMed
  • Sickle cell microvascular paradox-oxygen supply-demand mismatch Am J Hematol. 2019 06; 94(6):678-688. . View in PubMed
  • White matter has impaired resting oxygen delivery in sickle cell patients Am J Hematol. 2019 04; 94(4):467-474. . View in PubMed
  • Hemodynamic provocation with acetazolamide shows impaired cerebrovascular reserve in adults with sickle cell disease Haematologica. 2019 04; 104(4):690-699. . View in PubMed
  • Assessment of Cardiac Iron Overload in Thalassemia With MRI on 30-T: High-Field T1, T2, and T2* Quantitative Parametric Mapping in Comparison to T2* on 1. 5-T. JACC Cardiovasc Imaging. 2019 04; 12(4):752-754. . View in PubMed
  • Brain O2 reserve in sickle cell disease Blood. 2019 05 30; 133(22):2356-2358. . View in PubMed
  • End points for sickle cell disease clinical trials: patient-reported outcomes, pain, and the brain Blood Adv. 2019 12 10; 3(23):3982-4001. . View in PubMed
  • A 4D flow MRI evaluation of the impact of shear-dependent fluid viscosity on in vitro Fontan circulation flow Am J Physiol Heart Circ Physiol. 2019 12 01; 317(6):H1243-H1253. . View in PubMed
  • Postoperative Serum Troponin Trends in Infants Undergoing Cardiac Surgery Semin Thorac Cardiovasc Surg. 2019; 31(2):244-251. . View in PubMed
  • Patients with sickle-cell disease exhibit greater functional connectivity and centrality in the locus coeruleus compared to anemic controls Neuroimage Clin. 2019; 21:101686. . View in PubMed
  • Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt Front Physiol. 2019; 10:381. . View in PubMed
  • CEREBRAL BLOOD FLOW AND PREDICTORS OF WHITE MATTER LESIONS IN ADULTS WITH TETRALOGY OF FALLOT Proc IEEE Int Symp Biomed Imaging. 2018 Apr; 2018:1309-1312. . View in PubMed
  • ORCHESTRAL FULLY CONVOLUTIONAL NETWORKS FOR SMALL LESION SEGMENTATION IN BRAIN MRI Proc IEEE Int Symp Biomed Imaging. 2018 Apr; 2018:889-892. . View in PubMed
  • Experimental Investigation of the Effect of Non-Newtonian Behavior of Blood Flow in the Fontan Circulation Eur J Mech B Fluids. 2018 Mar-Apr; 68:184-192. . View in PubMed
  • Serum ferritin in the diagnosis of cardiac and liver iron overload in thalassaemia patients real-world practice: a multicentre study Br J Haematol. 2018 07; 182(2):301-305. . View in PubMed
  • Diminished cerebral oxygen extraction and metabolic rate in sickle cell disease using T2 relaxation under spin tagging MRI Magn Reson Med. 2018 07; 80(1):294-303. . View in PubMed
  • Pseudo continuous arterial spin labeling quantification in anemic subjects with hyperemic cerebral blood flow Magn Reson Imaging. 2018 04; 47:137-146. . View in PubMed
  • Ultra-short echo time images quantify high liver iron Magn Reson Med. 2018 03; 79(3):1579-1585. . View in PubMed
  • Intracranial 4D flow magnetic resonance imaging reveals altered haemodynamics in sickle cell disease Br J Haematol. 2018 02; 180(3):432-442. . View in PubMed
  • Prediction of cardiac complications for thalassemia major in the widespread cardiac magnetic resonance era: a prospective multicentre study by a multi-parametric approach Eur Heart J Cardiovasc Imaging. 2018 03 01; 19(3):299-309. . View in PubMed
  • Unwinding the path from anemia to stroke Blood. 2018 03 01; 131(9):950-952. . View in PubMed
  • Positive Iron Balance in Chronic Kidney Disease: How Much is Too Much and How to Tell? Am J Nephrol. 2018; 47(2):72-83.. View in PubMed
  • A novel cross-correlation methodology for assessing biophysical responses associated with pain J Pain Res. 2018; 11:2207-2219. . View in PubMed
  • Increased brain iron deposition in patients with sickle cell disease: an MRI quantitative susceptibility mapping study Blood. 2018 10 11; 132(15):1618-1621. . View in PubMed
  • Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain Am J Hematol. 2017 Nov; 92(11):1137-1145. . View in PubMed
  • Measuring Stroke Volume: Impedance Cardiography vs Phase-Contrast Magnetic Resonance Imaging Am J Crit Care. 2017 Sep; 26(5):408-415. . View in PubMed
  • Graph Lasso-Based Test for Evaluating Functional Brain Connectivity in Sickle Cell Disease Brain Connect. 2017 09; 7(7):443-453. . View in PubMed
  • The use of MRI to monitor iron overload in SCD Blood Cells Mol Dis. 2017 09; 67:120-125. . View in PubMed
  • How we manage iron overload in sickle cell patients Br J Haematol. 2017 06; 177(5):703-716. . View in PubMed
  • Magn Reson Med. 2017 06; 77(6):2364-2371. . View in PubMed
  • Contrasting resting-state fMRI abnormalities from sickle and non-sickle anemia PLoS One. 2017; 12(10):e0184860. . View in PubMed
  • Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease PLoS One. 2017; 12(5):e0178353. . View in PubMed
  • Hemoglobin and mean platelet volume predicts diffuse T1-MRI white matter volume decrease in sickle cell disease patients Neuroimage Clin. 2017; 15:239-246. . View in PubMed
  • Persistent Microvascular Obstruction After Myocardial Infarction Culminates in the Confluence of Ferric Iron Oxide Crystals, Proinflammatory Burden, and Adverse Remodeling Circ Cardiovasc Imaging. 2016 Nov; 9(11). . View in PubMed
  • Comparison between different software programs and post-processing techniques for the MRI quantification of liver iron concentration in thalassemia patients Radiol Med. 2016 Oct; 121(10):751-62. . View in PubMed
  • In Vivo T1 of Blood Measurements in Children with Sickle Cell Disease Improve Cerebral Blood Flow Quantification from Arterial Spin-Labeling MRI AJNR Am J Neuroradiol. 2016 Sep; 37(9):1727-32. . View in PubMed
  • Elevated Low-Shear Blood Viscosity is Associated with Decreased Pulmonary Blood Flow in Children with Univentricular Heart Defects Pediatr Cardiol. 2016 Apr; 37(4):789-801. . View in PubMed
  • Determinants of resting cerebral blood flow in sickle cell disease Am J Hematol. 2016 09; 91(9):912-7. . View in PubMed
  • Management of iron overload in hemoglobinopathies: what is the appropriate target iron level? Ann N Y Acad Sci. 2016 03; 1368(1):95-106.. View in PubMed
  • The heart in sickle cell disease, a model for heart failure with preserved ejection fraction Proc Natl Acad Sci U S A. 2016 08 30; 113(35):9670-2. . View in PubMed
  • Organ iron accumulation in chronically transfused children with sickle cell anaemia: baseline results from the TWiTCH trial Br J Haematol. 2016 Jan; 172(1):122-30. . View in PubMed
  • Liver iron concentration measurements by MRI in chronically transfused children with sickle cell anemia: baseline results from the TWiTCH trial Am J Hematol. 2015 Sep; 90(9):806-10. . View in PubMed
  • Relaxivity-iron calibration in hepatic iron overload: Predictions of a Monte Carlo model Magn Reson Med. 2015 Sep; 74(3):879-83. . View in PubMed
  • Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease Blood. 2015 Aug 06; 126(6):703-10. . View in PubMed
  • Autonomic responses to cold face stimulation in sickle cell disease: a time-varying model analysis Physiol Rep. 2015 Jul 14; 3(7). . View in PubMed
  • Liver MRI is more precise than liver biopsy for assessing total body iron balance: a comparison of MRI relaxometry with simulated liver biopsy results Magn Reson Imaging. 2015 Jul; 33(6):761-7. . View in PubMed
  • Estimating tissue iron burden: current status and future prospects Br J Haematol. 2015 Jul; 170(1):15-28. . View in PubMed
  • Effect of inversion recovery fat suppression on hepatic R2* quantitation in transfusional siderosis AJR Am J Roentgenol. 2015 Mar; 204(3):625-9. . View in PubMed
  • Pulmonary hypertension in well-transfused thalassemia major patients Blood Cells Mol Dis. 2015 Feb; 54(2):189-94. . View in PubMed
  • A significant proportion of thalassemia major patients have adrenal insufficiency detectable on provocative testing J Pediatr Hematol Oncol. 2015 Jan; 37(1):54-9. . View in PubMed
  • Guidelines for quantifying iron overload Hematology Am Soc Hematol Educ Program. 2014 Dec 05; 2014(1):210-5. . View in PubMed
  • Mechanisms of plasma non-transferrin bound iron generation: insights from comparing transfused diamond blackfan anaemia with sickle cell and thalassaemia patients Br J Haematol. 2014 Dec; 167(5):692-6. . View in PubMed
  • mRNA regulation of cardiac iron transporters and ferritin subunits in a mouse model of iron overload Exp Hematol. 2014 Dec; 42(12):1059-67. . View in PubMed
  • Characterization of transfusion-derived iron deposition in childhood cancer survivors Cancer Epidemiol Biomarkers Prev. 2014 Sep; 23(9):1913-9. . View in PubMed
  • Calibration of myocardial T2 and T1 against iron concentration J Cardiovasc Magn Reson. 2014 Aug 12; 16:62. . View in PubMed
  • Cardiac R2* values are independent of the image analysis approach employed Magn Reson Med. 2014 Aug; 72(2):485-91. . View in PubMed
  • Use of magnetic resonance imaging to monitor iron overload Hematol Oncol Clin North Am. 2014 Aug; 28(4):747-64vii. . View in PubMed
  • Cardiac iron overload in sickle-cell disease Am J Hematol. 2014 Jul; 89(7):678-83. . View in PubMed
  • Dose titration of deferasirox iron chelation therapy by magnetic resonance imaging for chronic iron storage disease in three adult red bald-headed uakari (Cacajao calvus rubicundus) J Zoo Wildl Med. 2014 Jun; 45(2):339-49. . View in PubMed
  • R2 and R2* are equally effective in evaluating chronic response to iron chelation Am J Hematol. 2014 May; 89(5):505-8. . View in PubMed
  • Robust estimation of pulse wave transit time using group delay J Magn Reson Imaging. 2014 Mar; 39(3):550-8. . View in PubMed
  • Sex differences and steroid modulation of cardiac iron in a mouse model of iron overload Transl Res. 2014 Feb; 163(2):151-9. . View in PubMed
  • Deformability analysis of sickle blood using ektacytometry Biorheology. 2014; 51(2-3):159-70. . View in PubMed
  • Tissue iron evaluation in chronically transfused children shows significant levels of iron loading at a very young age Am J Hematol. 2013 Nov; 88(11):E283-5. . View in PubMed
  • Fast approximation to pixelwise relaxivity maps: validation in iron overloaded subjects Magn Reson Imaging. 2013 Sep; 31(7):1074-80. . View in PubMed
  • The use of appropriate calibration curves corrects for systematic differences in liver R2* values measured using different software packages Br J Haematol. 2013 Jun; 161(6):888-91. . View in PubMed
  • Patients with sickle cell anemia on simple chronic transfusion protocol show sex differences for hemodynamic and hematologic responses to transfusion Transfusion. 2013 May; 53(5):1059-68. . View in PubMed
  • Exercise performance in thalassemia major: correlation with cardiac iron burden Am J Hematol. 2013 Mar; 88(3):193-7. . View in PubMed
  • Comparison of biventricular dimensions and function between pediatric sickle-cell disease and thalassemia major patients without cardiac iron Am J Hematol. 2013 Mar; 88(3):213-8. . View in PubMed
  • Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy Transfusion. 2013 Feb; 53(2):297-305. . View in PubMed
  • Ascorbate status modulates reticuloendothelial iron stores and response to deferasirox iron chelation in ascorbate-deficient rats Exp Hematol. 2012 Oct; 40(10):820-7. . View in PubMed
  • Pancreatic iron stores assessed by magnetic resonance imaging (MRI) in beta thalassemic patients Eur J Radiol. 2012 Jul; 81(7):1465-70. . View in PubMed
  • Systemic endothelial dysfunction in children with idiopathic pulmonary arterial hypertension correlates with disease severity J Heart Lung Transplant. 2012 Jun; 31(6):642-7. . View in PubMed
  • A phase 2 study of the safety, tolerability, and pharmacodynamics of FBS0701, a novel oral iron chelator, in transfusional iron overload Blood. 2012 Apr 05; 119(14):3263-8. . View in PubMed
  • Iron overload in non-transfusion-dependent thalassemia: a clinical perspective Blood Rev. 2012 Apr; 26 Suppl 1:S16-9. . View in PubMed
  • Inter-site validations of the Pixel-Wise method for cardiac T2* analysis in transfusion-dependent Thai thalassemia patients J Med Assoc Thai. 2012 Feb; 95 Suppl 2:S165-72. . View in PubMed
  • Pituitary iron and volume imaging in healthy controls AJNR Am J Neuroradiol. 2012 Feb; 33(2):259-65. . View in PubMed
  • Pancreatic iron and glucose dysregulation in thalassemia major Am J Hematol. 2012 Feb; 87(2):155-60. . View in PubMed
  • Pituitary iron and volume predict hypogonadism in transfusional iron overload Am J Hematol. 2012 Feb; 87(2):167-71. . View in PubMed
  • Electrocardiographic consequences of cardiac iron overload in thalassemia major Am J Hematol. 2012 Feb; 87(2):139-44. . View in PubMed
  • Intersite validations of the pixel-wise method for liver R2* analysis in transfusion-dependent thalassemia patients: a more accessible and affordable diagnostic technology Hematol Oncol Stem Cell Ther. 2012; 5(2):91-5. . View in PubMed
  • Elevated liver iron concentration is a marker of increased morbidity in patients with ß thalassemia intermedia Haematologica. 2011 Nov; 96(11):1605-12. . View in PubMed
  • Pulmonary function in thalassaemia major and its correlation with body iron stores Br J Haematol. 2011 Oct; 155(1):102-5. . View in PubMed
  • Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease Am J Respir Crit Care Med. 2011 Aug 15; 184(4):474-81. . View in PubMed
  • Relationship between labile plasma iron, liver iron concentration and cardiac response in a deferasirox monotherapy trial Haematologica. 2011 Jul; 96(7):1055-8. . View in PubMed
  • Iron overload in Brazilian thalassemic patients Einstein (Sao Paulo). 2011 Jun; 9(2):165-72. . View in PubMed
  • Quantitative computed tomography assessment of transfusional iron overload Br J Haematol. 2011 Jun; 153(6):780-5. . View in PubMed
  • Comparison of the region-based and pixel-wise methods for cardiac T2* analysis in 50 transfusion-dependent Thai thalassemia patients J Comput Assist Tomogr. 2011 May-Jun; 35(3):375-81. . View in PubMed
  • On T2* magnetic resonance and cardiac iron Circulation. 2011 Apr 12; 123(14):1519-28. . View in PubMed
  • Relaxivity-iron calibration in hepatic iron overload: probing underlying biophysical mechanisms using a Monte Carlo model Magn Reson Med. 2011 Mar; 65(3):837-47. . View in PubMed
  • Iron chelation in thalassemia: time to reconsider our comfort zones Expert Rev Hematol. 2011 Feb; 4(1):17-26. . View in PubMed
  • Polystyrene microsphere-ferritin conjugates: a robust phantom for correlation of relaxivity and size distribution Magn Reson Med. 2011 Feb; 65(2):522-30. . View in PubMed
  • Revisiting the relationship between vitamin D deficiency, cardiac iron and cardiac function in thalassemia major Eur J Haematol. 2011 Feb; 86(2):176-7. . View in PubMed
  • Interdependence of cardiac iron and calcium in a murine model of iron overload Transl Res. 2011 Feb; 157(2):92-9. . View in PubMed
  • Pancreatic iron loading in chronically transfused sickle cell disease is lower than in thalassaemia major Br J Haematol. 2011 Jan; 152(2):229-33. . View in PubMed
  • Impact of iron assessment by MRI Hematology Am Soc Hematol Educ Program. 2011; 2011:443-50. . View in PubMed
  • Combining two orally active iron chelators for thalassemia Ann Hematol. 2010 Nov; 89(11):1177-8. . View in PubMed
  • Follow-up report on the 2-year cardiac data from a deferasirox monotherapy trial Am J Hematol. 2010 Oct; 85(10):818-9. . View in PubMed
  • Predicting pituitary iron and endocrine dysfunction Ann N Y Acad Sci. 2010 Aug; 1202:123-8. . View in PubMed
  • Cardiovascular MRI in thalassemia major Ann N Y Acad Sci. 2010 Aug; 1202:173-9. . View in PubMed
  • The effect of deferasirox on cardiac iron in thalassemia major: impact of total body iron stores Blood. 2010 Jul 29; 116(4):537-43. . View in PubMed
  • Absence of cardiac siderosis despite hepatic iron overload in Italian patients with thalassemia intermedia: an MRI T2* study Ann Hematol. 2010 Jun; 89(6):585-9. . View in PubMed
  • Quantitative analysis and modelling of hepatic iron stores using stereology and spatial statistics J Microsc. 2010 Jun 01; 238(3):265-74. . View in PubMed
  • Iron overload indices rise linearly with transfusion rate in patients with sickle cell disease Blood. 2010 Apr 08; 115(14):2980-1; author reply 2981-2. . View in PubMed
  • Magnetic resonance evaluation of hepatic and myocardial iron deposition in transfusion-independent thalassemia intermedia compared to regularly transfused thalassemia major patients Am J Hematol. 2010 Apr; 85(4):288-90. . View in PubMed
  • Time-varying analysis of autonomic control in response to spontaneous sighs in sickle cell anemia Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:1626-9. . View in PubMed
  • Absence of cardiac siderosis by MRI T2* despite transfusion burden, hepatic and serum iron overload in Lebanese patients with sickle cell disease Eur J Haematol. 2009 Dec 01; 83(6):565-71. . View in PubMed
  • History and current impact of cardiac magnetic resonance imaging on the management of iron overload Circulation. 2009 Nov 17; 120(20):1937-9. . View in PubMed
  • Pancreatic iron loading predicts cardiac iron loading in thalassemia major Blood. 2009 Nov 05; 114(19):4021-6. . View in PubMed
  • Patterns of hepatic iron distribution in patients with chronically transfused thalassemia and sickle cell disease Am J Hematol. 2009 Aug; 84(8):480-3. . View in PubMed
  • Nutritional deficiencies in iron overloaded patients with hemoglobinopathies Am J Hematol. 2009 Jun; 84(6):344-8. . View in PubMed
  • Spleen R2 and R2* in iron-overloaded patients with sickle cell disease and thalassemia major J Magn Reson Imaging. 2009 Feb; 29(2):357-64. . View in PubMed
  • Cardiac complications in thalassemia major Hemoglobin. 2009; 33 Suppl 1:S81-6. . View in PubMed
  • Cardiac iron across different transfusion-dependent diseases Blood Rev. 2008 Dec; 22 Suppl 2:S14-21. . View in PubMed
  • Cardiac medications are not associated with clinically important preoperative electrolyte disturbances in children presenting for cardiac surgery Anesth Analg. 2008 Dec; 107(6):1840-7. . View in PubMed
  • Longitudinal analysis of heart and liver iron in thalassemia major Blood. 2008 Oct 01; 112(7):2973-8. . View in PubMed
  • Magnetic resonance detection of kidney iron deposition in sickle cell disease: a marker of chronic hemolysis J Magn Reson Imaging. 2008 Sep; 28(3):698-704. . View in PubMed
  • Influence of iron chelation on R1 and R2 calibration curves in gerbil liver and heart Magn Reson Med. 2008 Jul; 60(1):82-9. . View in PubMed
  • Vitamin D deficiency, cardiac iron and cardiac function in thalassaemia major Br J Haematol. 2008 Jun; 141(6):891-4. . View in PubMed
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