Kelly N Street, PhD

Assistant Professor of Population and Public Health Sciences

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Overview

Kelly Street is an Assistant Professor of Population and Public Health Sciences in the Division of Biostatistics at the Keck School of Medicine of USC. His research interests include the development and evaluation of computational methods for high-dimensional genomic data. Much of his work has focused on applications in single-cell RNA sequencing, particularly for the analysis of continuous differentiation trajectories. He also has experience working with data on chromatin structure (ATAC-seq), DNA methylation (WGBS), mass cytometry (CyTOF, IMC), and immune repertoire (TCR-seq). He is currently interested in multi-omic integration, the problem of combining information from different genomic assays to reveal novel relationships between biological systems.

Education and Training

  • University of California, Berkeley, Berkeley, CA — Ph.D. — 12/2018 — Biostatistics
  • University of California, Berkeley, Berkeley, CA — MA — 05/2014 — Biostatistics
  • University of Chicago, Chicago, IL — BS — 06/2012 — Mathematics

Research Keywords

  • Genomics
  • Data Science
  • Statistical Computing

Publications

  • Patterning human kidney organoids with synthetic Wnt-secreting organizers. Science. 2026 Jul 02; 393(6806):eadu9122.. View in PubMed
  • Annotation-Based Gene-Peak Links Improve Regulatory Network Prediction of Gene Expression in Human Kidney Multi-Omics. bioRxiv. 2026 Jun 17.. View in PubMed
  • Neutrophil Transcriptomic Changes in Severe Sterile Vasoplegic Syndrome Resemble a Distinct Molecular Subtype of Septic Shock. Shock. 2026 May 01; 65(5):801-811.. View in PubMed
  • Blunt trauma induces a proinvasive transcriptional program in isolated circulating human neutrophils. J Trauma Acute Care Surg. 2026 Apr 01; 100(4):571-579.. View in PubMed
  • A latent activated olfactory stem cell state revealed by single-cell transcriptomic and epigenomic profiling. Stem Cell Reports. 2026 02 10; 21(2):102778.. View in PubMed
  • Single-Cell Multiomic Profiling Uncovers Radiation Dosage-Sensitive, Cluster-Specific Regulatory Dynamics in Glioblastoma. bioRxiv. 2025 Dec 03.. View in PubMed
  • Epigenetic conservation infers that colorectal cancer progenitors retain the phenotypic plasticity of normal colon. Sci Rep. 2025 Nov 20; 15(1):40941.. View in PubMed
  • Presence of Tertiary Lymphoid Structures and Exhausted Tissue-Resident T Cells Determines Clinical Response to PD-1 Blockade in Renal Cell Carcinoma. Cancer Discov. 2025 May 02; 15(5):948-968.. View in PubMed
  • Attenuated kidney oxidative metabolism in young adults with type 1 diabetes. J Clin Invest. 2024 10 22; 134(24).. View in PubMed
  • A review of single-cell transcriptomics and epigenomics studies in maternal and child health. Epigenomics. 2024; 16(10):775-793.. View in PubMed