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Jon A. Detterich, MD

Professor of Clinical Pediatrics and Physiology and Biophysics

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Phone +1 323 361 5473
Email jdetterich@chla.usc.edu
CTSI Profile

Publications

  • Multiresolution comparison of fetal real-time and CINE MRI at 055T. J Cardiovasc Magn Reson. 2025 Feb 07; 101856. . View in PubMed
  • The impact of measurement techniques and common effectors on red blood cell aggregation Biorheology. 2024 Dec 22; 6355X241297017. . View in PubMed
  • Feasibility of fetal cardiac function and anatomy assessment by real-time spiral balanced steady-state free precession magnetic resonance imaging at 055T. J Cardiovasc Magn Reson. 2024 Dec 03; 27(1):101130. . View in PubMed
  • Nitrosyl hemoglobin formation from nitrite in normal and sickle blood Free Radic Biol Med. 2024 Nov 20; 225:316-322. . View in PubMed
  • The impact of blood viscosity modeling on computational fluid dynamic simulations of pediatric patients with Fontan circulation Phys Fluids (1994). 2024 Nov; 36(11):111911. . View in PubMed
  • Myocardial Scarring and Sudden Cardiac Death in Young Patients With Hypertrophic Cardiomyopathy: A Multicenter Cohort Study JAMA Cardiol. 2024 Nov 01; 9(11):1001-1008. . View in PubMed
  • Exercise Performance: A Fontan Phenotype Predictive of Long-Term Survival JACC Adv. 2024 Oct; 3(10):101253. . View in PubMed
  • Blood Rheology and Hemodynamics: Still Illuminating after 20 Years Semin Thromb Hemost. 2024 Sep; 50(6):916-918. . View in PubMed
  • Non-invasive in-utero quantification of vascular reactivity in human placenta Ultrasound Obstet Gynecol. 2024 04; 63(4):481-488. . View in PubMed
  • Decreased erythrocyte aggregation in Glenn and Fontan: univentricular circulation as a rheologic disease model Pediatr Res. 2024 Apr; 95(5):1335-1345. . View in PubMed
  • The Effect of Udenafil on Heart Rate and Blood Pressure in Adolescents With the Fontan Circulation Am J Cardiol. 2024 01 01; 210:183-187. . View in PubMed
  • The Fontan Udenafil Exercise Longitudinal Trial: Subgroup Analysis Pediatr Cardiol. 2023 Dec; 44(8):1691-1701. . View in PubMed
  • The prevalence of abnormal spirometry in children with CHD Cardiol Young. 2023 Dec; 33(12):2548-2552. . View in PubMed
  • Longitudinal Follow-Up of Children With HLHS and Association Between Norwood Shunt Type and Long-Term Outcomes: The SVR III Study Circulation. 2023 10 24; 148(17):1330-1339. . View in PubMed
  • Cardiac Magnetic Resonance Imaging to Determine Single Ventricle Function in a Pediatric Population is Feasible in a Large Trial Setting: Experience from the Single Ventricle Reconstruction Trial Longitudinal Follow up Pediatr Cardiol. 2023 Oct; 44(7):1454-1461. . View in PubMed
  • Single Ventricle Reconstruction III: Brain Connectome and Neurodevelopmental Outcomes: Design, Recruitment, and Technical Challenges of a Multicenter, Observational Neuroimaging Study Diagnostics (Basel). 2023 Apr 30; 13(9). . View in PubMed
  • Single Ventricle Reconstruction III: Brain Connectome and Neurodevelopmental Outcomes: Design, Recruitment, and Technical Challenges of a Multicenter, Observational Neuroimaging Study medRxiv. 2023 Apr 17. . View in PubMed
  • The pediatric heart network’s study on long-term outcomes of children with HLHS and the impact of Norwood Shunt type in the single ventricle reconstruction trial cohort (SVRIII): Design and adaptations Am Heart J. 2022 Dec; 254:216-227. . View in PubMed
  • Mediastinal infantile hemangioma with spinal canal extension and extensive gastrointestinal involvement complicated by respiratory failure Pediatr Blood Cancer. 2022 11; 69(11):e29934. . View in PubMed
  • Impaired Neurovascular Function Underlies Poor Neurocognitive Outcomes and Is Associated with Nitric Oxide Bioavailability in Congenital Heart Disease Metabolites. 2022 Sep 19; 12(9). . View in PubMed
  • Early initiation of disease-modifying therapy can impede or prevent diffuse myocardial fibrosis in sickle cell anemia Blood. 2022 09 15; 140(11):1322-1324. . View in PubMed
  • Myocardial Iron Overload Causes Subclinical Myocardial Dysfunction in Sickle Cell Disease JACC Cardiovasc Imaging. 2022 08; 15(8):1510-1512. . View in PubMed
  • Reduced Forced Vital Capacity and the Number of Chest Wall Surgeries are Associated with Decreased Exercise Capacity in Children with Congenital Heart Disease Pediatr Cardiol. 2022 Jan; 43(1):54-61. . View in PubMed
  • Physical Properties of Blood and their Relationship to Clinical Conditions Front Physiol. 2022; 13:906768. . View in PubMed
  • Considerations for Biventricular Conversion of Fontan Circulation Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2022; 25:11-18. . View in PubMed
  • Non-invasive biomarkers of Fontan-associated liver disease JHEP Rep. 2021 Dec; 3(6):100362. . View in PubMed
  • Individual red blood cell nitric oxide production in sickle cell anemia: Nitric oxide production is increased and sickle shaped cells have unique morphologic change compared to discoid cells Free Radic Biol Med. 2021 08 01; 171:143-155. . View in PubMed
  • Kidney iron deposition by R2* is associated with haemolysis and urinary iron Br J Haematol. 2021 05; 193(3):633-636. . View in PubMed
  • Loss of alpha-globin genes in human subjects is associated with improved nitric oxide-mediated vascular perfusion Am J Hematol. 2021 03 01; 96(3):277-281. . View in PubMed
  • Extracardiac Doppler indices predict perinatal mortality in fetuses with Ebstein anomaly and tricuspid valve dysplasia Prenat Diagn. 2021 02; 41(3):332-340. . View in PubMed
  • Am J Hematol. 2021 01; 96(1):31-39. . View in PubMed
  • Progressive vasoconstriction with sequential thermal stimulation indicates vascular dysautonomia in sickle cell disease Blood. 2020 09 03; 136(10):1191-1200. . View in PubMed
  • Procedural, pregnancy, and short-term outcomes after fetal aortic valvuloplasty Catheter Cardiovasc Interv. 2020 09 01; 96(3):626-632. . View in PubMed
  • Mental stress causes vasoconstriction in subjects with sickle cell disease and in normal controls Haematologica. 2020 01; 105(1):83-90. . View in PubMed
  • Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents Free Radic Biol Med. 2019 09; 141:408-415. . View in PubMed
  • Sickle cell microvascular paradox-oxygen supply-demand mismatch Am J Hematol. 2019 06; 94(6):678-688. . View in PubMed
  • Differences in Right Ventricular Physiologic Response to Chronic Volume Load in Patients with Repaired Pulmonary Atresia Intact Ventricular Septum/Critical Pulmonary Stenosis Versus Tetralogy of Fallot Pediatr Cardiol. 2019 Mar; 40(3):526-536. . View in PubMed
  • Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt Front Physiol. 2019; 10:381. . View in PubMed
  • Red blood cell mechanical sensitivity improves in patients with sickle cell disease undergoing chronic transfusion after prolonged, subhemolytic shear exposure Transfusion. 2018 12; 58(12):2788-2796. . View in PubMed
  • Accuracy of a Novel Handheld Wireless Platform for Detection of Cardiac Dysfunction in Anthracycline-Exposed Survivors of Childhood Cancer Clin Cancer Res. 2018 07 01; 24(13):3119-3125. . View in PubMed
  • Simple chronic transfusion therapy, a crucial therapeutic option for sickle cell disease, improves but does not normalize blood rheology: What should be our goals for transfusion therapy? Clin Hemorheol Microcirc. 2018; 68(2-3):173-186.. View in PubMed
  • A novel cross-correlation methodology for assessing biophysical responses associated with pain J Pain Res. 2018; 11:2207-2219. . View in PubMed
  • Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain Am J Hematol. 2017 Nov; 92(11):1137-1145. . View in PubMed
  • Myocardial fibrosis: the heart of diastole? Blood. 2017 07 13; 130(2):104-105.. View in PubMed
  • Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease PLoS One. 2017; 12(5):e0178353. . View in PubMed
  • Elevated Low-Shear Blood Viscosity is Associated with Decreased Pulmonary Blood Flow in Children with Univentricular Heart Defects Pediatr Cardiol. 2016 Apr; 37(4):789-801. . View in PubMed
  • The role of blood rheology in sickle cell disease Blood Rev. 2016 Mar; 30(2):111-8. . View in PubMed
  • Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease Blood. 2015 Aug 06; 126(6):703-10. . View in PubMed
  • Giant Pseudoaneurysm of Reconstructed Right Ventricular Outflow Tract Ann Thorac Surg. 2015 Aug; 100(2):734. . View in PubMed
  • Autonomic responses to cold face stimulation in sickle cell disease: a time-varying model analysis Physiol Rep. 2015 Jul 14; 3(7). . View in PubMed
  • Pulmonary hypertension in well-transfused thalassemia major patients Blood Cells Mol Dis. 2015 Feb; 54(2):189-94. . View in PubMed
  • Outcomes of critical congenital heart disease requiring emergent neonatal cardiac intervention Prenat Diagn. 2014 Dec; 34(12):1127-32. . View in PubMed
  • Effects of ethanol on red blood cell rheological behavior Clin Hemorheol Microcirc. 2014; 56(2):87-99. . View in PubMed
  • Nitric oxide, vasodilation and the red blood cell Biorheology. 2014; 51(2-3):121-34. . View in PubMed
  • Deformability analysis of sickle blood using ektacytometry Biorheology. 2014; 51(2-3):159-70. . View in PubMed
  • Abnormal cerebral microstructure in premature neonates with congenital heart disease AJNR Am J Neuroradiol. 2013 Oct; 34(10):2026-33. . View in PubMed
  • Patients with sickle cell anemia on simple chronic transfusion protocol show sex differences for hemodynamic and hematologic responses to transfusion Transfusion. 2013 May; 53(5):1059-68. . View in PubMed
  • Comparison of biventricular dimensions and function between pediatric sickle-cell disease and thalassemia major patients without cardiac iron Am J Hematol. 2013 Mar; 88(3):213-8. . View in PubMed
  • Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy Transfusion. 2013 Feb; 53(2):297-305. . View in PubMed
  • Prenatal diagnosis of congenital heart disease: impact of mode of delivery on neonatal outcome Prenat Diagn. 2012 Dec; 32(13):1250-5. . View in PubMed
  • Color M-mode sonography for evaluation of fetal arrhythmias J Ultrasound Med. 2012 Oct; 31(10):1681-8. . View in PubMed
  • Systemic endothelial dysfunction in children with idiopathic pulmonary arterial hypertension correlates with disease severity J Heart Lung Transplant. 2012 Jun; 31(6):642-7. . View in PubMed
  • Electrocardiographic consequences of cardiac iron overload in thalassemia major Am J Hematol. 2012 Feb; 87(2):139-44. . View in PubMed
  • Analysis of light scattering by red blood cells in ektacytometry using global pattern fitting Biorheology. 2012; 49(5-6):317-28. . View in PubMed
  • Fetoscopic laser photocoagulation of feeding vessels to a large placental chorioangioma following fetal deterioration after amnioreduction Fetal Diagn Ther. 2012; 31(3):191-5. . View in PubMed
  • Twin-twin transfusion syndrome treated with laser surgery: postnatal prevalence of congenital heart disease in surviving recipients and donors Prenat Diagn. 2011 Oct; 31(10):973-7. . View in PubMed
  • Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease Am J Respir Crit Care Med. 2011 Aug 15; 184(4):474-81. . View in PubMed
  • Prenatal diagnosis of cor triatriatum sinister in association with hypoplastic left heart syndrome Pediatr Cardiol. 2011 Aug; 32(6):818-21. . View in PubMed
  • Time-varying analysis of autonomic control in response to spontaneous sighs in sickle cell anemia Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:1626-9. . View in PubMed
  • Integrin subunit gene expression is regionally differentiated in adult brain J Neurosci. 1999 Mar 01; 19(5):1541-56. . View in PubMed

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