Keck School Faculty

Josh Neman-Ebrahim, PhD
Josh Neman-Ebrahim, PhD
Assistant Professor of Neurological Surgery
Neurological Surgery
HMR 2011 Zonal Ave Bldg HMR University Park Campus Los Angeles
Dr. Neman is an Assistant Professor of Neurosurgery and member of the Norris Comprehensive Cancer Center at the Keck School of Medicine of USC. Dr. Neman received his doctoral degree at the UCLA David Geffen School of Medicine in neurobiology. He then went on to complete his cancer biology fellowship at the City of Hope’s Beckman Research Institute where he was a California Institute for Regenerative Medicine (CIRM) Fellow. Dr. Neman’s research at USC investigates the biology of breast to brain metastases and medulloblastoma (the most aggressive pediatric brain tumor).

His expertise and strengths in stem cell biology and neuroscience have allowed him to develop novel molecular, cellular, and systems approach to study the interaction between the brain and cancer cells (termed the tumor microenvironment)–a bidirectional interplay poorly understood. As a neuroscientist, Dr. Neman’s goal is to raise awareness that transdisciplinary research between neurobiology and cancer foundations can advance our current understanding of how the nervous system contributes to primary and metastatic brain tumors. This will ultimately result in development of improved strategies for cancer prevention and treatment of patients with these devastating diseases.

Regional Delivery of Chimeric Antigen Receptor-Engineered T Cells Effectively Targets HER2+ Breast Cancer Metastasis to the Brain Clin Cancer Res. 2018 Jan 01; 24(1):95-105. . View in PubMed

Cooperation of neurotrophin receptor TrkB and Her2 in breast cancer cells facilitates brain metastases Breast Cancer Res. 2017 Apr 26; 19(1):51. . View in PubMed

Meeting report: Metastasis Research Society-Chinese Tumor Metastasis Society joint conference on metastasis Clin Exp Metastasis. 2017 Apr; 34(3-4):203-213. . View in PubMed

Meeting report: Metastasis Research Society-Chinese Tumor Metastasis Society joint conference on metastasis Clin Exp Metastasis. 2017 04; 34(3-4):203-213. . View in PubMed

Cooperation of neurotrophin receptor TrkB and Her2 in breast cancer cells facilitates brain metastases Breast Cancer Res. 2017 04 26; 19(1):51. . View in PubMed

Inhibition of ß2-adrenergic receptor reduces triple-negative breast cancer brain metastases: The potential benefit of perioperative ß-blockade Oncol Rep. 2016 Jun; 35(6):3135-42. . View in PubMed

Medulloblastoma initiation and spread: Where neurodevelopment, microenvironment and cancer cross pathways J Neurosci Res. 2016 12; 94(12):1511-1519. . View in PubMed

Role of the neural niche in brain metastatic cancer Cancer Res. 2014 Aug 01; 74(15):4011-5. . View in PubMed

Therapeutic disruption of the blood brain barrier in metastasis Neurosurgery. 2014 Apr; 74(4):N11-2. . View in PubMed

Human breast cancer metastases to the brain display GABAergic properties in the neural niche Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):984-9. . View in PubMed

Co-evolution of breast-to-brain metastasis and neural progenitor cells Clin Exp Metastasis. 2013 Aug; 30(6):753-68. . View in PubMed

Lineage mapping and characterization of the native progenitor population in cellular allograft Spine J. 2013 Feb; 13(2):162-174. . View in PubMed

Altered expression of polycomb group genes in glioblastoma multiforme PLoS One. 2013; 8(11):e80970. . View in PubMed

A method for deriving homogenous population of oligodendrocytes from mouse embryonic stem cells Dev Neurobiol. 2012 Jun; 72(6):777-88. . View in PubMed

Genetic mutations and tissue type lead to heterogeneous metabolic profiles in tumors Neurosurgery. 2012 Jun; 70(6):N20-1. . View in PubMed

Cytotoxic T lymphocyte trafficking and survival in an augmented fibrin matrix carrier PLoS One. 2012; 7(4):e34652. . View in PubMed

Stem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering Biologics. 2012; 6:47-57. . View in PubMed

Clinical efficacy of stem cell mediated osteogenesis and bioceramics for bone tissue engineering Adv Exp Med Biol. 2012; 760:174-87. . View in PubMed

Emerging role of brain metastases in the prognosis of breast cancer patients Breast Cancer (Dove Med Press). 2011 Aug 10; 3:79-91. . View in PubMed

Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: what should be the policy? Neuroimage. 2011 Jan; 54 Suppl 1:S106-24.. View in PubMed

Classification of genomic changes in breast cancer brain metastasis Neurosurgery. 2010 Aug; 67(2):N18-9. . View in PubMed

Decreasing glioma recurrence through adjuvant cancer stem cell inhibition Biologics. 2010 Jun 24; 4:157-62. . View in PubMed

Translational emphasis: hypoxia and vasculogenesis in glioma recurrence Neurosurgery. 2010 Jun; 66(6):N20-1. . View in PubMed

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