Leonardo Morsut

Morsut Lab Website

• Derivation of cardiomyocyte-propelled motile aggregates from stem cells. bioRxiv. 2025 Jul 09.. View in PubMed
• Programming the elongation of mammalian cell aggregates with synthetic gene circuits. bioRxiv. 2024 Dec 11.. View in PubMed
• Control of spatio-temporal patterning via cell growth in a multicellular synthetic gene circuit. Nat Commun. 2024 11 19; 15(1):9867.. View in PubMed
• Author Correction: Engineering programmable material-to-cell pathways via synthetic notch receptors to spatially control differentiation in multicellular constructs. Nat Commun. 2024 Aug 01; 15(1):6490.. View in PubMed
• Engineering programmable material-to-cell pathways via synthetic notch receptors to spatially control differentiation in multicellular constructs. Nat Commun. 2024 Jul 13; 15(1):5891.. View in PubMed
• Parsing patterns: Emerging roles of tissue self-organization in health and disease. Cell. 2024 Jun 20; 187(13):3165-3186.. View in PubMed
• Programming Juxtacrine-Based Synthetic Signaling Networks in a Cellular Potts Framework. Methods Mol Biol. 2024; 2760:283-307.. View in PubMed
• Engineering Programmable Material-To-Cell Pathways Via Synthetic Notch Receptors To Spatially Control Cellular Phenotypes In Multi-Cellular Constructs. bioRxiv. 2023 May 20.. View in PubMed
• The sound of silence: Transgene silencing in mammalian cell engineering. Cell Syst. 2022 12 21; 13(12):950-973.. View in PubMed
• Parameterized Computational Framework for the Description and Design of Genetic Circuits of Morphogenesis Based on Contact-Dependent Signaling and Changes in Cell-Cell Adhesion. ACS Synth Biol. 2022 04 15; 11(4):1417-1439.. View in PubMed
• The living interface between synthetic biology and biomaterial design. Nat Mater. 2022 04; 21(4):390-397.. View in PubMed
• The evolution of synthetic receptor systems. Nat Chem Biol. 2022 03; 18(3):244-255.. View in PubMed
• Novel synthetic biology approaches for developmental systems. Stem Cell Reports. 2021 05 11; 16(5):1051-1064.. View in PubMed
• How Has the COVID-19 Pandemic Changed How You Will Approach Research and Lab Work in the Future? Cell Syst. 2020 12 16; 11(6):550-554.. View in PubMed
• Synthetic development: building mammalian multicellular structures with artificial genetic programs. Curr Opin Biotechnol. 2019 10; 59:130-140.. View in PubMed
• Simple Rules Determine Distinct Patterns of Branching Morphogenesis. Cell Syst. 2019 09 25; 9(3):221-227.. View in PubMed
• Guiding human development in a dish. Nat Methods. 2019 07; 16(7):585-586.. View in PubMed
• Tissue Patterning: The Winner Takes It All, the Losers Standing Small. Curr Biol. 2019 05 06; 29(9):R334-R337.. View in PubMed
• Programming self-organizing multicellular structures with synthetic cell-cell signaling. Science. 2018 07 13; 361(6398):156-162.. View in PubMed
• Engineering multicellular systems: using synthetic biology to control tissue self-organization. Curr Opin Biomed Eng. 2017 Dec; 4:163-173.. View in PubMed
• Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell. 2016 Oct 06; 167(2):419-432.e16.. View in PubMed
• Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors. Cell. 2016 Feb 11; 164(4):780-91.. View in PubMed
• Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits. Cell. 2016 Feb 11; 164(4):770-9.. View in PubMed
• CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell. 2013 Jul 18; 154(2):442-51.. View in PubMed
• USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat Cell Biol. 2011 Sep 25; 13(11):1368-75.. View in PubMed
• Role of YAP/TAZ in mechanotransduction. Nature. 2011 Jun 08; 474(7350):179-83.. View in PubMed
• Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo. Development. 2010 Aug 01; 137(15):2571-8.. View in PubMed
• FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell. 2009 Jan 09; 136(1):123-35.. View in PubMed
• MicroRNA control of Nodal signalling. Nature. 2007 Sep 13; 449(7159):183-8.. View in PubMed
• Microvascular patterns in human medullary tegmentum at the level of the area postrema. J Anat. 2005 Apr; 206(4):405-10.. View in PubMed

• McMahon, Andrew
• Chuong, Cheng-Ming
• Chai, Yang
• Crump, Gage
• Murry, Charles