Keck School Faculty

Jon A. Detterich

Jon A. Detterich

Associate Professor Of Clinical Pediatrics
CHL Mail Stop 34 Off Campus Los Angeles

The prevalence of abnormal spirometry in children with CHD Cardiol Young. 2023 Mar 31; 1-5. . View in PubMed

Impaired Neurovascular Function Underlies Poor Neurocognitive Outcomes and Is Associated with Nitric Oxide Bioavailability in Congenital Heart Disease Metabolites. 2022 Sep 19; 12(9). . View in PubMed

The pediatric heart network's study on long-term outcomes of children with HLHS and the impact of Norwood Shunt type in the single ventricle reconstruction trial cohort (SVRIII): Design and adaptations Am Heart J. 2022 Sep 15; 254:216-227. . View in PubMed

Mediastinal infantile hemangioma with spinal canal extension and extensive gastrointestinal involvement complicated by respiratory failure Pediatr Blood Cancer. 2022 11; 69(11):e29934. . View in PubMed

Myocardial Iron Overload Causes Subclinical Myocardial Dysfunction in Sickle Cell Disease JACC Cardiovasc Imaging. 2022 08; 15(8):1510-1512. . View in PubMed

Considerations for Biventricular Conversion of Fontan Circulation Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2022; 25:11-18. . View in PubMed

Reduced Forced Vital Capacity and the Number of Chest Wall Surgeries are Associated with Decreased Exercise Capacity in Children with Congenital Heart Disease Pediatr Cardiol. 2022 Jan; 43(1):54-61. . View in PubMed

Early initiation of disease-modifying therapy can impede or prevent diffuse myocardial fibrosis in sickle cell anemia Blood. 2022 09 15; 140(11):1322-1324. . View in PubMed

Physical Properties of Blood and their Relationship to Clinical Conditions Front Physiol. 2022; 13:906768. . View in PubMed

Non-invasive biomarkers of Fontan-associated liver disease JHEP Rep. 2021 Dec; 3(6):100362. . View in PubMed

Kidney iron deposition by R2* is associated with haemolysis and urinary iron Br J Haematol. 2021 05; 193(3):633-636. . View in PubMed

Extracardiac Doppler indices predict perinatal mortality in fetuses with Ebstein anomaly and tricuspid valve dysplasia Prenat Diagn. 2021 02; 41(3):332-340. . View in PubMed

Am J Hematol. 2021 01; 96(1):31-39. . View in PubMed

Loss of alpha-globin genes in human subjects is associated with improved nitric oxide-mediated vascular perfusion Am J Hematol. 2021 03 01; 96(3):277-281. . View in PubMed

Individual red blood cell nitric oxide production in sickle cell anemia: Nitric oxide production is increased and sickle shaped cells have unique morphologic change compared to discoid cells Free Radic Biol Med. 2021 08 01; 171:143-155. . View in PubMed

Mental stress causes vasoconstriction in subjects with sickle cell disease and in normal controls Haematologica. 2020 01; 105(1):83-90. . View in PubMed

Progressive vasoconstriction with sequential thermal stimulation indicates vascular dysautonomia in sickle cell disease Blood. 2020 09 03; 136(10):1191-1200. . View in PubMed

Procedural, pregnancy, and short-term outcomes after fetal aortic valvuloplasty Catheter Cardiovasc Interv. 2020 09 01; 96(3):626-632. . View in PubMed

Differences in Right Ventricular Physiologic Response to Chronic Volume Load in Patients with Repaired Pulmonary Atresia Intact Ventricular Septum/Critical Pulmonary Stenosis Versus Tetralogy of Fallot Pediatr Cardiol. 2019 Mar; 40(3):526-536. . View in PubMed

Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents Free Radic Biol Med. 2019 09; 141:408-415. . View in PubMed

Sickle cell microvascular paradox-oxygen supply-demand mismatch Am J Hematol. 2019 06; 94(6):678-688. . View in PubMed

Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt Front Physiol. 2019; 10:381. . View in PubMed

Red blood cell mechanical sensitivity improves in patients with sickle cell disease undergoing chronic transfusion after prolonged, subhemolytic shear exposure Transfusion. 2018 12; 58(12):2788-2796. . View in PubMed

Accuracy of a Novel Handheld Wireless Platform for Detection of Cardiac Dysfunction in Anthracycline-Exposed Survivors of Childhood Cancer Clin Cancer Res. 2018 07 01; 24(13):3119-3125. . View in PubMed

Simple chronic transfusion therapy, a crucial therapeutic option for sickle cell disease, improves but does not normalize blood rheology: What should be our goals for transfusion therapy? Clin Hemorheol Microcirc. 2018; 68(2-3):173-186.. View in PubMed

A novel cross-correlation methodology for assessing biophysical responses associated with pain J Pain Res. 2018; 11:2207-2219. . View in PubMed

Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain Am J Hematol. 2017 Nov; 92(11):1137-1145. . View in PubMed

Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease PLoS One. 2017; 12(5):e0178353. . View in PubMed

Myocardial fibrosis: the heart of diastole? Blood. 2017 07 13; 130(2):104-105.. View in PubMed

Elevated Low-Shear Blood Viscosity is Associated with Decreased Pulmonary Blood Flow in Children with Univentricular Heart Defects Pediatr Cardiol. 2016 Apr; 37(4):789-801. . View in PubMed

The role of blood rheology in sickle cell disease Blood Rev. 2016 Mar; 30(2):111-8. . View in PubMed

Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease Blood. 2015 Aug 06; 126(6):703-10. . View in PubMed

Giant Pseudoaneurysm of Reconstructed Right Ventricular Outflow Tract Ann Thorac Surg. 2015 Aug; 100(2):734. . View in PubMed

Autonomic responses to cold face stimulation in sickle cell disease: a time-varying model analysis Physiol Rep. 2015 Jul 14; 3(7). . View in PubMed

Pulmonary hypertension in well-transfused thalassemia major patients Blood Cells Mol Dis. 2015 Feb; 54(2):189-94. . View in PubMed

Outcomes of critical congenital heart disease requiring emergent neonatal cardiac intervention Prenat Diagn. 2014 Dec; 34(12):1127-32. . View in PubMed

Nitric oxide, vasodilation and the red blood cell Biorheology. 2014; 51(2-3):121-34. . View in PubMed

Effects of ethanol on red blood cell rheological behavior Clin Hemorheol Microcirc. 2014; 56(2):87-99. . View in PubMed

Deformability analysis of sickle blood using ektacytometry Biorheology. 2014; 51(2-3):159-70. . View in PubMed

Abnormal cerebral microstructure in premature neonates with congenital heart disease AJNR Am J Neuroradiol. 2013 Oct; 34(10):2026-33. . View in PubMed

Patients with sickle cell anemia on simple chronic transfusion protocol show sex differences for hemodynamic and hematologic responses to transfusion Transfusion. 2013 May; 53(5):1059-68. . View in PubMed

Comparison of biventricular dimensions and function between pediatric sickle-cell disease and thalassemia major patients without cardiac iron Am J Hematol. 2013 Mar; 88(3):213-8. . View in PubMed

Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy Transfusion. 2013 Feb; 53(2):297-305. . View in PubMed

Prenatal diagnosis of congenital heart disease: impact of mode of delivery on neonatal outcome Prenat Diagn. 2012 Dec; 32(13):1250-5. . View in PubMed

Color M-mode sonography for evaluation of fetal arrhythmias J Ultrasound Med. 2012 Oct; 31(10):1681-8. . View in PubMed

Systemic endothelial dysfunction in children with idiopathic pulmonary arterial hypertension correlates with disease severity J Heart Lung Transplant. 2012 Jun; 31(6):642-7. . View in PubMed

Electrocardiographic consequences of cardiac iron overload in thalassemia major Am J Hematol. 2012 Feb; 87(2):139-44. . View in PubMed

Fetoscopic laser photocoagulation of feeding vessels to a large placental chorioangioma following fetal deterioration after amnioreduction Fetal Diagn Ther. 2012; 31(3):191-5. . View in PubMed

Analysis of light scattering by red blood cells in ektacytometry using global pattern fitting Biorheology. 2012; 49(5-6):317-28. . View in PubMed

Twin-twin transfusion syndrome treated with laser surgery: postnatal prevalence of congenital heart disease in surviving recipients and donors Prenat Diagn. 2011 Oct; 31(10):973-7. . View in PubMed

Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease Am J Respir Crit Care Med. 2011 Aug 15; 184(4):474-81. . View in PubMed

Prenatal diagnosis of cor triatriatum sinister in association with hypoplastic left heart syndrome Pediatr Cardiol. 2011 Aug; 32(6):818-21. . View in PubMed

Time-varying analysis of autonomic control in response to spontaneous sighs in sickle cell anemia Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:1626-9. . View in PubMed

Integrin subunit gene expression is regionally differentiated in adult brain J Neurosci. 1999 Mar 01; 19(5):1541-56. . View in PubMed

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