Keck School Faculty

Jon A. Detterich

Jon A. Detterich

Associate Professor Of Clinical Pediatrics
CHL Mail Stop 34 Off Campus Los Angeles

Early initiation of disease-modifying therapy can impede or prevent diffuse myocardial fibrosis in sickle cell anemia Blood. 2022 Jul 20. . View in PubMed

Reduced Forced Vital Capacity and the Number of Chest Wall Surgeries are Associated with Decreased Exercise Capacity in Children with Congenital Heart Disease Pediatr Cardiol. 2022 Jan; 43(1):54-61. . View in PubMed

Physical Properties of Blood and their Relationship to Clinical Conditions Front Physiol. 2022; 13:906768. . View in PubMed

Considerations for Biventricular Conversion of Fontan Circulation Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2022; 25:11-18. . View in PubMed

Non-invasive biomarkers of Fontan-associated liver disease JHEP Rep. 2021 Dec; 3(6):100362. . View in PubMed

Kidney iron deposition by R2* is associated with haemolysis and urinary iron Br J Haematol. 2021 05; 193(3):633-636. . View in PubMed

Extracardiac Doppler indices predict perinatal mortality in fetuses with Ebstein anomaly and tricuspid valve dysplasia Prenat Diagn. 2021 02; 41(3):332-340. . View in PubMed

Am J Hematol. 2021 01; 96(1):31-39. . View in PubMed

Loss of alpha-globin genes in human subjects is associated with improved nitric oxide-mediated vascular perfusion Am J Hematol. 2021 03 01; 96(3):277-281. . View in PubMed

Individual red blood cell nitric oxide production in sickle cell anemia: Nitric oxide production is increased and sickle shaped cells have unique morphologic change compared to discoid cells Free Radic Biol Med. 2021 08 01; 171:143-155. . View in PubMed

Mental stress causes vasoconstriction in subjects with sickle cell disease and in normal controls Haematologica. 2020 01; 105(1):83-90. . View in PubMed

Procedural, pregnancy, and short-term outcomes after fetal aortic valvuloplasty Catheter Cardiovasc Interv. 2020 09 01; 96(3):626-632. . View in PubMed

Progressive vasoconstriction with sequential thermal stimulation indicates vascular dysautonomia in sickle cell disease Blood. 2020 09 03; 136(10):1191-1200. . View in PubMed

Differences in Right Ventricular Physiologic Response to Chronic Volume Load in Patients with Repaired Pulmonary Atresia Intact Ventricular Septum/Critical Pulmonary Stenosis Versus Tetralogy of Fallot Pediatr Cardiol. 2019 Mar; 40(3):526-536. . View in PubMed

Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents Free Radic Biol Med. 2019 09; 141:408-415. . View in PubMed

Sickle cell microvascular paradox-oxygen supply-demand mismatch Am J Hematol. 2019 06; 94(6):678-688. . View in PubMed

Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt Front Physiol. 2019; 10:381. . View in PubMed

Red blood cell mechanical sensitivity improves in patients with sickle cell disease undergoing chronic transfusion after prolonged, subhemolytic shear exposure Transfusion. 2018 12; 58(12):2788-2796. . View in PubMed

Accuracy of a Novel Handheld Wireless Platform for Detection of Cardiac Dysfunction in Anthracycline-Exposed Survivors of Childhood Cancer Clin Cancer Res. 2018 07 01; 24(13):3119-3125. . View in PubMed

A novel cross-correlation methodology for assessing biophysical responses associated with pain J Pain Res. 2018; 11:2207-2219. . View in PubMed

Simple chronic transfusion therapy, a crucial therapeutic option for sickle cell disease, improves but does not normalize blood rheology: What should be our goals for transfusion therapy? Clin Hemorheol Microcirc. 2018; 68(2-3):173-186.. View in PubMed

Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain Am J Hematol. 2017 Nov; 92(11):1137-1145. . View in PubMed

Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease PLoS One. 2017; 12(5):e0178353. . View in PubMed

Myocardial fibrosis: the heart of diastole? Blood. 2017 07 13; 130(2):104-105.. View in PubMed

Elevated Low-Shear Blood Viscosity is Associated with Decreased Pulmonary Blood Flow in Children with Univentricular Heart Defects Pediatr Cardiol. 2016 Apr; 37(4):789-801. . View in PubMed

The role of blood rheology in sickle cell disease Blood Rev. 2016 Mar; 30(2):111-8. . View in PubMed

Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease Blood. 2015 Aug 06; 126(6):703-10. . View in PubMed

Giant Pseudoaneurysm of Reconstructed Right Ventricular Outflow Tract Ann Thorac Surg. 2015 Aug; 100(2):734. . View in PubMed

Autonomic responses to cold face stimulation in sickle cell disease: a time-varying model analysis Physiol Rep. 2015 Jul 14; 3(7). . View in PubMed

Pulmonary hypertension in well-transfused thalassemia major patients Blood Cells Mol Dis. 2015 Feb; 54(2):189-94. . View in PubMed

Outcomes of critical congenital heart disease requiring emergent neonatal cardiac intervention Prenat Diagn. 2014 Dec; 34(12):1127-32. . View in PubMed

Deformability analysis of sickle blood using ektacytometry Biorheology. 2014; 51(2-3):159-70. . View in PubMed

Nitric oxide, vasodilation and the red blood cell Biorheology. 2014; 51(2-3):121-34. . View in PubMed

Effects of ethanol on red blood cell rheological behavior Clin Hemorheol Microcirc. 2014; 56(2):87-99. . View in PubMed

Abnormal cerebral microstructure in premature neonates with congenital heart disease AJNR Am J Neuroradiol. 2013 Oct; 34(10):2026-33. . View in PubMed

Patients with sickle cell anemia on simple chronic transfusion protocol show sex differences for hemodynamic and hematologic responses to transfusion Transfusion. 2013 May; 53(5):1059-68. . View in PubMed

Comparison of biventricular dimensions and function between pediatric sickle-cell disease and thalassemia major patients without cardiac iron Am J Hematol. 2013 Mar; 88(3):213-8. . View in PubMed

Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy Transfusion. 2013 Feb; 53(2):297-305. . View in PubMed

Prenatal diagnosis of congenital heart disease: impact of mode of delivery on neonatal outcome Prenat Diagn. 2012 Dec; 32(13):1250-5. . View in PubMed

Color M-mode sonography for evaluation of fetal arrhythmias J Ultrasound Med. 2012 Oct; 31(10):1681-8. . View in PubMed

Systemic endothelial dysfunction in children with idiopathic pulmonary arterial hypertension correlates with disease severity J Heart Lung Transplant. 2012 Jun; 31(6):642-7. . View in PubMed

Electrocardiographic consequences of cardiac iron overload in thalassemia major Am J Hematol. 2012 Feb; 87(2):139-44. . View in PubMed

Fetoscopic laser photocoagulation of feeding vessels to a large placental chorioangioma following fetal deterioration after amnioreduction Fetal Diagn Ther. 2012; 31(3):191-5. . View in PubMed

Analysis of light scattering by red blood cells in ektacytometry using global pattern fitting Biorheology. 2012; 49(5-6):317-28. . View in PubMed

Twin-twin transfusion syndrome treated with laser surgery: postnatal prevalence of congenital heart disease in surviving recipients and donors Prenat Diagn. 2011 Oct; 31(10):973-7. . View in PubMed

Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease Am J Respir Crit Care Med. 2011 Aug 15; 184(4):474-81. . View in PubMed

Prenatal diagnosis of cor triatriatum sinister in association with hypoplastic left heart syndrome Pediatr Cardiol. 2011 Aug; 32(6):818-21. . View in PubMed

Time-varying analysis of autonomic control in response to spontaneous sighs in sickle cell anemia Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:1626-9. . View in PubMed

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