USC.edu
Are You a Patient?

Lucy Mary Golden, PhD

Research Professor of Medicine (Part-Time)

Image of Lucy Mary Golden, PhD
Is this your profile? Click to edit
Phone +1 323 442 1319
Email [email protected]
Orcid ID CTSI Profile

Publications

  • Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23. Nat Commun. 2022 03 17; 13(1):1440.. View in PubMed
  • In Utero Exposure to Mercury Is Associated With Increased Susceptibility to Liver Injury and Inflammation in Childhood. Hepatology. 2021 09; 74(3):1546-1559.. View in PubMed
  • Single-cell transcriptomic analyses of T cells in chronic HCV-infected patients dominated by DAA-induced interferon signaling changes. PLoS Pathog. 2021 08; 17(8):e1009799.. View in PubMed
  • Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease. iScience. 2021 May 21; 24(5):102457.. View in PubMed
  • Cholesterol-Induced M4-Like Macrophages Recruit Neutrophils and Induce NETosis. Front Immunol. 2021; 12:671073.. View in PubMed
  • Control of HCV Infection by Natural Killer Cells and Macrophages. Cold Spring Harb Perspect Med. 2020 09 01; 10(9).. View in PubMed
  • Increased hepatic and circulating chemokine and osteopontin expression occurs early in human NAFLD development. PLoS One. 2020; 15(7):e0236353.. View in PubMed
  • Dietary Lipids Differentially Shape Nonalcoholic Steatohepatitis Progression and the Transcriptome of Kupffer Cells and Infiltrating Macrophages. Hepatology. 2019 07; 70(1):67-83.. View in PubMed
  • HCMV jogs the ‘memory’ of NK cells in HBV. J Hepatol. 2019 03; 70(3):343-345.. View in PubMed
  • Revisiting the Paradox of Interferon-Stimulated Gene Expression as a Predictor of Hepatitis C Virus Treatment Response, a Decade Later. Hepatology. 2018 12; 68(6):2053-2055.. View in PubMed
  • Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment. Hepatol Commun. 2018 04; 2(4):364-375.. View in PubMed
  • Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection. Hepatology. 2018 01; 67(1):71-85.. View in PubMed
  • Galectin-9: Diverse roles in hepatic immune homeostasis and inflammation. Hepatology. 2017 07; 66(1):271-279.. View in PubMed
  • Neutrophil-to-lymphocyte ratio correlates with proinflammatory neutrophils and predicts death in low model for end-stage liver disease patients with cirrhosis. Liver Transpl. 2017 02; 23(2):155-165.. View in PubMed
  • NK cells regulate CXCR2+ neutrophil recruitment during acute lung injury. J Leukoc Biol. 2017 02; 101(2):471-480.. View in PubMed
  • Correction: Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission. J Immunol. 2017 01 15; 198(2):972.. View in PubMed
  • Variants in the LGALS9 Gene Are Associated With Development of Liver Disease in Heavy Consumers of Alcohol. Clin Gastroenterol Hepatol. 2016 May; 14(5):762-8.e1.. View in PubMed
  • CD4+ and CD8+ T Cell Activation in Children with Hepatitis C. J Pediatr. 2016 Mar; 170:142-8.e1.. View in PubMed
  • HCV-infected cells and differentiation increase monocyte immunoregulatory galectin-9 production. J Leukoc Biol. 2016 Mar; 99(3):495-503.. View in PubMed
  • Hepatitis C Virus-Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-γ Production by Altering Cellular Metabolism via Arginase-1. J Immunol. 2016 Mar 01; 196(5):2283-92.. View in PubMed
  • Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission. J Immunol. 2015 10 15; 195(8):3737-47.. View in PubMed
  • Hepatitis C viral infection is associated with activated cytolytic natural killer cells expressing high levels of T cell immunoglobulin- and mucin-domain-containing molecule-3. Clin Immunol. 2015 May; 158(1):114-25.. View in PubMed
  • Transmitted/founder hepatitis C viruses induce cell-type- and genotype-specific differences in innate signaling within the liver. mBio. 2015 Feb 24; 6(2):e02510.. View in PubMed
  • Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication. Gastroenterology. 2015 Feb; 148(2):392-402.e13.. View in PubMed
  • Class I HDACs regulate angiotensin II-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes. J Mol Cell Cardiol. 2014 Feb; 67:112-25.. View in PubMed
  • Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation. Immunity. 2014 Jan 16; 40(1):66-77.. View in PubMed
  • Hepatitis C virus core protein inhibits interferon production by a human plasmacytoid dendritic cell line and dysregulates interferon regulatory factor-7 and signal transducer and activator of transcription (STAT) 1 protein expression. PLoS One. 2014; 9(5):e95627.. View in PubMed
  • Extracellular HCV-core protein induces an immature regulatory phenotype in NK cells: implications for outcome of acute infection. PLoS One. 2014; 9(7):e103219.. View in PubMed
  • Natural killer cells: multifaceted players with key roles in hepatitis C immunity. Immunol Rev. 2013 Sep; 255(1):68-81.. View in PubMed
  • Galectin-9 functionally impairs natural killer cells in humans and mice. J Virol. 2013 May; 87(9):4835-45.. View in PubMed
  • Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease. J Biol Chem. 2013 Apr 26; 288(17):11761-70.. View in PubMed
  • Hepatitis C virus pathogen associated molecular pattern (PAMP) triggers production of lambda-interferons by human plasmacytoid dendritic cells. PLoS Pathog. 2013; 9(4):e1003316.. View in PubMed
  • Race- and gender-related variation in natural killer p46 expression associated with differential anti-hepatitis C virus immunity. Hepatology. 2012 Oct; 56(4):1214-22.. View in PubMed
  • Interleukin (IL)-17/IL-22-producing T cells enriched within the liver of patients with chronic hepatitis C viral (HCV) infection. Dig Dis Sci. 2012 Feb; 57(2):381-9.. View in PubMed
  • A summary of the 18th International Symposium on Hepatitis C Virus and Related Viruses. Gastroenterology. 2012 Jan; 142(1):e1-5.. View in PubMed
  • Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C. Hepatology. 2011 Nov; 54(5):1559-69.. View in PubMed
  • Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease. Gastroenterology. 2011 Jul; 141(1):208-16.. View in PubMed
  • Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion. Hepatology. 2011 Jun; 53(6):1846-53.. View in PubMed
  • Differential expression of NK receptors CD94 and NKG2A by T cells in rheumatoid arthritis patients in remission compared to active disease. PLoS One. 2011; 6(11):e27182.. View in PubMed
  • Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity. J Clin Invest. 2010 Dec; 120(12):4546-57.. View in PubMed
  • Increased natural killer cell cytotoxicity and NKp30 expression protects against hepatitis C virus infection in high-risk individuals and inhibits replication in vitro. Hepatology. 2010 Nov; 52(5):1581-9.. View in PubMed
  • Regulation of virus-specific CD4+ T cell function by multiple costimulatory receptors during chronic HIV infection. J Immunol. 2010 Sep 01; 185(5):3007-18.. View in PubMed
  • Innate immune function in placenta and cord blood of hepatitis C–seropositive mother-infant dyads. PLoS One. 2010 Aug 30; 5(8):e12232.. View in PubMed
  • Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity. PLoS Pathog. 2010 Jul 29; 6(7):e1001018.. View in PubMed
  • A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection. PLoS One. 2010 Mar 04; 5(3):e9504.. View in PubMed
  • Comprehensive assessment of chemokine expression profiles by flow cytometry. J Clin Invest. 2010 Mar; 120(3):907-23.. View in PubMed
  • Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells. J Virol. 2009 Sep; 83(18):9122-30.. View in PubMed
  • Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertility. Am J Reprod Immunol. 2009 Apr; 61(4):265-76.. View in PubMed
  • Natural killer cells play divergent roles in shaping the outcome of hepatitis C virus recurrence following liver transplantation. Liver Transpl. 2009 Apr; 15(4):357-9.. View in PubMed
  • Prospective analysis of effector and regulatory CD4+ T cells in chronic HCV patients undergoing combination antiviral therapy. J Hepatol. 2008 Sep; 49(3):329-38.. View in PubMed
  • Cutting edge: programmed death-1 expression is increased on immunocytes in chronic hepatitis C virus and predicts failure of response to antiviral therapy: race-dependent differences. J Immunol. 2008 Mar 15; 180(6):3637-41.. View in PubMed
  • Spontaneous recovery in acute human hepatitis C virus infection: functional T-cell thresholds and relative importance of CD4 help. J Virol. 2008 Feb; 82(4):1827-37.. View in PubMed
  • Functional suppression by FoxP3+CD4+CD25(high) regulatory T cells during acute hepatitis C virus infection. J Infect Dis. 2008 Jan 01; 197(1):46-57.. View in PubMed
  • Pretransplantation CD56(+) innate lymphocyte populations associated with severity of hepatitis C virus recurrence. Liver Transpl. 2008 Jan; 14(1):31-40.. View in PubMed
  • Mechanisms of Disease: HCV-induced liver injury. Nat Clin Pract Gastroenterol Hepatol. 2007 Nov; 4(11):622-34.. View in PubMed
  • Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection. J Virol. 2007 Sep; 81(17):9292-8.. View in PubMed
  • Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction. J Virol. 2007 Sep; 81(17):9249-58.. View in PubMed
  • Loss of IL-7 receptor alpha-chain (CD127) expression in acute HCV infection associated with viral persistence. Hepatology. 2006 Nov; 44(5):1098-109.. View in PubMed
  • Changes in hepatic immunoregulatory cytokines in patients with metastatic colorectal carcinoma: implications for hepatic anti-tumour immunity. Cytokine. 2006 Aug; 35(3-4):171-9.. View in PubMed
  • Resolution of endothelial activation and down-regulation of Tie2 receptor in psoriatic skin after infliximab therapy. J Am Acad Dermatol. 2006 Jun; 54(6):1003-12.. View in PubMed
  • Detection and characterization of hemopoietic stem cells in the adult human small intestine. J Immunol. 2006 May 01; 176(9):5199-204.. View in PubMed
  • Natural killer cells: primary target for hepatitis C virus immune evasion strategies? Liver Transpl. 2006 Mar; 12(3):363-72.. View in PubMed
  • The hepatitis C envelope 2 protein inhibits LFA-1-transduced protein kinase C signaling for T-lymphocyte migration. Gastroenterology. 2006 Feb; 130(2):482-92.. View in PubMed
  • Acute-phase serum amyloid A stimulation of angiogenesis, leukocyte recruitment, and matrix degradation in rheumatoid arthritis through an NF-kappaB-dependent signal transduction pathway. Arthritis Rheum. 2006 Jan; 54(1):105-14.. View in PubMed
  • Trephine biopsies are enriched for activated T/NK cells and cytotoxic T cells. Immunol Lett. 2005 Jun 15; 99(1):94-102.. View in PubMed
  • Distinct subpopulations of gamma delta T cells are present in normal and tumor-bearing human liver. Clin Immunol. 2004 Oct; 113(1):56-63.. View in PubMed
  • Nitric oxide in early ischaemia reperfusion injury during human orthotopic liver transplantation. Transplantation. 2004 Jul 27; 78(2):250-6.. View in PubMed
  • Adult human liver contains CD8pos T cells with naive phenotype, but is not a site for conventional alpha beta T cell development. J Immunol. 2004 May 15; 172(10):5980-5.. View in PubMed
  • Cortisol does not mediate the suppressive effects of psychiatric morbidity on natural killer cell activity: a cross-sectional study of patients with early breast cancer. Psychol Med. 2004 Apr; 34(3):481-90.. View in PubMed
  • Interleukin 12 (IL-12) is increased in tumour bearing human liver and expands CD8(+) and CD56(+) T cells in vitro but not in vivo. Cytokine. 2004 Mar 21; 25(6):273-82.. View in PubMed
  • Localization of T and B lymphocytes in histologically normal adult human donor liver. Hepatogastroenterology. 2003 Sep-Oct; 50(53):1311-5.. View in PubMed
  • NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells. J Immunol. 2003 Aug 15; 171(4):1775-9.. View in PubMed
  • Stress-related hormonal suppression of natural killer activity does not show menstrual cycle variations: implications for timing of surgery for breast cancer. Anticancer Res. 2003 May-Jun; 23(3B):2531-5.. View in PubMed
  • Expansion of innate CD5pos B cells expressing high levels of CD81 in hepatitis C virus infected liver. J Hepatol. 2003 May; 38(5):642-50.. View in PubMed
  • Decrease in hepatic CD56(+) T cells and V alpha 24(+) natural killer T cells in chronic hepatitis C viral infection. J Hepatol. 2002 Jul; 37(1):101-8.. View in PubMed
  • Having it all? Stem cells, haematopoiesis and lymphopoiesis in adult human liver. Immunol Cell Biol. 2002 Feb; 80(1):45-51.. View in PubMed

Similar People