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Marc Vermulst

Associate Professor of Gerontology

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Phone +1 213 821 2488
Email [email protected]
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Publications

  • Induction of ferroptotic and amyloidogenic signatures linked to Alzheimer’s disease by chemically distinct air pollutants. bioRxiv. 2026 Jan 07.. View in PubMed
  • The hidden costs of imperfection: transcription errors in protein aggregation diseases. Curr Opin Genet Dev. 2025 Aug; 93:102350.. View in PubMed
  • The mutational landscape of SARS-CoV-2 provides new insight into viral evolution and fitness. Nat Commun. 2025 Jul 11; 16(1):6425.. View in PubMed
  • A narrow range of transcript-error rates across the Tree of Life. Sci Adv. 2025 Jul 11; 11(28):eadv9898.. View in PubMed
  • The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome. bioRxiv. 2025 Jun 06.. View in PubMed
  • Down syndrome with Alzheimer’s disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis. Alzheimers Dement. 2025 Jun; 21(6):e70322.. View in PubMed
  • Down syndrome with Alzheimer’s disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis. bioRxiv. 2025 Feb 06.. View in PubMed
  • A Narrow Range of Transcript-error Rates Across the Tree of Life. bioRxiv. 2025 Jan 14.. View in PubMed
  • Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging. Geroscience. 2024 Dec; 46(6):6009-6028.. View in PubMed
  • Linking Environmental Genotoxins to Neurodegenerative Diseases Through Transcriptional Mutagenesis. Int J Mol Sci. 2024 Oct 24; 25(21).. View in PubMed
  • Transcript errors generate amyloid-like proteins in huwman cells. Nat Commun. 2024 10 07; 15(1):8676.. View in PubMed
  • MADDD-seq, a novel massively parallel sequencing tool for simultaneous detection of DNA damage and mutations. Nucleic Acids Res. 2024 Sep 09; 52(16):e76.. View in PubMed
  • Effects of the glyphosate-based herbicide roundup on C. elegans and S. cerevisiae mortality, reproduction, and transcription fidelity. Environ Pollut. 2024 Sep 01; 356:124203.. View in PubMed
  • The cycad genotoxin methylazoxymethanol, linked to Guam ALS/PDC, induces transcriptional mutagenesis. Acta Neuropathol Commun. 2024 02 21; 12(1):30.. View in PubMed
  • Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc Natl Acad Sci U S A. 2023 12 19; 120(51):e2306767120.. View in PubMed
  • Identification of RBM46 as a novel APOBEC1 cofactor for C-to-U RNA-editing activity. J Mol Biol. 2023 12 15; 435(24):168333.. View in PubMed
  • Investigating impacts of marine sponge derived mycothiazole and its acetylated derivative on mitochondrial function and aging. bioRxiv. 2023 Nov 27.. View in PubMed
  • Tau Filaments from Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) adopt the CTE Fold. bioRxiv. 2023 Apr 28.. View in PubMed
  • Evolutionary conservation of the fidelity of transcription. Nat Commun. 2023 03 20; 14(1):1547.. View in PubMed
  • The fidelity of transcription in human cells. Proc Natl Acad Sci U S A. 2023 01 31; 120(5):e2210038120.. View in PubMed
  • Genome-wide surveillance of transcription errors in response to genotoxic stress. Proc Natl Acad Sci U S A. 2021 01 05; 118(1).. View in PubMed
  • Correction to: Somatic mutations in neurons during aging and neurodegeneration. Acta Neuropathol. 2020 09; 140(3):415.. View in PubMed
  • Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans. BMC Biol. 2020 02 24; 18(1):18.. View in PubMed
  • Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice. Exp Gerontol. 2019 10 01; 125:110675.. View in PubMed
  • Oxygen Consumption Measurements in Caenorhabditis elegans Using the Seahorse XF24. Bio Protoc. 2019 Jul 05; 9(13):e3288.. View in PubMed
  • Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy. Cell Metab. 2019 01 08; 29(1):78-90.e5.. View in PubMed
  • Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms. J Vis Exp. 2018 09 13; (139).. View in PubMed
  • Somatic mutations in neurons during aging and neurodegeneration. Acta Neuropathol. 2018 06; 135(6):811-826.. View in PubMed
  • Multiple Molecular Mechanisms Rescue mtDNA Disease in C. elegans. Cell Rep. 2018 03 20; 22(12):3115-3125.. View in PubMed
  • The landscape of transcription errors in eukaryotic cells. Sci Adv. 2017 10; 3(10):e1701484.. View in PubMed
  • Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice. PLoS One. 2017; 12(2):e0171159.. View in PubMed
  • Linking mitochondrial dynamics to mitochondrial protein quality control. Curr Opin Genet Dev. 2016 06; 38:68-74.. View in PubMed
  • Corrigendum: Transcription errors induce proteotoxic stress and shorten cellular lifespan. Nat Commun. 2015 Oct 14; 6:8738.. View in PubMed
  • Transcription errors induce proteotoxic stress and shorten cellular lifespan. Nat Commun. 2015 Aug 25; 6:8065.. View in PubMed
  • Decreased mitochondrial DNA mutagenesis in human colorectal cancer. PLoS Genet. 2012; 8(6):e1002689.. View in PubMed
  • Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell. 2010 Apr 16; 141(2):280-9.. View in PubMed
  • On mitochondria, mutations, and methodology. Cell Metab. 2009 Dec; 10(6):437.. View in PubMed
  • Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. Circulation. 2009 Jun 02; 119(21):2789-97.. View in PubMed
  • Quantification of random mutations in the mitochondrial genome. Methods. 2008 Dec; 46(4):263-8.. View in PubMed
  • DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet. 2008 Apr; 40(4):392-4.. View in PubMed
  • Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet. 2007 Apr; 39(4):540-3.. View in PubMed

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