Lucas J Osborn, PhD

Dr. Osborn is the Director of Microbiology at Keck Medical Center of USC and an Assistant Professor of Clinical Pathology at Keck School of Medicine of USC in Los Angeles, California, USA. Dr. Osborn earned his PhD in Molecular Medicine at Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and completed a postdoctoral fellowship in Medical and Public Health Microbiology at Children’s Hospital Los Angeles. Dr. Osborn’s research interests include applications of machine learning in clinical microbiology, reducing the turnaround time of infectious disease diagnostics, next generation sequencing, and diagnostic stewardship. Dr. Osborn is a Diplomate of the American Board of Medical Microbiology.

• Gut microbe-derived N-acyl serinol lipids shape host postprandial metabolic homeostasis. Proc Natl Acad Sci U S A. 2026 Mar 24; 123(12):e2517314123.. View in PubMed
• The diet-derived gut microbial metabolite 3-phenylpropionic acid reverses insulin resistance and obesity-associated metabolic dysfunction. Mol Metab. 2025 Dec; 102:102272.. View in PubMed
• Gut Microbe-Derived Trimethylamine Shapes Circadian Rhythms Through the Host Receptor TAAR5. bioRxiv. 2025 Oct 14.. View in PubMed
• Performance evaluation of early growth isolates for automated and manual broth microdilution antimicrobial-susceptibility testing. J Clin Microbiol. 2025 Aug 13; 63(8):e0023625.. View in PubMed
• The Lipid Hydrolase ABHD6 is a Therapeutic Target in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-Related Hepatocellular Carcinoma. bioRxiv. 2025 Aug 01.. View in PubMed
• Gut microbial conversion of dietary elderberry extract to hydrocinnamic acid improves obesity-associated metabolic disorders. bioRxiv. 2025 May 18.. View in PubMed
• Development of an automated amplicon-based next-generation sequencing pipeline for rapid detection of bacteria and fungi directly from clinical specimens. J Clin Microbiol. 2024 05 08; 62(5):e0174923.. View in PubMed
• Metaorganismal choline metabolism shapes olfactory perception. J Biol Chem. 2023 11; 299(11):105299.. View in PubMed
• Clinical utility of SARS-CoV-2 subgenomic RT-PCR in a pediatric quaternary care setting. J Clin Virol. 2023 07; 164:105494.. View in PubMed
• Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome. Cell. 2023 06 22; 186(13):2839-2852.e21.. View in PubMed
• A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis. Proc Natl Acad Sci U S A. 2022 11 29; 119(48):e2202934119.. View in PubMed
• Monkeypox: Clinical Considerations, Epidemiology, and Laboratory Diagnostics. Clin Microbiol Newsl. 2022 Nov 15; 44(22):199-208.. View in PubMed
• Multicenter Evaluation of a Gradient Diffusion Method for Antimicrobial Susceptibility Testing of Helicobacter pylori. Microbiol Spectr. 2022 04 27; 10(2):e0211121.. View in PubMed
• Flavin-Containing Monooxygenase 3 (FMO3) Is Critical for Dioxin-Induced Reorganization of the Gut Microbiome and Host Insulin Sensitivity. Metabolites. 2022 Apr 18; 12(4).. View in PubMed
• A 3D-printable device allowing fast and reproducible longitudinal preparation of mouse intestines. Animal Model Exp Med. 2022 04; 5(2):189-196.. View in PubMed
• Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice. Elife. 2022 01 27; 11.. View in PubMed
• Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms. Elife. 2022 01 24; 11.. View in PubMed
• The Nutritional Supplement L-Alpha Glycerylphosphorylcholine Promotes Atherosclerosis. Int J Mol Sci. 2021 Dec 15; 22(24).. View in PubMed
• Microbial Flavonoid Metabolism: A Cardiometabolic Disease Perspective. Annu Rev Nutr. 2021 10 11; 41:433-454.. View in PubMed
• Identification of essential genes for Escherichia coli aryl polyene biosynthesis and function in biofilm formation. NPJ Biofilms Microbiomes. 2021 07 02; 7(1):56.. View in PubMed
• A surgical method for continuous intraportal infusion of gut microbial metabolites in mice. JCI Insight. 2021 05 10; 6(9).. View in PubMed
• A Single Human-Relevant Fast Food Meal Rapidly Reorganizes Metabolomic and Transcriptomic Signatures in a Gut Microbiota-Dependent Manner. Immunometabolism. 2021; 3(4).. View in PubMed
• Simultaneous Measurement of Urinary Trimethylamine (TMA) and Trimethylamine N-Oxide (TMAO) by Liquid Chromatography-Mass Spectrometry. Molecules. 2020 Apr 17; 25(8).. View in PubMed
• Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease. Elife. 2019 10 17; 8.. View in PubMed

• Gonzalez, Frank
• Goran, Michael