Katherine Matho

How do developmental and genetic programs build brain circuits for complex behavior? My lab investigates this question by integrating developmental neuroscience, molecular genetics, and multi-scale circuit mapping to study cortical sensorimotor circuits underlying goal-directed actions and perception. Using interdisciplinary approaches, such as gene knockin mouse lines and single cell profiling, we examine how neuronal identity and connectivity emerge during development. Our goal is to uncover the molecular and developmental logic of circuit assembly in neurotypical development and how the key building blocks that make up the circuits—cell types—are disrupted in neurodevelopmental disorders. We hypothesize that a temporal patterning program during pregnancy specifies neuron subtype and wiring, shaping sensorimotor function in the mature brain.

• Union College, Schenectady, NY — BS — 06/2007 — Biology (Poli Sci & Chem minors)
• Sorbonne Université, Paris, France — PhD — 09/2013 — Neuroscience

• sensorimotor processing
• genetically specified neuron populations
• lineage tracing
• circuit mapping
• input-output connectivity

• Thompson, Paul
• Toga, Arthur
• Levitt, Pat
• Peterson, Bradley
• Jahanshad, Neda
• Finch, Caleb