Lin Zhang

Visiting Professor of Medicine

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Overview

The immediate goal of our research is to understand how anticancer drugs kill cancer cells, and more importantly, why they fail so often. Our research has focused on proteins that control discrete steps of programmed cell death, including PUMA, Bax, BID, SMAC, and Mcl-1, which are directly or indirectly regulated by the most frequently mutated or altered tumor suppressors and oncogenes such as p53, APC, c-Myc and KRAS. Through analyses of these cell death regulators and their associated protein networks under the influence of oncogenic mutations and other alterations, we try to gain deep understanding on how cell death is initiated and executed in colon cancer cells, why some colon cancer cells are not sensitive to anticancer drugs, and what can be done to restore their sensitivity. Our long-term goal is to develop novel strategies and agents to improve colon cancer therapy and prevention.

The specific projects in our lab are focused on four areas: (1) understand how cell death regulators modulate therapeutic response; (2) determine how anticancer drugs kill colon cancer cells; (3) delineate the role of cancer stem cell in cancer prevention; and (4) identify novel small molecules to target cell death regulators to improve colon cancer therapy and prevention.

Awards

  • University of Pittsburgh: Pitt Innovator Award, 2011-2011
  • Hillman Foundation: Hillman Fellow for Innovative Cancer Research, 2010-2010
  • American Lung Association (ALA)/Chest Foundation: Career Investigator Award, 2007-2011
  • American Cancer Society (ACS): Research Scholar Award, 2007-2011
  • University of Pittsburgh Cancer Institute : Junior Scholar Award, 2006-2006
  • Edward Mallinckrodt, Jr. Foundation : Scholar Award, 2003-2007
  • V Foundation: Scholar Award, 2003-2005
  • General Motors (GM) Cancer Research Foundation: Scholar Award, 2003-2005

Publications

  • Targeting Myc-driven stress addiction in colorectal cancer Drug Resist Updat. 2023 Jul; 69:100963. . View in PubMed
  • mTOR inhibition suppresses Myc-driven polyposis by inducing immunogenic cell death Oncogene. 2023 Jun; 42(24):2007-2016. . View in PubMed
  • Inhibition of multiple CDKs potentiates colon cancer chemotherapy via p73-mediated DR5 induction Oncogene. 2023 03; 42(12):869-880. . View in PubMed
  • Role of Receptor Interacting Protein (RIP) kinases in cancer Genes Dis. 2022 Nov; 9(6):1579-1593. . View in PubMed
  • Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer Mol Biomed. 2022 Mar 21; 3(1):10. . View in PubMed
  • CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade Cancer Res. 2022 04 01; 82(7):1340-1352. . View in PubMed
  • Dual inhibition of BET and HAT/p300 suppresses colorectal cancer via DR5- and p53/PUMA-mediated cell death Front Oncol. 2022; 12:1018775. . View in PubMed
  • Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer Proc Natl Acad Sci U S A. 2022 12 20; 119(51):e2211775119. . View in PubMed
  • Interferon b drives intestinal regeneration after radiation Sci Adv. 2021 Oct 08; 7(41):eabi5253. . View in PubMed
  • BET protein degradation triggers DR5-mediated immunogenic cell death to suppress colorectal cancer and potentiate immune checkpoint blockade Oncogene. 2021 12; 40(48):6566-6578. . View in PubMed
  • Glucose deprivation-induced endoplasmic reticulum stress response plays a pivotal role in enhancement of TRAIL cytotoxicity J Cell Physiol. 2021 09; 236(9):6666-6677. . View in PubMed
  • Non-steroidal anti-inflammatory drugs induce immunogenic cell death in suppressing colorectal tumorigenesis Oncogene. 2021 03; 40(11):2035-2050. . View in PubMed
  • A novel immunochemotherapy based on targeting of cyclooxygenase and induction of immunogenic cell death Biomaterials. 2021 03; 270:120708. . View in PubMed
  • Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside Biochim Biophys Acta Rev Cancer. 2020 12; 1874(2):188447. . View in PubMed
  • Immunogenic cell death in colon cancer prevention and therapy Mol Carcinog. 2020 07; 59(7):783-793. . View in PubMed
  • Long noncoding RNA PiHL regulates p53 protein stability through GRWD1/RPL11/MDM2 axis in colorectal cancer Theranostics. 2020; 10(1):265-280. . View in PubMed
  • High Loading of Hydrophobic and Hydrophilic Agents via Small Immunostimulatory Carrier for Enhanced Tumor Penetration and Combinational Therapy Theranostics. 2020; 10(3):1136-1150. . View in PubMed
  • Mcl-1 inhibition overcomes intrinsic and acquired regorafenib resistance in colorectal cancer Theranostics. 2020; 10(18):8098-8110. . View in PubMed
  • Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis Nat Commun. 2020 04 20; 11(1):1899. . View in PubMed
  • eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis Elife. 2020 11 02; 9. . View in PubMed
  • p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice Hepatology. 2019 05; 69(5):2164-2179. . View in PubMed
  • BET Inhibitors Potentiate Chemotherapy and Killing of SPOP-Mutant Colon Cancer Cells via Induction of DR5 Cancer Res. 2019 03 15; 79(6):1191-1203. . View in PubMed
  • Immunogenic effects of chemotherapy-induced tumor cell death Genes Dis. 2018 Sep; 5(3):194-203. . View in PubMed
  • Colorectal cancer prevention: Immune modulation taking the stage Biochim Biophys Acta Rev Cancer. 2018 Apr; 1869(2):138-148. . View in PubMed
  • Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer Oncogene. 2018 08; 37(33):4599-4610. . View in PubMed
  • Targeting p53-dependent stem cell loss for intestinal chemoprotection Sci Transl Med. 2018 02 07; 10(427). . View in PubMed
  • PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors Proc Natl Acad Sci U S A. 2018 04 10; 115(15):3930-3935. . View in PubMed
  • The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice Sci Rep. 2018 02 01; 8(1):2072. . View in PubMed
  • Mcl-1 Phosphorylation without Degradation Mediates Sensitivity to HDAC Inhibitors by Liberating BH3-Only Proteins Cancer Res. 2018 08 15; 78(16):4704-4715. . View in PubMed
  • Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress Oncotarget. 2017 Feb 07; 8(6):9280-9292. . View in PubMed
  • FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors Mol Cancer Ther. 2017 09; 16(9):1979-1988. . View in PubMed
  • Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells Cancer Res. 2017 05 01; 77(9):2512-2521. . View in PubMed
  • FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation Oncogene. 2017 02 09; 36(6):787-796. . View in PubMed
  • The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity Cell Rep. 2017 08 15; 20(7):1692-1704. . View in PubMed
  • BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells Oncotarget. 2016 Jul 26; 7(30):47699-47710. . View in PubMed
  • Necroptosis: an alternative cell death program defending against cancer Biochim Biophys Acta. 2016 Apr; 1865(2):228-36. . View in PubMed
  • mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation Oncogene. 2016 Jan 14; 35(2):148-57. . View in PubMed
  • Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice J Clin Invest. 2016 11 01; 126(11):4076-4087. . View in PubMed
  • 5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers J Immunother Cancer. 2016; 4:65. . View in PubMed
  • Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers Nat Commun. 2015 Sep 22; 6:8305. . View in PubMed
  • Amphiphilic sugar poly(orthoesters) as pH-responsive nanoscopic assemblies for acidity-enhanced drug delivery and cell killing Chem Commun (Camb). 2015 Aug 25; 51(66):13078-81. . View in PubMed
  • Fibulin-5 inhibits Wnt/ß-catenin signaling in lung cancer Oncotarget. 2015 Jun 20; 6(17):15022-34. . View in PubMed
  • Loss of caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis Cell Death Dis. 2015 Apr 23; 6:e1729. . View in PubMed
  • Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation Sci Rep. 2015 Apr 10; 5:8566. . View in PubMed
  • Mutant KRAS as a critical determinant of the therapeutic response of colorectal cancer Genes Dis. 2015 Mar; 2(1):4-12. . View in PubMed
  • BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16520-5. . View in PubMed
  • Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer Cell Death Dis. 2014 Oct 30; 5:e1504. . View in PubMed
  • Synthesis of clickable amphiphilic polysaccharides as nanoscopic assemblies Chem Commun (Camb). 2014 Oct 28; 50(84):12742-5. . View in PubMed
  • TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity Oncotarget. 2014 Sep 30; 5(18):8107-22. . View in PubMed
  • Fibulin-3 suppresses Wnt/ß-catenin signaling and lung cancer invasion Carcinogenesis. 2014 Aug; 35(8):1707-16. . View in PubMed
  • Regorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis Clin Cancer Res. 2014 Jul 01; 20(13):3472-84. . View in PubMed
  • Mol Cancer Ther. 2014 May; 13(5):1298-308. . View in PubMed
  • Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice Nat Commun. 2014 Mar 18; 5:3494. . View in PubMed
  • Role of Bcl-xL/Beclin-1 in interplay between apoptosis and autophagy in oxaliplatin and bortezomib-induced cell death Biochem Pharmacol. 2014 Mar 15; 88(2):178-88. . View in PubMed
  • Receptor interactive protein kinase 3 promotes Cisplatin-triggered necrosis in apoptosis-resistant esophageal squamous cell carcinoma cells PLoS One. 2014; 9(6):e100127. . View in PubMed
  • Role of apoptosis in colon cancer biology, therapy, and prevention Curr Colorectal Cancer Rep. 2013 Dec; 9(4). . View in PubMed
  • Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax Mol Cancer Ther. 2013 Nov; 12(11):2559-68. . View in PubMed
  • An apoptosis-independent role of SMAC in tumor suppression Oncogene. 2013 May 09; 32(19):2380-9. . View in PubMed
  • Crizotinib induces PUMA-dependent apoptosis in colon cancer cells Mol Cancer Ther. 2013 May; 12(5):777-86. . View in PubMed
  • Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation Cell Death Differ. 2013 May; 20(5):744-54. . View in PubMed
  • ADAR1 is essential for intestinal homeostasis and stem cell maintenance Cell Death Dis. 2013 Apr 18; 4:e599. . View in PubMed
  • PEG-farnesylthiosalicylate conjugate as a nanomicellar carrier for delivery of paclitaxel Bioconjug Chem. 2013 Mar 20; 24(3):464-72. . View in PubMed
  • Oncogene. 2012 Nov 15; 31(46):4848-58. . View in PubMed
  • Investigation of nuclear nano-morphology marker as a biomarker for cancer risk assessment using a mouse model J Biomed Opt. 2012 Jun; 17(6):066014. . View in PubMed
  • p53/HMGB1 complexes regulate autophagy and apoptosis Cancer Res. 2012 Apr 15; 72(8):1996-2005. . View in PubMed
  • The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA PLoS One. 2012; 7(8):e43158. . View in PubMed
  • Cleaving Beclin 1 to suppress autophagy in chemotherapy-induced apoptosis Autophagy. 2011 Oct; 7(10):1239-41. . View in PubMed
  • PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice Hepatology. 2011 Oct; 54(4):1249-58. . View in PubMed
  • p53 and PUMA independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis Gastroenterology. 2011 Sep; 141(3):1036-45. . View in PubMed
  • Role of Smac in determining the chemotherapeutic response of esophageal squamous cell carcinoma Clin Cancer Res. 2011 Aug 15; 17(16):5412-22. . View in PubMed
  • Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1 Cancer Res. 2011 May 15; 71(10):3625-34. . View in PubMed
  • PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice J Clin Invest. 2011 May; 121(5):1722-32. . View in PubMed
  • Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21 Mol Cancer Res. 2011 May; 9(5):616-25. . View in PubMed
  • Smac modulates chemosensitivity in head and neck cancer cells through the mitochondrial apoptotic pathway Clin Cancer Res. 2011 Apr 15; 17(8):2361-72. . View in PubMed
  • Development of small-molecule PUMA inhibitors for mitigating radiation-induced cell death Curr Top Med Chem. 2011; 11(3):281-90. . View in PubMed
  • Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46):20027-32. . View in PubMed
  • Nanoscale nuclear architecture for cancer diagnosis beyond pathology via spatial-domain low-coherence quantitative phase microscopy J Biomed Opt. 2010 Nov-Dec; 15(6):066028. . View in PubMed
  • PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01 Mol Cancer Ther. 2010 Nov; 9(11):2893-902. . View in PubMed
  • An insight into statistical refractive index properties of cell internal structure via low-coherence statistical amplitude microscopy Opt Express. 2010 Oct 11; 18(21):21950-8. . View in PubMed
  • Ligand-independent antiapoptotic function of estrogen receptor-beta in lung cancer cells Mol Endocrinol. 2010 Sep; 24(9):1737-47. . View in PubMed
  • p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress J Biol Chem. 2010 Jun 25; 285(26):19910-20. . View in PubMed
  • Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation Blood. 2010 Apr 29; 115(17):3472-80. . View in PubMed
  • IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells Cell Death Differ. 2010 Apr; 17(4):699-709. . View in PubMed
  • Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis Oncogene. 2010 Mar 18; 29(11):1622-32. . View in PubMed
  • microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells Cancer Res. 2009 Oct 15; 69(20):8157-65. . View in PubMed
  • Hypoxia-mediated regulation of Cdc25A phosphatase by p21 and miR-21 Cell Cycle. 2009 Oct 01; 8(19):3157-64. . View in PubMed
  • PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis Cell Death Differ. 2009 Sep; 16(9):1192-202. . View in PubMed
  • Fibulin-5 suppresses lung cancer invasion by inhibiting matrix metalloproteinase-7 expression Cancer Res. 2009 Aug 01; 69(15):6339-46. . View in PubMed
  • PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells Oncogene. 2009 Jun 18; 28(24):2348-57. . View in PubMed
  • PUMA suppresses intestinal tumorigenesis in mice Cancer Res. 2009 Jun 15; 69(12):4999-5006. . View in PubMed
  • PUMA, a potent killer with or without p53 Oncogene. 2008 Dec; 27 Suppl 1:S71-83. . View in PubMed
  • Sp1 and p73 activate PUMA following serum starvation Carcinogenesis. 2008 Oct; 29(10):1878-84. . View in PubMed
  • Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis Mol Cell Biol. 2008 Sep; 28(17):5391-402. . View in PubMed
  • PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome Cell Stem Cell. 2008 Jun 05; 2(6):576-83. . View in PubMed
  • Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells Biochem Pharmacol. 2008 May 15; 75(10):2020-33. . View in PubMed
  • Anti-cancer effects of JKA97 are associated with its induction of cell apoptosis via a Bax-dependent and p53-independent pathway J Biol Chem. 2008 Mar 28; 283(13):8624-33. . View in PubMed
  • PINCH-1 regulates the ERK-Bim pathway and contributes to apoptosis resistance in cancer cells J Biol Chem. 2008 Feb 01; 283(5):2508-17. . View in PubMed
  • SMAC mimetics sensitize nonsteroidal anti-inflammatory drug-induced apoptosis by promoting caspase-3-mediated cytochrome c release Cancer Res. 2008 Jan 01; 68(1):276-84. . View in PubMed
  • Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer Carcinogenesis. 2008 Jan; 29(1):84-92. . View in PubMed
  • NSAIDs downregulate Bcl-X(L) and dissociate BAX and Bcl-X(L) to induce apoptosis in colon cancer cells Nutr Cancer. 2008; 60 Suppl 1:98-103. . View in PubMed
  • BH3 mimetics to improve cancer therapy; mechanisms and examples Drug Resist Updat. 2007 Dec; 10(6):207-17. . View in PubMed
  • Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation Clin Cancer Res. 2007 Aug 01; 13(15 Pt 1):4336-44. . View in PubMed
  • SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events Oncogene. 2007 Jun 21; 26(29):4189-98. . View in PubMed
  • p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion Gut. 2007 May; 56(5):645-54. . View in PubMed
  • The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):4054-9. . View in PubMed
  • A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells Mol Cancer Ther. 2007 Mar; 6(3):1062-9. . View in PubMed
  • Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis Oncogene. 2006 Jul 06; 25(29):4056-66. . View in PubMed
  • PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells J Biol Chem. 2006 Jun 09; 281(23):16034-42. . View in PubMed
  • PUMA sensitizes lung cancer cells to chemotherapeutic agents and irradiation Clin Cancer Res. 2006 May 01; 12(9):2928-36. . View in PubMed
  • Administration of PUMA adenovirus increases the sensitivity of esophageal cancer cells to anticancer drugs Cancer Biol Ther. 2006 Apr; 5(4):380-5. . View in PubMed
  • The transcriptional targets of p53 in apoptosis control Biochem Biophys Res Commun. 2005 Jun 10; 331(3):851-8. . View in PubMed
  • SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells Proc Natl Acad Sci U S A. 2004 Nov 30; 101(48):16897-902. . View in PubMed
  • Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C J Biol Chem. 2004 Jun 11; 279(24):25813-22. . View in PubMed
  • Apoptosis in human cancer cells Curr Opin Oncol. 2004 Jan; 16(1):19-24. . View in PubMed
  • Differential apoptotic response to the proteasome inhibitor Bortezomib [VELCADE, PS-341] in Bax-deficient and p21-deficient colon cancer cells Cancer Biol Ther. 2003 Nov-Dec; 2(6):694-9. . View in PubMed
  • No PUMA, no death: implications for p53-dependent apoptosis Cancer Cell. 2003 Oct; 4(4):248-9. . View in PubMed
  • Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers Cancer Res. 2003 Mar 01; 63(5):994-9. . View in PubMed
  • PUMA mediates the apoptotic response to p53 in colorectal cancer cells Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1931-6. . View in PubMed
  • Screening poly [dA/dT(-)] cDNA for gene identification Methods Mol Biol. 2003; 221:197-205. . View in PubMed
  • Single-sperm typingCurr Protoc Hum Genet. 2002 May; Chapter 1:Unit 1. 6. . View in PubMed
  • Secreted and cell surface genes expressed in benign and malignant colorectal tumors Cancer Res. 2001 Oct 01; 61(19):6996-7001. . View in PubMed
  • Serial analysis of gene expression in the frontal cortex of patients with bipolar disorder Br J Psychiatry Suppl. 2001 Jun; 41:s137-41. . View in PubMed
  • Short mononucleotide repeat sequence variability in mismatch repair-deficient cancers Cancer Res. 2001 May 01; 61(9):3801-5. . View in PubMed
  • PUMA induces the rapid apoptosis of colorectal cancer cells Mol Cell. 2001 Mar; 7(3):673-82. . View in PubMed
  • Role of BAX in the apoptotic response to anticancer agents Science. 2000 Nov 03; 290(5493):989-92. . View in PubMed
  • The mRNA of L-type calcium channel elevated in colon cancer: protein distribution in normal and cancerous colon Am J Pathol. 2000 Nov; 157(5):1549-62. . View in PubMed
  • Screening poly(dA/dT)- cDNAs for gene identification Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4162-7. . View in PubMed
  • Identification and classification of p53-regulated genes Proc Natl Acad Sci U S A. 1999 Dec 07; 96(25):14517-22. . View in PubMed
  • Analysis of human transcriptomes Nat Genet. 1999 Dec; 23(4):387-8. . View in PubMed
  • A public database for gene expression in human cancers Cancer Res. 1999 Nov 01; 59(21):5403-7. . View in PubMed
  • The mutation properties of spinal and bulbar muscular atrophy disease alleles Neurogenetics. 1998 Aug; 1(4):249-52. . View in PubMed
  • Identifying markers for pancreatic cancer by gene expression analysis Cancer Epidemiol Biomarkers Prev. 1998 Feb; 7(2):109-12. . View in PubMed
  • 14-3-3sigma is a p53-regulated inhibitor of G2/M progression Mol Cell. 1997 Dec; 1(1):3-11. . View in PubMed
  • Gene expression profiles in normal and cancer cells Science. 1997 May 23; 276(5316):1268-72. . View in PubMed
  • Characterization of the yeast transcriptome Cell. 1997 Jan 24; 88(2):243-51. . View in PubMed
  • Serial analysis of gene expression Science. 1995 Oct 20; 270(5235):484-7. . View in PubMed
  • Single sperm analysis of the trinucleotide repeats in the Huntington’s disease gene: quantification of the mutation frequency spectrum Hum Mol Genet. 1995 Sep; 4(9):1519-26. . View in PubMed
  • Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis Cell. 1995 Jul 28; 82(2):309-19. . View in PubMed
  • CAG repeat length variation in sperm from a patient with Kennedy’s disease Hum Mol Genet. 1995 Feb; 4(2):303-5. . View in PubMed
  • Studying human mutations by sperm typing: instability of CAG trinucleotide repeats in the human androgen receptor gene Nat Genet. 1994 Aug; 7(4):531-5. . View in PubMed
  • A new source of polymorphic DNA markers for sperm typing: analysis of microsatellite repeats in single cells Am J Hum Genet. 1992 Nov; 51(5):985-91. . View in PubMed
  • Whole genome amplification from a single cell: implications for genetic analysis Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):5847-51. . View in PubMed