Jonathan Nelson, PhD

Jonathan Nelson is an Assistant Professor in the Division of Nephrology & Hypertension at the USC Keck School of Medicine. A native of the Pacific Northwest, Dr. Nelson attended the University of Washington for his undergraduate degree in Biochemistry before pursuing a PhD in Molecular and Medical Genetics at Oregon Health & Science University. Dr. Nelson trained in multiple clinical departments at Oregon Health & Science University including Anesthesiology and Perioperative Medicine, the Knight Cardiovascular Institute, and the Division of Nephrology & Hypertension. His research focuses on the intersection of vascular biology and medicine with an emphasis on understanding the role of the renin angiotensin system in regulating the kidney microvasculature. His research has been funded by the National Institutes of Health, American Heart Association, and Collins Medical Trust.

• Optimizing renal transporter immunodetection: consequences of freeze-thaw during sample preparation Am J Physiol Renal Physiol. 2024 Oct 01; 327(4):F655-F666. . View in PubMed
• Angiotensin II Directly Increases Endothelial Calcium and Nitric Oxide in Kidney and Brain Microvessels In Vivo With Reduced Efficacy in Hypertension J Am Heart Assoc. 2024 May 21; 13(10):e033998. . View in PubMed
• Soluble ACE2 Is Filtered into the Urine Kidney360. 2022 12 29; 3(12):2086-2094. . View in PubMed
• COP9 signalosome deletion promotes renal injury and distal convoluted tubule remodeling Am J Physiol Renal Physiol. 2022 07 01; 323(1):F4-F19. . View in PubMed
• Age-dependent transcriptional alterations in cardiac endothelial cells Physiol Genomics. 2021 07 01; 53(7):295-308. . View in PubMed
• Local and downstream actions of proximal tubule angiotensin II signaling on Na+ transporters in the mouse nephron Am J Physiol Renal Physiol. 2021 07 01; 321(1):F69-F81. . View in PubMed
• Advances in use of mouse models to study the renin-angiotensin system Mol Cell Endocrinol. 2021 06 01; 529:111255. . View in PubMed
• Mg2+ restriction downregulates NCC through NEDD4-2 and prevents its activation by hypokalemia Am J Physiol Renal Physiol. 2019 10 01; 317(4):F825-F838. . View in PubMed
• Renal COP9 Signalosome Deficiency Alters CUL3-KLHL3-WNK Signaling Pathway J Am Soc Nephrol. 2018 11; 29(11):2627-2640. . View in PubMed
• Soluble epoxide hydrolase: sex differences and role in endothelial cell survival Arterioscler Thromb Vasc Biol. 2012 Aug; 32(8):1936-42. . View in PubMed

• McDonough, Alicia
• Bernstein, Kenneth
• Gurley, Susan
• McMahon, Andrew
• Lindstrom, Nils
• Kloner, Robert