Keck School Faculty

John S. Oghalai, MD
John S. Oghalai, MD
Chair and Professor of Otolaryngology - Head and Neck Surgery, Leon J. Tiber and David S. Alpert Chair in Medicine
Otolaryngology
1540 Alcazar Street Health Sciences Campus Los Angeles
Dr. Oghalai is the Department Chair of Otolaryngology-Head and Neck Surgery at USC. He has followed a clinician-scientist pathway, both caring for patients and performing research in the lab. His clinical areas of focus are skull base surgery, chronic ear disease and cochlear implantation. His NIH-funded lab seeks to better understand the fundamental changes within the inner ear that underlie progressive hearing loss and to develop novel techniques to treat this problem before it worsens.

https://keck.usc.edu/otolaryngology/

Picometer scale vibrometry in the human middle ear using a surgical microscope based optical coherence tomography and vibrometry system Biomed Opt Express. 2019 Sep 01; 10(9):4395-4410. . View in PubMed

Amplification and Suppression of Traveling Waves along the Mouse Organ of Corti: Evidence for Spatial Variation in the Longitudinal Coupling of Outer Hair Cell-Generated Forces J Neurosci. 2019 Mar 06; 39(10):1805-1816. . View in PubMed

LMO7 deficiency reveals the significance of the cuticular plate for hearing function Nat Commun. 2019 03 08; 10(1):1117. . View in PubMed

Endoscopic optical coherence tomography enables morphological and subnanometer vibratory imaging of the porcine cochlea through the round window Opt Lett. 2018 May 01; 43(9):1966-1969. . View in PubMed

Osmotic stabilization prevents cochlear synaptopathy after blast trauma Proc Natl Acad Sci U S A. 2018 05 22; 115(21):E4853-E4860. . View in PubMed

Organ of Corti vibration within the intact gerbil cochlea measured by volumetric optical coherence tomography and vibrometry J Neurophysiol. 2018 12 01; 120(6):2847-2857. . View in PubMed

Mammalian Auditory Hair Cell Bundle Stiffness Affects Frequency Tuning by Increasing Coupling along the Length of the Cochlea Cell Rep. 2018 06 05; 23(10):2915-2927. . View in PubMed

Otosclerosis With Concomitant Anterior Malleolar Ligament Fixation Otol Neurotol. 2018 Jan; 39(1):e58-e59. . View in PubMed

ELHnet: a convolutional neural network for classifying cochlear endolymphatic hydrops imaged with optical coherence tomography Biomed Opt Express. 2017 Oct 01; 8(10):4579-4594. . View in PubMed

Computer-aided detection and quantification of endolymphatic hydrops within the mouse cochlea in vivo using optical coherence tomography J Biomed Opt. 2017 07 01; 22(7):76002. . View in PubMed

Mechanical tuning and amplification within the apex of the guinea pig cochlea J Physiol. 2017 07 01; 595(13):4549-4561. . View in PubMed

PHOEBE: a method for real time mapping of optodes-scalp coupling in functional near-infrared spectroscopy Biomed Opt Express. 2016 Dec 01; 7(12):5104-5119. . View in PubMed

Diagnosis and Management of Congenital Sensorineural Hearing Loss Curr Treat Options Pediatr. 2016 Sep; 2(3):256-265. . View in PubMed

Facial Nerve Outcome and Tumor Control Rate as a Function of Degree of Resection in Treatment of Large Acoustic Neuromas: Preliminary Report of the Acoustic Neuroma Subtotal Resection Study (ANSRS) Neurosurgery. 2016 Aug; 79(2):194-203. . View in PubMed

Cortical Activation Patterns Correlate with Speech Understanding After Cochlear Implantation Ear Hear. 2016 May-Jun; 37(3):e160-72. . View in PubMed

High-speed spectral calibration by complex FIR filter in phase-sensitive optical coherence tomography Biomed Opt Express. 2016 Apr 01; 7(4):1430-44. . View in PubMed

Functional near-infrared spectroscopy for neuroimaging in cochlear implant recipients Hear Res. 2016 08; 338:64-75. . View in PubMed

New Web-based tool for generating scattergrams to report hearing results Laryngoscope. 2016 06; 126(6):1267. . View in PubMed

New Web-Based Tool for Generating Scattergrams to Report Hearing Results Otolaryngol Head Neck Surg. 2016 06; 154(6):981. . View in PubMed

New Web-based Tool for Generating Scattergrams to Report Hearing Results Otol Neurotol. 2016 06; 37(5):419. . View in PubMed

Bilirubin-Induced Audiologic Injury in Preterm Infants Clin Perinatol. 2016 06; 43(2):313-23. . View in PubMed

Hair cell force generation does not amplify or tune vibrations within the chicken basilar papilla Nat Commun. 2016 10 31; 7:13133. . View in PubMed

Optical Coherence Tomography to Measure Sound-Induced Motions Within the Mouse Organ of Corti In Vivo Methods Mol Biol. 2016; 1427:449-62. . View in PubMed

Neuroplastin Isoform Np55 Is Expressed in the Stereocilia of Outer Hair Cells and Required for Normal Outer Hair Cell Function J Neurosci. 2016 08 31; 36(35):9201-16. . View in PubMed

Activity-dependent regulation of prestin expression in mouse outer hair cells J Neurophysiol. 2015 Jun 01; 113(10):3531-42. . View in PubMed

Miniature, minimally invasive, tunable endoscope for investigation of the middle ear Biomed Opt Express. 2015 Jun 01; 6(6):2246-57. . View in PubMed

DNA sequence analysis and genotype-phenotype assessment in 71 patients with syndromic hearing loss or auditory neuropathy BMJ Open. 2015 May 19; 5(5):e007506. . View in PubMed

Noninvasive in vivo imaging reveals differences between tectorial membrane and basilar membrane traveling waves in the mouse cochlea Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):3128-33. . View in PubMed

Audiologic impairment associated with bilirubin-induced neurologic damage Semin Fetal Neonatal Med. 2015 Feb; 20(1):42-46. . View in PubMed

Changes in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea Front Cell Neurosci. 2015; 9:110. . View in PubMed

Modality use in joint attention between hearing parents and deaf children Front Psychol. 2015; 6:1556. . View in PubMed

Exome sequencing and genome-wide copy number variant mapping reveal novel associations with sensorineural hereditary hearing loss BMC Genomics. 2014 Dec 20; 15:1155. . View in PubMed

Phase-sensitive optical coherence tomography using an Vernier-tuned distributed Bragg reflector swept laser in the mouse middle ear Opt Lett. 2014 Nov 01; 39(21):6233-6. . View in PubMed

Otalgia, Facial Nerve Paralysis, and Hearing Loss JAMA Otolaryngol Head Neck Surg. 2014 Jun; 140(6):575-6. . View in PubMed

Is office-based myringoplasty a suitable alternative to surgical tympanoplasty? Laryngoscope. 2014 May; 124(5):1053-4.. View in PubMed

Auditory cortex activation to natural speech and simulated cochlear implant speech measured with functional near-infrared spectroscopy Hear Res. 2014 Mar; 309:84-93. . View in PubMed

Nonverbal cognitive development in children with cochlear implants: relationship between the Mullen Scales of Early Learning and later performance on the Leiter International Performance Scales-Revised Assessment. 2014 Feb; 21(1):119-28. . View in PubMed

Cochlear implant considerations in children with additional disabilities Curr Otorhinolaryngol Rep. 2013 Jun 01; 1(2):61-68. . View in PubMed

Cochlear implant electrode misplacement: incidence, evaluation, and management Laryngoscope. 2013 Mar; 123(3):757-66. . View in PubMed

In vivo vibrometry inside the apex of the mouse cochlea using spectral domain optical coherence tomography Biomed Opt Express. 2013 Feb 01; 4(2):230-40. . View in PubMed

Mechanisms of hearing loss after blast injury to the ear PLoS One. 2013; 8(7):e67618. . View in PubMed

A point mutation in the gene for asparagine-linked glycosylation 10B (Alg10b) causes nonsyndromic hearing impairment in mice (Mus musculus) PLoS One. 2013; 8(11):e80408. . View in PubMed

An allelic series of mice reveals a role for RERE in the development of multiple organs affected in chromosome 1p36 deletions PLoS One. 2013; 8(2):e57460. . View in PubMed

Prestin regulation and function in residual outer hair cells after noise-induced hearing loss PLoS One. 2013; 8(12):e82602. . View in PubMed

Cognitive outcomes and familial stress after cochlear implantation in deaf children with and without developmental delays Otol Neurotol. 2012 Aug; 33(6):947-56. . View in PubMed

Is it valid to calculate the 3-kilohertz threshold by averaging 2 and 4 kilohertz? Otolaryngol Head Neck Surg. 2012 Jul; 147(1):102-4.. View in PubMed

Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness J Assoc Res Otolaryngol. 2012 Jun; 13(3):335-49. . View in PubMed

Are mastoid pressure dressings necessary after otologic surgery to prevent postoperative hematomas? Laryngoscope. 2012 Mar; 122(3):485-6.. View in PubMed

Imaging high-frequency periodic motion in the mouse ear with coherently interleaved optical coherence tomography Opt Lett. 2011 Dec 01; 36(23):4716-8. . View in PubMed

Biophysical mechanisms underlying outer hair cell loss associated with a shortened tectorial membrane J Assoc Res Otolaryngol. 2011 Oct; 12(5):577-94. . View in PubMed

Quantitative imaging of cochlear soft tissues in wild-type and hearing-impaired transgenic mice by spectral domain optical coherence tomography Opt Express. 2011 Aug 01; 19(16):15415-28. . View in PubMed

Middle ear volume as an adjunct measure in congenital aural atresia Int J Pediatr Otorhinolaryngol. 2011 Jul; 75(7):910-4. . View in PubMed

Comprehensive diagnostic battery for evaluating sensorineural hearing loss in children Otol Neurotol. 2011 Feb; 32(2):259-64. . View in PubMed

Can radiologic imaging replace second-look procedures for cholesteatoma? Laryngoscope. 2011 Jan; 121(1):4-5.. View in PubMed

Neuroimaging with near-infrared spectroscopy demonstrates speech-evoked activity in the auditory cortex of deaf children following cochlear implantation Hear Res. 2010 Dec 01; 270(1-2):39-47. . View in PubMed

Deficient forward transduction and enhanced reverse transduction in the alpha tectorin C1509G human hearing loss mutation Dis Model Mech. 2010 Mar-Apr; 3(3-4):209-23. . View in PubMed

Characteristics of malfunctioning channels in pediatric cochlear implants Laryngoscope. 2010 Feb; 120(2):399-404. . View in PubMed

Calcium imaging of inner ear hair cells within the cochlear epithelium of mice using two-photon microscopy J Biomed Opt. 2010 Jan-Feb; 15(1):016002. . View in PubMed

Auditory performance after cochlear implantation in late septuagenarians and octogenarians Otol Neurotol. 2009 Oct; 30(7):916-20. . View in PubMed

Atoh1-lineal neurons are required for hearing and for the survival of neurons in the spiral ganglion and brainstem accessory auditory nuclei J Neurosci. 2009 Sep 09; 29(36):11123-33. . View in PubMed

Advanced pediatric mastoiditis with and without intracranial complications Laryngoscope. 2009 Aug; 119(8):1610-5. . View in PubMed

Intra-operative monitoring of cochlear function during cochlear implantation Cochlear Implants Int. 2009 Mar; 10(1):1-18. . View in PubMed

Neurocognitive functioning of a child with partial trisomy 6 and monosomy 21 Neurocase. 2009; 15(2):97-100. . View in PubMed

Hearing loss in children with very low birth weight: current review of epidemiology and pathophysiology Arch Dis Child Fetal Neonatal Ed. 2008 Nov; 93(6):F462-8. . View in PubMed

Functional prestin transduction of immature outer hair cells from normal and prestin-null mice J Assoc Res Otolaryngol. 2008 Sep; 9(3):307-20. . View in PubMed

Perilymph osmolality modulates cochlear function Laryngoscope. 2008 Sep; 118(9):1621-9. . View in PubMed

Infrequency of two deletion mutations at the DFNB1 locus in patients and controls Am J Med Genet A. 2008 Apr 01; 146A(7):934-6. . View in PubMed

Chronic pachymeningitis and bilateral facial paralysis secondary to renal osteodystrophy Arch Otolaryngol Head Neck Surg. 2008 Mar; 134(3):324-6. . View in PubMed

Altered traveling wave propagation and reduced endocochlear potential associated with cochlear dysplasia in the BETA2/NeuroD1 null mouse J Assoc Res Otolaryngol. 2007 Dec; 8(4):447-63. . View in PubMed

Helper-dependent adenovirus-mediated gene transfer into the adult mouse cochlea Otol Neurotol. 2007 Dec; 28(8):1100-8. . View in PubMed

Peripetrosal arachnoid cysts Curr Opin Otolaryngol Head Neck Surg. 2007 Oct; 15(5):323-9. . View in PubMed

Cognition in children with sensorineural hearing loss: etiologic considerations Laryngoscope. 2007 Sep; 117(9):1661-5. . View in PubMed

Laser-induced collagen remodeling and deposition within the basilar membrane of the mouse cochlea J Biomed Opt. 2007 Mar-Apr; 12(2):021007. . View in PubMed

Intelligence, parental depression, and behavior adaptability in deaf children being considered for cochlear implantation J Deaf Stud Deaf Educ. 2007; 12(3):335-49. . View in PubMed

Invasive cerebrospinal fluid cysts and cephaloceles of the petrous apex Otol Neurotol. 2006 Dec; 27(8):1131-41. . View in PubMed

DNA sequence analysis of GJB2, encoding connexin 26: observations from a population of hearing impaired cases and variable carrier rates, complex genotypes, and ethnic stratification of alleles among controls Am J Med Genet A. 2006 Nov 15; 140(22):2401-15. . View in PubMed

Circumferential petrosectomy for petrous apicitis and cranial base osteomyelitis Otol Neurotol. 2006 Oct; 27(7):1003-13. . View in PubMed

Dyslipidemia and auditory function Otol Neurotol. 2006 Aug; 27(5):609-14. . View in PubMed

Photometric recording of transmembrane potential in outer hair cells J Neural Eng. 2006 Jun; 3(2):79-86. . View in PubMed

Adult spontaneous CSF otorrhea: correlation with radiographic empty sella Otolaryngol Head Neck Surg. 2006 May; 134(5):767-71. . View in PubMed

Familial unilateral cochlear nerve aplasia Otol Neurotol. 2006 Apr; 27(3):443-4. . View in PubMed

High frequency of the IVS2-2A>G DNA sequence variation in SLC26A5, encoding the cochlear motor protein prestin, precludes its involvement in hereditary hearing loss BMC Med Genet. 2005 Aug 08; 6:30. . View in PubMed

Predicting the effect of post-implant cochlear fibrosis on residual hearing Hear Res. 2005 Jul; 205(1-2):193-200. . View in PubMed

Management of superior canal dehiscence syndrome with extensive skull-base deficiency ORL J Otorhinolaryngol Relat Spec. 2005; 67(4):192-5. . View in PubMed

Chlorpromazine inhibits cochlear function in guinea pigs Hear Res. 2004 Dec; 198(1-2):59-68. . View in PubMed

Combination of aberrant internal carotid artery and persistent stapedial artery Otol Neurotol. 2004 Sep; 25(5):850-1. . View in PubMed

Chronic pachymeningitis presenting as asymmetric sensorineural hearing loss Otol Neurotol. 2004 Jul; 25(4):616-21. . View in PubMed

Laser irradiation of the guinea pig basilar membrane Lasers Surg Med. 2004; 35(3):174-80. . View in PubMed

Anatomy of the combined retrolabyrinthine-middle fossa craniotomy Neurosurg Focus. 2003 Jun 15; 14(6):e8. . View in PubMed

Is it worthwhile to attempt hearing preservation in larger acoustic neuromas? Otol Neurotol. 2003 May; 24(3):460-4.. View in PubMed

Aspiration of a dental appliance in a patient with Alzheimer disease JAMA. 2002 Nov 27; 288(20):2543-4. . View in PubMed

Limitations to mobilizing the intrapetrous carotid artery Ann Otol Rhinol Laryngol. 2002 Sep; 111(9):860. . View in PubMed

Neonatal hearing loss in the indigent Laryngoscope. 2002 Feb; 112(2):281-6. . View in PubMed

Harvesting human hair cells Ann Otol Rhinol Laryngol. 2000 Jan; 109(1):9-16. . View in PubMed

Aggressive cervical lymphoma presenting as airway obstruction Otolaryngol Head Neck Surg. 1999 Apr; 120(4):610-3. . View in PubMed

Ionic currents and electromotility in inner ear hair cells from humans J Neurophysiol. 1998 Apr; 79(4):2235-9. . View in PubMed

Fluorescence-imaged microdeformation of the outer hair cell lateral wall J Neurosci. 1998 Jan 01; 18(1):48-58. . View in PubMed

Lack of mutations in the biotin-binding region of the pyruvate carboxylase (PC) gene in a family with partial PC deficiency Clin Biochem. 1997 Feb; 30(1):79-81. . View in PubMed

Imaging quiz case 2Soft tissue fibrosis. Arch Otolaryngol Head Neck Surg. 1996 Nov; 122(11):1267-9. . View in PubMed

A neural network-based spike discriminator J Neurosci Methods. 1994 Sep; 54(1):9-22. . View in PubMed

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