Meredith N. Braskie, PhD

Assistant Professor of Neurology

INI Director of Education

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Overview

The Braskie lab seeks to gain a better understanding of risk factors for Alzheimer’s disease (AD), in particular, vascular and metabolic risk and inflammation. We do this by relating measures of multimodal imaging (structural and functional MRI, diffusion tensor imaging, and amyloid and tau PET) both to relevant blood and cerebrospinal fluid measures and to other medical and demographic data. We collaborate widely, including with wet labs that are researching similar topics.

Awards

  • Bosco S. Tjan Mentorship Award, 2023
  • Turken Award for Alzheimer’s Disease Research, 2011
  • Ruth L. Kirschstein National Research Service Award, 2009-2010
  • Achievement Rewards for College Scientists (ARCS) fellowship, 2004-2006
  • Ruth L Kirschstein National Research Service Award, 2003-2006

Publications

  • The Association between Exposure to Fine Particulate Matter and MRI-Assessed Locus Coeruleus Integrity in the Vietnam Era Twin Study of Aging (VETSA) Environ Health Perspect. 2024 Jul; 132(7):77006. . View in PubMed
  • Age-Related Decline in BBB Function is More Pronounced in Males than Females bioRxiv. 2024 Jan 15. . View in PubMed
  • Using Neuroimaging to Study Cerebral Amyloid Angiopathy and Its Relationship to Alzheimer’s Disease J Alzheimers Dis. 2024; 97(4):1479-1502. . View in PubMed
  • White matter hyperintensity volume modifies the association between CSF vascular inflammatory biomarkers and regional FDG-PET along the Alzheimer’s disease continuum Neurobiol Aging. 2023 Dec; 132:1-12. . View in PubMed
  • Alzheimer’s Related Neurodegeneration Mediates Air Pollution Effects on Medial Temporal Lobe Atrophy medRxiv. 2023 Nov 29. . View in PubMed
  • Association between late-life air pollution exposure and medial temporal lobe atrophy in older women medRxiv. 2023 Nov 29. . View in PubMed
  • Correction: Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE Mol Psychiatry. 2023 Apr; 28(4):1827. . View in PubMed
  • Associations of ApoE4 status and DHA supplementation on plasma and CSF lipid profiles and entorhinal cortex thickness J Lipid Res. 2023 06; 64(6):100354. . View in PubMed
  • Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE Mol Psychiatry. 2023 04; 28(4):1813-1826. . View in PubMed
  • Baseline Findings of PreventE4: A Double-Blind Placebo Controlled Clinical Trial Testing High Dose DHA in APOE4 Carriers before the Onset of Dementia J Prev Alzheimers Dis. 2023; 10(4):810-820. . View in PubMed
  • Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon-like peptide-1 receptor agonists Alzheimers Dement. 2022 03; 18(3):478-497. . View in PubMed
  • Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study Alzheimers Dement. 2022 02; 18(2):240-250. . View in PubMed
  • A blood screening tool for detecting mild cognitive impairment and Alzheimer’s disease among community-dwelling Mexican Americans and non-Hispanic Whites: A method for increasing representation of diverse populations in clinical research Alzheimers Dement. 2022 01; 18(1):77-87. . View in PubMed
  • Testing a convolutional neural network-based hippocampal segmentation method in a stroke population Hum Brain Mapp. 2022 01; 43(1):234-243. . View in PubMed
  • Proteomic Profiles of Neurodegeneration Among Mexican Americans and Non-Hispanic Whites in the HABS-HD Study J Alzheimers Dis. 2022; 86(3):1243-1254. . View in PubMed
  • Characterization of Mild Cognitive Impairment and Dementia among Community-Dwelling Mexican Americans and Non-Hispanic Whites J Alzheimers Dis. 2022; 90(2):905-915. . View in PubMed
  • Racial/Ethnic Disparities in Alzheimer’s Disease Risk: Role of Exposure to Ambient Fine Particles J Gerontol A Biol Sci Med Sci. 2022 05 05; 77(5):977-985. . View in PubMed
  • Neurodegeneration from the AT(N) framework is different among Mexican Americans compared to non-Hispanic Whites: A Health & Aging Brain among Latino Elders (HABLE) Study Alzheimers Dement (Amst). 2022; 14(1):e12267. . View in PubMed
  • Vascular risk profile and white matter hyperintensity volume among Mexican Americans and non-Hispanic Whites: The HABLE study Alzheimers Dement (Amst). 2022; 14(1):e12263. . View in PubMed
  • Regional relationships between CSF VEGF levels and Alzheimer’s disease brain biomarkers and cognition Neurobiol Aging. 2021 09; 105:241-251. . View in PubMed
  • MRI biomarkers of small vessel disease and cognition: A cross-sectional study of a cognitively normal Mexican American cohort Alzheimers Dement (Amst). 2021; 13(1):e12236. . View in PubMed
  • The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics Alzheimers Dement (Amst). 2021; 13(1):e12202. . View in PubMed
  • Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial EBioMedicine. 2020 Sep; 59:102883. . View in PubMed
  • Effect of APOE Genotype on Plasma Docosahexaenoic Acid (DHA), Eicosapentaenoic Acid, Arachidonic Acid, and Hippocampal Volume in the Alzheimer’s Disease Cooperative Study-Sponsored DHA Clinical Trial J Alzheimers Dis. 2020; 74(3):975-990. . View in PubMed
  • White matter hyperintensities and their relationship to cognition: Effects of segmentation algorithm Neuroimage. 2020 02 01; 206:116327. . View in PubMed
  • White matter hypointensities and hyperintensities have equivalent correlations with age and CSF ß-amyloid in the nondemented elderly Brain Behav. 2019 12; 9(12):e01457. . View in PubMed
  • Sulcal morphology in Alzheimer’s disease: an effective marker of diagnosis and cognition Neurobiol Aging. 2019 12; 84:41-49. . View in PubMed
  • Systemic inflammation as a predictor of brain aging: Contributions of physical activity, metabolic risk, and genetic risk Neuroimage. 2018 05 15; 172:118-129. . View in PubMed
  • Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E e4 Carriers: A Review JAMA Neurol. 2017 Mar 01; 74(3):339-347. . View in PubMed
  • Resting-state networks associated with cognitive processing show more age-related decline than those associated with emotional processing Neurobiol Aging. 2017 06; 54:152-162. . View in PubMed
  • Independent value added by diffusion MRI for prediction of cognitive function in older adults Neuroimage Clin. 2017; 14:166-173. . View in PubMed
  • Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans J Neurosci. 2017 02 15; 37(7):1696-1707. . View in PubMed
  • Relationship of a common OXTR gene variant to brain structure and default mode network function in healthy humans Neuroimage. 2017 02 15; 147:500-506. . View in PubMed
  • A COMPARISON OF NETWORK DEFINITIONS FOR DETECTING SEX DIFFERENCES IN BRAIN CONNECTIVITY USING SUPPORT VECTOR MACHINES Proc IEEE Int Symp Biomed Imaging. 2017; 2017:961-965. . View in PubMed
  • Cerebral amyloid is associated with greater white-matter hyperintensity accrual in cognitively normal older adults Neurobiol Aging. 2016 12; 48:48-52. . View in PubMed
  • Widespread white matter and conduction defects in PSEN1-related spastic paraparesis Neurobiol Aging. 2016 11; 47:201-209. . View in PubMed
  • Cerebral Amyloid and Hypertension are Independently Associated with White Matter Lesions in Elderly Front Aging Neurosci. 2015; 7:221. . View in PubMed
  • Obesity gene NEGR1 associated with white matter integrity in healthy young adults Neuroimage. 2014 Nov 15; 102 Pt 2:548-57. . View in PubMed
  • Physical activity, inflammation, and volume of the aging brain Neuroscience. 2014 Jul 25; 273:199-209. . View in PubMed
  • A focus on structural brain imaging in the Alzheimer’s disease neuroimaging initiative Biol Psychiatry. 2014 Apr 01; 75(7):527-33. . View in PubMed
  • Memory performance and fMRI signal in presymptomatic familial Alzheimer’s disease Hum Brain Mapp. 2013 Dec; 34(12):3308-19. . View in PubMed
  • Relation between variants in the neurotrophin receptor gene, NTRK3, and white matter integrity in healthy young adults Neuroimage. 2013 Nov 15; 82:146-53. . View in PubMed
  • Understanding cognitive deficits in Alzheimer’s disease based on neuroimaging findings Trends Cogn Sci. 2013 Oct; 17(10):510-6. . View in PubMed
  • Regional brain volume differences in symptomatic and presymptomatic carriers of familial Alzheimer’s disease mutations J Neurol Neurosurg Psychiatry. 2013 Feb; 84(2):154-62. . View in PubMed
  • Recent advances in imaging Alzheimer’s disease J Alzheimers Dis. 2013; 33 Suppl 1:S313-27. . View in PubMed
  • How a common variant in the growth factor receptor gene, NTRK1, affects white matter Bioarchitecture. 2012 Sep-Oct; 2(5):181-4. . View in PubMed
  • Predicting white matter integrity from multiple common genetic variants Neuropsychopharmacology. 2012 Aug; 37(9):2012-9. . View in PubMed
  • Prediction of cognitive decline based on hemispheric cortical surface maps of FDDNP PET Neuroimage. 2012 Jul 16; 61(4):749-60. . View in PubMed
  • Relationship of a variant in the NTRK1 gene to white matter microstructure in young adults J Neurosci. 2012 Apr 25; 32(17):5964-72. . View in PubMed
  • Dopamine and frontostriatal networks in cognitive agingNeurobiol Aging. 2012 Mar; 33(3):623. e15-24. . View in PubMed
  • Increased fMRI signal with age in familial Alzheimer’s disease mutation carriersNeurobiol Aging. 2012 Feb; 33(2):424. e11-21. . View in PubMed
  • Correlations of striatal dopamine synthesis with default network deactivations during working memory in younger adults Hum Brain Mapp. 2011 Jun; 32(6):947-61. . View in PubMed
  • Common Alzheimer’s disease risk variant within the CLU gene affects white matter microstructure in young adults J Neurosci. 2011 May 04; 31(18):6764-70. . View in PubMed
  • Effects of risk genes on BOLD activation in presymptomatic carriers of familial Alzheimer’s disease mutations during a novelty encoding task Cereb Cortex. 2011 Apr; 21(4):877-83. . View in PubMed
  • Neuroimaging measures as endophenotypes in Alzheimer’s disease Int J Alzheimers Dis. 2011 Mar 31; 2011:490140. . View in PubMed
  • Cortical and hippocampal atrophy in patients with autosomal dominant familial Alzheimer’s disease Dement Geriatr Cogn Disord. 2011; 32(2):118-25. . View in PubMed
  • Plaque and tangle imaging and cognition in normal aging and Alzheimer’s disease Neurobiol Aging. 2010 Oct; 31(10):1669-78. . View in PubMed
  • Vascular health risks and fMRI activation during a memory task in older adults Neurobiol Aging. 2010 Sep; 31(9):1532-42. . View in PubMed
  • FDDNP binding using MR derived cortical surface maps Neuroimage. 2010 Jan 01; 49(1):240-8. . View in PubMed
  • Overeating Behavior and Striatal Dopamine with 6-[F]-Fluoro-L-m-Tyrosine PET J Obes. 2010; 2010. . View in PubMed
  • Entorhinal cortex structure and functional MRI response during an associative verbal memory task Hum Brain Mapp. 2009 Dec; 30(12):3981-92. . View in PubMed
  • Relationship of striatal dopamine synthesis capacity to age and cognition J Neurosci. 2008 Dec 24; 28(52):14320-8. . View in PubMed
  • Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriers Neuroimage. 2008 Jul 15; 41(4):1177-83. . View in PubMed