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Keane K.Y. Lai, MD

Associate Professor Of Clinical Pathology

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Email [email protected]
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Awards

  • American Cancer Society IRG
  • Wright Foundation
  • STOP CANCER
  • NIH

Publications

  • Heterozygous midnolin knockout attenuates severity of nonalcoholic fatty liver disease in mice fed a Western-style diet high in fat, cholesterol, and fructose. Am J Physiol Gastrointest Liver Physiol. 2023 08 01; 325(2):G147-G157.. View in PubMed
  • Midnolin Regulates Liver Cancer Cell Growth In Vitro and In Vivo. Cancers (Basel). 2022 Mar 10; 14(6).. View in PubMed
  • Thioacetamide-Induced Norepinephrine Production by Hepatocytes is Associated with Hepatic Stellate Cell Activation and Liver Fibrosis. Curr Mol Pharmacol. 2022; 15(2):454-461.. View in PubMed
  • Magnetic resonance imaging for characterization of hepatocellular carcinoma metabolism. Front Physiol. 2022; 13:1056511.. View in PubMed
  • Differential Kat3 Usage Orchestrates the Integration of Cellular Metabolism with Differentiation. Cancers (Basel). 2021 Nov 23; 13(23).. View in PubMed
  • p300 Serine 89: A Critical Signaling Integrator and Its Effects on Intestinal Homeostasis and Repair. Cancers (Basel). 2021 Mar 14; 13(6).. View in PubMed
  • Pharmacologically Targeting the WNT/β-Catenin Signaling Cascade: Avoiding the Sword of Damocles. Handb Exp Pharmacol. 2021; 269:383-422.. View in PubMed
  • In Memoriam: David Bruce Endres, PhD, DABCC (1945-2021). J Appl Lab Med. 2021; 6(4):1097-1098.
  • Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells. Cancers (Basel). 2020 Jun 05; 12(6).. View in PubMed
  • Moderate alcohol intake promotes pancreatic ductal adenocarcinoma development in mice expressing oncogenic Kras. Am J Physiol Gastrointest Liver Physiol. 2020 02 01; 318(2):G265-G276.. View in PubMed
  • HBV X protein mutations affect HBV transcription and association of histone-modifying enzymes with covalently closed circular DNA. Sci Rep. 2020 01 21; 10(1):802.. View in PubMed
  • Targeted genomic profiling identifies frequent deleterious mutations in FAT4 and TP53 genes in HBV-associated hepatocellular carcinoma. BMC Cancer. 2019 Aug 08; 19(1):789.. View in PubMed
  • The Mode of Stem Cell Division Is Dependent on the Differential Interaction of β-Catenin with the Kat3 Coactivators CBP or p300. Cancers (Basel). 2019 Jul 09; 11(7).. View in PubMed
  • Animal Models: Challenges and Opportunities to Determine Optimal Experimental Models of Pancreatitis and Pancreatic Cancer. Pancreas. 2019 07; 48(6):759-779.. View in PubMed
  • Convergence of Canonical and Non-Canonical Wnt Signal: Differential Kat3 Coactivator Usage. Curr Mol Pharmacol. 2019; 12(3):167-183.. View in PubMed
  • Differentiation Therapy Targeting the β-Catenin/CBP Interaction in Pancreatic Cancer. Cancers (Basel). 2018 Mar 29; 10(4).. View in PubMed
  • Nuclear receptor/Wnt beta-catenin interactions are regulated via differential CBP/p300 coactivator usage. PLoS One. 2018; 13(7):e0200714.. View in PubMed
  • Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6. Gastroenterology. 2017 05; 152(6):1477-1491.. View in PubMed
  • Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1. PLoS One. 2017; 12(8):e0181052.. View in PubMed
  • Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-γ in Activation of Hepatic Stellate Cells. PLoS One. 2016; 11(5):e0156111.. View in PubMed
  • Simultaneous detection of 19 drugs of abuse on dried urine spot by liquid chromatography-tandem mass spectrometry. Clin Biochem. 2013 Aug; 46(12):1118-1124.. View in PubMed
  • Endogenous Antibody Interferences in Immunoassays. Lab Med. 2013; 44(1):69-73.
  • Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. J Hepatol. 2011 Sep; 55(3):673-682.. View in PubMed
  • Improved reflexive testing algorithm for hepatitis C infection using signal-to-cutoff ratios of a hepatitis C virus antibody assay. Clin Chem. 2011 Jul; 57(7):1050-6.. View in PubMed
  • Extracellular matrix dynamics in hepatocarcinogenesis: a comparative proteomics study of PDGFC transgenic and Pten null mouse models. PLoS Genet. 2011 Jun; 7(6):e1002147.. View in PubMed
  • Comprehensive and quantitative proteome profiling of the mouse liver and plasma. Hepatology. 2008 Mar; 47(3):1043-51.. View in PubMed
  • Productive replication of hepatitis C virus in perihepatic lymph nodes in vivo: implications of HCV lymphotropism. Gastroenterology. 2006 Apr; 130(4):1107-16.. View in PubMed
  • Calibration curves for real-time PCR. Clin Chem. 2005 Jul; 51(7):1132-6.. View in PubMed
  • Evaluation of real-time PCR versus PCR with liquid-phase hybridization for detection of enterovirus RNA in cerebrospinal fluid. J Clin Microbiol. 2003 Jul; 41(7):3133-41.. View in PubMed
  • Sir Patrick Manson: good medicine for the people of Hong Kong. Hong Kong Med J. 2003 Apr; 9(2):145-7.. View in PubMed
  • Tc-99m hexamethylpropylene amine oxime scintigraphy in the diagnosis of brain death and its implications for the harvesting of organs used for transplantation. Clin Nucl Med. 2000 Jan; 25(1):7-10.. View in PubMed
  • I-131 orthoiodohippurate assessment of renal function after heart transplantation. Clin Nucl Med. 1999 Feb; 24(2):117-9.. View in PubMed

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