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Judith G. Villablanca, MD

Clinical Professor of Pediatrics (Part-Time)

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Phone +1 323 361 5687
Email jvillablanca@chla.usc.edu
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Publications

  • Lorlatinib with or without chemotherapy in ALK-driven refractory/relapsed neuroblastoma: phase 1 trial results Nat Med. 2023 05; 29(5):1092-1102. . View in PubMed
  • Expression of neuroblastoma-related genes in bone marrow at end of high-risk neuroblastoma therapy Pediatr Blood Cancer. 2022 09; 69(9):e29719. . View in PubMed
  • Early-phase clinical trial eligibility and response evaluation criteria for refractory, relapsed, or progressive neuroblastoma: A consensus statement from the National Cancer Institute Clinical Trials Planning Meeting Cancer. 2022 11 01; 128(21):3775-3783. . View in PubMed
  • A safety and feasibility trial of 131 I-MIBG in newly diagnosed high-risk neuroblastoma: A Children’s Oncology Group study Pediatr Blood Cancer. 2021 10; 68(10):e29117. . View in PubMed
  • Randomized Phase II Trial of MIBG Versus MIBG, Vincristine, and Irinotecan Versus MIBG and Vorinostat for Patients With Relapsed or Refractory Neuroblastoma: A Report From NANT Consortium J Clin Oncol. 2021 11 01; 39(31):3506-3514. . View in PubMed
  • A single-arm study of systemic and sub-Tenon chemotherapy for Groups C and D intraocular retinoblastoma: A Children’s Oncology Group study (ARET 0231) Pediatr Blood Cancer. 2020 09; 67(9):e28502. . View in PubMed
  • Premature epiphyseal growth plate arrest after isotretinoin therapy for high-risk neuroblastoma: A case series and review of the literature Pediatr Blood Cancer. 2020 08; 67(8):e28236. . View in PubMed
  • Role of the extent of prophylactic regional lymph node radiotherapy on survival in high-risk neuroblastoma: A report from the COG A3973 study Pediatr Blood Cancer. 2019 07; 66(7):e27736. . View in PubMed
  • Phase I study of vorinostat in combination with isotretinoin in patients with refractory/recurrent neuroblastoma: A new approaches to Neuroblastoma Therapy (NANT) trial Pediatr Blood Cancer. 2018 07; 65(7):e27023. . View in PubMed
  • Predictors of response, progression-free survival, and overall survival using NANT Response Criteria (v10) in relapsed and refractory high-risk neuroblastoma. Pediatr Blood Cancer. 2018 05; 65(5):e26940. . View in PubMed
  • Expression of Five Neuroblastoma Genes in Bone Marrow or Blood of Patients with Relapsed/Refractory Neuroblastoma Provides a New Biomarker for Disease and Prognosis Clin Cancer Res. 2017 Sep 15; 23(18):5374-5383. . View in PubMed
  • Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting J Clin Oncol. 2017 Aug 01; 35(22):2580-2587. . View in PubMed
  • A Phase I New Approaches to Neuroblastoma Therapy Study of Buthionine Sulfoximine and Melphalan With Autologous Stem Cells for Recurrent/Refractory High-Risk Neuroblastoma Pediatr Blood Cancer. 2016 08; 63(8):1349-56. . View in PubMed
  • Different outcomes for relapsed versus refractory neuroblastoma after therapy with (131)I-metaiodobenzylguanidine ((131)I-MIBG) Eur J Cancer. 2015 Nov; 51(16):2465-72. . View in PubMed
  • Pilot study of intravenous melphalan combined with continuous infusion L-S,R-buthionine sulfoximine for children with recurrent neuroblastoma Pediatr Blood Cancer. 2015 Oct; 62(10):1739-46. . View in PubMed
  • Phase I Study of Vorinostat as a Radiation Sensitizer with 131I-Metaiodobenzylguanidine (131I-MIBG) for Patients with Relapsed or Refractory Neuroblastoma Clin Cancer Res. 2015 Jun 15; 21(12):2715-21. . View in PubMed
  • 131I-metaiodobenzylguanidine with intensive chemotherapy and autologous stem cell transplantation for high-risk neuroblastomaA new approaches to neuroblastoma therapy (NANT) phase II study. Biol Blood Marrow Transplant. 2015 Apr; 21(4):673-81. . View in PubMed
  • Probable fatal drug interaction between intravenous fenretinide, ceftriaxone, and acetaminophen: a case report from a New Approaches to Neuroblastoma (NANT) Phase I study BMC Res Notes. 2014 Apr 23; 7:256. . View in PubMed
  • Phase I trial of fenretinide delivered orally in a novel organized lipid complex in patients with relapsed/refractory neuroblastoma: a report from the New Approaches to Neuroblastoma Therapy (NANT) consortium Pediatr Blood Cancer. 2013 Nov; 60(11):1801-8. . View in PubMed
  • Purged versus non-purged peripheral blood stem-cell transplantation for high-risk neuroblastoma (COG A3973): a randomised phase 3 trial Lancet Oncol. 2013 Sep; 14(10):999-1008. . View in PubMed
  • Semiquantitative mIBG scoring as a prognostic indicator in patients with stage 4 neuroblastoma: a report from the Children’s oncology group J Nucl Med. 2013 Apr; 54(4):541-8. . View in PubMed
  • Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma J Clin Oncol. 2012 Oct 01; 30(28):3525-32. . View in PubMed
  • Dose escalation study of no-carrier-added 131I-metaiodobenzylguanidine for relapsed or refractory neuroblastoma: new approaches to neuroblastoma therapy consortium trial J Nucl Med. 2012 Jul; 53(7):1155-63. . View in PubMed
  • Choroid plexus tumors; management, outcome, and association with the Li-Fraumeni syndrome: the Children’s Hospital Los Angeles (CHLA) experience, 1991-2010 Pediatr Blood Cancer. 2012 Jun; 58(6):905-9. . View in PubMed
  • Phase I study of vincristine, irinotecan, and ¹³¹I-metaiodobenzylguanidine for patients with relapsed or refractory neuroblastoma: a new approaches to neuroblastoma therapy trial Clin Cancer Res. 2012 May 01; 18(9):2679-86. . View in PubMed
  • The significance of serial histopathology in a residual mass for outcome of intermediate risk stage 3 neuroblastoma Pediatr Blood Cancer. 2012 May; 58(5):675-81. . View in PubMed
  • Phase II study of oral capsular 4-hydroxyphenylretinamide (4-HPR/fenretinide) in pediatric patients with refractory or recurrent neuroblastoma: a report from the Children’s Oncology Group Clin Cancer Res. 2011 Nov 01; 17(21):6858-66. . View in PubMed
  • Phase I trial of lestaurtinib for children with refractory neuroblastoma: a new approaches to neuroblastoma therapy consortium study Cancer Chemother Pharmacol. 2011 Oct; 68(4):1057-65. . View in PubMed
  • A phase I study of zoledronic acid and low-dose cyclophosphamide in recurrent/refractory neuroblastoma: a new approaches to neuroblastoma therapy (NANT) study Pediatr Blood Cancer. 2011 Aug; 57(2):275-82. . View in PubMed
  • Thyroid and hepatic function after high-dose 131 I-metaiodobenzylguanidine (131 I-MIBG) therapy for neuroblastoma Pediatr Blood Cancer. 2011 Feb; 56(2):191-201. . View in PubMed
  • Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma N Engl J Med. 2010 Sep 30; 363(14):1324-34. . View in PubMed
  • Treatment of primary CNS germinomatous germ cell tumors with chemotherapy prior to reduced dose whole ventricular and local boost irradiation Pediatr Blood Cancer. 2010 Jul 15; 55(1):42-6. . View in PubMed
  • Peripheral blood stem cell support for multiple cycles of dose intensive induction therapy is feasible with little risk of tumor contamination in advanced stage neuroblastoma: a report from the Childrens Oncology Group Pediatr Blood Cancer. 2010 Apr; 54(4):596-602. . View in PubMed
  • Comparison of iodine-123 metaiodobenzylguanidine (MIBG) scan and [18F]fluorodeoxyglucose positron emission tomography to evaluate response after iodine-131 MIBG therapy for relapsed neuroblastoma J Clin Oncol. 2009 Nov 10; 27(32):5343-9. . View in PubMed
  • Phase I trial of oral irinotecan and temozolomide for children with relapsed high-risk neuroblastoma: a new approach to neuroblastoma therapy consortium study J Clin Oncol. 2009 Mar 10; 27(8):1290-6. . View in PubMed
  • Iodine-131–metaiodobenzylguanidine double infusion with autologous stem-cell rescue for neuroblastoma: a new approaches to neuroblastoma therapy phase I study J Clin Oncol. 2009 Mar 01; 27(7):1020-5. . View in PubMed
  • Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a children’s oncology group study J Clin Oncol. 2009 Mar 01; 27(7):1007-13. . View in PubMed
  • Outcome of high-risk stage 3 neuroblastoma with myeloablative therapy and 13-cis-retinoic acid: a report from the Children’s Oncology Group Pediatr Blood Cancer. 2009 Jan; 52(1):44-50. . View in PubMed
  • Phase I trial of oral fenretinide in children with high-risk solid tumors: a report from the Children’s Oncology Group (CCG 09709) J Clin Oncol. 2006 Jul 20; 24(21):3423-30. . View in PubMed
  • Phase I dose escalation of iodine-131-metaiodobenzylguanidine with myeloablative chemotherapy and autologous stem-cell transplantation in refractory neuroblastoma: a new approaches to Neuroblastoma Therapy Consortium Study J Clin Oncol. 2006 Jan 20; 24(3):500-6. . View in PubMed
  • A Phase I study of concurrent RMP-7 and carboplatin with radiation therapy for children with newly diagnosed brainstem gliomas Cancer. 2005 Nov 01; 104(9):1968-74. . View in PubMed
  • Phase 1 study of concurrent RMP-7 and carboplatin with radiotherapy for children with newly diagnosed brainstem gliomas Cancer. 2005 Sep 15; 104(6):1281-7. . View in PubMed
  • Approaches to treatment for extraocular retinoblastoma: Children’s Hospital Los Angeles experience J Pediatr Hematol Oncol. 2004 Jan; 26(1):31-4. . View in PubMed
  • Retinoid therapy of high-risk neuroblastoma Cancer Lett. 2003 Jul 18; 197(1-2):185-92. . View in PubMed
  • Successful multimodality therapy of recurrent multifocal juvenile granulosa cell tumor of the ovary J Pediatr Hematol Oncol. 2002 Mar-Apr; 24(3):229-33. . View in PubMed
  • Long-term quality of life and neuropsychologic functioning for patients with CNS germ-cell tumors: from the First International CNS Germ-Cell Tumor Study Neuro Oncol. 2001 07; 3(3):174-83. . View in PubMed
  • Phase I topotecan preparative regimen for high-risk neuroblastoma, high-grade glioma, and refractory/recurrent pediatric solid tumors Med Pediatr Oncol. 2000 Dec; 35(6):719-23. . View in PubMed
  • Surveillance imaging in children with medulloblastoma (posterior fossa PNET) Pediatr Radiol. 2000 Jul; 30(7):447-50. . View in PubMed
  • Treatment of progressive or recurrent pediatric malignant supratentorial brain tumors with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration J Neurosurg. 2000 Feb; 92(2):249-54. . View in PubMed
  • Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acidChildren’s Cancer Group. N Engl J Med. 1999 Oct 14; 341(16):1165-73. . View in PubMed
  • Double-alkylator non-total-body irradiation regimen with autologous hematopoietic stem-cell transplantation in pediatric solid tumors J Clin Oncol. 1998 Mar; 16(3):937-44. . View in PubMed
  • A Phase I study of human gamma interferon gene-transduced tumor cells in patients with neuroblastoma Hum Gene Ther. 1998 Feb 10; 9(3):379-90. . View in PubMed
  • Chemotherapy plus local treatment in the management of intraocular retinoblastoma Arch Ophthalmol. 1996 Nov; 114(11):1348-56. . View in PubMed
  • Chemotherapy without irradiation–a novel approach for newly diagnosed CNS germ cell tumors: results of an international cooperative trialThe First International Central Nervous System Germ Cell Tumor Study. J Clin Oncol. 1996 Nov; 14(11):2908-15. . View in PubMed
  • Esthesioneuroblastoma in the pediatric age-group: the role of chemotherapy and autologous bone marrow transplantation Int J Pediatr Otorhinolaryngol. 1996 Sep; 37(1):45-52. . View in PubMed
  • Pharmacokinetic studies of 13-cis-retinoic acid in pediatric patients with neuroblastoma following bone marrow transplantation Cancer Chemother Pharmacol. 1996; 39(1-2):34-41. . View in PubMed
  • Phase I trial of 13-cis-retinoic acid in children with neuroblastoma following bone marrow transplantation J Clin Oncol. 1995 Apr; 13(4):894-901. . View in PubMed
  • Role of myeloablative therapy in improved outcome for high risk neuroblastoma: review of recent Children’s Cancer Group results Eur J Cancer. 1995; 31A(4):572-5. . View in PubMed
  • Bone abnormalities detected with skeletal scintigraphy after bone marrow harvest in patients with childhood neuroblastoma Radiology. 1994 Sep; 192(3):755-8. . View in PubMed
  • Gene therapy for the treatment of recurrent pediatric malignant astrocytomas with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system Hum Gene Ther. 1994 Jul; 5(7):863-90. . View in PubMed
  • Hypercalcemia: a dose-limiting toxicity associated with 13-cis-retinoic acid Am J Pediatr Hematol Oncol. 1993 Nov; 15(4):410-5. . View in PubMed
  • Viridans streptococcal shock in bone marrow transplantation patients Am J Hematol. 1993 Apr; 42(4):354-8. . View in PubMed
  • Escalating dose of continuous infusion combination chemotherapy for refractory neuroblastoma J Clin Oncol. 1993 Apr; 11(4):623-9. . View in PubMed
  • Intensive chemoradiotherapy and autologous bone marrow transplantation for poor prognosis neuroblastoma Prog Clin Biol Res. 1991; 366:527-33. . View in PubMed

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