John David Carmichael, MD

Associate Professor of Clinical Medicine

Co-Director, Pituitary Program at Keck Medical Center

Endocrine Clinical Chief

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Overview

Dr. John Carmichael is the Clinical Chief for the Division of Endocrinology, and serves as the Associate Chief Medical Informatics Officer for Keck Medicine of USC. He joined the Keck as Co-Director for the USC Pituitary Center. He attended Brown University where he obtained a BA in Biomedical Ethics. Dr. Carmichael attended medical school at the Virginia Commonwealth University/Medical College of Virginia and then completed Internal Medicine residency at the Virginia Mason Medical Center at Seattle Washington.

Following his Fellowship in Endocrinology, Diabetes and Metabolism at New York University, Dr. Carmichael received specialized training in Translational Research at UCLA. He has received NIH funding for his research in growth hormone feedback in patients with acromegaly and diabetes mellitus.

Dr. Carmichael has written articles for The Journal of Clinical Endocrinology and Metabolism, Clinical Endocrinology, Pituitary, Endocrine, and Current Opinion in Endocrinology and Diabetes. He is a member of the American Association of Clinical Endocrinologists, the Pituitary Society, and the Endocrine Society where he serves on the Endocrine Board Review Committee for the pituitary section.

After finishing his clinical training at NYU in 2004, Dr. Carmichael worked as a clinical researcher at NYU focusing on clinical trials in pituitary disease. He received a grant from Genentech to support his work during this time. In 2006, he went on to work at Cedars-Sinai Medical Center in their pituitary center. His work included care of patients with pituitary disease and clinical research in the diagnosis and treatment of patients with pituitary tumors. He held an appointment in the department of medicine at UCLA, devoting his time to the education of medical students, residents and fellows in multiple topics related to pituitary disorders. In 2014, Dr. Carmichael joined the faculty at the Keck School of Medicine of USC where he is Associate Professor of Clinical Medicine. Dr. Carmichael is available to see patients at the Neurosurgery Suites in HC2 on the USC Health Science Campus.

Awards

  • NIH Loan Repayment Program: Growth Hormone Feedback in Patients with Acromegaly, Type 2 Diabetes Mellitus, and Healthy Adults, 2009-2013
  • NIH Clinical Research Feasibility Funds (CReFF): Growth Hormone Feedback in Patients with Acromegaly, Type 2 Diabetes Mellitus, and Healthy Adults, 2008-2009

Publications

  • Endoscopic Endonasal Transsphenoidal Resection of Pituitary Adenomas in Patients Presenting With Monocular Blindness Oper Neurosurg (Hagerstown). 2024 Apr 10. . View in PubMed
  • Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment Phys Rev Lett. 2024 Feb 09; 132(6):065102. . View in PubMed
  • Clinical Implications of Pituitary Adenomas Exhibiting Dual Transcription Factor Staining: A Case Series of 27 Patients World Neurosurg. 2024 Feb; 182:e62-e66. . View in PubMed
  • Management of growth hormone-secreting pituitary adenomas causing acromegaly: a practical review of surgical and multimodal management strategies for neurosurgeons J Neurosurg. 2023 Nov 10; 1-10. . View in PubMed
  • Endoscopic endonasal approach for MRI-Negative Cushing’s microadenoma Neurosurg Focus Video. 2023 Jul; 9(1):V5. . View in PubMed
  • Validation of Myc-Associated Protein X (MAX) regulation in growth hormone secreting and nonfunctional pituitary adenoma PLoS One. 2023; 18(4):e0284949. . View in PubMed
  • Treatment of Cushing Disease With Pituitary-Targeting Seliciclib J Clin Endocrinol Metab. 2023 02 15; 108(3):726-735. . View in PubMed
  • Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment Phys Rev Lett. 2022 Aug 12; 129(7):075001. . View in PubMed
  • Growth hormone secreting pituitary adenomas show distinct extrasellar extension patterns compared to nonfunctional pituitary adenomas Pituitary. 2022 Jun; 25(3):480-485. . View in PubMed
  • Evaluating the predictive value of comorbidity indices in pituitary surgery: a mixed-effects modeling study using the Nationwide Readmissions Database J Neurosurg. 2022 Mar 18; 1-9. . View in PubMed
  • Treatment strategies for giant pituitary adenomas in the era of endoscopic transsphenoidal surgery: a multicenter series J Neurosurg. 2022 Mar 01; 136(3):776-785. . View in PubMed
  • Association between socioeconomic status and presenting characteristics and extent of disease in patients with surgically resected nonfunctioning pituitary adenoma J Neurosurg. 2022 12 01; 137(6):1699-1706. . View in PubMed
  • Ultra-high field 7 T MRI localizes regional brain volume recovery following corticotroph adenoma resection and hormonal remission in Cushing’s disease: A case series Surg Neurol Int. 2022; 13:239. . View in PubMed
  • Use of predictive spatial modeling to reveal that primary cancers have distinct central nervous system topography patterns of brain metastasis J Neurosurg. 2022 01 01; 136(1):88-96. . View in PubMed
  • Cure and Hormonal Control After Prolactinoma Resection: Case Series and Systematic Review J Endocr Soc. 2021 Oct 01; 5(10):bvab074. . View in PubMed
  • Multivariable analysis of 63 contemporary patients diagnosed with nelson’s syndrome: A nationwide readmission database study J Clin Neurosci. 2021 Oct; 92:45-48. . View in PubMed
  • Neural network modeling for prediction of recurrence, progression, and hormonal non-remission in patients following resection of functional pituitary adenomas Pituitary. 2021 Aug; 24(4):523-529. . View in PubMed
  • Melanoma metastasis to a nonfunctioning pituitary macroadenoma: illustrative case J Neurosurg Case Lessons. 2021 Jun 07; 1(23):CASE2167. . View in PubMed
  • Silent corticotroph pituitary adenomas: clinical characteristics, long-term outcomes, and management of disease recurrence J Neurosurg. 2021 May 07; 135(6):1706-1713. . View in PubMed
  • Consensus on diagnosis and management of Cushing’s disease: a guideline update Lancet Diabetes Endocrinol. 2021 12; 9(12):847-875. . View in PubMed
  • Safety and Effectiveness of the Direct Endoscopic Endonasal Approach for Primary Sellar Pathology: A Contemporary Case Series of More Than 400 Patients World Neurosurg. 2021 04; 148:e536-e546. . View in PubMed
  • The role of reoperation after recurrence of Cushing’s disease Best Pract Res Clin Endocrinol Metab. 2021 03; 35(2):101489. . View in PubMed
  • Discrepancies in the Recommended Management of Adrenal Incidentalomas by Various Guidelines J Urol. 2021 Jan; 205(1):52-59. . View in PubMed
  • Postoperative GH and Degree of Reduction in IGF-1 Predicts Postoperative Hormonal Remission in Acromegaly Front Endocrinol (Lausanne). 2021; 12:743052. . View in PubMed
  • Ultra-high field magnetic resonance imaging for localization of corticotropin-secreting pituitary adenomas Neuroradiology. 2020 Aug; 62(8):1051-1054. . View in PubMed
  • Comparative preoperative characteristics and postoperative outcomes at a private versus a safety-net hospital following endoscopic endonasal transsphenoidal resection of pituitary adenomas J Neurosurg. 2020 Feb 28; 134(3):742-749. . View in PubMed
  • Role of KCNAB2 expression in modulating hormone secretion in somatotroph pituitary adenoma J Neurosurg. 2020 Feb 28; 134(3):787-793. . View in PubMed
  • Calcified Prolactinoma of the Pituitary Gland: Illustrative Case Reports Highlighting Medical versus Surgical Intervention J Neurol Surg B Skull Base. 2020 Feb; 81(1):22-29. . View in PubMed
  • Stereotactic Radiosurgery for Residual and Recurrent Nonfunctioning Pituitary Adenomas: A Contemporary Case Series of GammaKnife and CyberKnife Radiosurgery World Neurosurg. 2020 11; 143:e60-e69. . View in PubMed
  • Impact of tumor characteristics and pre- and postoperative hormone levels on hormonal remission following endoscopic transsphenoidal surgery in patients with acromegaly Neurosurg Focus. 2020 06; 48(6):E10. . View in PubMed
  • Pituitary Apoplexy Case Series: Outcomes After Endoscopic Endonasal Transsphenoidal Surgery at a Single Tertiary Center World Neurosurg. 2020 05; 137:e366-e372. . View in PubMed
  • Development and clinical validation of a grading system for pituitary adenoma consistency J Neurosurg. 2020 06 05; 134(6):1800-1807. . View in PubMed
  • Differential Clinical Presentation, Intraoperative Management Strategies, and Surgical Outcomes After Endoscopic Endonasal Treatment of Cystic Sellar Masses World Neurosurg. 2020 Jan; 133:e241-e251. . View in PubMed
  • Letter to the EditorGamma Knife radiosurgery for Cushing’s disease after prior resection. J Neurosurg. 2020 07 31; 134(3):1012-1014. . View in PubMed
  • Cost-Effectiveness and Efficacy of a Novel Combination Regimen in Acromegaly: A Prospective, Randomized Trial J Clin Endocrinol Metab. 2020 09 01; 105(9). . View in PubMed
  • Hemorrhagic Presentation of Rathke Cleft Cysts: A Surgical Case Series Oper Neurosurg (Hagerstown). 2020 05 01; 18(5):470-479. . View in PubMed
  • Surgical management of clinically silent thyrotropin pituitary adenomas: A single center series of 20 patients J Clin Neurosci. 2020 Jan; 71:70-75. . View in PubMed
  • AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF GROWTH HORMONE DEFICIENCY IN ADULTS AND PATIENTS TRANSITIONING FROM PEDIATRIC TO ADULT CARE Endocr Pract. 2019 Nov; 25(11):1191-1232. . View in PubMed
  • Clinical utility of routine postoperative morning cortisol monitoring in detecting new hypothalamic-pituitary-adrenal axis insufficiency following endoscopic transsphenoidal surgery for sellar lesions J Neurosurg. 2019 Mar 01; 132(4):1054-1058. . View in PubMed
  • Surgical Outcomes Following Repeat Transsphenoidal Surgery for Nonfunctional Pituitary Adenomas: A Retrospective Comparative Study Oper Neurosurg (Hagerstown). 2019 02 01; 16(2):127-135. . View in PubMed
  • Outcomes Following Transsphenoidal Pituitary Surgery in the Elderly: A Retrospective Single-Center Review Oper Neurosurg (Hagerstown). 2019 03 01; 16(3):302-309. . View in PubMed
  • Recurrent Rathke’s Cleft Cysts: Incidence and Surgical Management in a Tertiary Pituitary Center over 2 Decades Oper Neurosurg (Hagerstown). 2019 06 01; 16(6):675-684. . View in PubMed
  • Complications associated with microscopic and endoscopic transsphenoidal pituitary surgery: experience of 1153 consecutive cases treated at a single tertiary care pituitary center J Neurosurg. 2018 Jun 01; 1-8. . View in PubMed
  • Outcomes following transsphenoidal surgical management of incidental pituitary adenomas: a series of 52 patients over a 17-year period J Neurosurg. 2018 Jun 01; 1-9. . View in PubMed
  • Value of pituitary gland MRI at 7 T in Cushing’s disease and relationship to inferior petrosal sinus sampling: case report J Neurosurg. 2018 Mar 01; 1-5. . View in PubMed
  • Discordance between mass spectrometry and immunometric IGF-1 assay in pituitary disease: a prospective study Pituitary. 2018 Feb; 21(1):65-75. . View in PubMed
  • Identification and repair of intraoperative cerebrospinal fluid leaks in endonasal transsphenoidal pituitary surgery: surgical experience in a series of 1002 patients J Neurosurg. 2018 08; 129(2):425-429. . View in PubMed
  • Long-term surgical outcomes following transsphenoidal surgery in patients with Rathke’s cleft cysts J Neurosurg. 2018 05 18; 130(3):831-837. . View in PubMed
  • Endoscopic Endonasal Transsphenoidal Drainage of a Spontaneous Candida glabrata Pituitary Abscess World Neurosurg. 2018 Jan; 109:467-470. . View in PubMed
  • Variability and Lack of Prognostic Value Associated With Atypical Pituitary Adenoma Diagnosis: A Systematic Review and Critical Assessment of the Diagnostic Criteria Neurosurgery. 2018 10 01; 83(4):602-610. . View in PubMed
  • The Influence of Hormonal Fluctuation on Inflammatory Bowel Disease Symptom Severity-A Cross-Sectional Cohort Study Inflamm Bowel Dis. 2018 01 18; 24(2):387-393. . View in PubMed
  • Surgical debulking of pituitary adenomas improves responsiveness to octreotide lar in the treatment of acromegaly Pituitary. 2017 Dec; 20(6):668-675. . View in PubMed
  • Long-term treatment outcomes of acromegaly patients presenting biochemically-uncontrolled at a tertiary pituitary center BMC Endocr Disord. 2017 Aug 04; 17(1):49. . View in PubMed
  • Follow-up intervals in patients with Cushing’s disease: recommendations from a panel of experienced pituitary clinicians Pituitary. 2017 Aug; 20(4):422-429. . View in PubMed
  • Long-Term Endocrine Outcomes Following Endoscopic Endonasal Transsphenoidal Surgery for Acromegaly and Associated Prognostic Factors Neurosurgery. 2017 Aug 01; 81(2):357-366. . View in PubMed
  • BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY Endocr Pract. 2017 Aug; 23(8):962-970. . View in PubMed
  • The association between biochemical control and cardiovascular risk factors in acromegaly BMC Endocr Disord. 2017 Mar 09; 17(1):15. . View in PubMed
  • Management of aggressive growth hormone secreting pituitary adenomas Pituitary. 2017 Feb; 20(1):169-178. . View in PubMed
  • Prolactin-Secreting Pituitary Carcinoma with Dural Metastasis: Diagnosis, Treatment, and Future DirectionsWorld Neurosurg. 2016 Jul; 91:676. e23-8. . View in PubMed
  • Comparative analysis of outcomes following craniotomy and expanded endoscopic endonasal transsphenoidal resection of craniopharyngioma and related tumors: a single-institution study J Neurosurg. 2016 Mar; 124(3):627-38. . View in PubMed
  • Gene expression in prolactinomas: a systematic review Pituitary. 2016 Feb; 19(1):93-104. . View in PubMed
  • Patterns of pharmacologic treatment in US patients with acromegaly Curr Med Res Opin. 2016 05; 32(5):799-805. . View in PubMed
  • AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY DISEASE STATE CLINICAL REVIEW: POSTOPERATIVE MANAGEMENT FOLLOWING PITUITARY SURGERY Endocr Pract. 2015 Jul; 21(7):832-8. . View in PubMed
  • Effects of low dose versus high dose human growth hormone on body composition and lipids in adults with GH deficiency: a meta-analysis of placebo-controlled randomized trials Pituitary. 2015 Jun; 18(3):297-305. . View in PubMed
  • Hyperprolactinemia due to spontaneous intracranial hypotension J Neurosurg. 2015 May; 122(5):1020-5. . View in PubMed
  • Demographic factors, outcomes, and patient access to transsphenoidal surgery for Cushing’s disease: analysis of the Nationwide Inpatient Sample from 2002 to 2010 Neurosurg Focus. 2015 Feb; 38(2):E2. . View in PubMed
  • Ectopic ACTH-secreting pituitary adenoma of the sphenoid sinus: case report of endoscopic endonasal resection and systematic review of the literature Neurosurg Focus. 2015 Feb; 38(2):E10. . View in PubMed
  • Gene and protein expression in pituitary corticotroph adenomas: a systematic review of the literature Neurosurg Focus. 2015 Feb; 38(2):E17. . View in PubMed
  • Introduction: Cushing’s disease: a century of evolving diagnostics and therapeutics for an often elusive entity Neurosurg Focus. 2015 Feb; 38(2):E1. . View in PubMed
  • Cyclic Cushing’s disease with misleading inferior petrosal sinus sampling results during a trough phase Neurosurg Focus. 2015 Feb; 38(2):E7. . View in PubMed
  • Making the diagnosis of cyclic Cushing’s syndrome: a position statement from the topic editors Neurosurg Focus. 2015 Feb; 38(2):E8. . View in PubMed
  • A structural and functional acromegaly classification J Clin Endocrinol Metab. 2015 Jan; 100(1):122-31. . View in PubMed
  • A protracted and aggressive variant of lymphocytic hypophysitis with mammillary body involvement and cognitive dysfunction Endocr Pract. 2014 Nov; 20(11):e225-9. . View in PubMed
  • Surgical management of pituicytomas: case series and comprehensive literature review Pituitary. 2014 Oct; 17(5):399-413. . View in PubMed
  • Prolactinoma ErbB receptor expression and targeted therapy for aggressive tumors Endocrine. 2014 Jun; 46(2):318-27. . View in PubMed
  • Acromegaly clinical trial methodology impact on reported biochemical efficacy rates of somatostatin receptor ligand treatments: a meta-analysis J Clin Endocrinol Metab. 2014 May; 99(5):1825-33. . View in PubMed
  • Single-surgeon fully endoscopic endonasal transsphenoidal surgery: outcomes in three-hundred consecutive cases Pituitary. 2013 Sep; 16(3):393-401. . View in PubMed
  • Mifepristone: is there a place in the treatment of Cushing’s disease? Endocrine. 2013 Aug; 44(1):20-32.. View in PubMed
  • Endocrinol Diabetes Metab Case Rep. 2013; 2013:130036. . View in PubMed
  • Update on the diagnosis and management of hypophysitis Curr Opin Endocrinol Diabetes Obes. 2012 Aug; 19(4):314-21. . View in PubMed
  • Lanreotide depot deep subcutaneous injection: a new method of delivery and its associated benefits Patient Prefer Adherence. 2012; 6:73-82. . View in PubMed
  • Atypical pituitary adenoma with malignant features Pituitary. 2011 Mar; 14(1):92-7. . View in PubMed
  • The utility of oral glucose tolerance testing for diagnosis and assessment of treatment outcomes in 166 patients with acromegaly J Clin Endocrinol Metab. 2009 Feb; 94(2):523-7. . View in PubMed
  • Lipodystrophy in patients with acromegaly receiving pegvisomant J Clin Endocrinol Metab. 2008 Sep; 93(9):3515-8. . View in PubMed
  • Medical therapy: options and uses Rev Endocr Metab Disord. 2008 Mar; 9(1):71-81. . View in PubMed
  • GH peak response to GHRH-arginine: relationship to insulin resistance and other cardiovascular risk factors in a population of adults aged 50-90 Clin Endocrinol (Oxf). 2006 Aug; 65(2):169-77. . View in PubMed
  • Variability and reliability of single serum IGF-I measurements: impact on determining predictability of risk ratios in disease development J Clin Endocrinol Metab. 2004 May; 89(5):2271-4. . View in PubMed
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