Lucas J. Osborn, PhD

Assistant Professor Of Clinical Pathology

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Overview

Dr. Osborn is the Director of Microbiology at Keck Medical Center of USC and an Assistant Professor of Clinical Pathology at Keck School of Medicine of USC in Los Angeles, California, USA. Dr. Osborn earned his PhD in Molecular Medicine at Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and completed a postdoctoral fellowship in Medical and Public Health Microbiology at Children’s Hospital Los Angeles. Dr. Osborn’s research interests include applications of machine learning in clinical microbiology, reducing the turnaround time of infectious disease diagnostics, next generation sequencing, and diagnostic stewardship. Dr. Osborn is a Diplomate of the American Board of Medical Microbiology.

Education and Training

  • Children's Hospital Los Angeles, Los Angeles, CA, USA — Medical and Public Health Microbiology Fellowship
  • Cleveland Clinic Lerner College of Medicine | Case Western Reserve University, Cleveland, OH, USA — PhD — Molecular Medicine
  • Michigan State University, East Lansing, MI, USA — BS — Biomedical Laboratory Science

Publications

  • Cell-free DNA metagenomic next generation sequencing for the diagnosis of infectious diseases: a retrospective assessment of clinical utility in a tertiary and quaternary care facility. Front Microbiol. 2026; 17:1879762.. View in PubMed
  • Gut microbe-derived N-acyl serinol lipids shape host postprandial metabolic homeostasis. Proc Natl Acad Sci U S A. 2026 Mar 24; 123(12):e2517314123.. View in PubMed
  • Gut microbe-derived trimethylamine shapes circadian rhythms through the host receptor TAAR5. Elife. 2026 Jan 29; 14.. View in PubMed
  • The diet-derived gut microbial metabolite 3-phenylpropionic acid reverses insulin resistance and obesity-associated metabolic dysfunction. Mol Metab. 2025 Dec; 102:102272.. View in PubMed
  • Gut Microbe-Derived Trimethylamine Shapes Circadian Rhythms Through the Host Receptor TAAR5. bioRxiv. 2025 Oct 14.. View in PubMed
  • The Lipid Hydrolase ABHD6 is a Therapeutic Target in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-Related Hepatocellular Carcinoma. bioRxiv. 2025 Aug 01.. View in PubMed
  • Performance evaluation of early growth isolates for automated and manual broth microdilution antimicrobial-susceptibility testing. J Clin Microbiol. 2025 08 13; 63(8):e0023625.. View in PubMed
  • Gut microbial conversion of dietary elderberry extract to hydrocinnamic acid improves obesity-associated metabolic disorders. bioRxiv. 2025 May 18.. View in PubMed
  • Development of an automated amplicon-based next-generation sequencing pipeline for rapid detection of bacteria and fungi directly from clinical specimens. J Clin Microbiol. 2024 05 08; 62(5):e0174923.. View in PubMed
  • Metaorganismal choline metabolism shapes olfactory perception. J Biol Chem. 2023 11; 299(11):105299.. View in PubMed