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Julie Culver

Clinical Assistant Professor of Medicine (Clinician Edcuator)

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Phone +1 323 865 0806
Email jculver@med.usc.edu
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Overview

Julie Culver, MS, LCGC, CCRP is the Director of Genetic Counseling at the USC Norris Cancer Hospital and is a Clinical Instructor of Medicine in the USC Keck School of Medicine. She provides cancer genetic counseling for individuals and family at risk of having inherited cancer syndromes.
Her research pertains to genetic testing for hereditary cancer, medical decision-making following genetic testing, implementation of genetic testing, and participant engagement in genomics research. She has taught breast cancer risk assessment to health professionals and students since 2004.

Publications

  • Integrative multi-omics profiling of colorectal cancer from a Hispanic/Latino cohort of patients medRxiv. 2024 Nov 15. . View in PubMed
  • EPR24-111: The Clinical Effect of a Community-Based Genetic Testing ProgramJ Natl Compr Canc Netw. 2024 Apr 05; 22(2. 5). . View in PubMed
  • Systematic evidence review and meta-analysis of outcomes associated with cancer genetic counseling Genet Med. 2024 01; 26(1):100980. . View in PubMed
  • Integration of Universal Germline Genetic Testing for All New Breast Cancer Patients Ann Surg Oncol. 2023 Feb; 30(2):1017-1025. . View in PubMed
  • Clinical implications of conflicting variant interpretations in the cancer genetics clinic Genet Med. 2023 07; 25(7):100837. . View in PubMed
  • Clinical and laboratory genetic counselor attitudes on the reporting of variants of uncertain significance for multigene cancer panels J Genet Couns. 2023 06; 32(3):706-716. . View in PubMed
  • ASO Author Reflections: A Green Light for Genetic Testing in All Patients with Breast Cancer Ann Surg Oncol. 2023 02; 30(2):1026-1027. . View in PubMed
  • Transcriptome analysis provides critical answers to the “variants of uncertain significance” conundrum Hum Mutat. 2022 11; 43(11):1590-1608. . View in PubMed
  • Risk-reducing mastectomy decisions among women with mutations in high- and moderate- penetrance breast cancer susceptibility genes Mol Genet Genomic Med. 2022 10; 10(10):e2031. . View in PubMed
  • Psychosocial outcomes following germline multigene panel testing in an ethnically and economically diverse cohort of patients Cancer. 2021 04 15; 127(8):1275-1285. . View in PubMed
  • Inhibition of poly(ADP-ribose) polymerase induces synthetic lethality in BRIP1 deficient ovarian epithelial cells Gynecol Oncol. 2020 12; 159(3):869-876. . View in PubMed
  • Ovarian and Breast Cancer Risks Associated With Pathogenic Variants in RAD51C and RAD51D J Natl Cancer Inst. 2020 12 14; 112(12):1242-1250. . View in PubMed
  • Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 Families J Clin Oncol. 2020 03 01; 38(7):674-685. . View in PubMed
  • Multicenter Prospective Cohort Study of the Diagnostic Yield and Patient Experience of Multiplex Gene Panel Testing For Hereditary Cancer Risk JCO Precis Oncol. 2019 Mar; 3. . View in PubMed
  • Patient communication of cancer genetic test results in a diverse population Transl Behav Med. 2018 01 29; 8(1):85-94. . View in PubMed
  • Clinical testing of BRCA1 and BRCA2: a worldwide snapshot of technological practices NPJ Genom Med. 2018; 3:7. . View in PubMed
  • Prospective Study of Cancer Genetic Variants: Variation in Rate of Reclassification by Ancestry J Natl Cancer Inst. 2018 10 01; 110(10):1059-1066. . View in PubMed
  • Unexpected CDH1 Mutations Identified on Multigene Panels Pose Clinical Management Challenges JCO Precis Oncol. 2017 Nov; 1:1-12. . View in PubMed
  • Increased yield of actionable mutations using multi-gene panels to assess hereditary cancer susceptibility in an ethnically diverse clinical cohort Cancer Genet. 2016 Apr; 209(4):130-7. . View in PubMed
  • A novel BAP1 mutation is associated with melanocytic neoplasms and thyroid cancer Cancer Genet. 2016 Mar; 209(3):75-81. . View in PubMed
  • Next-Generation Testing for Cancer Risk: Perceptions, Experiences, and Needs Among Early Adopters in Community Healthcare Settings Genet Test Mol Biomarkers. 2015 Dec; 19(12):657-65. . View in PubMed
  • Variants of uncertain significance in BRCA testing: evaluation of surgical decisions, risk perception, and cancer distress Clin Genet. 2013 Nov; 84(5):464-72. . View in PubMed
  • Tumor protein p53 (TP53) testing and Li-Fraumeni syndrome : current status of clinical applications and future directions Mol Diagn Ther. 2013 Feb; 17(1):31-47. . View in PubMed
  • Closing the loop: action research in a multimodal hereditary cancer patient conference is an effective tool to assess and address patient needs J Cancer Educ. 2012 Jun; 27(3):467-77. . View in PubMed
  • Essential elements of genetic cancer risk assessment, counseling, and testing: updated recommendations of the National Society of Genetic Counselors J Genet Couns. 2012 Apr; 21(2):151-61. . View in PubMed
  • Personalized cancer genetics training for personalized medicine: improving community-based healthcare through a genetically literate workforce Genet Med. 2011 Sep; 13(9):832-40. . View in PubMed
  • Genetics, genomics, and cancer risk assessment: State of the Art and Future Directions in the Era of Personalized Medicine CA Cancer J Clin. 2011 Sep-Oct; 61(5):327-59. . View in PubMed
  • Development and evaluation of a decision aid for BRCA carriers with breast cancer J Genet Couns. 2011 Jun; 20(3):294-307. . View in PubMed
  • Health literacy, numeracy, and interpretation of graphical breast cancer risk estimates Patient Educ Couns. 2011 Apr; 83(1):92-8. . View in PubMed
  • Recurrence and variability of germline EPCAM deletions in Lynch syndrome Hum Mutat. 2011 Apr; 32(4):407-14. . View in PubMed
  • Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study Lancet Oncol. 2011 Jan; 12(1):49-55. . View in PubMed
  • Breast cancer risk communication: assessment of primary care physicians by standardized patients Genet Med. 2009 Oct; 11(10):735-41. . View in PubMed
  • Genetic assessment of breast cancer risk in primary care practice Am J Med Genet A. 2009 Mar; 149A(3):349-56. . View in PubMed
  • Limited family structure and BRCA gene mutation status in single cases of breast cancer JAMA. 2007 Jun 20; 297(23):2587-95. . View in PubMed
  • Results of a randomized study of telephone versus in-person breast cancer risk counseling Patient Educ Couns. 2006 Dec; 64(1-3):96-103. . View in PubMed
  • Assessing breast cancer risk and BRCA1/2 carrier probability Breast Dis. 2006-2007; 27:5-20. . View in PubMed
  • Effects of counseling Ashkenazi Jewish women about breast cancer risk Cultur Divers Ethnic Minor Psychol. 2006 Jan; 12(1):45-56. . View in PubMed
  • Genetic cancer risk assessment and counseling: recommendations of the national society of genetic counselors J Genet Couns. 2004 Apr; 13(2):83-114. . View in PubMed
  • Oncologists’ opinions on genetic testing for breast and ovarian cancer Genet Med. 2001 Mar-Apr; 3(2):120-5. . View in PubMed
  • Genetic counseling for women with an intermediate family history of breast cancer Am J Med Genet. 2000 Feb 28; 90(5):361-8. . View in PubMed

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