Keck School Faculty

Michael Frederick Press, MD, PhD
Michael Frederick Press, MD, PhD
Professor of Pathology;Harold E. Lee Chair in Breast Cancer Research;Director of Breast Cancer Analysis Lab
Pathology
NTT 1441 Eastlake Ave Health Sciences Campus Los Angeles
Michael F. Press, M.D., Ph.D. is a professor in the Department of Pathology and co-leader of the Women’s Cancers Program. He received his M.D., Ph.D. and residency training at the University of Chicago. He was a member of the University of Chicago faculty for seven years before joining the faculty of the University of Southern California in 1988. Dr. Press is currently the director for the Breast Cancer International Research Group Central Laboratory, the coordinator of the Breast Cancer Program at USC Norris Cancer Center and holds the Harold E. Lee Chair in Cancer Research in the USC Norris Cancer Center. His research interests are molecular genetic alterations in breast and gynecologic cancers.

Assessment of ERBB2/HER2 Status in HER2-Equivocal Breast Cancers by FISH and 2013/2014 ASCO-CAP Guidelines JAMA Oncol. 2019 Mar 01; 5(3):366-375. . View in PubMed

Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy Nat Commun. 2019 Feb 08; 10(1):657. . View in PubMed

Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy Nat Commun. 2019 02 08; 10(1):657. . View in PubMed

Assessment of ERBB2/HER2 Status in HER2-Equivocal Breast Cancers by FISH and 2013/2014 ASCO-CAP Guidelines JAMA Oncol. 2018 Dec 06. . View in PubMed

Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update Arch Pathol Lab Med. 2018 Nov; 142(11):1364-1382. . View in PubMed

Comparison of central laboratory assessments of ER, PR, HER2, and Ki67 by IHC/FISH and the corresponding mRNAs (ESR1, PGR, ERBB2, and MKi67) by RT-qPCR on an automated, broadly deployed diagnostic platform Breast Cancer Res Treat. 2018 Nov; 172(2):327-338. . View in PubMed

Comparison of central laboratory assessments of ER, PR, HER2, and Ki67 by IHC/FISH and the corresponding mRNAs (ESR1, PGR, ERBB2, and MKi67) by RT-qPCR on an automated, broadly deployed diagnostic platform Breast Cancer Res Treat. 2018 Aug 17. . View in PubMed

Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update Arch Pathol Lab Med. 2018 May 30. . View in PubMed

Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis Breast Cancer Res. 2018 Jan 22; 20(1):5. . View in PubMed

Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis Breast Cancer Res. 2018 01 22; 20(1):5. . View in PubMed

Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry Cancer Epidemiol Biomarkers Prev. 2017 Jul; 26(7):1016-1026. . View in PubMed

Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium PLoS Genet. 2017 Apr; 13(4):e1006719. . View in PubMed

Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry Cancer Epidemiol Biomarkers Prev. 2017 07; 26(7):1016-1026. . View in PubMed

HER2 Status in Advanced or Metastatic Gastric, Esophageal, or Gastroesophageal Adenocarcinoma for Entry to the TRIO-013/LOGiC Trial of Lapatinib Mol Cancer Ther. 2017 01; 16(1):228-238. . View in PubMed

A functionally significant SNP in TP53 and breast cancer risk in African-American women NPJ Breast Cancer. 2017; 3:5. . View in PubMed

HER2 Gene Amplification Testing by Fluorescent In Situ Hybridization (FISH): Comparison of the ASCO-College of American Pathologists Guidelines With FISH Scores Used for Enrollment in Breast Cancer International Research Group Clinical Trials J Clin Oncol. 2016 Oct 10; 34(29):3518-3528. . View in PubMed

Assessing the New American Society of Clinical Oncology/College of American Pathologists Guidelines for HER2 Testing by Fluorescence In Situ Hybridization: Experience of an Academic Consultation Practice Arch Pathol Lab Med. 2016 Apr 15. . View in PubMed

Antibody targeting facilitates effective intratumoral siRNA nanoparticle delivery to HER2-overexpressing cancer cells Oncotarget. 2016 Feb 23; 7(8):9561-75. . View in PubMed

A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci Cancer Epidemiol Biomarkers Prev. 2016 12; 25(12):1609-1618. . View in PubMed

Genetic variants in microRNA and microRNA biogenesis pathway genes and breast cancer risk among women of African ancestry Hum Genet. 2016 10; 135(10):1145-59. . View in PubMed

Genome-wide association studies in women of African ancestry identified 3q2621 as a novel susceptibility locus for oestrogen receptor negative breast cancer. Hum Mol Genet. 2016 11 01; 25(21):4835-4846. . View in PubMed

HER2 Gene Amplification Testing by Fluorescent In Situ Hybridization (FISH): Comparison of the ASCO-College of American Pathologists Guidelines With FISH Scores Used for Enrollment in Breast Cancer International Research Group Clinical Trials J Clin Oncol. 2016 10 10; 34(29):3518-3528. . View in PubMed

A Big Bang model of human colorectal tumor growth Nat Genet. 2015 Mar; 47(3):209-16. . View in PubMed

Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia Clin Epigenetics. 2015; 7:117. . View in PubMed

A comprehensive examination of breast cancer risk loci in African American women Hum Mol Genet. 2014 Oct 15; 23(20):5518-26. . View in PubMed

Genome-wide scan of 29,141 African Americans finds no evidence of directional selection since admixture Am J Hum Genet. 2014 Oct 02; 95(4):437-44. . View in PubMed

HER2 and TOP2A amplification in a hospital-based cohort of breast cancer patients: associations with patient and tumor characteristics Breast Cancer Res Treat. 2014 May; 145(1):193-203. . View in PubMed

Characterization of HER2 status by fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) Methods Mol Biol. 2014; 1180:181-207. . View in PubMed

A conceptual and methodological framework for investigating etiologic heterogeneity Stat Med. 2013 Dec 20; 32(29):5039-52. . View in PubMed

Genome-wide association study of age at menarche in African-American women Hum Mol Genet. 2013 Aug 15; 22(16):3329-46. . View in PubMed

Assessment of HER2 gene amplification in adenocarcinomas of the stomach or gastroesophageal junction in the INT-0116/SWOG9008 clinical trial Ann Oncol. 2013 Jul; 24(7):1754-61. . View in PubMed

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry Nat Genet. 2013 Jun; 45(6):690-6. . View in PubMed

Genome-wide association studies identify four ER negative-specific breast cancer risk loci Nat Genet. 2013 Apr; 45(4):392-8, 398e1-2. . View in PubMed

A genome-wide scan for breast cancer risk haplotypes among African American women PLoS One. 2013; 8(2):e57298. . View in PubMed

A genome-wide association study of breast cancer in women of African ancestry Hum Genet. 2013 Jan; 132(1):39-48. . View in PubMed

A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11 Hum Mol Genet. 2012 Dec 15; 21(24):5373-84. . View in PubMed

Endometrial cancer survival after breast cancer in relation to tamoxifen treatment: pooled results from three countries Breast Cancer Res. 2012 Jun 12; 14(3):R91. . View in PubMed

Fine-mapping of breast cancer susceptibility loci characterizes genetic risk in African Americans Hum Mol Genet. 2011 Nov 15; 20(22):4491-503. . View in PubMed

A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer Nat Genet. 2011 Oct 30; 43(12):1210-4. . View in PubMed

Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium PLoS Genet. 2011 Apr; 7(4):e1001371. . View in PubMed

Alteration of topoisomerase II-alpha gene in human breast cancer: association with responsiveness to anthracycline-based chemotherapy J Clin Oncol. 2011 Mar 01; 29(7):859-67. . View in PubMed

Genome-scale screen for DNA methylation-based detection markers for ovarian cancer PLoS One. 2011; 6(12):e28141. . View in PubMed

Fine scale mapping of the breast cancer 16q12 locus Hum Mol Genet. 2010 Jun 15; 19(12):2507-15. . View in PubMed

A case-control study of body mass index and breast cancer risk in white and African-American women Cancer Epidemiol Biomarkers Prev. 2010 Jun; 19(6):1532-44. . View in PubMed

Chromosome 17 polysomy without human epidermal growth factor receptor 2 amplification does not predict response to lapatinib plus paclitaxel compared with paclitaxel in metastatic breast cancer Clin Cancer Res. 2010 Feb 15; 16(4):1281-8. . View in PubMed

An admixture scan in 1,484 African American women with breast cancer Cancer Epidemiol Biomarkers Prev. 2009 Nov; 18(11):3110-7. . View in PubMed

Estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2), and epidermal growth factor receptor expression and benefit from lapatinib in a randomized trial of paclitaxel with lapatinib or placebo as first-line treatment in HER2-negative or unknown metastatic breast cancer J Clin Oncol. 2009 Aug 20; 27(24):3908-15. . View in PubMed

Breast cancer receptor status: do results from a centralized pathology laboratory agree with SEER registry reports? Cancer Epidemiol Biomarkers Prev. 2009 Aug; 18(8):2214-20.. View in PubMed

Alterations in the TOP2A and HER2 genes: association with adjuvant anthracycline sensitivity in human breast cancers J Natl Cancer Inst. 2009 May 06; 101(9):615-8. . View in PubMed

Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X PLoS Genet. 2009 May; 5(5):e1000490. . View in PubMed

FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation Hum Mol Genet. 2009 May 01; 18(9):1692-703. . View in PubMed

Guidelines for human epidermal growth factor receptor 2 testing: biologic and methodologic considerations J Clin Oncol. 2009 Mar 10; 27(8):1323-33. . View in PubMed

A phase I/II trial of trastuzumab plus erlotinib in metastatic HER2-positive breast cancer: a dual ErbB targeted approach Clin Breast Cancer. 2009 Feb; 9(1):16-22. . View in PubMed

HER2 gene amplification and EGFR expression in a large cohort of surgically staged patients with nonendometrioid (type II) endometrial cancer Br J Cancer. 2009 Jan 13; 100(1):89-95. . View in PubMed

HER-2 gene amplification, HER-2 and epidermal growth factor receptor mRNA and protein expression, and lapatinib efficacy in women with metastatic breast cancer Clin Cancer Res. 2008 Dec 01; 14(23):7861-70. . View in PubMed

Breast cancer risk and hormone receptor status in older women by parity, age of first birth, and breastfeeding: a case-control study Cancer Epidemiol Biomarkers Prev. 2008 Jul; 17(7):1723-30. . View in PubMed

A variant in the cytochrome p450 oxidoreductase gene is associated with breast cancer risk in African Americans Cancer Res. 2007 Apr 15; 67(8):3565-8. . View in PubMed

American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer J Clin Oncol. 2007 Jan 01; 25(1):118-45. . View in PubMed

EGFR, HER2 and VEGF pathways: validated targets for cancer treatment Drugs. 2007; 67(14):2045-75. . View in PubMed

American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer Arch Pathol Lab Med. 2007; 131(1):18-43. . View in PubMed

How is Her-2/neu status established when Her-2/neu and chromosome 17 centromere are both amplified? Am J Clin Pathol. 2006 Nov; 126(5):673-4.. View in PubMed

HER2 testing in breast cancer: NCCN Task Force report and recommendations J Natl Compr Canc Netw. 2006 Jul; 4 Suppl 3:S1-22; quiz S23-4. . View in PubMed

Breast cancer risk estimates for relatives of white and African American women with breast cancer in the Women's Contraceptive and Reproductive Experiences Study J Clin Oncol. 2006 Jun 01; 24(16):2498-504. . View in PubMed

Diagnostic evaluation of HER-2 as a molecular target: an assessment of accuracy and reproducibility of laboratory testing in large, prospective, randomized clinical trials Clin Cancer Res. 2005 Sep 15; 11(18):6598-607. . View in PubMed

Determination of HER2 gene amplification by fluorescence in situ hybridization and concordance with the clinical trials immunohistochemical assay in women with metastatic breast cancer evaluated for treatment with trastuzumab Breast Cancer Res Treat. 2005 Sep; 93(1):3-11. . View in PubMed

Association of p53 mutations and a codon 72 single nucleotide polymorphism with lower overall survival and responsiveness to adjuvant radiotherapy in endometrioid endometrial carcinomas Int J Gynecol Cancer. 2005 Sep-Oct; 15(5):952-63. . View in PubMed

Evaluation of clinical outcomes according to HER2 detection by fluorescence in situ hybridization in women with metastatic breast cancer treated with trastuzumab Clin Breast Cancer. 2005 Aug; 6(3):240-6. . View in PubMed

Consensus statement: Expedition Inspiration 2004 Breast Cancer Symposium 'Breast Cancer--The Development and Validation of New Therapeutics' Breast Cancer Res Treat. 2005 Mar; 90(1):1-3. . View in PubMed

Characterization of engineered anti-p185HER-2 (scFv-CH3)2 antibody fragments (minibodies) for tumor targeting Protein Eng Des Sel. 2004 Apr; 17(4):315-23. . View in PubMed

Antibody-mediated targeting of replication-competent retroviral vectors Hum Gene Ther. 2003 May 20; 14(8):789-802. . View in PubMed

Comparison of different antibodies for detection of progesterone receptor in breast cancer Steroids. 2002 Aug; 67(9):799-813. . View in PubMed

Heritable breast cancer in twins Br J Cancer. 2002 Jul 29; 87(3):294-300. . View in PubMed

Evaluation of HER-2/neu gene amplification and overexpression: comparison of frequently used assay methods in a molecularly characterized cohort of breast cancer specimens J Clin Oncol. 2002 Jul 15; 20(14):3095-105. . View in PubMed

Germ-line HER-2 variant and breast cancer risk by stage of disease Cancer Res. 2001 Dec 01; 61(23):8393-4. . View in PubMed

Correlation of p53 mutations with resistance to platinum-based chemotherapy and shortened survival in ovarian cancer Clin Cancer Res. 2001 Oct; 7(10):2984-97. . View in PubMed

Alternative and aberrant messenger RNA splicing of the mdm2 oncogene in invasive breast cancer Cancer Res. 2001 Apr 01; 61(7):3212-9. . View in PubMed

Breast cancer susceptibility gene 1 (BRCAI) is a coactivator of the androgen receptor Cancer Res. 2000 Nov 01; 60(21):5946-9. . View in PubMed

Comparison of TP53 mutations identified by oligonucleotide microarray and conventional DNA sequence analysis Cancer Res. 2000 May 15; 60(10):2716-22. . View in PubMed

Assessment of novel anti-p185HER-2 monoclonal antibodies for internalization-dependent therapies Hybridoma. 1999 Dec; 18(6):487-95. . View in PubMed

Does estrogen receptor expression in normal breast tissue predict breast cancer risk? J Natl Cancer Inst. 1998 Jan 07; 90(1):5-7.. View in PubMed

Genomic semi-automated cycle sequencing as a sensitive screening technique for p53 mutations in frozen tumor samples Oncol Rep. 1998 Jan-Feb; 5(1):65-8. . View in PubMed

HER-2/neu gene amplification characterized by fluorescence in situ hybridization: poor prognosis in node-negative breast carcinomas J Clin Oncol. 1997 Aug; 15(8):2894-904. . View in PubMed

Chicken ovalbumin upstream promoter--transcription factor (COUP-TF) expression in human endometrial cancer cell lines Anticancer Res. 1996 Nov-Dec; 16(6B):3371-6. . View in PubMed

Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization Oncogene. 1996 Jul 04; 13(1):63-72. . View in PubMed

Clonal analysis of bilateral breast cancer Clin Cancer Res. 1996 Apr; 2(4):743-8. . View in PubMed

Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival Cancer Res. 1995 Dec 01; 55(23):5693-8. . View in PubMed

Expression patterns of immediate early transcription factors in human non-small cell lung cancerThe Lung Cancer Study Group. Oncogene. 1995 Oct 05; 11(7):1261-9. . View in PubMed

[Prognostic differentiation of ovarian carcinomas by immunohistochemical analysis of estrogen receptor expression] Geburtshilfe Frauenheilkd. 1995 Apr; 55(4):189-94. . View in PubMed

[Overexpression of p53 protein in ovarian carcinomas: correlation with histopathologic data and clinical course] Gynakol Geburtshilfliche Rundsch. 1995; 35 Suppl 1:93-7. . View in PubMed

Amplification and overexpression of HER-2/neu in carcinomas of the salivary gland: correlation with poor prognosis Cancer Res. 1994 Nov 01; 54(21):5675-82. . View in PubMed

Her-2/neu expression in node-negative breast cancer: direct tissue quantitation by computerized image analysis and association of overexpression with increased risk of recurrent disease Cancer Res. 1993 Oct 15; 53(20):4960-70. . View in PubMed

Evaluating the effect of age on endometrial responsiveness to hormone replacement therapy: a histologic ultrasonographic, and tissue receptor analysis J Assist Reprod Genet. 1993 Jan; 10(1):47-52. . View in PubMed

Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk Epidemiol Rev. 1993; 15(1):17-35. . View in PubMed

Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues Oncogene. 1990 Jul; 5(7):953-62. . View in PubMed

HER-2/neu oncogene expression and DNA ploidy analysis in breast cancer Arch Pathol Lab Med. 1990 Feb; 114(2):164-9. . View in PubMed

HER-2/neu oncogene amplification and expression in breast and ovarian cancers Prog Clin Biol Res. 1990; 354A:209-21. . View in PubMed

Estrogen and progesterone receptors in meningiomas: comparison of nuclear binding, dextran-coated charcoal, and immunoperoxidase staining assays Neurosurgery. 1989 Oct; 25(4):546-52; discussion 552-3. . View in PubMed

Comparison of the quantity of estrogen receptors in human endometrium and myometrium by steroid-binding assay and enzyme immunoassay based on monoclonal antibodies to human estrophilin Am J Obstet Gynecol. 1989 Mar; 160(3):592-7. . View in PubMed

Estrogen receptor localization in formalin-fixed, paraffin-embedded endometrium and endometriotic tissues Int J Gynecol Pathol. 1987; 6(2):140-51. . View in PubMed

Estrogen receptor localization in the female genital tract Am J Pathol. 1986 May; 123(2):280-92. . View in PubMed

Distribution of peroxidase and granulocytes in the human uterus Lab Invest. 1986 Feb; 54(2):188-203. . View in PubMed

Endometrial "sarcomas" complicating ovarian thecoma, polycystic ovarian disease and estrogen therapy Gynecol Oncol. 1985 Jun; 21(2):135-54. . View in PubMed

An immunocytochemical method for demonstrating estrogen receptor in human uterus using monoclonal antibodies to human estrophilin Lab Invest. 1984 Apr; 50(4):480-6. . View in PubMed

Epithelial peroxidase and endometrial granulocytes in the normal cyclic human endometrium J Clin Endocrinol Metab. 1983 Aug; 57(2):254-61. . View in PubMed

Estrogen receptor and peroxidase activity in epithelial ovarian carcinomas J Natl Cancer Inst. 1981 Aug; 67(2):307-18. . View in PubMed

Cytomegalovirus inclusion diseaseIts occurrence in the myenteric plexus of a renal transplant patient. Arch Pathol Lab Med. 1980 Nov; 104(11):580-3. . View in PubMed

Animal model: Lead Encephalopathy in Neonatal Long-Evans Rats Poisoned via an Esophageal Catheter Am J Pathol. 1977 Feb; 86(2):485-8. . View in PubMed

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