Lidia Minguez Alarcon

Dr. Mínguez-Alarcón is a Spanish epidemiologist and her research focuses on identifying chemical and non-chemical stressors of human fertility, reproductive and cardiometabolic health with special interest in chemical mixtures, diet-chemical interactions and paternal contributions to pregnancy outcomes. She is an Associate Professor at USC Keck School of Medicine in the Department of Population and Public Health Sciences (Division of Environmental Health) and a Department Associate at the Harvard TH Chan School of Public Health. Prior to join USC, Dr. Mínguez-Alarcón was an Assistant Professor at the Harvard Medical School/Brigham and Women’s Hospital in Boston. Results from her work have been used by national and international agencies (e.g. European Food Safety Authority). Dr. Mínguez-Alarcón is the founding PI of the NIH Longitudinal Investigation of Health and Diseases after Infertility (LIHDI) Study, which is prospectively exploring chemical exposures during reproductive years in relation to long-term cardiovascular and metabolic health. She is also the PI of other NIH projects examining paternal pesticide exposure and sperm/leukocyte epigenome in relation to couple’s pregnancy outcomes as well as phthalate-diet interactions on reproductive health outcomes. She brings her expertise to Environmental Research as an Executive Editor and the Reproductive, Perinatal and Pediatric Health (RPPH) NIH study section as a Grant Reviewer.

• University of Murcia — PhD
• University of Murcia — MPH
• University of Valencia — BPharm

• Phthalate exposure, diet effect modification and human reproductive health
  NIH · R01ES038742 · Aug 25, 2026 – Aug 24, 2030 · Role: Principal Investigator
• Pediatric HIV/AIDS Cohort Study (PHACS): Research on Immune Aging, Sexual and Reproductive Health, and Perinatal Acquisition: Elucidating Relationships in HIV (RISE)
  NIH · U19HD119901 · Sep 12, 2025 – Aug 31, 2030 · Role: Co-Investigator
• Male pesticide exposure, reproductive health and epigenetics
  NIH · R01ES034700 · Aug 1, 2023 – May 31, 2028 · Role: Principal Investigator
• Exposure to phthalates and OP flame retardants and long-term maternal cardiovascular and metabolic health
  NIH · R01ES033651 · Jul 5, 2022 – Apr 30, 2027 · Role: Co-Principal Investigator

• Hair Mercury Levels, Serum n-3 Fatty Acids, and Pregnancy Glucose Outcomes Among Women From a Fertility Center. J Clin Endocrinol Metab. 2026 Apr 22; 111(5):e1427-e1434.. View in PubMed
• Associations Between Perceived Stress and Sperm DNA Methylation Among Men Attending a Fertility Center. Andrology. 2026 Apr 21.. View in PubMed
• Diet, lifestyle factors, and human fertility: what we know, what we wish we knew, and what we may never know. Fertil Steril. 2026 Jun; 125(6):947-962.. View in PubMed
• Environmental Chemicals as Modifiers of the Association between Age and Ovarian Reserve. medRxiv. 2025 Dec 11.. View in PubMed
• Maternal and paternal smoking and offspring antral follicle count in women from an infertility clinic. Int J Hyg Environ Health. 2026 Mar; 272:114719.. View in PubMed
• Hair Mercury, Serum ?-3 Fatty Acids, and Menstrual Symptoms among Women Seeking Fertility Care. J Nutr. 2026 Jan; 156(1):101253.. View in PubMed
• Male urinary phthalate metabolite concentrations and serum metabolic signatures in relation to live birth among couples undergoing in vitro fertilization. Sci Total Environ. 2025 Dec 15; 1008:181007.. View in PubMed
• Preconception Hair Mercury and Serum Omega-3 Fatty Acids in Relation to Gestational Weight Gain Among Women Seeking Fertility Care. Toxics. 2025 Nov 06; 13(11).. View in PubMed
• Male partner pesticide residue exposure from fruit and vegetable intake in relation to outcomes of infertility treatment: a prospective cohort study. Am J Clin Nutr. 2025 Dec; 122(6):1701-1712.. View in PubMed
• Maternal Intake of Sugar- and Artificially Sweetened Beverages and Outcomes of Assisted Reproduction: A Prospective Cohort Study. BJOG. 2026 Jan; 133(2):302-310.. View in PubMed
• Urinary phthalates, serum omega-3 fatty acids and ovarian reserve among women seeking fertility treatment. Int J Hyg Environ Health. 2025 Aug; 269:114642.. View in PubMed
• Editorial: Environmental risk factors in noncommunicable diseases: new insights into the molecular mechanisms. Front Public Health. 2025; 13:1632200.. View in PubMed
• Phenol biomarker concentrations in human ovarian follicular fluid and the associations with in-vitro fertilization outcomes. Int J Hyg Environ Health. 2025 Jul; 268:114617.. View in PubMed
• Preconception thyroid function in relation to pregnancy lipids among women attending a fertility center. Thyroid Res. 2025 Jul 01; 18(1):32.. View in PubMed
• Pregnancy urinary phenol biomarker concentrations in relation to serum levels of inflammatory cytokines: Results from the EARTH study. Environ Int. 2025 Aug; 202:109652.. View in PubMed
• Effect Modification of Serum Omega-3 Fatty Acids on the Associations between Urinary Phthalate Biomarkers Mixture and Pregnancy Outcomes among Women Seeking Fertility Care. Environ Health Perspect. 2025 Jun; 133(6):67005.. View in PubMed
• Using mixture and exposome methods to assess the associations and interactions of chemical biomarkers with semen parameters. Environ Int. 2025 Jul; 201:109568.. View in PubMed
• Association of urinary phthalate metabolite concentrations with inflammatory biomarker levels among pregnant women. Environ Res. 2025 Aug 15; 279(Pt 2):121911.. View in PubMed
• Environment and Reproduction. Semin Reprod Med. 2024 Dec; 42(4):251-252.. View in PubMed
• Perceived stress in relation to testicular function markers among men attending a fertility center. Fertil Steril. 2025 Jul; 124(1):62-70.. View in PubMed
• Antioxidant Intake and Ovarian Reserve in Women Attending a Fertility Center. Nutrients. 2025 Jan 31; 17(3).. View in PubMed
• Association of Glycemic Index, Glycemic Load, and Carbohydrate Intake with Antral Follicle Counts Among Subfertile Females. Nutrients. 2025 Jan 21; 17(3).. View in PubMed
• Lifting of travel restrictions brings additional noise in COVID-19 surveillance through wastewater-based epidemiology in post-pandemic period. Water Res. 2025 Apr 15; 274:123114.. View in PubMed
• Associations of Pesticide Residue Exposure from Fruit and Vegetable Intake with Ovarian Reserve. J Nutr. 2025 Mar; 155(3):957-967.. View in PubMed
• Associations of gestation length and offspring birthweight for gestational age with menopausal symptoms and age of natural menopause at midlife among women enrolled in a prebirth longitudinal cohort. Menopause. 2025 Apr 01; 32(4):323-330.. View in PubMed
• The association of men’s beverage intake with semen quality and assisted reproduction outcomes in patients undergoing fertility treatment. Andrology. 2025 Mar; 13(3):473-484.. View in PubMed
• Associations of maternal and paternal preconception and maternal pregnancy urinary phthalate biomarker and bisphenol A concentrations with offspring autistic behaviors: The PEACE study. Environ Res. 2024 Dec 15; 263(Pt 3):120253.. View in PubMed
• Urinary concentrations of phthalate and phthalate alternative metabolites and sperm DNA methylation: A multi-cohort and meta-analysis of men in preconception studies. Environ Int. 2024 Oct; 192:109049.. View in PubMed
• Pregnancy complications and birth outcomes following low-level exposure to per- and polyfluoroalkyl substances in the vitamin D antenatal asthma reduction trial. Env Sci Adv. 2024 Oct 02; 3(10):1426-1437.. View in PubMed
• Mixtures of Urinary Phenol and Phthalate Metabolite Concentrations in Relation to Serum Lipid Levels among Pregnant Women: Results from the EARTH Study. Toxics. 2024 Aug 07; 12(8).. View in PubMed
• BMI status and weight trajectories across females’ reproductive years and risk of adverse pregnancy outcomes: a prospective cohort study. Am J Clin Nutr. 2024 Jul; 120(1):225-231.. View in PubMed
• The associations between pre-conception urinary phthalate concentrations, the serum metabolome, and live birth among women undergoing assisted reproduction. Environ Res. 2024 Jul 01; 252(Pt 4):119149.. View in PubMed
• Urinary benzophenone-3 concentrations and ovarian reserve in a cohort of subfertile women. Fertil Steril. 2024 Sep; 122(3):494-503.. View in PubMed
• Associations of parental preconception and maternal pregnancy urinary phthalate biomarker and bisphenol-a concentrations with child eating behaviors. Int J Hyg Environ Health. 2024 Apr; 257:114334.. View in PubMed
• Women’s preconception psychological stress and birth outcomes in a fertility clinic: the EARTH study. Front Glob Womens Health. 2024; 5:1293255.. View in PubMed
• Paternal and maternal preconception and maternal pregnancy urinary concentrations of parabens in relation to child behavior. Andrology. 2025 Jan; 13(1):22-33.. View in PubMed
• Preconception Stress and Pregnancy Serum Glucose Levels Among Women Attending a Fertility Center. J Endocr Soc. 2023 Dec 01; 8(1):bvad152.. View in PubMed
• Paternal and maternal preconception and maternal pregnancy urinary phthalate metabolite and BPA concentrations in relation to child behavior. Environ Int. 2024 Jan; 183:108337.. View in PubMed
• Fruits, vegetables, pesticide residues and health-a cause for concern? Am J Obstet Gynecol. 2024 Mar; 230(3):e19. Chavarro JE, Mitsunami M, Minguez-Alarcon L . View in PubMed
• Endocrine-disrupting chemicals and male reproductive health. Fertil Steril. 2023 Dec; 120(6):1138-1149.. View in PubMed
• Prepregnancy plant-based diets and risk of hypertensive disorders of pregnancy. Am J Obstet Gynecol. 2024 Mar; 230(3):366.e1-366.e19.. View in PubMed
• Women’s Adherence to Healthy Dietary Patterns and Outcomes of Infertility Treatment. JAMA Netw Open. 2023 Aug 01; 6(8):e2329982.. View in PubMed
• Iron intake in relation to ovarian reserve among women seeking infertility treatment. Hum Reprod. 2023 Aug 01; 38(8):1613-1620.. View in PubMed
• Temporal trends in urinary concentrations of phenols, phthalate metabolites and phthalate replacements between 2000 and 2017 in Boston, MA. Sci Total Environ. 2023 Nov 10; 898:165353.. View in PubMed
• Mixtures of urinary concentrations of phenols and phthalate biomarkers in relation to the ovarian reserve among women attending a fertility clinic. Sci Total Environ. 2023 Nov 10; 898:165536.. View in PubMed
• Longitudinal association of prepubertal urinary phthalate metabolite concentrations with pubertal progression among a cohort of boys. Environ Res. 2023 Sep 15; 233:116330.. View in PubMed
• Preconception antibiotic use and decreased fecundability: confounding by indication? Fertil Steril. 2023 Sep; 120(3 Pt 2):660. Mínguez-Alarcón L . View in PubMed
• Associations of Maternal Urinary Concentrations of Phenols, Individually and as a Mixture, with Serum Biomarkers of Thyroid Function and Autoimmunity: Results from the EARTH Study. Toxics. 2023 Jun 09; 11(6).. View in PubMed
• Invited Perspective: Measuring Biomarkers of Exposure in Target Organs-What Is Needed to Move Forward? Environ Health Perspect. 2023 Jun; 131(6):61304. Hauser R, Mínguez-Alarcón L . . View in PubMed
• Pregnancy Intention, Changes in Pregnancy Intention, and Pregnancy Incidence Among Female Nurses in North America. JAMA Netw Open. 2023 May 01; 6(5):e2311301.. View in PubMed
• Occupational factors and markers of testicular function among men attending a fertility center. Hum Reprod. 2023 Apr 03; 38(4):529-536.. View in PubMed
• Corrigendum to “Plasma concentrations of per- and polyfluoroalkyl substances are associated with perturbations in lipid and amino acid metabolism” [Chemosphere 324 (2023)138228]. Chemosphere. 2023 Jun; 327:138420.. View in PubMed
• Plasma concentrations of per- and polyfluoroalkyl substances are associated with perturbations in lipid and amino acid metabolism. Chemosphere. 2023 May; 324:138228.. View in PubMed
• Intake of soy products and soy isoflavones in relation to ovarian reserve. Fertil Steril. 2023 Jun; 119(6):1017-1029.. View in PubMed
• Exposure to perfluoroalkyl substances and women’s fertility outcomes in a Singaporean population-based preconception cohort. Sci Total Environ. 2023 May 15; 873:162267.. View in PubMed
• Perceived stress and markers of ovarian reserve among subfertile women. Reprod Biomed Online. 2023 Jun; 46(6):956-964.. View in PubMed
• Self-reported history of comorbidities and markers of ovarian reserve among subfertile women. J Assist Reprod Genet. 2022 Dec; 39(12):2719-2728.. View in PubMed
• Pre-pregnancy fat intake in relation to hypertensive disorders of pregnancy. Am J Clin Nutr. 2022 Sep 02; 116(3):750-758.. View in PubMed
• Self-reported menstrual cycle length during reproductive years in relation to menopausal symptoms at midlife in Project Viva. Menopause. 2022 Oct 01; 29(10):1130-1136.. View in PubMed
• Associations of hypertensive disorders of pregnancy and gestational diabetes mellitus with menopausal symptoms at midlife in Project Viva. Menopause. 2022 Sep 01; 29(9):1021-1027.. View in PubMed
• Beverage intake and ovarian reserve among women from a fertility center. Fertil Steril. 2022 Jul; 118(1):148-157.. View in PubMed
• Association of Urinary Phthalate and Phthalate Replacement Metabolite Concentrations with Serum Lipid Biomarker Levels among Pregnant Women Attending a Fertility Center. Toxics. 2022 May 28; 10(6).. View in PubMed
• Urinary phthalate metabolite concentrations during four windows spanning puberty (prepuberty through sexual maturity) and association with semen quality among young Russian men. Int J Hyg Environ Health. 2022 Jun; 243:113977.. View in PubMed
• Associations between mixtures of urinary phthalate metabolite concentrations and oxidative stress biomarkers among couples undergoing fertility treatment. Environ Res. 2022 Sep; 212(Pt B):113342.. View in PubMed
• Pregnancy urinary concentrations of bisphenol A, parabens and other phenols in relation to serum levels of lipid biomarkers: Results from the EARTH study. Sci Total Environ. 2022 Aug 10; 833:155191.. View in PubMed
• Associations of prepubertal urinary phthalate metabolite concentrations with pubertal onset among a longitudinal cohort of boys. Environ Res. 2022 Sep; 212(Pt A):113218.. View in PubMed
• Association of peripubertal blood lead levels with reproductive hormones and semen parameters in a longitudinal cohort of Russian men. Hum Reprod. 2022 Apr 01; 37(4):848-858.. View in PubMed
• Women’s and men’s intake of omega-3 fatty acids and their food sources and assisted reproductive technology outcomes. Am J Obstet Gynecol. 2022 Aug; 227(2):246.e1-246.e11.. View in PubMed
• Male waist circumference in relation to semen quality and partner infertility treatment outcomes among couples undergoing infertility treatment with assisted reproductive technologies. Am J Clin Nutr. 2022 Mar 04; 115(3):833-842.. View in PubMed
• Pregnancy loss and risk of cardiovascular disease: the Nurses’ Health Study II. Eur Heart J. 2022 Jan 25; 43(3):190-199.. View in PubMed
• Association of mode of delivery with offspring pubertal development in Project Viva: a prospective pre-birth cohort study in the USA. Hum Reprod. 2021 Dec 27; 37(1):54-65.. View in PubMed
• Physical activity before pregnancy and the risk of hypertensive disorders of pregnancy. Am J Obstet Gynecol MFM. 2022 Mar; 4(2):100556.. View in PubMed
• Paternal adherence to healthy dietary patterns in relation to sperm parameters and outcomes of assisted reproductive technologies. Fertil Steril. 2022 Feb; 117(2):298-312.. View in PubMed
• Intake of fruits and vegetables according to pesticide residue status in relation to all-cause and disease-specific mortality: Results from three prospective cohort studies. Environ Int. 2022 Jan 15; 159:107024.. View in PubMed
• Folate intake and ovarian reserve among women attending a fertility center. Fertil Steril. 2022 Jan; 117(1):171-180.. View in PubMed
• Association of Mode of Obstetric Delivery With Child and Adolescent Body Composition. JAMA Netw Open. 2021 Oct 01; 4(10):e2125161.. View in PubMed
• A dietary score representing the overall relation of men’s diet with semen quality in relation to outcomes of infertility treatment with assisted reproduction. F S Rep. 2021 Dec; 2(4):396-404.. View in PubMed
• Hair mercury levels, intake of omega-3 fatty acids and ovarian reserve among women attending a fertility center. Int J Hyg Environ Health. 2021 Aug; 237:113825.. View in PubMed
• Urinary phthalate metabolite concentrations are negatively associated with follicular fluid anti-müllerian hormone concentrations in women undergoing fertility treatment. Environ Int. 2021 Dec; 157:106809.. View in PubMed
• Intake of fruits and vegetables by pesticide residue status in relation to cancer risk. Environ Int. 2021 Nov; 156:106744.. View in PubMed
• Men’s dietary patterns in relation to infertility treatment outcomes among couples undergoing in vitro fertilization. J Assist Reprod Genet. 2021 Sep; 38(9):2307-2318.. View in PubMed
• Impact of ambient temperature on ovarian reserve. Fertil Steril. 2021 Oct; 116(4):1052-1060.. View in PubMed
• The influence of fine particulate matter on the association between residential greenness and ovarian reserve. Environ Res. 2021 06; 197:111162.. View in PubMed
• Cesarean delivery and metabolic health and inflammation biomarkers during mid-childhood and early adolescence. Pediatr Res. 2022 Feb; 91(3):672-680.. View in PubMed
• Association of spontaneous abortion with all cause and cause specific premature mortality: prospective cohort study. BMJ. 2021 Mar 24; 372:n530.. View in PubMed
• Substantial Weight Gain in Adulthood Is Associated with Lower Probability of Live Birth Following Assisted Reproduction. J Nutr. 2021 Mar 11; 151(3):649-656.. View in PubMed
• Identifying windows of susceptibility to endocrine disrupting chemicals in relation to gestational weight gain among pregnant women attending a fertility clinic. Environ Res. 2021 Mar; 194:110638.. View in PubMed
• Paternal mixtures of urinary concentrations of phthalate metabolites, bisphenol A and parabens in relation to pregnancy outcomes among couples attending a fertility center. Environ Int. 2021 Jan; 146:106171.. View in PubMed
• Association of personal exposure to power-frequency magnetic fields with pregnancy outcomes among women seeking fertility treatment in a longitudinal cohort study. Fertil Steril. 2020 Nov; 114(5):1058-1066.. View in PubMed
• Follicular fluid anti-Müllerian hormone (AMH) concentrations and outcomes of in vitro fertilization cycles with fresh embryo transfer among women at a fertility center. J Assist Reprod Genet. 2020 Nov; 37(11):2757-2766.. View in PubMed
• Reproductive outcomes associated with flame retardants among couples seeking fertility treatment: A paternal perspective. Environ Res. 2021 Jan; 192:110226.. View in PubMed
• Ambient air pollution and risk of pregnancy loss among women undergoing assisted reproduction. Environ Res. 2020 Dec; 191:110201.. View in PubMed
• Peripubertal serum concentrations of organochlorine pesticides and semen parameters in Russian young men. Environ Int. 2020 Nov; 144:106085.. View in PubMed
• Dietary patterns and ovarian reserve among women attending a fertility clinic. Fertil Steril. 2020 Sep; 114(3):610-617.. View in PubMed
• Urinary Concentrations of Phthalate Metabolite Mixtures in Relation to Serum Biomarkers of Thyroid Function and Autoimmunity among Women from a Fertility Center. Environ Health Perspect. 2020 Jun; 128(6):67007.. View in PubMed
• Exploring reproductive associations of serum polybrominated diphenyl ether and hydroxylated brominated diphenyl ether concentrations among women undergoing in vitro fertilization. Hum Reprod. 2020 May 01; 35(5):1199-1210.. View in PubMed
• Perinatal urinary benzophenone-3 concentrations and glucose levels among women from a fertility clinic. Environ Health. 2020 Apr 28; 19(1):45.. View in PubMed
• Parental preconception and prenatal urinary bisphenol A and paraben concentrations and child behavior. Environ Epidemiol. 2020 Feb; 4(1):e082.. View in PubMed
• Urinary oxidative stress biomarker levels and reproductive outcomes among couples undergoing fertility treatments. Hum Reprod. 2019 Dec 01; 34(12):2399-2409.. View in PubMed
• Paternal preconception folate intake in relation to gestational age at delivery and birthweight of newborns conceived through assisted reproduction. Reprod Biomed Online. 2019 Nov; 39(5):835-843.. View in PubMed

• Chatzi, Vaia
• Paulson, Richard
• Peters, Anne
• Farzan, Shohreh
• Hu, Howard
• Goran, Michael