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Juan Pablo Lewinger, PhD

Assistant Professor of Clinical Population and Public Health Sciences

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Phone +1 323 442 1932
Email lewinger@usc.edu
CTSI Profile

Publications

  • Genome-wide interaction study of dietary intake of fibre, fruits, and vegetables with risk of colorectal cancer EBioMedicine. 2024 Jun; 104:105146. . View in PubMed
  • Two genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer Sci Adv. 2024 May 31; 10(22):eadk3121. . View in PubMed
  • A Regularized Cox Hierarchical Model for Incorporating Annotation Information in Predictive Omic Studies bioRxiv. 2024 May 02. . View in PubMed
  • Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk Br J Cancer. 2024 Apr 01. . View in PubMed
  • Genome-Wide Gene-Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk Cancer Epidemiol Biomarkers Prev. 2024 03 01; 33(3):400-410. . View in PubMed
  • A note on p-value multiple-testing adjustment for two-step genome-wide gene-environment interactions scans medRxiv. 2023 Jun 28. . View in PubMed
  • Genome-wide interaction analysis of folate for colorectal cancer risk Am J Clin Nutr. 2023 11; 118(5):881-891. . View in PubMed
  • Probing the diabetes and colorectal cancer relationship using gene – environment interaction analyses Br J Cancer. 2023 08; 129(3):511-520. . View in PubMed
  • Improved two-step testing of genome-wide gene-environment interactions Genet Epidemiol. 2023 03; 47(2):152-166. . View in PubMed
  • Prenatal exposure to tailpipe and non-tailpipe tracers of particulate matter pollution and autism spectrum disorders Environ Int. 2023 01; 171:107736. . View in PubMed
  • Classification of Angle Closure Severity by Hierarchical Cluster Analysis of Ocular Biometrics in the Dark and Light Transl Vis Sci Technol. 2023 09 01; 12(9):4. . View in PubMed
  • A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk Cancer Res. 2023 08 01; 83(15):2572-2583. . View in PubMed
  • Associations of Autism Spectrum Disorder with PM25 Components: A Comparative Study Using Two Different Exposure Models. Environ Sci Technol. 2023 01 10; 57(1):405-414. . View in PubMed
  • PEACOCK: a machine learning approach to assess the validity of cell type-specific enhancer-gene regulatory relationships NPJ Syst Biol Appl. 2023 04 03; 9(1):9. . View in PubMed
  • Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response Cancer Epidemiol Biomarkers Prev. 2023 03 06; 32(3):315-328. . View in PubMed
  • OvaPrint-A Cell-free DNA Methylation Liquid Biopsy for the Risk Assessment of High-grade Serous Ovarian Cancer Clin Cancer Res. 2023 12 15; 29(24):5196-5206. . View in PubMed
  • Effect of UNOS policy change and exception status request on outcomes in patients bridged to heart transplant with an intra-aortic balloon pump Artif Organs. 2022 May; 46(5):838-849. . View in PubMed
  • Two-step hypothesis testing to detect gene-environment interactions in a genome-wide scan with a survival endpoint Stat Med. 2022 04 30; 41(9):1644-1657. . View in PubMed
  • A scalable hierarchical lasso for gene-environment interactions J Comput Graph Stat. 2022; 31(4):1091-1103. . View in PubMed
  • Hierarchical Ridge Regression for Incorporating Prior Information in Genomic Studies J Data Sci. 2022 Jan; 20(1):34-50. . View in PubMed
  • Interactions between folate intake and genetic predictors of gene expression levels associated with colorectal cancer risk Sci Rep. 2022 11 07; 12(1):18852. . View in PubMed
  • Genome-Wide Interaction Analysis of Genetic Variants With Menopausal Hormone Therapy for Colorectal Cancer Risk J Natl Cancer Inst. 2022 08 08; 114(8):1135-1148. . View in PubMed
  • Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q242 Region. Cancer Epidemiol Biomarkers Prev. 2022 05 04; 31(5):1077-1089. . View in PubMed
  • Differences in Ocular Biometric Measurements among Subtypes of Primary Angle Closure Disease: The Chinese American Eye Study Ophthalmol Glaucoma. 2021 Mar-Apr; 4(2):224-231. . View in PubMed
  • Incorporating prior knowledge into regularized regression Bioinformatics. 2021 05 01; 37(4):514-521. . View in PubMed
  • Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk Cancer Med. 2020 05; 9(10):3563-3573. . View in PubMed
  • Female vulnerability to the effects of smoking on health outcomes in older people PLoS One. 2020; 15(6):e0234015. . View in PubMed
  • PEREGRINE: A genome-wide prediction of enhancer to gene relationships supported by experimental evidence PLoS One. 2020; 15(12):e0243791. . View in PubMed
  • Improvements to the Escalation with Overdose Control design and a comparison with the restricted Continual Reassessment Method Pharm Stat. 2019 11; 18(6):659-670. . View in PubMed
  • Preoperative hemoglobin A1c levels and increased risk of adverse limb events in diabetic patients undergoing infrainguinal lower extremity bypass surgery in the Vascular Quality InitiativeJ Vasc Surg. 2019 10; 70(4):1225-1234. e1. . View in PubMed
  • Genet Epidemiol. 2019 03; 43(2):150-165. . View in PubMed
  • A Unified Model for the Analysis of Gene-Environment Interaction Am J Epidemiol. 2019 04 01; 188(4):760-767. . View in PubMed
  • Correlation between Intraocular Pressure and Angle Configuration Measured by OCT: The Chinese American Eye Study Ophthalmol Glaucoma. 2018 Nov-Dec; 1(3):158-166. . View in PubMed
  • Data integration by multi-tuning parameter elastic net regression BMC Bioinformatics. 2018 Oct 10; 19(1):369. . View in PubMed
  • Comparison of devices used in carotid artery stenting: A vascular quality initiative analysis of commonly used carotid stents and embolic protection devices Catheter Cardiovasc Interv. 2018 10 01; 92(4):743-749. . View in PubMed
  • Update on the State of the Science for Analytical Methods for Gene-Environment Interactions Am J Epidemiol. 2017 Oct 01; 186(7):762-770. . View in PubMed
  • Increased risk of mortality after lower extremity bypass in individuals with acute kidney injury in the Vascular Quality Initiative J Vasc Surg. 2017 Apr; 65(4):1055-1061. . View in PubMed
  • Adaptive Set-Based Methods for Association Testing Genet Epidemiol. 2016 Feb; 40(2):113-22. . View in PubMed
  • Novel Gene Expression Signature Predictive of Clinical Recurrence After Radical Prostatectomy in Early Stage Prostate Cancer Patients Prostate. 2016 10; 76(14):1239-56. . View in PubMed
  • Erratum to: Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls Hum Genet. 2016 08; 135(8):963. . View in PubMed
  • Detecting Gene-Environment Interactions for a Quantitative Trait in a Genome-Wide Association Study Genet Epidemiol. 2016 07; 40(5):394-403. . View in PubMed
  • Radical Prostatectomy or External Beam Radiation Therapy vs No Local Therapy for Survival Benefit in Metastatic Prostate Cancer: A SEER-Medicare Analysis J Urol. 2015 Aug; 194(2):378-85. . View in PubMed
  • Meat intake, cooking methods, dietary carcinogens, and colorectal cancer risk: findings from the Colorectal Cancer Family Registry Cancer Med. 2015 Jun; 4(6):936-52. . View in PubMed
  • Hormone metabolism pathway genes and mammographic density change after quitting estrogen and progestin combined hormone therapy in the California Teachers Study Breast Cancer Res. 2014 Dec 11; 16(6):477. . View in PubMed
  • Tobacco smoking, polymorphisms in carcinogen metabolism enzyme genes, and risk of localized and advanced prostate cancer: results from the California Collaborative Prostate Cancer Study Cancer Med. 2014 Dec; 3(6):1644-55. . View in PubMed
  • Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai Int J Cancer. 2014 Jul 15; 135(2):335-47. . View in PubMed
  • Angiogenesis genes, dietary oxidative balance and breast cancer risk and progression: the Breast Cancer Health Disparities Study Int J Cancer. 2014 Feb 01; 134(3):629-44. . View in PubMed
  • Null association between histology of first and second primary malignancies in men with bilateral testicular germ cell tumors Am J Epidemiol. 2013 Oct 15; 178(8):1240-5. . View in PubMed
  • Finding novel genes by testing G × E interactions in a genome-wide association study Genet Epidemiol. 2013 Sep; 37(6):603-13. . View in PubMed
  • Efficient two-step testing of gene-gene interactions in genome-wide association studies Genet Epidemiol. 2013 Jul; 37(5):440-51. . View in PubMed
  • Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23 Hum Mol Genet. 2013 Jul 01; 22(13):2748-53. . View in PubMed
  • Hormone metabolism genes and mammographic density in Singapore Chinese women Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):984-6. . View in PubMed
  • Genetic admixture and risk of hypertensive disorders of pregnancy among Latinas in Los Angeles County Epidemiology. 2013 Mar; 24(2):285-94. . View in PubMed
  • Confounding and heterogeneity in genetic association studies with admixed populations Am J Epidemiol. 2013 Feb 15; 177(4):351-60. . View in PubMed
  • Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls Hum Genet. 2013 05; 132(5):579-89. . View in PubMed
  • Genetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk PLoS One. 2013; 8(8):e71211. . View in PubMed
  • Variants in tamoxifen metabolizing genes: a case-control study of contralateral breast cancer risk in the WECARE study Int J Mol Epidemiol Genet. 2013; 4(1):35-48. . View in PubMed
  • Red meat and poultry, cooking practices, genetic susceptibility and risk of prostate cancer: results from a multiethnic case-control study Carcinogenesis. 2012 Nov; 33(11):2108-18. . View in PubMed
  • Polymorphisms in carcinogen metabolism enzymes, fish intake, and risk of prostate cancer Carcinogenesis. 2012 Jul; 33(7):1352-9. . View in PubMed
  • Invited commentary: GE-Whiz! Ratcheting gene-environment studies up to the whole genome and the whole exposome Am J Epidemiol. 2012 Feb 01; 175(3):203-7; discussion 208-9. . View in PubMed
  • Cryptorchidism and testicular germ cell tumors: comprehensive meta-analysis reveals that association between these conditions diminished over time and is modified by clinical characteristics Front Endocrinol (Lausanne). 2012; 3:182. . View in PubMed
  • Using extreme phenotype sampling to identify the rare causal variants of quantitative traits in association studies Genet Epidemiol. 2011 Dec; 35(8):790-9. . View in PubMed
  • Genotype-environment interactions in microsatellite stable/microsatellite instability-low colorectal cancer: results from a genome-wide association study Cancer Epidemiol Biomarkers Prev. 2011 May; 20(5):758-66. . View in PubMed
  • Sample size requirements to detect gene-environment interactions in genome-wide association studies Genet Epidemiol. 2011 Apr; 35(3):201-10. . View in PubMed
  • The association of polymorphisms in hormone metabolism pathway genes, menopausal hormone therapy, and breast cancer risk: a nested case-control study in the California Teachers Study cohort Breast Cancer Res. 2011 Apr 01; 13(2):R37. . View in PubMed
  • Efficient genome-wide association testing of gene-environment interaction in case-parent trios Am J Epidemiol. 2010 Jul 01; 172(1):116-22. . View in PubMed
  • Genes involved with folate uptake and distribution and their association with colorectal cancer risk Cancer Causes Control. 2010 Apr; 21(4):597-608. . View in PubMed
  • Methodological Issues in Multistage Genome-wide Association Studies Stat Sci. 2009 Nov 01; 24(4):414-429. . View in PubMed
  • Gene-environment interaction in genome-wide association studies Am J Epidemiol. 2009 Jan 15; 169(2):219-26. . View in PubMed
  • Detecting gene-environment interactions in genome-wide association data Genet Epidemiol. 2009; 33 Suppl 1:S68-73. . View in PubMed
  • Hierarchical Bayes prioritization of marker associations from a genome-wide association scan for further investigation Genet Epidemiol. 2007 Dec; 31(8):871-82. . View in PubMed
  • Confidence intervals for multinomial logistic regression in sparse data Stat Med. 2007 Feb 20; 26(4):903-18. . View in PubMed
  • Validity, efficiency, and robustness of a family-based test of association Genet Epidemiol. 2006 Jan; 30(1):62-76. . View in PubMed
  • Comparison of family-based association tests in chromosome regions selected by linkage-based confidence intervals BMC Genet. 2005 Dec 30; 6 Suppl 1:S62. . View in PubMed
  • Does simultaneous consideration of multiple regions improve disease gene localization? Genet Epidemiol. 2001; 21 Suppl 1:S504-9.. View in PubMed

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