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Juan Pablo Lewinger, PhD

Associate Professor of Clinical Population and Public Health Sciences

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Phone +1 323 442 1932
Email lewinger@usc.edu
CTSI Profile

Publications

  • Genetic risk factors modulate the association between physical activity and colorectal cancer. Res Sq. 2025 Sep 02.. View in PubMed
  • Pathway polygenic risk scores (pPRS) for the analysis of gene-environment interaction. PLoS Genet. 2025 Aug; 21(8):e1011543.. View in PubMed
  • Red meat intake interacts with a TGF-β-pathway-based polygenic risk score to impact colorectal cancer risk: Application of a novel approach for polygenic risk score construction. medRxiv. 2025 Jun 16.. View in PubMed
  • MammaTrace – a cell-free DNA methylation plasma only assay for minimal residual disease detection in breast cancer patients. medRxiv. 2025 May 21.. View in PubMed
  • Characterization of Additive Gene-environment Interactions For Colorectal Cancer Risk. Epidemiology. 2025 Jan 01; 36(1):126-138.. View in PubMed
  • Pathway Polygenic Risk Scores (pPRS) for the Analysis of Gene-environment Interaction. bioRxiv. 2024 Dec 19.. View in PubMed
  • A regularized Cox hierarchical model for incorporating annotation information in predictive omic studies. BioData Min. 2024 Oct 24; 17(1):44.. View in PubMed
  • A Regularized Cox Hierarchical Model for Incorporating Annotation Information in Predictive Omic Studies. bioRxiv. 2024 Jul 29.. View in PubMed
  • Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk. Br J Cancer. 2024 Jun; 130(10):1687-1696.. View in PubMed
  • Genome-wide interaction study of dietary intake of fibre, fruits, and vegetables with risk of colorectal cancer. EBioMedicine. 2024 Jun; 104:105146.. View in PubMed
  • Two genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer. Sci Adv. 2024 05 31; 10(22):eadk3121.. View in PubMed
  • Genome-Wide Gene-Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk. Cancer Epidemiol Biomarkers Prev. 2024 03 01; 33(3):400-410.. View in PubMed
  • OvaPrint-A Cell-free DNA Methylation Liquid Biopsy for the Risk Assessment of High-grade Serous Ovarian Cancer. Clin Cancer Res. 2023 12 15; 29(24):5196-5206.. View in PubMed
  • Genome-wide interaction analysis of folate for colorectal cancer risk. Am J Clin Nutr. 2023 11; 118(5):881-891.. View in PubMed
  • Classification of Angle Closure Severity by Hierarchical Cluster Analysis of Ocular Biometrics in the Dark and Light. Transl Vis Sci Technol. 2023 09 01; 12(9):4.. View in PubMed
  • A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk. Cancer Res. 2023 08 01; 83(15):2572-2583.. View in PubMed
  • Probing the diabetes and colorectal cancer relationship using gene – environment interaction analyses. Br J Cancer. 2023 08; 129(3):511-520.. View in PubMed
  • A note on p-value multiple-testing adjustment for two-step genome-wide gene-environment interactions scans. medRxiv. 2023 Jun 28.. View in PubMed
  • PEACOCK: a machine learning approach to assess the validity of cell type-specific enhancer-gene regulatory relationships. NPJ Syst Biol Appl. 2023 04 03; 9(1):9.. View in PubMed
  • Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response. Cancer Epidemiol Biomarkers Prev. 2023 03 06; 32(3):315-328.. View in PubMed
  • Improved two-step testing of genome-wide gene-environment interactions. Genet Epidemiol. 2023 03; 47(2):152-166.. View in PubMed
  • Associations of Autism Spectrum Disorder with PM2.5 Components: A Comparative Study Using Two Different Exposure Models. Environ Sci Technol. 2023 01 10; 57(1):405-414.. View in PubMed
  • Prenatal exposure to tailpipe and non-tailpipe tracers of particulate matter pollution and autism spectrum disorders. Environ Int. 2023 01; 171:107736.. View in PubMed
  • Interactions between folate intake and genetic predictors of gene expression levels associated with colorectal cancer risk. Sci Rep. 2022 11 07; 12(1):18852.. View in PubMed
  • Genome-Wide Interaction Analysis of Genetic Variants With Menopausal Hormone Therapy for Colorectal Cancer Risk. J Natl Cancer Inst. 2022 08 08; 114(8):1135-1148.. View in PubMed
  • Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region. Cancer Epidemiol Biomarkers Prev. 2022 05 04; 31(5):1077-1089.. View in PubMed
  • Effect of UNOS policy change and exception status request on outcomes in patients bridged to heart transplant with an intra-aortic balloon pump. Artif Organs. 2022 May; 46(5):838-849.. View in PubMed
  • Two-step hypothesis testing to detect gene-environment interactions in a genome-wide scan with a survival endpoint. Stat Med. 2022 04 30; 41(9):1644-1657.. View in PubMed
  • Hierarchical Ridge Regression for Incorporating Prior Information in Genomic Studies. J Data Sci. 2022 Jan; 20(1):34-50.. View in PubMed
  • A scalable hierarchical lasso for gene-environment interactions. J Comput Graph Stat. 2022; 31(4):1091-1103.. View in PubMed
  • Incorporating prior knowledge into regularized regression. Bioinformatics. 2021 05 01; 37(4):514-521.. View in PubMed
  • Differences in Ocular Biometric Measurements among Subtypes of Primary Angle Closure Disease: The Chinese American Eye Study. Ophthalmol Glaucoma. 2021 Mar-Apr; 4(2):224-231.. View in PubMed
  • Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk. Cancer Med. 2020 05; 9(10):3563-3573.. View in PubMed
  • Female vulnerability to the effects of smoking on health outcomes in older people. PLoS One. 2020; 15(6):e0234015.. View in PubMed
  • PEREGRINE: A genome-wide prediction of enhancer to gene relationships supported by experimental evidence. PLoS One. 2020; 15(12):e0243791.. View in PubMed
  • Improvements to the Escalation with Overdose Control design and a comparison with the restricted Continual Reassessment Method. Pharm Stat. 2019 11; 18(6):659-670.. View in PubMed
  • Preoperative hemoglobin A1c levels and increased risk of adverse limb events in diabetic patients undergoing infrainguinal lower extremity bypass surgery in the Vascular Quality Initiative. J Vasc Surg. 2019 10; 70(4):1225-1234.e1.. View in PubMed
  • A Unified Model for the Analysis of Gene-Environment Interaction. Am J Epidemiol. 2019 04 01; 188(4):760-767.. View in PubMed
  • Using Bayes model averaging to leverage both gene main effects and G ×  E interactions to identify genomic regions in genome-wide association studies. Genet Epidemiol. 2019 03; 43(2):150-165.. View in PubMed
  • Correlation between Intraocular Pressure and Angle Configuration Measured by OCT: The Chinese American Eye Study. Ophthalmol Glaucoma. 2018 Nov-Dec; 1(3):158-166.. View in PubMed
  • Data integration by multi-tuning parameter elastic net regression. BMC Bioinformatics. 2018 Oct 10; 19(1):369.. View in PubMed
  • Comparison of devices used in carotid artery stenting: A vascular quality initiative analysis of commonly used carotid stents and embolic protection devices. Catheter Cardiovasc Interv. 2018 10 01; 92(4):743-749.. View in PubMed
  • Update on the State of the Science for Analytical Methods for Gene-Environment Interactions. Am J Epidemiol. 2017 Oct 01; 186(7):762-770.. View in PubMed
  • Increased risk of mortality after lower extremity bypass in individuals with acute kidney injury in the Vascular Quality Initiative. J Vasc Surg. 2017 Apr; 65(4):1055-1061.. View in PubMed
  • Novel Gene Expression Signature Predictive of Clinical Recurrence After Radical Prostatectomy in Early Stage Prostate Cancer Patients. Prostate. 2016 10; 76(14):1239-56.. View in PubMed
  • Erratum to: Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls. Hum Genet. 2016 08; 135(8):963.. View in PubMed
  • Detecting Gene-Environment Interactions for a Quantitative Trait in a Genome-Wide Association Study. Genet Epidemiol. 2016 07; 40(5):394-403.. View in PubMed
  • Adaptive Set-Based Methods for Association Testing. Genet Epidemiol. 2016 Feb; 40(2):113-22.. View in PubMed
  • Radical Prostatectomy or External Beam Radiation Therapy vs No Local Therapy for Survival Benefit in Metastatic Prostate Cancer: A SEER-Medicare Analysis. J Urol. 2015 Aug; 194(2):378-85.. View in PubMed
  • Meat intake, cooking methods, dietary carcinogens, and colorectal cancer risk: findings from the Colorectal Cancer Family Registry. Cancer Med. 2015 Jun; 4(6):936-52.. View in PubMed
  • Hormone metabolism pathway genes and mammographic density change after quitting estrogen and progestin combined hormone therapy in the California Teachers Study. Breast Cancer Res. 2014 Dec 11; 16(6):477.. View in PubMed
  • Tobacco smoking, polymorphisms in carcinogen metabolism enzyme genes, and risk of localized and advanced prostate cancer: results from the California Collaborative Prostate Cancer Study. Cancer Med. 2014 Dec; 3(6):1644-55.. View in PubMed
  • Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai. Int J Cancer. 2014 Jul 15; 135(2):335-47.. View in PubMed
  • Angiogenesis genes, dietary oxidative balance and breast cancer risk and progression: the Breast Cancer Health Disparities Study. Int J Cancer. 2014 Feb 01; 134(3):629-44.. View in PubMed
  • Null association between histology of first and second primary malignancies in men with bilateral testicular germ cell tumors. Am J Epidemiol. 2013 Oct 15; 178(8):1240-5.. View in PubMed
  • Finding novel genes by testing G × E interactions in a genome-wide association study. Genet Epidemiol. 2013 Sep; 37(6):603-13.. View in PubMed
  • Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23. Hum Mol Genet. 2013 Jul 01; 22(13):2748-53.. View in PubMed
  • Efficient two-step testing of gene-gene interactions in genome-wide association studies. Genet Epidemiol. 2013 Jul; 37(5):440-51.. View in PubMed
  • Hormone metabolism genes and mammographic density in Singapore Chinese women. Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):984-6.. View in PubMed
  • Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls. Hum Genet. 2013 05; 132(5):579-89.. View in PubMed
  • Genetic admixture and risk of hypertensive disorders of pregnancy among Latinas in Los Angeles County. Epidemiology. 2013 Mar; 24(2):285-94.. View in PubMed
  • Confounding and heterogeneity in genetic association studies with admixed populations. Am J Epidemiol. 2013 Feb 15; 177(4):351-60.. View in PubMed
  • Genetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk. PLoS One. 2013; 8(8):e71211.. View in PubMed
  • Variants in tamoxifen metabolizing genes: a case-control study of contralateral breast cancer risk in the WECARE study. Int J Mol Epidemiol Genet. 2013; 4(1):35-48.. View in PubMed
  • Red meat and poultry, cooking practices, genetic susceptibility and risk of prostate cancer: results from a multiethnic case-control study. Carcinogenesis. 2012 Nov; 33(11):2108-18.. View in PubMed
  • Polymorphisms in carcinogen metabolism enzymes, fish intake, and risk of prostate cancer. Carcinogenesis. 2012 Jul; 33(7):1352-9.. View in PubMed
  • Invited commentary: GE-Whiz! Ratcheting gene-environment studies up to the whole genome and the whole exposome. Am J Epidemiol. 2012 Feb 01; 175(3):203-7; discussion 208-9.. View in PubMed
  • Cryptorchidism and testicular germ cell tumors: comprehensive meta-analysis reveals that association between these conditions diminished over time and is modified by clinical characteristics. Front Endocrinol (Lausanne). 2012; 3:182.. View in PubMed
  • Using extreme phenotype sampling to identify the rare causal variants of quantitative traits in association studies. Genet Epidemiol. 2011 Dec; 35(8):790-9.. View in PubMed
  • Genotype-environment interactions in microsatellite stable/microsatellite instability-low colorectal cancer: results from a genome-wide association study. Cancer Epidemiol Biomarkers Prev. 2011 May; 20(5):758-66.. View in PubMed
  • The association of polymorphisms in hormone metabolism pathway genes, menopausal hormone therapy, and breast cancer risk: a nested case-control study in the California Teachers Study cohort. Breast Cancer Res. 2011 Apr 01; 13(2):R37.. View in PubMed
  • Sample size requirements to detect gene-environment interactions in genome-wide association studies. Genet Epidemiol. 2011 Apr; 35(3):201-10.. View in PubMed
  • Efficient genome-wide association testing of gene-environment interaction in case-parent trios. Am J Epidemiol. 2010 Jul 01; 172(1):116-22.. View in PubMed
  • Genes involved with folate uptake and distribution and their association with colorectal cancer risk. Cancer Causes Control. 2010 Apr; 21(4):597-608.. View in PubMed
  • Methodological Issues in Multistage Genome-wide Association Studies. Stat Sci. 2009 Nov 01; 24(4):414-429.. View in PubMed
  • Gene-environment interaction in genome-wide association studies. Am J Epidemiol. 2009 Jan 15; 169(2):219-26.. View in PubMed
  • Detecting gene-environment interactions in genome-wide association data. Genet Epidemiol. 2009; 33 Suppl 1:S68-73.. View in PubMed
  • Hierarchical Bayes prioritization of marker associations from a genome-wide association scan for further investigation. Genet Epidemiol. 2007 Dec; 31(8):871-82.. View in PubMed
  • Confidence intervals for multinomial logistic regression in sparse data. Stat Med. 2007 Feb 20; 26(4):903-18.. View in PubMed
  • Validity, efficiency, and robustness of a family-based test of association. Genet Epidemiol. 2006 Jan; 30(1):62-76.. View in PubMed
  • Comparison of family-based association tests in chromosome regions selected by linkage-based confidence intervals. BMC Genet. 2005 Dec 30; 6 Suppl 1:S62.. View in PubMed
  • Does simultaneous consideration of multiple regions improve disease gene localization? Genet Epidemiol. 2001; 21 Suppl 1:S504-9.. View in PubMed

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