Keck School Faculty

Lucy Mary Golden

Lucy Mary Golden

Professor of Clinical Medicine
NOR 4501 Health Sciences Campus Los Angeles

Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23 Nat Commun. 2022 03 17; 13(1):1440. . View in PubMed

Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease iScience. 2021 May 21; 24(5):102457. . View in PubMed

In Utero Exposure to Mercury Is Associated With Increased Susceptibility to Liver Injury and Inflammation in Childhood Hepatology. 2021 09; 74(3):1546-1559. . View in PubMed

Single-cell transcriptomic analyses of T cells in chronic HCV-infected patients dominated by DAA-induced interferon signaling changes PLoS Pathog. 2021 08; 17(8):e1009799. . View in PubMed

Cholesterol-Induced M4-Like Macrophages Recruit Neutrophils and Induce NETosis Front Immunol. 2021; 12:671073. . View in PubMed

Control of HCV Infection by Natural Killer Cells and Macrophages Cold Spring Harb Perspect Med. 2020 09 01; 10(9). . View in PubMed

Increased hepatic and circulating chemokine and osteopontin expression occurs early in human NAFLD development PLoS One. 2020; 15(7):e0236353. . View in PubMed

Dietary Lipids Differentially Shape Nonalcoholic Steatohepatitis Progression and the Transcriptome of Kupffer Cells and Infiltrating Macrophages Hepatology. 2019 07; 70(1):67-83. . View in PubMed

HCMV jogs the 'memory' of NK cells in HBV J Hepatol. 2019 03; 70(3):343-345. . View in PubMed

Revisiting the Paradox of Interferon-Stimulated Gene Expression as a Predictor of Hepatitis C Virus Treatment Response, a Decade Later Hepatology. 2018 12; 68(6):2053-2055. . View in PubMed

Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment Hepatol Commun. 2018 04; 2(4):364-375. . View in PubMed

Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection Hepatology. 2018 01; 67(1):71-85. . View in PubMed

Galectin-9: Diverse roles in hepatic immune homeostasis and inflammation Hepatology. 2017 07; 66(1):271-279. . View in PubMed

NK cells regulate CXCR2+ neutrophil recruitment during acute lung injury J Leukoc Biol. 2017 02; 101(2):471-480. . View in PubMed

Neutrophil-to-lymphocyte ratio correlates with proinflammatory neutrophils and predicts death in low model for end-stage liver disease patients with cirrhosis Liver Transpl. 2017 02; 23(2):155-165. . View in PubMed

Correction: Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission J Immunol. 2017 01 15; 198(2):972. . View in PubMed

Variants in the LGALS9 Gene Are Associated With Development of Liver Disease in Heavy Consumers of AlcoholClin Gastroenterol Hepatol. 2016 May; 14(5):762-8. e1. . View in PubMed

J Immunol. 2016 Mar 01; 196(5):2283-92. . View in PubMed

HCV-infected cells and differentiation increase monocyte immunoregulatory galectin-9 production J Leukoc Biol. 2016 Mar; 99(3):495-503. . View in PubMed

CD4+ and CD8+ T Cell Activation in Children with Hepatitis CJ Pediatr. 2016 Mar; 170:142-8. e1. . View in PubMed

Hepatitis C viral infection is associated with activated cytolytic natural killer cells expressing high levels of T cell immunoglobulin- and mucin-domain-containing molecule-3 Clin Immunol. 2015 May; 158(1):114-25. . View in PubMed

Transmitted/founder hepatitis C viruses induce cell-type- and genotype-specific differences in innate signaling within the liver mBio. 2015 Feb 24; 6(2):e02510. . View in PubMed

Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replicationGastroenterology. 2015 Feb; 148(2):392-402. e13. . View in PubMed

Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission J Immunol. 2015 10 15; 195(8):3737-47. . View in PubMed

Class I HDACs regulate angiotensin II-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes J Mol Cell Cardiol. 2014 Feb; 67:112-25. . View in PubMed

Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation Immunity. 2014 Jan 16; 40(1):66-77. . View in PubMed

Extracellular HCV-core protein induces an immature regulatory phenotype in NK cells: implications for outcome of acute infection PLoS One. 2014; 9(7):e103219. . View in PubMed

Hepatitis C virus core protein inhibits interferon production by a human plasmacytoid dendritic cell line and dysregulates interferon regulatory factor-7 and signal transducer and activator of transcription (STAT) 1 protein expression PLoS One. 2014; 9(5):e95627. . View in PubMed

Natural killer cells: multifaceted players with key roles in hepatitis C immunity Immunol Rev. 2013 Sep; 255(1):68-81. . View in PubMed

Galectin-9 functionally impairs natural killer cells in humans and mice J Virol. 2013 May; 87(9):4835-45. . View in PubMed

Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease J Biol Chem. 2013 Apr 26; 288(17):11761-70. . View in PubMed

Hepatitis C virus pathogen associated molecular pattern (PAMP) triggers production of lambda-interferons by human plasmacytoid dendritic cells PLoS Pathog. 2013; 9(4):e1003316. . View in PubMed

Race- and gender-related variation in natural killer p46 expression associated with differential anti-hepatitis C virus immunity Hepatology. 2012 Oct; 56(4):1214-22. . View in PubMed

Interleukin (IL)-17/IL-22-producing T cells enriched within the liver of patients with chronic hepatitis C viral (HCV) infection Dig Dis Sci. 2012 Feb; 57(2):381-9. . View in PubMed

A summary of the 18th International Symposium on Hepatitis C Virus and Related Viruses Gastroenterology. 2012 Jan; 142(1):e1-5. . View in PubMed

Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C Hepatology. 2011 Nov; 54(5):1559-69. . View in PubMed

Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease Gastroenterology. 2011 Jul; 141(1):208-16. . View in PubMed

Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion Hepatology. 2011 Jun; 53(6):1846-53. . View in PubMed

Differential expression of NK receptors CD94 and NKG2A by T cells in rheumatoid arthritis patients in remission compared to active disease PLoS One. 2011; 6(11):e27182. . View in PubMed

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity J Clin Invest. 2010 Dec; 120(12):4546-57. . View in PubMed

Increased natural killer cell cytotoxicity and NKp30 expression protects against hepatitis C virus infection in high-risk individuals and inhibits replication in vitro Hepatology. 2010 Nov; 52(5):1581-9. . View in PubMed

Regulation of virus-specific CD4+ T cell function by multiple costimulatory receptors during chronic HIV infection J Immunol. 2010 Sep 01; 185(5):3007-18. . View in PubMed

Innate immune function in placenta and cord blood of hepatitis C--seropositive mother-infant dyads PLoS One. 2010 Aug 30; 5(8):e12232. . View in PubMed

Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity PLoS Pathog. 2010 Jul 29; 6(7):e1001018. . View in PubMed

A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection PLoS One. 2010 Mar 04; 5(3):e9504. . View in PubMed

Comprehensive assessment of chemokine expression profiles by flow cytometry J Clin Invest. 2010 Mar; 120(3):907-23. . View in PubMed

Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells J Virol. 2009 Sep; 83(18):9122-30. . View in PubMed

Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertility Am J Reprod Immunol. 2009 Apr; 61(4):265-76. . View in PubMed

Natural killer cells play divergent roles in shaping the outcome of hepatitis C virus recurrence following liver transplantation Liver Transpl. 2009 Apr; 15(4):357-9. . View in PubMed

Prospective analysis of effector and regulatory CD4+ T cells in chronic HCV patients undergoing combination antiviral therapy J Hepatol. 2008 Sep; 49(3):329-38. . View in PubMed

Cutting edge: programmed death-1 expression is increased on immunocytes in chronic hepatitis C virus and predicts failure of response to antiviral therapy: race-dependent differences J Immunol. 2008 Mar 15; 180(6):3637-41. . View in PubMed

Spontaneous recovery in acute human hepatitis C virus infection: functional T-cell thresholds and relative importance of CD4 help J Virol. 2008 Feb; 82(4):1827-37. . View in PubMed

Pretransplantation CD56(+) innate lymphocyte populations associated with severity of hepatitis C virus recurrence Liver Transpl. 2008 Jan; 14(1):31-40. . View in PubMed

Functional suppression by FoxP3+CD4+CD25(high) regulatory T cells during acute hepatitis C virus infection J Infect Dis. 2008 Jan 01; 197(1):46-57. . View in PubMed

Mechanisms of Disease: HCV-induced liver injury Nat Clin Pract Gastroenterol Hepatol. 2007 Nov; 4(11):622-34. . View in PubMed

Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection J Virol. 2007 Sep; 81(17):9292-8. . View in PubMed

Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction J Virol. 2007 Sep; 81(17):9249-58. . View in PubMed

Loss of IL-7 receptor alpha-chain (CD127) expression in acute HCV infection associated with viral persistence Hepatology. 2006 Nov; 44(5):1098-109. . View in PubMed

Changes in hepatic immunoregulatory cytokines in patients with metastatic colorectal carcinoma: implications for hepatic anti-tumour immunity Cytokine. 2006 Aug; 35(3-4):171-9. . View in PubMed

Resolution of endothelial activation and down-regulation of Tie2 receptor in psoriatic skin after infliximab therapy J Am Acad Dermatol. 2006 Jun; 54(6):1003-12. . View in PubMed

Detection and characterization of hemopoietic stem cells in the adult human small intestine J Immunol. 2006 May 01; 176(9):5199-204. . View in PubMed

Natural killer cells: primary target for hepatitis C virus immune evasion strategies? Liver Transpl. 2006 Mar; 12(3):363-72.. View in PubMed

The hepatitis C envelope 2 protein inhibits LFA-1-transduced protein kinase C signaling for T-lymphocyte migration Gastroenterology. 2006 Feb; 130(2):482-92. . View in PubMed

Acute-phase serum amyloid A stimulation of angiogenesis, leukocyte recruitment, and matrix degradation in rheumatoid arthritis through an NF-kappaB-dependent signal transduction pathway Arthritis Rheum. 2006 Jan; 54(1):105-14. . View in PubMed

Trephine biopsies are enriched for activated T/NK cells and cytotoxic T cells Immunol Lett. 2005 Jun 15; 99(1):94-102. . View in PubMed

Distinct subpopulations of gamma delta T cells are present in normal and tumor-bearing human liver Clin Immunol. 2004 Oct; 113(1):56-63. . View in PubMed

Nitric oxide in early ischaemia reperfusion injury during human orthotopic liver transplantation Transplantation. 2004 Jul 27; 78(2):250-6. . View in PubMed

Adult human liver contains CD8pos T cells with naive phenotype, but is not a site for conventional alpha beta T cell development J Immunol. 2004 May 15; 172(10):5980-5. . View in PubMed

Cortisol does not mediate the suppressive effects of psychiatric morbidity on natural killer cell activity: a cross-sectional study of patients with early breast cancer Psychol Med. 2004 Apr; 34(3):481-90. . View in PubMed

Interleukin 12 (IL-12) is increased in tumour bearing human liver and expands CD8(+) and CD56(+) T cells in vitro but not in vivo Cytokine. 2004 Mar 21; 25(6):273-82. . View in PubMed

Localization of T and B lymphocytes in histologically normal adult human donor liver Hepatogastroenterology. 2003 Sep-Oct; 50(53):1311-5. . View in PubMed

NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells J Immunol. 2003 Aug 15; 171(4):1775-9. . View in PubMed

Stress-related hormonal suppression of natural killer activity does not show menstrual cycle variations: implications for timing of surgery for breast cancer Anticancer Res. 2003 May-Jun; 23(3B):2531-5. . View in PubMed

Expansion of innate CD5pos B cells expressing high levels of CD81 in hepatitis C virus infected liver J Hepatol. 2003 May; 38(5):642-50. . View in PubMed

Decrease in hepatic CD56(+) T cells and V alpha 24(+) natural killer T cells in chronic hepatitis C viral infection J Hepatol. 2002 Jul; 37(1):101-8. . View in PubMed

Immunol Cell Biol. 2002 Feb; 80(1):45-51. . View in PubMed

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