Jorge Nieva, MD

Associate Professor of Clinical Medicine

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Overview

Dr. Jorge Nieva graduated from the University of California, Irvine College of Medicine in 1997, trained in internal medicine at University of California, San Diego and in oncology and hematology at the Scripps Clinic. In 2003 he joined the faculty of the Scripps Research Institute and the medical staff of the Scripps Clinic in La Jolla, CA. While at Scripps, Dr. Nieva pioneered new technology for the detection of cancer cells in the peripheral blood and discoveries related to the fundamental mechanisms of the immune system.

Dr. Nieva was recruited to the Billings Clinic in Montana in 2007 where he served as department chair and was a program leader who established the multidisciplinary lung cancer and head/neck cancer clinics at the cancer center. While in Billings, Dr. Nieva led efforts to establish a research program in virus-delivered cancer gene therapy and immunotherapy. His teams were awarded certificates for excellence in the conduct of cancer clinical trials from the National Cancer Institute and the American Society of Clinical Oncology. Dr. Nieva returned to California, joining the faculty of the Keck School of Medicine in 2014.

Publications

  • Influence of TP53 Comutation on the Tumor Immune Microenvironment and Clinical Outcomes With Immune Checkpoint Inhibitors in STK11-Mutant Non-Small-Cell Lung Cancer JCO Precis Oncol. 2024 Feb; 8:e2300371. . View in PubMed
  • Berzosertib Plus Topotecan vs Topotecan Alone in Patients With Relapsed Small Cell Lung Cancer: A Randomized Clinical Trial JAMA Oncol. 2023 Dec 01; 9(12):1669-1677. . View in PubMed
  • Complete response with pembrolizumab in recurrent squamous cell carcinoma of the oral tongue: A case report Oral Oncol. 2023 Dec; 147:106597. . View in PubMed
  • Pan-tumor survey of ROS1 fusions detected by next-generation RNA and whole transcriptome sequencing BMC Cancer. 2023 Oct 18; 23(1):1000. . View in PubMed
  • Pan-tumor survey of RET fusions as detected by next-generation RNA sequencing identified RET fusion positive colorectal carcinoma as a unique molecular subset Transl Oncol. 2023 Oct; 36:101744. . View in PubMed
  • Response to Letter to the Editor Titled “Seize the Opportunity With Small Tissue Samples: The Tailor Teaches!” JTO Clin Res Rep 2023 Jul; 4(7):100531. . View in PubMed
  • Biopsy Method and Needle Size on Success of Next-Generation Sequencing in NSCLC: A Brief Report JTO Clin Res Rep. 2023 Apr; 4(4):100497. . View in PubMed
  • Understanding KRAS for better targeting Transl Lung Cancer Res. 2023 Feb 28; 12(2):181-183. . View in PubMed
  • Phase II Randomized Trial of Carboplatin, Pemetrexed, and Bevacizumab With and Without Atezolizumab in Stage IV Nonsquamous Non-Small-Cell Lung Cancer Patients Who Harbor a Sensitizing EGFR Mutation or Have Never Smoked Clin Lung Cancer. 2023 11; 24(7):e242-e246. . View in PubMed
  • A Multicenter Retrospective Chart Review of Clinical Outcomes Among Patients With KRAS G12C Mutant Non-Small Cell Lung Cancer Clin Lung Cancer. 2023 05; 24(3):228-234. . View in PubMed
  • Real world prognostic utility of platelet lymphocyte ratio and nutritional status in first-line immunotherapy response in stage IV non-small cell lung cancer Cancer Treat Res Commun. 2023; 36:100752. . View in PubMed
  • Editorial: Equity in cancer care Front Oncol. 2023; 13:1346785. . View in PubMed
  • Implementation planning for equitable tobacco treatment services: a mixed methods assessment of contextual facilitators and barriers in a large comprehensive cancer center Transl Behav Med. 2023 08 11; 13(8):539-550. . View in PubMed
  • Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center: Structure, Innovations, and Initial Outcomes Cancer Control. 2023 Jan-Dec; 30:10732748231197878. . View in PubMed
  • Impact of gender and mutational differences in hormone receptor expressing non-small cell lung cancer Front Oncol. 2023; 13:1215524. . View in PubMed
  • TRUST-II: a global phase II study of taletrectinib in ROS1-positive non-small-cell lung cancer and other solid tumors Future Oncol. 2023 Jan; 19(2):123-135. . View in PubMed
  • Evaluating Real World Mutational Differences Between Hispanics and Asians in NSCLC at a Large Academic Institution in Los Angeles Clin Lung Cancer. 2022 Nov; 23(7):e443-e452. . View in PubMed
  • Multianalyte liquid biopsy to aid the diagnostic workup of breast cancer NPJ Breast Cancer. 2022 Sep 27; 8(1):112. . View in PubMed
  • Retrospective Analysis of Real-World Management of EGFR-Mutated Advanced NSCLC, After First-Line EGFR-TKI Treatment: US Treatment Patterns, Attrition, and Survival Data Drugs Real World Outcomes. 2022 Sep; 9(3):333-345. . View in PubMed
  • Characterization of Cellular and Acellular Analytes from Pre-Cystectomy Liquid Biopsies in Patients Newly Diagnosed with Primary Bladder Cancer Cancers (Basel). 2022 Feb 01; 14(3). . View in PubMed
  • Effect of sponsor on enrollment criteria in non-small cell lung cancer clinical trials J Cancer Policy. 2022 09; 33:100336. . View in PubMed
  • NTRK1 Fusions identified by non-invasive plasma next-generation sequencing (NGS) across 9 cancer types Br J Cancer. 2022 02; 126(3):514-520. . View in PubMed
  • Characterization of mortality and high-risk characteristics of thyroid cancer in Filipinos using the California Cancer Registry Front Public Health. 2022; 10:1104607. . View in PubMed
  • Molecular characterization of Kita-Kyushu lung cancer antigen (KK-LC-1) expressing carcinomas Oncotarget. 2021 Dec 07; 12(25):2449-2458. . View in PubMed
  • Blood-Based Multi-Cancer Detection Using a Novel Variant Calling Assay (DEEPGENTM): Early Clinical Results Cancers (Basel). 2021 Aug 15; 13(16). . View in PubMed
  • Effect of prior therapy on tumor mutational burden in NSCLC Transl Lung Cancer Res. 2021 Mar; 10(3):1231-1238. . View in PubMed
  • Characterization of KRAS Mutation Subtypes in Non-small Cell Lung Cancer Mol Cancer Ther. 2021 12; 20(12):2577-2584. . View in PubMed
  • Clinical management of immune-related adverse events following immunotherapy treatment in patients with non-small cell lung cancer J Investig Med. 2021 10; 69(7):1281-1286. . View in PubMed
  • Impact of XPO1 mutations on survival outcomes in metastatic non-small cell lung cancer (NSCLC) Lung Cancer. 2021 10; 160:92-98. . View in PubMed
  • Treatment response and tumor evolution: lessons from an extended series of multianalyte liquid biopsies in a metastatic breast cancer patient Cold Spring Harb Mol Case Stud. 2020 12; 6(6). . View in PubMed
  • Use of Wearable Activity Tracker in Patients With Cancer Undergoing Chemotherapy: Toward Evaluating Risk of Unplanned Health Care Encounters JCO Clin Cancer Inform. 2020 09; 4:839-853. . View in PubMed
  • Quantified Kinematics to Evaluate Patient Chemotherapy Risks in Clinic JCO Clin Cancer Inform. 2020 06; 4:583-601. . View in PubMed
  • Intravenous 5-fluoro-2′-deoxycytidine administered with tetrahydrouridine increases the proportion of p16-expressing circulating tumor cells in patients with advanced solid tumors Cancer Chemother Pharmacol. 2020 05; 85(5):979-993. . View in PubMed
  • Preanalytical Variables for the Genomic Assessment of the Cellular and Acellular Fractions of the Liquid Biopsy in a Cohort of Breast Cancer Patients J Mol Diagn. 2020 03; 22(3):319-337. . View in PubMed
  • Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials Lancet Oncol. 2020 02; 21(2):271-282. . View in PubMed
  • A Randomized Double-Blind Phase II Study of the Seneca Valley Virus (NTX-010) versus Placebo for Patients with Extensive-Stage SCLC (ES SCLC) Who Were Stable or Responding after at Least Four Cycles of Platinum-Based Chemotherapy: North Central Cancer Treatment Group (Alliance) N0923 Study J Thorac Oncol. 2020 01; 15(1):110-119. . View in PubMed
  • Trimodality vs Chemoradiation and Salvage Resection in cN2 Stage IIIA Non-Small Cell Lung Cancer Semin Thorac Cardiovasc Surg. 2020; 32(1):153-159. . View in PubMed
  • A Systematic Review of the Efficacy of Preclinical Models of Lung Cancer Drugs Front Oncol. 2020; 10:591. . View in PubMed
  • Single cell correlation analysis of liquid and solid biopsies in metastatic colorectal cancer Oncotarget. 2019 Dec 17; 10(66):7016-7030. . View in PubMed
  • Detection of NRG1 Gene Fusions in Solid Tumors Clin Cancer Res. 2019 Aug 15; 25(16):4966-4972. . View in PubMed
  • Patient reported outcomes can improve performance status assessment: a pilot study J Patient Rep Outcomes. 2019 Jul 16; 3(1):41. . View in PubMed
  • Monitoring Therapeutic Response and Resistance: Analysis of Circulating Tumor DNA in Patients With ALK+ Lung Cancer J Thorac Oncol. 2019 11; 14(11):1901-1911. . View in PubMed
  • Radiomics in Pulmonary Lesion Imaging AJR Am J Roentgenol. 2019 03; 212(3):497-504. . View in PubMed
  • Circulating tumor cells as a response monitor in stage IV non-small cell lung cancer J Transl Med. 2019 08 28; 17(1):294. . View in PubMed
  • A new anion exchange purification method for Cu stable isotopes in blood samples Anal Bioanal Chem. 2019 Jan; 411(3):765-776. . View in PubMed
  • Tuberculosis following PD-1 blockade for cancer immunotherapy Sci Transl Med. 2019 01 16; 11(475). . View in PubMed
  • Mandatory Research Biopsy Requirements Delay Initiation of Clinical Trials Front Oncol. 2019; 9:968. . View in PubMed
  • Effect of Blood Collection Tube Type and Time to Processing on the Enumeration and High-Content Characterization of Circulating Tumor Cells Using the High-Definition Single-Cell Assay Arch Pathol Lab Med. 2018 Feb; 142(2):198-207. . View in PubMed
  • Low-dimensional dynamical characterization of human performance of cancer patients using motion data Clin Biomech (BristolAvon). 2018 07; 56:61-69. . View in PubMed
  • When it comes to genomic analysis of tumours, don’t buy in bulk Br J Cancer. 2018 05; 118(10):1281-1282. . View in PubMed
  • Development of metastatic brain disease involves progression through lung metastases in EGFR mutated non-small cell lung cancer Converg Sci Phys Oncol. 2017 Sep; 3(3). . View in PubMed
  • Biophysical technologies for understanding circulating tumor cell biology and metastasis Transl Lung Cancer Res. 2017 Aug; 6(4):473-485. . View in PubMed
  • Cellular Expression of PD-L1 in the Peripheral Blood of Lung Cancer Patients is Associated with Worse Survival Cancer Epidemiol Biomarkers Prev. 2017 07; 26(7):1139-1145. . View in PubMed
  • A Randomized Phase II Study of Linsitinib (OSI-906) Versus Topotecan in Patients With Relapsed Small-Cell Lung Cancer Oncologist. 2016 10; 21(10):1163-1164. . View in PubMed
  • Oncolytic viruses: perspectives on clinical development Curr Opin Virol. 2015 Aug; 13:55-60. . View in PubMed
  • A randomized phase II efficacy and correlative studies of cetuximab with or without sorafenib in recurrent and/or metastatic head and neck squamous cell carcinoma Oral Oncol. 2015 Apr; 51(4):376-82. . View in PubMed
  • Spatiotemporal progression of metastatic breast cancer: a Markov chain model highlighting the role of early metastatic sites NPJ Breast Cancer. 2015; 1:15018. . View in PubMed
  • Entropy, complexity, and Markov diagrams for random walk cancer models Sci Rep. 2014 Dec 19; 4:7558. . View in PubMed
  • Circulating tumor microemboli diagnostics for patients with non-small-cell lung cancer J Thorac Oncol. 2014 Aug; 9(8):1111-9. . View in PubMed
  • Adrenal metastases in lung cancer: clinical implications of a mathematical model J Thorac Oncol. 2014 Apr; 9(4):442-6. . View in PubMed
  • Symptomatic reduction in free testosterone levels secondary to crizotinib use in male cancer patients Cancer. 2013 Jul 01; 119(13):2383-90. . View in PubMed
  • Spreaders and sponges define metastasis in lung cancer: a Markov chain Monte Carlo mathematical model Cancer Res. 2013 May 01; 73(9):2760-9. . View in PubMed
  • An observational study of circulating tumor cells and (18)F-FDG PET uptake in patients with treatment-naive non-small cell lung cancer PLoS One. 2013; 8(7):e67733. . View in PubMed
  • Fluid biopsy for solid tumors: a patient’s companion for lifelong characterization of their disease Future Oncol. 2012 Aug; 8(8):989-98. . View in PubMed
  • ERCC1 expression in circulating tumor cells (CTCs) using a novel detection platform correlates with progression-free survival (PFS) in patients with metastatic non-small-cell lung cancer (NSCLC) receiving platinum chemotherapy Lung Cancer. 2012 Aug; 77(2):421-6. . View in PubMed
  • Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology Phys Biol. 2012 Feb; 9(1):016005. . View in PubMed
  • Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers Phys Biol. 2012 Feb; 9(1):016003. . View in PubMed
  • Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors Phys Biol. 2012 Feb; 9(1):016001. . View in PubMed
  • High-definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients: a longitudinal analysis Phys Biol. 2012 Feb; 9(1):016004. . View in PubMed
  • A stochastic Markov chain model to describe lung cancer growth and metastasis PLoS One. 2012; 7(4):e34637. . View in PubMed
  • A pilot study of long-acting octreotide for symptomatic malignant ascites Oncology. 2012; 82(6):315-20. . View in PubMed
  • Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans Nature. 2011 Aug 31; 477(7362):99-102. . View in PubMed
  • Cholesterol secosterol aldehydes induce amyloidogenesis and dysfunction of wild-type tumor protein p53 Chem Biol. 2011 Jul 29; 18(7):920-7. . View in PubMed
  • Cytomorphology of circulating colorectal tumor cells:a small case series J Oncol. 2010; 2010:861341. . View in PubMed
  • Circulating tumor cells from well-differentiated lung adenocarcinoma retain cytomorphologic features of primary tumor type Arch Pathol Lab Med. 2009 Sep; 133(9):1468-71. . View in PubMed
  • The ratio of cholesterol 5,6-secosterols formed from ozone and singlet oxygen offers insight into the oxidation of cholesterol in vivo Chem Commun (Camb). 2009 Jun 07; (21):3098-100. . View in PubMed
  • Purification and characterization of sideroblasts from patients with acquired and hereditary sideroblastic anaemia Br J Haematol. 2008 Nov; 143(3):446-50. . View in PubMed
  • Lipid-derived aldehydes accelerate light chain amyloid and amorphous aggregation Biochemistry. 2008 Jul 22; 47(29):7695-705. . View in PubMed
  • Tissue factor activity is increased in a combined platelet and microparticle sample from cancer patients Thromb Res. 2008; 122(5):604-9. . View in PubMed
  • Understanding hairy cell leukemia genetics Leuk Lymphoma. 2007 Apr; 48(4):653-4. . View in PubMed
  • Case study of the morphologic variation of circulating tumor cells Hum Pathol. 2007 Mar; 38(3):514-9. . View in PubMed
  • The clinical significance of circulating tissue factor in prostate cancer Thromb Haemost. 2007 Mar; 97(3):329-30. . View in PubMed
  • AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP N Engl J Med. 2006 Oct 19; 355(16):1672-81. . View in PubMed
  • Use of optophoresis as an in vitro predictor of cell response to chemotherapy for chronic lymphocytic leukemia Leuk Lymphoma. 2006 Oct; 47(10):2194-202. . View in PubMed
  • Proatherogenic effects of the cholesterol ozonolysis products, atheronal-A and atheronal-B Biochemistry. 2006 Jun 13; 45(23):7162-70. . View in PubMed
  • Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization Nat Chem Biol. 2006 May; 2(5):249-53. . View in PubMed
  • High speed detection of circulating tumor cells Biosens Bioelectron. 2006 Apr 15; 21(10):1893-9. . View in PubMed
  • Immunoglobulins can utilize riboflavin (Vitamin B2) to activate the antibody-catalyzed water oxidation pathway Immunol Lett. 2006 Feb 28; 103(1):33-8. . View in PubMed
  • SHP1 expression in bone marrow biopsies of myelodysplastic syndrome patients: a new prognostic factor Br J Haematol. 2005 Jun; 129(6):791-4. . View in PubMed
  • The antibody-catalyzed water oxidation pathway–a new chemical arm to immune defense? Trends Biochem Sci. 2004 May; 29(5):274-8.. View in PubMed
  • Metabolite-initiated protein misfolding may trigger Alzheimer’s disease Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):4752-7. . View in PubMed
  • Cladribine activity in systemic mast cell disease: application of biochemistry in the modern era of molecular biology Leuk Res. 2004 Feb; 28(2):113-4. . View in PubMed
  • Evidence for ozone formation in human atherosclerotic arteries Science. 2003 Nov 07; 302(5647):1053-6. . View in PubMed
  • Phase 2 study of rituximab in the treatment of cladribine-failed patients with hairy cell leukemia Blood. 2003 Aug 01; 102(3):810-3. . View in PubMed
  • Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation Science. 2002 Dec 13; 298(5601):2195-9. . View in PubMed
  • Injuries in youth ice hockey: a pilot surveillance strategy Mayo Clin Proc. 1995 Apr; 70(4):350-6. . View in PubMed