Jubin P Joseph

Dr Jubin P. Joseph, MD PhD is the Director of the Cardiac Catheterization Laboratories and Director of Structural Interventions in the Cardiac & Vascular Institute and Clinical Assistant Professor of Medicine at the Keck School of Medicine of the University of Southern California.

Dr Joseph graduated from Cambridge University in 2005 and completed his medical education at Oxford University in 2008. He completed internal medicine and cardiology training in prestigious programs in England. He was awarded a competitive clinical research fellowship grant to undertake invasive physiology research which he performed at St Thomas’ Hospital in London, UK which resulted in the award of a PhD whilst also learning interventional cardiology. He then completed a two-year advanced coronary and structural intervention fellowship at Oxford University Hospitals in Oxford, England. Following this, he was recruited to Cedars Sinai Medical Center in Los Angeles, California in 2020 where he underwent further advanced training in structural heart interventions – performing a large number of transcatheter aortic, mitral and tricuspid valve replacements and repairs with both commercially available and emerging research devices, before joining as faculty at Keck Medical Center of USC in 2022.

Dr Joseph is an Interventional Cardiologist with specialized clinical and research interests in structural heart disease, particularly transcatheter valve therapy. He has a large volume of expertise in transcatheter aortic, mitral and tricuspid replacement, percutaneous mitral valve repair (i.e. MitraClip procedure), left atrial appendage occlusion (i.e. Watchman procedure), PFO/ASD/VSD closure, paravalvular leak closure, alcohol septal ablation and cerebral protection. He is a clinical investigator in ongoing national multi-center research studies and clinical trials and has co-authored numerous peer reviewed, scientific articles and book chapters. He has research interests in cardiovascular physiology, microvascular dysfunction, structural heart disease and emerging transcatheter therapy devices. Dr Joseph speaks regularly at major national and international cardiology meetings.

• Cambridge University: Preparing for Patients Prize, 2003
   – 2003
• Nichol Young Foundation Scholarship: Medical Education Travel Award, 2008
   – 2008
• Southdown Trust: Medical Education Travel Award, 2008
   – 2008
• Royal College of Surgeons, London: Preiskel Prize, 2008
   – 2008
• Royal Berkshire Hospital, Reading: Chairman’s Prize, 2015
   – 2015
• European Society of Cardiology: Cardiologist of Tomorrow, 2014
   – 2017
• The Peel Foundation: The Peel and Rothwell Jackson Postgraduate Fellowship, 2020
   – 2021

• Cedars Sinai Medical Center, Los Angeles, CA — 09/2022 — Interventional & Structural Cardiology
• Oxford University Hospitals, Oxford, UK — 06/2020 — Interventional Cardiology Fellowship
• Kings College London, London, England — PhD — 11/2020 — Cardiovascular Physiology
• Oxford Hospitals, Oxford, UK — 10/2015 — General Cardiology Fellowship
• University of Zurich, Zurich, Switzerland — Certificate of Advanced Studies — 10/2015 — Heart Failure
• Oxford Hospitals, Oxford, UK — 08/2012 — Internal Medicine Residency
• Oxford University, Oxford, England — M.D. — 06/2008 — Clinical Medicine
• Cambridge University, Cambridge, England — B.A. — 06/2005 — Medical Sciences

• Cardiovascular Disease
• Coronary Artery Disease
• Coronary Artery Stenosis
• Percutaneous Coronary Intervention
• Complex Coronary Intervention
• Aortic Valve Stenosis
• Aortic Valve Regurgitation
• Bicuspid Aortic Valve Disease
• Mitral Regurgitation
• Mitral Stenosis
• Mitral Valve Prolapse
• Functional Mitral Regurgitation
• Tricuspid Valve Disease
• Tricuspid Regurgitation
• Tricuspid Stenosis
• TAVR
• Transcatheter Aortic Valve Replacement
• MitraClip
• Transcatheter edge-to-edge repair
• Tricuspid Clip
• Trancatheter Mitral Valve Replacement
• Transcatheter Mitral Valve Repair
• Transcatheter tricuspid valve replacement
• Transcatheter tricuspid valve repair
• Atrial Septal Defect Closure
• PFO Closure
• VSD Closure
• ASD Closure
• Paravalvular Leak Closure
• Left Atrial Appendage Occlusion
• Watchman Procedure
• Alcohol Septal Ablation
• Microvascular Disease
• Mechanical Circulatory Support
• Rotational Atherectomy

• Hemodynamic and Mid-Term Outcomes for Transcatheter Aortic Valve Replacement in Degenerated Internally Stented Valves. JACC Cardiovasc Interv. 2023 03 13; 16(5):542-554.. View in PubMed
• Two-year outcomes from the MitrAl ValvE RepaIr Clinical (MAVERIC) trial: a novel percutaneous treatment of functional mitral regurgitation. Eur J Heart Fail. 2021 10; 23(10):1775-1783.. View in PubMed
• Usefulness of Computed Tomography to Predict Mitral Stenosis After Transcatheter Mitral Valve Edge-to-Edge Repair. Am J Cardiol. 2021 08 15; 153:109-118.. View in PubMed
• Percutaneous Edge-to-Edge Mitral Valve Repair With the MitraClip System Following Surgical Annuloplasty Ring Dehiscence. JACC Cardiovasc Interv. 2021 06 14; 14(11):1267-1269.. View in PubMed
• Impact of coronary artery disease on contractile function and ventricular-arterial coupling during exercise: Simultaneous assessment of left-ventricular pressure-volume and coronary pressure and flow during cardiac catheterization. Physiol Rep. 2021 05; 9(10):e14768.. View in PubMed
• Physiological Impact of Afterload Reduction on Cardiac Mechanics and Coronary Hemodynamics Following Isosorbide Dinitrate Administration in Ischemic Heart Disease. J Cardiovasc Transl Res. 2021 10; 14(5):962-974.. View in PubMed
• Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis Hospitalized With Acute Heart Failure. Am J Cardiol. 2021 04 01; 144:100-110.. View in PubMed
• Safety and Operational Efficiency of Restructuring and Redeploying a Transcatheter Aortic Valve Replacement Service During the COVID-19 Pandemic: The Oxford Experience. Cardiovasc Revasc Med. 2021 10; 31:26-31.. View in PubMed
• Baseline NT-proBNP Accurately Predicts Symptom Response to Transcatheter Aortic Valve Implantation. J Am Heart Assoc. 2020 12; 9(23):e017574.. View in PubMed
• Transcatheter Aortic Valve Replacement With the LOTUS Edge System: Early European Experience. JACC Cardiovasc Interv. 2021 01 25; 14(2):172-181.. View in PubMed
• Impact of Complications During Transfemoral Transcatheter Aortic Valve Replacement: How Can They Be Avoided and Managed? J Am Heart Assoc. 2019 09 17; 8(18):e013801. Scarsini R, De Maria GL, Joseph J . View in PubMed
• Women in Cardiology: The British Junior Cardiologists’ Association identifies challenges. Eur Heart J. 2019 01 14; 40(3):227-231.. View in PubMed
• CXCR2 Inhibition – a novel approach to treating CoronAry heart DiseAse (CICADA): study protocol for a randomised controlled trial. Trials. 2017 Oct 11; 18(1):473.. View in PubMed
• Young Investigators Prize finalists at the British Cardiovascular Society annual conference 2017. Heart. 2017 10; 103(20):1647-1649.. View in PubMed
• The big parade: emerging percutaneous mitral and tricuspid valve devices. EuroIntervention. 2017 Sep 24; 13(AA):AA51-AA59.. View in PubMed
• Guidelines in review: Comparison of ESC and ACC/AHA guidelines for the diagnosis and management of patients with stable coronary artery disease. J Nucl Cardiol. 2018 04; 25(2):509-515.. View in PubMed
• A Randomised tRial of Expedited transfer to a cardiac arrest centre for non-ST elevation ventricular fibrillation out-of-hospital cardiac arrest: The ARREST pilot randomised trial. Resuscitation. 2017 06; 115:185-191.. View in PubMed
• Timing of coronary angioplasty in patients with non-ST-segment elevation acute coronary syndromes. Eur Heart J Qual Care Clin Outcomes. 2017 01 01; 3(1):6-8.. View in PubMed
• Primary Angioplasty For Patients in Cardiogenic Shock: Optimal Management. Interv Cardiol. 2016 May; 11(1):39-43.. View in PubMed
• A prospective, double-blind, randomized controlled trial of the angiotensin-converting enzyme inhibitor Ramipril In Aortic Stenosis (RIAS trial). Eur Heart J Cardiovasc Imaging. 2015 Aug; 16(8):834-41.. View in PubMed
• Steerable sheath technology in the ablation of atrial fibrillation. Recent Pat Cardiovasc Drug Discov. 2013 Dec; 8(3):171-7.. View in PubMed
• Prioritizing echocardiography in Staphylococcus aureus bacteraemia. J Antimicrob Chemother. 2013 Feb; 68(2):444-9.. View in PubMed
• Maintenance of sinus rhythm with an ablation strategy in patients with atrial fibrillation is associated with a lower risk of stroke and death. Heart. 2012 Jan; 98(1):48-53.. View in PubMed

• Kloner, Robert
• Starnes, Vaughn
• Brown, David
• Peters, Anne
• Elkayam, Uri
• Berman, Darren