Keck School Faculty

Linda S. Sher, MD
Linda S. Sher, MD
Professor of Clinical Surgery;Vice Chair, HSC IRB;Division Chief, Clinical Research
Surgery
1510 San Pablo St. Health Sciences Campus Los Angeles
Dr. Sher is a Professor of Clinical Surgery and Director of Clinical Research in the Division of Hepatobiliary Surgery and Abdominal Organ Transplantation at Keck School of Medicine of USC. After completing her medical school education and surgical residency at Mount Sinai School of Medicine in New York, Dr. Sher undertook her fellowship training in Liver and Kidney Transplantation at the University of Pittsburgh. Following her fellowship in 1988, Dr. Sher was involved in the establishment of two liver transplant programs in Los Angeles prior to joining the USC program in 2001.

Dr. Sher has participated in and overseen over 50 research projects and is currently very active in the development of the clinical and basic science research components of the USC Abdominal Organ Transplantation Program. She has numerous publications on immunosuppression, chronic rejection, disease recurrence, infection, and prophylaxis and hepatobiliary surgery. Dr. Sher is one of the original editors of Current Opinion in Organ Transplantation and has endeavored over the years to provide the reader with an up to date overview of the entire field of organ transplantation.

Southeastern Surgical Congress: Society Membership, 1996-2014

American Liver Foundation: Society Membership, 1995-2014

American Society of Transplant Surgeons: Society Membership, 1993-2014

International Liver Transplantation Society: Society Membership, 1993-2014

American College of Surgeons : Society Membership, 1992-2014

International Transplantation Society: Society Membership, 1991-2014

Los Angeles Surgical Society: Society Membership, 1990-2014

Western Association for Transplant Surgeons: Society Membership , 1990-2014

American Association for the Study of Liver Diseases: Society Membership , 1990-2014

United Liver Association: Society Membership, 1990-1997

American Society of Transplantation: Society Membership , 1989-2014

University of Pittsburgh: Fellowship, 1986-1988

Mount Sinai Hospital: Fellowship, 1982-1983

American Medical Association: Society Membership , 1981-2014

Telomerase Variants in Patients with Cirrhosis Awaiting Liver Transplantation Hepatology. 2019 Jun; 69(6):2652-2663. . View in PubMed

Transplantation. 2019 Apr; 103(4):747-754. . View in PubMed

Variability in intensive care unit length of stay after liver transplant: Determinants and potential opportunities for improvement J Crit Care. 2019 Apr; 50:296-302. . View in PubMed

Variability in intensive care unit length of stay after liver transplant: Determinants and potential opportunities for improvement J Crit Care. 2019 Jan 09; 50:296-302. . View in PubMed

Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor-Initiating Stem Cell-Like Cells Resistant to mTORC1 Inhibition Hepatology. 2018 Nov; 68(5):1726-1740. . View in PubMed

Living donor liver transplantation: post-operative imaging follow-up of right lobe liver donors Abdom Radiol (NY). 2018 Oct; 43(10):2673-2678. . View in PubMed

CancerDetector: ultrasensitive and non-invasive cancer detection at the resolution of individual reads using cell-free DNA methylation sequencing data Nucleic Acids Res. 2018 Sep 06; 46(15):e89. . View in PubMed

CancerDetector: ultrasensitive and non-invasive cancer detection at the resolution of individual reads using cell-free DNA methylation sequencing data Nucleic Acids Res. 2018 Jun 12. . View in PubMed

Baicalein targets GTPase-mediated autophagy to eliminate liver tumor initiating stem cell-like cells resistant to mTORC1 inhibition Hepatology. 2018 May 05. . View in PubMed

Transplantation. 2018 Apr 18. . View in PubMed

Living donor liver transplantation: post-operative imaging follow-up of right lobe liver donors Abdom Radiol (NY). 2018 Feb 22. . View in PubMed

Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor-Initiating Stem Cell-Like Cells Resistant to mTORC1 Inhibition Hepatology. 2018 11; 68(5):1726-1740. . View in PubMed

Extracorporeal cellular therapy (ELAD) in severe alcoholic hepatitis: A multinational, prospective, controlled, randomized trial Liver Transpl. 2018 03; 24(3):380-393. . View in PubMed

Attitudes and barriers to the use of donation after cardiac death livers: Comparison of a United States transplant center survey to the united network for organ sharing data Liver Transpl. 2017 Nov; 23(11):1372-1383. . View in PubMed

Attitudes and barriers to the use of donation after cardiac death livers: Comparison of a United States transplant center survey to the united network for organ sharing data Liver Transpl. 2017 11; 23(11):1372-1383. . View in PubMed

Complicated gallstone disease: diagnosis and management of Mirizzi syndrome Surg Endosc. 2017 05; 31(5):2215-2222. . View in PubMed

Fibrin Sealant Patch (TachoSil) vs Oxidized Regenerated Cellulose Patch (Surgicel Original) for the Secondary Treatment of Local Bleeding in Patients Undergoing Hepatic Resection: A Randomized Controlled Trial J Am Coll Surg. 2016 Mar; 222(3):261-8. . View in PubMed

TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice Gastroenterology. 2016 Mar; 150(3):707-19. . View in PubMed

NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism Cell Metab. 2016 Jan 12; 23(1):206-19. . View in PubMed

A multicenter study of 30 days complications after deceased donor liver transplantation in the model for end-stage liver disease score era Liver Transpl. 2015 Sep; 21(9):1160-8. . View in PubMed

Liver transplantation for metastatic neuroendocrine tumors: Outcomes and prognostic variables J Surg Oncol. 2015 Aug; 112(2):125-32. . View in PubMed

Phase II study of avatrombopag in thrombocytopenic patients with cirrhosis undergoing an elective procedure J Hepatol. 2014 Dec; 61(6):1253-9. . View in PubMed

Imaging appearance in acute liver failure: correlation with clinical and pathology findings Dig Dis Sci. 2014 Aug; 59(8):1987-95. . View in PubMed

Predictive factors of neurological complications and one-month mortality after liver transplantation Front Neurol. 2014; 5:275. . View in PubMed

Renal function at two years in liver transplant patients receiving everolimus: results of a randomized, multicenter study Am J Transplant. 2013 Jul; 13(7):1734-45. . View in PubMed

Calcineurin inhibitor-free mycophenolate mofetil/sirolimus maintenance in liver transplantation: the randomized spare-the-nephron trial Liver Transpl. 2013 Jul; 19(7):675-89. . View in PubMed

Reciprocal regulation by TLR4 and TGF-ß in tumor-initiating stem-like cells J Clin Invest. 2013 Jul; 123(7):2832-49. . View in PubMed

Outcomes after liver transplantation in patients achieving a model for end-stage liver disease score of 40 or higher Transplantation. 2013 Feb 15; 95(3):507-12. . View in PubMed

Intra-aortic balloon pump for hemodynamic support in hepatobiliary surgery: report of a case Surg Today. 2012 Aug; 42(8):793-6. . View in PubMed

Results of live donor liver transplantation in patients with hepatitic C virus infection: the HCV 3 trial experience Clin Transplant. 2012 May-Jun; 26(3):502-9. . View in PubMed

Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:19-22. . View in PubMed

Sirolimus conversion regimen versus continued calcineurin inhibitors in liver allograft recipients: a randomized trial Am J Transplant. 2012 Mar; 12(3):694-705. . View in PubMed

A randomized, multicenter study comparing steroid-free immunosuppression and standard immunosuppression for liver transplant recipients with chronic hepatitis C Liver Transpl. 2011 Dec; 17(12):1394-403. . View in PubMed

Removal of a large hepatic neuroendocrine tumor causing Budd-Chiari syndrome using a median sternotomy approach in conjunction with a midline laparotomy incision Am Surg. 2011 Feb; 77(2):E27-9. . View in PubMed

Blood-management programs: a clinical and administrative model with program implementation strategies Perm J. 2009; 13(1):18-28. . View in PubMed

Intraoperative umbilical herniorrhaphy during liver transplantation Surgery. 2008 Mar; 143(3):451-2. . View in PubMed

Ischemic mass effect from biliary surgical clips J Laparoendosc Adv Surg Tech A. 2008 Feb; 18(1):84-7. . View in PubMed

Living related donor nephrectomy in transfusion refusing donors Transpl Int. 2007 Jun; 20(6):490-6. . View in PubMed

Impact of a transfusion-free program on non-Jehovah's Witness patients undergoing liver transplantation Arch Surg. 2006 Sep; 141(9):913-7. . View in PubMed

Extended pancreatectomy with resection of the celiac axis: the modified Appleby operation Am J Surg. 2006 Sep; 192(3):330-5. . View in PubMed

Expanding the donor kidney pool: utility of renal allografts procured in a setting of uncontrolled cardiac death Am J Transplant. 2006 Jul; 6(7):1682-8. . View in PubMed

Predictors of employment after liver transplantation Clin Transplant. 2006 Jul-Aug; 20(4):490-5. . View in PubMed

Risk factors for graft survival after liver transplantation from donation after cardiac death donors: an analysis of OPTN/UNOS data Am J Transplant. 2006 Apr; 6(4):791-6. . View in PubMed

Gallstone-induced inflammatory fibrosis: a relentless clinical course of retained gallstones after laparoscopic cholecystectomy Am Surg. 2006 Apr; 72(4):303-6. . View in PubMed

A comparison of sirolimus vscalcineurin inhibitor-based immunosuppressive therapies in liver transplantation. Aliment Pharmacol Ther. 2006 Feb 15; 23(4):513-20. . View in PubMed

Iatrogenic pseudoaneurysms of the extrahepatic arterial vasculature: management and outcome HPB (Oxford). 2006; 8(6):458-64. . View in PubMed

Pancreaticoduodenectomy in adults with congenital intestinal rotation disorders Pancreas. 2005 Nov; 31(4):413-5. . View in PubMed

Transfusion free surgery: single institution experience of 27 consecutive liver transplants in Jehovah's Witnesses J Am Coll Surg. 2005 Sep; 201(3):412-7. . View in PubMed

Transfusion-free techniques in pediatric live donor liver transplantation J Pediatr Gastroenterol Nutr. 2005 Apr; 40(4):521-3. . View in PubMed

Comparison of a new fibrin sealant with standard topical hemostatic agents Arch Surg. 2004 Nov; 139(11):1148-54. . View in PubMed

Live donor liver transplantation without blood products: strategies developed for Jehovah's Witnesses offer broad application Ann Surg. 2004 Aug; 240(2):350-7. . View in PubMed

Live donor liver transplantation: staging hepatectomy in a Jehovah's Witness recipient J Hepatobiliary Pancreat Surg. 2004; 11(3):211-4. . View in PubMed

Left portahepatic shunt: a novel technique to decrease excessive portal venous inflow during live donor liver transplantation J Am Coll Surg. 2003 Dec; 197(6):1056-7. . View in PubMed

Characteristics and management of splenic artery aneurysm in liver transplant candidates and recipients Am Surg. 2003 Nov; 69(11):933-40. . View in PubMed

Comparison of outcomes in noncomplicated and in higher-risk donors after standard versus hand-assisted laparoscopic nephrectomy Am Surg. 2003 Sep; 69(9):771-8. . View in PubMed

Cadaveric organ donor recruitment at Los Angeles County Hospital: improvement after formation of a structured clinical, educational and administrative service Clin Transplant. 2003; 17 Suppl 9:52-7. . View in PubMed

Histologic evaluation and treatment outcome after sequential radiofrequency ablation and hepatic resection for primary and metastatic tumors Am Surg. 2002 Dec; 68(12):1038-43. . View in PubMed

Long-term results of metallic stents for benign biliary strictures Arch Surg. 2001 Jun; 136(6):664-9. . View in PubMed

Metastasis of hepatocellular carcinoma to the right colon manifested by gastrointestinal bleeding Am Surg. 1999 Mar; 65(3):218-21. . View in PubMed

Phase I safety and pharmacokinetic studies of brequinar sodium after single ascending oral doses in stable renal, hepatic, and cardiac allograft recipients J Clin Pharmacol. 1997 Dec; 37(12):1121-8. . View in PubMed

Transarterial chemoembolization is a safe treatment for unresectable hepatic malignancies Am Surg. 1997 Oct; 63(10):923-6. . View in PubMed

Efficacy of tacrolimus as rescue therapy for chronic rejection in orthotopic liver transplantation: a report of the US. Multicenter Liver Study Group. Transplantation. 1997 Jul 27; 64(2):258-63. . View in PubMed

Transjugular intrahepatic portosystemic shunt: efficacy for the treatment of portal hypertension and impact on liver transplantation Am Surg. 1996 Oct; 62(10):835-9. . View in PubMed

Tacrolimus (FK 506) for rescue of chronic rejection following orthotopic liver transplantation Transplant Proc. 1996 Apr; 28(2):1011-3. . View in PubMed

Enhanced oral cyclosporine absorption with water-soluble vitamin E early after liver transplantation Pharmacotherapy. 1996 Jan-Feb; 16(1):59-65. . View in PubMed

Immunosuppression: now we have choices Hepatology. 1995 Sep; 22(3):996-7. . View in PubMed

Acute liver failure due to lymphomaA diagnostic concern when considering liver transplantation. Dig Dis Sci. 1994 Jun; 39(6):1351-8. . View in PubMed

The development of Brequinar as an immunosuppressive drug for transplantation Immunol Rev. 1993 Dec; 136:51-70. . View in PubMed

A team of experts from two leading transplant centers reviews current indications, survival rates, and methods of evaluating candidates for operation. Hosp Rec Study. 1988 Jun; 10(6):62-79. . View in PubMed

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