John S. Oghalai, MD

Professor of Otolaryngology-Head and Neck Surgery, Neurological Surgery, and Biomedical Engineering

Chair, Department of Otolaryngology-Head and Neck Surgery

Leon J. Tiber and David S. Alpert Chair in Medicine

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Overview

Dr. Oghalai is a Professor and Department Chair of Otolaryngology–Head and Neck Surgery at USC. He has followed a clinician-scientist pathway, both caring for patients and performing research in the lab. His clinical areas of focus are acoustic neuroma (vestibular schwannoma) surgery, chronic ear disease, and cochlear implantation. His NIH-funded lab seeks to better understand the fundamental changes within the inner ear that underlie progressive hearing loss and to develop novel techniques to treat this problem before it worsens.

Prior to joining USC, he was an Instructor at UCSF from 2001-2003 where he did fellowship training in Neurotology and Skull Base Surgery. He joined the faculty at Baylor College of Medicine in 2003 as an Assistant Professor and was promoted to Associate Professor in 2009. In 2010, he moved to Stanford University as an Associate Professor, and was promoted to Professor in 2015. In 2017, he took his current position at USC.

Research Funding

  • OCT imaging of the human inner ear
    NIH · R01DC022232 · Dec 1, 2024 – Nov 30, 2029 · Role: Principal Investigator
  • Otolaryngology Clinician-Scientist Training Program
    NIH · R25DC019700 · Jul 1, 2022 – Jun 30, 2027 · Role: Principal Investigator
  • Mechanisms of cochlear synaptopathy after noise or blast trauma
    NIH · R01DC017741 · Jan 1, 2020 – Dec 31, 2024 · Role: Principal Investigator
  • Conference on Implantable Auditory Prostheses
    NIH · R13DC015965 · Apr 1, 2017 – Mar 31, 2022 · Role: Principal Investigator
  • Clinician-scientist training program in otolaryngology
    NIH · T32DC015209 · Jul 1, 2016 – Jun 30, 2022 · Role: Principal Investigator
  • Cochlear mechanics in the mouse
    NIH · R01DC014450 · May 1, 2015 – Feb 28, 2031 · Role: Principal Investigator
  • Optical coherence tomography for 3D measures of cochlear mechanics in vivo
    NIH · R01DC013774 · Apr 10, 2015 – Mar 31, 2021 · Role: Principal Investigator
  • Translation of near-infrared spectroscopy for use in clinical neuro-imaging
    NIH · R56DC010164 · Aug 1, 2010 – Jul 31, 2012 · Role: Principal Investigator
  • Outcomes in Children with Developmental Delay and Deafness: a Randomized Trial
    NIH · R01DC010075 · Sep 18, 2009 – Aug 31, 2016 · Role: Principal Investigator
  • Modulation of Cochlear Tuning
    NIH · K08DC006671 · Mar 1, 2004 – Feb 28, 2010 · Role: Principal Investigator
  • Modulation of Cochlear Mechanics
    NIH · R03DC005131 · Aug 1, 2001 – May 31, 2004 · Role: Principal Investigator

Publications

  • Optical coherence tomography of the tympanic membrane and middle ear: clinical applications. Curr Opin Otolaryngol Head Neck Surg. 2026 Oct 01; 34(5):326-332.. View in PubMed
  • Diagnosing Eosinophilic Chronic Rhinosinusitis in Excised Tissue Using Optical Coherence Tomography. Laryngoscope. 2026 05; 136(5):2092-2100.. View in PubMed
  • The AudioScatter Package in RStudio to Generate Scattergrams for Reporting Hearing Results. Otol Neurotol. 2026 Jan 01; 47(1):7-10.. View in PubMed
  • Multimodal microscope for optical coherence microscopy, tomography, vibrometry, and two-photon microscopy in the living mouse cochlea. J Biomed Opt. 2025 Oct; 30(10):106005.. View in PubMed
  • Optical coherence tomography-based cochlear endoscopy through the human round window membrane. Opt Lett. 2025 Sep 15; 50(18):5797-5800.. View in PubMed
  • Optical coherence tomography imaging demonstrates endolymphatic hydrops in the lateral and posterior semicircular canals in noise-exposed mice. Hear Res. 2025 10; 466:109380.. View in PubMed
  • Human inner ear fluid imbalance detected by optical coherence tomography correlates with hearing loss. Sci Transl Med. 2025 Jul 23; 17(808):eadv3783.. View in PubMed
  • Quantitative measurement of tympanic membrane structure and symmetry with optical coherence tomography in normal human subjects. J Biomed Opt. 2025 05; 30(5):056007.. View in PubMed
  • Infrared light stimulates the cochlea through a mechanical displacement detected and amplified by hair cells. Proc Natl Acad Sci U S A. 2025 Apr 29; 122(17):e2422076122.. View in PubMed
  • Imaging the ex-vivo human cochlea using 1.3-μm and 1.7-μm optical coherence tomography. J Biomed Opt. 2025 04; 30(4):046007.. View in PubMed