Joshua Millstein, PhD

Associate Professor of Research Population and Public Health Sciences

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Overview

Dr. Millstein’s research is focused on developing and applying statistical methods to address the many challenges of high dimensional data, particularly in multi-omic population-based studies of the genome, epigenome, transcriptome, microbiome, etc., in the context of pathogenesis of complex diseases such as cancer. With massive amounts of data collected in typical studies due to these advancing technologies, it has become increasingly important to have computational tools able to sift through all the information to separate the signal of interest from the noise. Specific areas of methods development include, causal mediation (CIT), dimensionality reduction, causal networks, false discovery rates (FDR), and epistasis/statistical interactions.

Publications

  • Long non-coding RNAs in colorectal cancer: shaping the tumour microenvironment and advancing precision oncology. Nat Rev Gastroenterol Hepatol. 2026 Sep 01.. View in PubMed
  • Erratum to “Air pollution is linked to divergent cortical thickness patterns in brain regions vulnerable to Alzheimer’s disease” [Neurotoxicology 115 (2026) 103495]. Neurotoxicology. 2026 Sep; 116:103551.. View in PubMed
  • Dihydropyrimidine dehydrogenase modulates immune response to checkpoint inhibition in mismatch repair deficient/microsatellite instability-high colorectal cancer. J Immunother Cancer. 2026 Aug 17; 14(8).. View in PubMed
  • Activation of the endocytosis pathway stratifies subtypes and therapeutic sensitivity in colorectal cancer. Res Sq. 2026 Jul 05.. View in PubMed
  • Air pollution is linked to divergent cortical thickness patterns in brain regions vulnerable to Alzheimer’s disease. Neurotoxicology. 2026 Jul; 115:103495.. View in PubMed
  • Association between late-life air pollution exposure and medial temporal lobe atrophy in older women. Neurotoxicology. 2026 Jan; 112:103378.. View in PubMed
  • Clinical and molecular characterization of AXL in colorectal cancer, CALGB (Alliance)/SWOG 80405 and real-world data. J Immunother Cancer. 2025 Dec 21; 13(12).. View in PubMed
  • Age-diet interactions significantly influence intratumoral gene expression, gut microbiome signature and tumor microenvironment in colorectal cancer. Neoplasia. 2025 12; 70:101245.. View in PubMed
  • DNA methylation: a potential mediator between air pollution exposures and asthma control. Clin Epigenetics. 2025 Oct 21; 17(1):175.. View in PubMed
  • GABAergic signaling contributes to tumor cell invasion and poor overall survival in colorectal cancer. Oncogene. 2025 10; 44(41):3924-3938.. View in PubMed