Laurie D. De Leve, MD, PhD

Professor of Medicine

Vice Chair for Scientific Affairs, DOM

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Overview

Dr. DeLeve’s clinical interests include general gastroenterology, colon cancer screening, irritable bowel syndrome, drug-induced liver disease. Her research interests include the role of liver sinusoidal endothelial cell in liver injury recovery and liver fibrosis and drug-induced liver injury.

Born in New York City and raised in the Netherlands, Dr. DeLeve obtained a PhD in Pharmacology from the University of Toronto after receiving her medical degree from the Erasmus University of Rotterdam. Following her residency at the University of Michigan and fellowship at UCLA, Dr. DeLeve joined the Keck School of Medicine as an Assistant Professor in 1990.

Awards

  • Alpha Omega Alpha: Teaching Award, 2005
  • Western Society for Clinical Investigation: Outstanding Investigator Award, 2008
  • USC: Mellon Mentoring Award for Faculty Mentoring Faculty, 2015

Research Funding

  • Liver Sinusoidal Endothelial Cell Progenitor Cells (sprocs) and Chronic Liver Disease
    NIH · R01DK100580 · Aug 1, 2014 – Dec 31, 2024 · Role: Principal Investigator
  • Determinants of Sinusoidal Endothelial Cell Phenotype.
    NIH · R01DK066423 · Aug 15, 2003 – Jun 30, 2012 · Role: Principal Investigator
  • Liver Sinusoidal Endothelial Cell Progenitor Cells.
    NIH · R01DK046357 · Jan 1, 1994 – Mar 31, 2019 · Role: Principal Investigator
  • MECHANISMS OF TOXICITY IN SINUSOIDAL ENDOTHELIAL CELLS
    NIH · R29DK046357 · Jan 1, 1994 – Dec 31, 1998 · Role: Principal Investigator

Publications

  • Reversing liver sinusoidal endothelial aging restores clearance of amyloid-beta and LDL. J Biol Chem. 2026 Sep 26; 113608.. View in PubMed
  • Susceptibility of Rat Steatotic Liver to Ischemia-Reperfusion Is Treatable With Liver-Selective Matrix Metalloproteinase Inhibition. Hepatology. 2020 11; 72(5):1771-1785.. View in PubMed
  • Determination of fasiglifam-induced liver toxicity: Insights from the data monitoring committee of the fasiglifam clinical trials program. Clin Trials. 2019 06; 16(3):253-262.. View in PubMed
  • Sinusoids as Drivers of Liver Development: More Than Simple Chemistry. Hepatology. 2019 08; 70(2):737-739.. View in PubMed
  • Incomplete Differentiation of Engrafted Bone Marrow Endothelial Progenitor Cells Initiates Hepatic Fibrosis in the Rat. Hepatology. 2019 03; 69(3):1259-1272.. View in PubMed
  • Liver Complications Following Treatment of Hematologic Malignancy With Anti-CD22-Calicheamicin (Inotuzumab Ozogamicin). Hepatology. 2019 02; 69(2):831-844.. View in PubMed
  • Liver-Selective MMP-9 Inhibition in the Rat Eliminates Ischemia-Reperfusion Injury and Accelerates Liver Regeneration. Hepatology. 2019 01; 69(1):314-328.. View in PubMed
  • Liver Sinusoidal Endothelial Cell: An Update. Semin Liver Dis. 2017 11; 37(4):377-387.. View in PubMed
  • VEGF-sdf1 recruitment of CXCR7+ bone marrow progenitors of liver sinusoidal endothelial cells promotes rat liver regeneration. Am J Physiol Gastrointest Liver Physiol. 2016 05 01; 310(9):G739-46.. View in PubMed
  • Liver sinusoidal endothelial cells in hepatic fibrosis. Hepatology. 2015 May; 61(5):1740-6.. View in PubMed