Keck School Faculty

Karen Ting Chang

Karen Ting Chang

Associate Professor of Physiology and Neuroscience
ZNI 219, 1501 San Pablo Street Health Sciences Campus Los Angeles

DSCR1 upregulation enhances dural meningeal lymphatic drainage to attenuate amyloid pathology of Alzheimer's disease J Pathol. 2021 11; 255(3):296-310. . View in PubMed

Minibrain kinase and calcineurin coordinate activity-dependent bulk endocytosis through synaptojanin J Cell Biol. 2021; 12(220):e202011028. . View in PubMed

Minibrain kinase and calcineurin coordinate activity-dependent bulk endocytosis through synaptojanin J Cell Biol. 2021 12 06; 220(12). . View in PubMed

DSCR1-mediated TET1 splicing regulates miR-124 expression to control adult hippocampal neurogenesis EMBO J. 2019; 14(38):e101293. . View in PubMed

Activity-Induced Synaptic Structural Modifications by an Activator of Integrin Signaling at the Drosophila Neuromuscular Junction J Neurosci. 2017 03 22; 37(12):3246-3263. . View in PubMed

Maintenance of Stem Cell Niche Integrity by a Novel Activator of Integrin Signaling PLoS Genet. 2016 05; 12(5):e1006043. . View in PubMed

Phosphorylation of Synaptojanin Differentially Regulates Endocytosis of Functionally Distinct Synaptic Vesicle Pools J Neurosci. 2016 08 24; 36(34):8882-94. . View in PubMed

Dynamics of Mitochondrial Transport in Axons Front Cell Neurosci. 2016; 10:123. . View in PubMed

DSCR1 is required for both axonal growth cone extension and steering J Cell Biol. 2016 05 23; 213(4):451-62. . View in PubMed

Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down Syndrome J Neurosci. 2015 Aug 12; 35(32):11374-83. . View in PubMed

Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase Nat Commun. 2014 Jun 30; 5:4246. . View in PubMed

Meeting at the crossroads: common mechanisms in Fragile X and Down syndrome Trends Neurosci. 2013 Dec; 36(12):685-94. . View in PubMed

Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons Front Cell Neurosci. 2013 Sep 10; 7:148. . View in PubMed

Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3? signaling. PLoS Genet. 2013; 9(9):e1003792.. View in PubMed

DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis EMBO J. 2012 Sep 12; 31(18):3655-66. . View in PubMed

Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15456-61. . View in PubMed

Progress in molecular biology and translational scienceAnimal models of human disease. Preface. Prog Mol Biol Transl Sci. 2011; 100:xv. . View in PubMed

Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome Proc Natl Acad Sci U S A. 2009 Oct 06; 106(40):17117-22. . View in PubMed

Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila Proc Natl Acad Sci U S A. 2008 Jun 24; 105(25):8673-8. . View in PubMed

Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function Nat Neurosci. 2005 Nov; 8(11):1577-85. . View in PubMed

The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15794-9. . View in PubMed

Nicotinic regulation of CREB activation in hippocampal neurons by glutamatergic and nonglutamatergic pathways Mol Cell Neurosci. 2002 Dec; 21(4):616-25. . View in PubMed

Regulation of lifespan by histone deacetylase Ageing Res Rev. 2002 Jun; 1(3):313-26. . View in PubMed

Voltage-gated channels block nicotinic regulation of CREB phosphorylation and gene expression in neurons Neuron. 2001 Dec 06; 32(5):855-65. . View in PubMed

Synaptically driven calcium transients via nicotinic receptors on somatic spines J Neurosci. 2001 Feb 01; 21(3):771-81. . View in PubMed

Nicotinic acetylcholine receptors containing alpha7 subunits are required for reliable synaptic transmission in situ J Neurosci. 1999 May 15; 19(10):3701-10. . View in PubMed

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