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John Paul Murad

Assistant Professor of Research Medicine

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Email johnmura@usc.edu
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Publications

  • Universal off-the-shelf combination immunotherapy using oncolytic viruses to redirect T cell engagers to target solid tumors. J Immunother Cancer. 2025 Aug 11; 13(8).. View in PubMed
  • Solid tumor CAR T cells engineered with fusion proteins targeting PDL1 for localized IL-12 delivery. bioRxiv. 2025 May 19.. View in PubMed
  • Nonsignaling extracellular spacer regulates tumor antigen selectivity of CAR T cells. Mol Ther Oncol. 2024 Jun 20; 32(2):200789.. View in PubMed
  • PSCA-CAR T cell therapy in metastatic castration-resistant prostate cancer: a phase 1 trial. Nat Med. 2024 Jun; 30(6):1636-1644.. View in PubMed
  • Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting. Nat Commun. 2023 08 07; 14(1):4737.. View in PubMed
  • Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting. bioRxiv. 2023 Jan 07.. View in PubMed
  • Enhanced intratumoural activity of CAR T cells engineered to produce immunomodulators under photothermal control. Nat Biomed Eng. 2021 11; 5(11):1348-1359.. View in PubMed
  • Pre-conditioning modifies the TME to enhance solid tumor CAR T cell efficacy and endogenous protective immunity. Mol Ther. 2021 07 07; 29(7):2335-2349.. View in PubMed
  • Effective combination immunotherapy using oncolytic viruses to deliver CAR targets to solid tumors. Sci Transl Med. 2020 09 02; 12(559).. View in PubMed
  • Effective Targeting of TAG72+ Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells. Front Immunol. 2018; 9:2268.. View in PubMed
  • Regional Delivery of Chimeric Antigen Receptor-Engineered T Cells Effectively Targets HER2+ Breast Cancer Metastasis to the Brain. Clin Cancer Res. 2018 01 01; 24(1):95-105.. View in PubMed
  • Co-stimulatory signaling determines tumor antigen sensitivity and persistence of CAR T cells targeting PSCA+ metastatic prostate cancer. Oncoimmunology. 2018; 7(2):e1380764.. View in PubMed
  • Human brain metastatic stroma attracts breast cancer cells via chemokines CXCL16 and CXCL12. NPJ Breast Cancer. 2017; 3:6.. View in PubMed
  • Antigen-specific inhibition of high-avidity T cell target lysis by low-avidity T cells via trogocytosis. Cell Rep. 2014 Aug 07; 8(3):871-882.. View in PubMed
  • Current and experimental antibody-based therapeutics: insights, breakthroughs, setbacks and future directions. Curr Mol Med. 2013 Jan; 13(1):165-78.. View in PubMed
  • Thromboxane A2 receptor: biology and function of a peculiar receptor that remains resistant for therapeutic targeting. J Cardiovasc Pharmacol Ther. 2012 Sep; 17(3):248-59.. View in PubMed
  • Characterization of the in vivo antiplatelet activity of the antihypertensive agent losartan. J Cardiovasc Pharmacol Ther. 2012 Sep; 17(3):308-14.. View in PubMed
  • A novel antibody targeting the ligand binding domain of the thromboxane A₂ receptor exhibits antithrombotic properties in vivo. Biochem Biophys Res Commun. 2012 May 11; 421(3):456-61.. View in PubMed
  • Mouse transient receptor potential channel 6: role in hemostasis and thrombogenesis. Biochem Biophys Res Commun. 2012 Jan 13; 417(2):853-6.. View in PubMed
  • The C-terminal segment of the second extracellular loop of the thromboxane A2 receptor plays an important role in platelet aggregation. Biochem Pharmacol. 2012 Jan 01; 83(1):88-96.. View in PubMed
  • Aspirin: pharmacology and clinical applications. Thrombosis. 2012; 2012:173124.. View in PubMed

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