Michael Chee-Kuan Khoo, PhD

Michael C.K. Khoo received his BSc(Eng) degree in Mechanical Engineering from the Imperial College of Science and Technology, University of London, in 1976, and the M.S. and Ph.D. degrees in Biomedical Engineering from Harvard University in 1977 and 1981, respectively. Before joining the faculty at USC in 1983, Dr. Khoo worked as a research engineer on a collaborative project involving the Veterans Administration Medical Center (West Roxbury), Brigham and Women’s Hospital (Boston) and the Massachusetts Institute of Technology. Dr. Khoo has been the recipient of a Research Career Development Award from the National Institutes of Health and a Career Investigator Award from the American Lung Association. He is principal investigator of one of the Core Projects in the Biomedical Simulations Resource, a national center funded by the NIH National Institute of Biomedical Imaging and Bioengineering, dedicated to advancing the state of the art in biomedical modeling and computer simulation. He is also the co-principal investigator of an NIH training grant in Biomedical Imaging Informatics, and co-Director of Education and Outreach for the NSF-funded Engineering Research Center on Biomimetic Microelectronic Systems. Dr. Khoo is a Fellow of the American Institute of Medical and Biological Engineering (AIMBE) and the Biomedical Engineering Society (BMES). He was BME Department Chair 2003-2010.

• NEW NIH COLLABORATIVE GRANT (08/19/2013)

• Towards automatic home screening of obstructive sleep apnea using combined features from pulse wave amplitude, pulse-to-pulse interval and oxygen desaturation. Sleep Breath. 2026 Feb 19; 30(1):57.. View in PubMed
• Beat-to-beat analysis of hemodynamic response to mental and psychological stress in sickle cell anemia. J Sick Cell Dis. 2024; 1(1).. View in PubMed
• Treatment of Cheyne-Stokes Respiration in Heart Failure with Adaptive Servo-Ventilation: An Integrative Model. Adv Exp Med Biol. 2022; 1384:79-103.. View in PubMed
• Respiratory modulation of peripheral vasoconstriction: a modeling perspective. J Appl Physiol (1985). 2019 11 01; 127(5):1177-1186.. View in PubMed
• Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt. Front Physiol. 2019; 10:381.. View in PubMed
• Quantifying ventilatory control stability from spontaneous sigh responses during sleep: a comparison of two approaches. Physiol Meas. 2018 11 22; 39(11):114005.. View in PubMed
• Autonomic nervous system involvement in sickle cell disease. Clin Hemorheol Microcirc. 2018; 68(2-3):251-262.. View in PubMed
• Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease. PLoS One. 2017; 12(5):e0178353.. View in PubMed
• Model-Derived Markers of Autonomic Cardiovascular Dysfunction in Sleep-Disordered Breathing. Sleep Med Clin. 2016 Dec; 11(4):489-501.. View in PubMed
• Model-based stability assessment of ventilatory control in overweight adolescents with obstructive sleep apnea during NREM sleep. J Appl Physiol (1985). 2016 07 01; 121(1):185-97.. View in PubMed
• Sleep-related changes in autonomic control in obstructive sleep apnea: a model-based perspective. Respir Physiol Neurobiol. 2013 Sep 15; 188(3):267-76.. View in PubMed
• Understanding the metabolic syndrome: a modeling perspective. IEEE Rev Biomed Eng. 2013; 6:143-55.. View in PubMed
• Modeling the autonomic and metabolic effects of obstructive sleep apnea: a simulation study. Front Physiol. 2011; 2:111.. View in PubMed
• An integrative model of respiratory and cardiovascular control in sleep-disordered breathing. Respir Physiol Neurobiol. 2010 Nov 30; 174(1-2):4-28.. View in PubMed
• Modeling of autonomic control in sleep-disordered breathing. Cardiovasc Eng. 2008 Mar; 8(1):30-41.. View in PubMed
• Effects of CPAP therapy on cardiovascular variability in obstructive sleep apnea: a closed-loop analysis. Am J Physiol Heart Circ Physiol. 2002 Jan; 282(1):H110-21.. View in PubMed
• Cardiac autonomic control in obstructive sleep apnea: effects of long-term CPAP therapy. Am J Respir Crit Care Med. 2001 Sep 01; 164(5):807-12.. View in PubMed
• Determinants of ventilatory instability and variability. Respir Physiol. 2000 Sep; 122(2-3):167-82.. View in PubMed

• Wood, John
• Coates, Thomas
• Khemani, Robinder
• Newth, Christopher
• Shahidi, Mahnaz
• Nayak, Krishna