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Michael Lansdell Paine, BSc, BDS, PhD

Professor of Dentistry

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Phone +1 323 442 1728
Email [email protected]
CTSI Profile

Research Funding

  • Phosphate and Enamel Formation
    NIH · R01DE034447 · Apr 10, 2025 – Jan 31, 2030 · Role: Principal Investigator
  • CRE MOUSE MODELS TO STUDY AMELOGENESIS
    NIH · UH3DE028850 · Aug 1, 2021 – Jul 31, 2024 · Role: Principal Investigator
  • Amelogenesis and Ion Transport
    NIH · R01DE029445 · Mar 15, 2021 – Feb 28, 2025 · Role: Principal Investigator
  • CRE MOUSE MODELS TO STUDY AMELOGENESIS
    NIH · UG3DE028850 · Aug 1, 2019 – Jul 31, 2021 · Role: Principal Investigator
  • SODIUM-DEPENDENT PHOSPHATE TRANSPORTER FUNCTION IN ODONTOGENESIS
    NIH · R21DE024704 · Mar 1, 2016 – Feb 28, 2019 · Role: Principal Investigator
  • Doctoral and Post-doctoral Training in Craniofacial Biology
    NIH · R90DE022528 · Jul 1, 2011 – Jun 30, 2026 · Role: Principal Investigator
  • Doctoral and Post-doctoral Training in Craniofacial Biology
    NIH · T90DE021982 · Jul 1, 2011 – Jun 30, 2026 · Role: Principal Investigator
  • MOLECULAR MECHANISMS FOR EXTRACELLULAR PH CONTROL DURING AMELOGENESIS
    NIH · R01DE019629 · Sep 17, 2009 – Jun 30, 2016 · Role: Principal Investigator
  • TIP39KDA AND TOOTH FORMATION
    NIH · R01DE014867 · Jul 1, 2003 – Jun 30, 2010 · Role: Principal Investigator
  • ENAMEL MATRIX PROTEIN INTERACTION
    NIH · R01DE013404 · Mar 1, 2000 – Mar 31, 2014 · Role: Principal Investigator

Publications

  • A novel Ambn-IRESCre mouse line allows ameloblast-specific Smad4 silencing. Front Physiol. 2026; 17:1792453.. View in PubMed
  • Enamel Maturation as a Systems Physiology: Ion Transport and Pi Flux. Cells. 2025 Nov 20; 14(22).. View in PubMed
  • Pitx2-Sox2-Lef1 interactions specify progenitor oral/dental epithelial cell signaling centers. Development. 2020 06 04; 147(11).. View in PubMed
  • Oral Sciences PhD Program Enrollment, Graduates, and Placement: 1994 to 2016. J Dent Res. 2018 05; 97(5):483-491.. View in PubMed
  • Bicarbonate Transport During Enamel Maturation. Calcif Tissue Int. 2017 11; 101(5):457-464.. View in PubMed
  • DENTAL ENAMEL FORMATION AND IMPLICATIONS FOR ORAL HEALTH AND DISEASE. Physiol Rev. 2017 07 01; 97(3):939-993.. View in PubMed
  • Multiple Calcium Export Exchangers and Pumps Are a Prominent Feature of Enamel Organ Cells. Front Physiol. 2017; 8:336.. View in PubMed
  • Deletion of Slc26a1 and Slc26a7 Delays Enamel Mineralization in Mice. Front Physiol. 2017; 8:307.. View in PubMed
  • MiR-153 Regulates Amelogenesis by Targeting Endocytotic and Endosomal/lysosomal Pathways-Novel Insight into the Origins of Enamel Pathologies. Sci Rep. 2017 03 13; 7:44118.. View in PubMed
  • SLC26A Gene Family Participate in pH Regulation during Enamel Maturation. PLoS One. 2015; 10(12):e0144703.. View in PubMed
  • V-type ATPase proton pump expression during enamel formation. Matrix Biol. 2016 May-Jul; 52.. View in PubMed
  • Dental enamel cells express functional SOCE channels. Sci Rep. 2015 Oct 30; 5:15803.. View in PubMed
  • Protein Interaction between Ameloblastin and Proteasome Subunit α Type 3 Can Facilitate Redistribution of Ameloblastin Domains within Forming Enamel. J Biol Chem. 2015 Aug 21; 290(34):20661-20673.. View in PubMed
  • Regulation of the Stem Cell-Host Immune System Interplay Using Hydrogel Coencapsulation System with an Anti-Inflammatory Drug. Adv Funct Mater. 2015 Apr 15; 25(15):2296-2307.. View in PubMed
  • Dental and Cranial Pathologies in Mice Lacking the Cl(-) /H(+) -Exchanger ClC-7. Anat Rec (Hoboken). 2015 Aug; 298(8):1502-8.. View in PubMed
  • Genome-wide analysis of miRNA and mRNA transcriptomes during amelogenesis. BMC Genomics. 2014 Nov 19; 15:998.. View in PubMed
  • Comparison of two mouse ameloblast-like cell lines for enamel-specific gene expression. Front Physiol. 2014; 5:277.. View in PubMed
  • NBCe1 (SLC4A4) a potential pH regulator in enamel organ cells during enamel development in the mouse. Cell Tissue Res. 2014 Nov; 358(2):433-42.. View in PubMed
  • Prevention of the disrupted enamel phenotype in Slc4a4-null mice using explant organ culture maintained in a living host kidney capsule. PLoS One. 2014; 9(5):e97318.. View in PubMed
  • Gene-expression profile and localization of Na+/K(+)-ATPase in rat enamel organ cells. Eur J Oral Sci. 2014 Feb; 122(1):21-6.. View in PubMed
  • A model for the molecular underpinnings of tooth defects in Axenfeld-Rieger syndrome. Hum Mol Genet. 2014 Jan 01; 23(1):194-208.. View in PubMed
  • Facial morphogenesis of the earliest europeans. PLoS One. 2013; 8(6):e65199.. View in PubMed
  • Adaptor protein complex 2-mediated, clathrin-dependent endocytosis, and related gene activities, are a prominent feature during maturation stage amelogenesis. J Bone Miner Res. 2013 Mar; 28(3):672-87.. View in PubMed
  • Role of the NH2 -terminal fragment of dentin sialophosphoprotein in dentinogenesis. Eur J Oral Sci. 2013 Apr; 121(2):76-85.. View in PubMed
  • Iron deposition and ferritin heavy chain (Fth) localization in rodent teeth. BMC Res Notes. 2013 Jan 02; 6:1.. View in PubMed
  • New paradigms on the transport functions of maturation-stage ameloblasts. J Dent Res. 2013 Feb; 92(2):122-9.. View in PubMed
  • Cellular uptake and processing of enamel matrix derivative by human periodontal ligament fibroblasts. Arch Oral Biol. 2013 Apr; 58(4):348-54.. View in PubMed
  • Expression of the sodium/calcium/potassium exchanger, NCKX4, in ameloblasts. Cells Tissues Organs. 2012; 196(6):501-9.. View in PubMed
  • The circadian clock modulates enamel development. J Biol Rhythms. 2012 Jun; 27(3):237-45.. View in PubMed
  • Identification of novel candidate genes involved in mineralization of dental enamel by genome-wide transcript profiling. J Cell Physiol. 2012 May; 227(5):2264-75.. View in PubMed
  • Targeted overexpression of amelotin disrupts the microstructure of dental enamel. PLoS One. 2012; 7(4):e35200.. View in PubMed
  • Requirements for ion and solute transport, and pH regulation during enamel maturation. J Cell Physiol. 2012 Apr; 227(4):1776-85.. View in PubMed
  • Ameloblastin upstream region contains structural elements regulating transcriptional activity in a stromal cell line derived from bone marrow. Eur J Oral Sci. 2011 Dec; 119.. View in PubMed
  • Gene-expression analysis of early- and late-maturation-stage rat enamel organ. Eur J Oral Sci. 2011 Dec; 119.. View in PubMed
  • Identification of a pH-responsive DNA region upstream of the transcription start site of human NBCe1-B. Eur J Oral Sci. 2011 Dec; 119.. View in PubMed
  • Chymotrypsin C (caldecrin) is associated with enamel development. J Dent Res. 2011 Oct; 90(10):1228-33.. View in PubMed
  • Enamel pathology resulting from loss of function in the cystic fibrosis transmembrane conductance regulator in a porcine animal model. Cells Tissues Organs. 2011; 194(2-4):249-54.. View in PubMed
  • Structural analysis of a repetitive protein sequence motif in strepsirrhine primate amelogenin. PLoS One. 2011 Mar 18; 6(3):e18028.. View in PubMed
  • A simplified genetic design for mammalian enamel. Biomaterials. 2011 Apr; 32(12):3151-7.. View in PubMed
  • The sodium bicarbonate cotransporter (NBCe1) is essential for normal development of mouse dentition. J Biol Chem. 2010 Aug 06; 285(32):24432-8.. View in PubMed
  • A survey of carbonic anhydrase mRNA expression in enamel cells. Biochem Biophys Res Commun. 2010 Mar 19; 393(4):883-7.. View in PubMed
  • Regulation of pH During Amelogenesis. Calcif Tissue Int. 2010 Feb; 86(2):91-103.. View in PubMed
  • Dental enamel: genes define biomechanics. J Calif Dent Assoc. 2009 Dec; 37(12):863-8.. View in PubMed
  • Identification of a novel nuclear localization signal and speckle-targeting sequence of tuftelin-interacting protein 11, a splicing factor involved in spliceosome disassembly. Biochem Biophys Res Commun. 2009 Dec 18; 390(3):1044-50.. View in PubMed
  • Enamel matrix proteins; old molecules for new applications. Orthod Craniofac Res. 2009 Aug; 12(3):243-53.. View in PubMed
  • TFIP11 interacts with mDEAH9, an RNA helicase involved in spliceosome disassembly. Int J Mol Sci. 2008 Nov; 9(11):2105-2113.. View in PubMed
  • Biglycan overexpression on tooth enamel formation in transgenic mice. Anat Rec (Hoboken). 2008 Oct; 291(10):1246-53.. View in PubMed
  • TFIP11, CCNL1 and EWSR1 Protein-protein Interactions, and Their Nuclear Localization. Int J Mol Sci. 2008 Aug; 9(8):1504-1514.. View in PubMed
  • Role of NBCe1 and AE2 in secretory ameloblasts. J Dent Res. 2008 Apr; 87(4):391-5.. View in PubMed
  • Determination of protein regions responsible for interactions of amelogenin with CD63 and LAMP1. Biochem J. 2007 Dec 15; 408(3):347-54.. View in PubMed
  • PBL Core Skills Faculty Development Workshop 3: understanding PBL process assessment and feedback via scenario-based discussions, observation, and role-play. J Dent Educ. 2007 Dec; 71(12):1561-73.. View in PubMed
  • The nucleation and growth of calcium phosphate by amelogenin. J Cryst Growth. 2007 Jun 15; 304(2):407-415.. View in PubMed
  • PBL core skills faculty development workshop 1: An experiential exercise with the PBL process. J Dent Educ. 2007 Feb; 71(2):249-59.. View in PubMed
  • Cellular uptake of amelogenin, and its localization to CD63, and Lamp1-positive vesicles. Cell Mol Life Sci. 2007 Jan; 64(2):244-56.. View in PubMed
  • Ectopic expression of dentin sialoprotein during amelogenesis hardens bulk enamel. J Biol Chem. 2007 Feb 23; 282(8):5340-5.. View in PubMed
  • Altering biomineralization by protein design. J Biol Chem. 2006 Jul 28; 281(30):21173-21182.. View in PubMed
  • Amelogenins regulate expression of genes associated with cementoblasts in vitro. Eur J Oral Sci. 2006 May; 114.. View in PubMed
  • Using the yeast two-hybrid assay to discover protein partners for the leucine-rich amelogenin peptide and for tuftelin-interacting protein 11. Eur J Oral Sci. 2006 May; 114.. View in PubMed
  • 3. Protein-protein interactions of the developing enamel matrix. Curr Top Dev Biol. 2006; 74:57-115.. View in PubMed
  • An amelogenin minigene to study alternative splicing. DNA Cell Biol. 2006 Jan; 25(1):1-5.. View in PubMed
  • Principles and applications of cell delivery systems for periodontal regeneration. Periodontol 2000. 2006; 41:123-35.. View in PubMed
  • Tooth developmental biology: disruptions to enamel-matrix assembly and its impact on biomineralization. Orthod Craniofac Res. 2005 Nov; 8(4):239-51.. View in PubMed
  • Controlled failure mechanisms toughen the dentino-enamel junction zone. J Prosthet Dent. 2005 Oct; 94(4):330-5.. View in PubMed
  • Structural characterization of the major extrapallial fluid protein of the mollusc Mytilus edulis: implications for function. Biochemistry. 2005 Aug 09; 44(31):10720-31.. View in PubMed
  • Dentin sialoprotein and dentin phosphoprotein overexpression during amelogenesis. J Biol Chem. 2005 Sep 09; 280(36):31991-8.. View in PubMed
  • Structural organization and cellular localization of tuftelin-interacting protein 11 (TFIP11). Cell Mol Life Sci. 2005 May; 62(9):1038-46.. View in PubMed
  • Enamel matrix protein interactions. J Bone Miner Res. 2005 Jun; 20(6):1032-40.. View in PubMed
  • The COOH terminus of the amelogenin, LRAP, is oriented next to the hydroxyapatite surface. J Biol Chem. 2004 Sep 24; 279(39):40263-6.. View in PubMed
  • Hair whorls and monozygosity. J Invest Dermatol. 2004 Apr; 122(4):1057-8.. View in PubMed
  • Overexpression of TRAP in the enamel matrix does not alter the enamel structural hierarchy. Cells Tissues Organs. 2004; 176(1-3):7-16.. View in PubMed
  • In vivo overexpression of tuftelin in the enamel organic matrix. Cells Tissues Organs. 2004; 177(4):212-20.. View in PubMed
  • Enamel structure properties controlled by engineered proteins in transgenic mice. J Bone Miner Res. 2003 Nov; 18(11):2052-9.. View in PubMed
  • A transgenic animal model resembling amelogenesis imperfecta related to ameloblastin overexpression. J Biol Chem. 2003 May 23; 278(21):19447-52.. View in PubMed
  • Functional domains for amelogenin revealed by compound genetic defects. J Bone Miner Res. 2003 Mar; 18(3):466-72.. View in PubMed
  • Amelogenin self-assembly and the role of the proline located within the carboxyl-teleopeptide. Connect Tissue Res. 2003; 44.. View in PubMed
  • Ultrastructure of forming enamel in mouse bearing a transgene that disrupts the amelogenin self-assembly domains. Calcif Tissue Int. 2002 Aug; 71(2):155-66.. View in PubMed
  • Altered amelogenin self-assembly based on mutations observed in human X-linked amelogenesis imperfecta (AIH1). J Biol Chem. 2002 May 10; 277(19):17112-6.. View in PubMed
  • Regulated gene expression dictates enamel structure and tooth function. Matrix Biol. 2001 Sep; 20(5-6):273-92.. View in PubMed
  • Biological organization of hydroxyapatite crystallites into a fibrous continuum toughens and controls anisotropy in human enamel. J Dent Res. 2001 Jan; 80(1):321-6.. View in PubMed
  • Trp-676 facilitates nicotinamide coenzyme exchange in the reductive half-reaction of human cytochrome P450 reductase: properties of the soluble W676H and W676A mutant reductases. Biochemistry. 2000 Dec 26; 39(51):15990-9.. View in PubMed
  • Enamel biomineralization defects result from alterations to amelogenin self-assembly. J Struct Biol. 2000 Dec; 132(3):191-200.. View in PubMed
  • A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts. J Biol Chem. 2000 Jul 21; 275(29):22284-92.. View in PubMed
  • Self-assembly properties of recombinant engineered amelogenin proteins analyzed by dynamic light scattering and atomic force microscopy. J Struct Biol. 2000 Jul; 131(1):27-37.. View in PubMed
  • Protein-to-protein interactions: criteria defining the assembly of the enamel organic matrix. J Dent Res. 1998 Mar; 77(3):496-502.. View in PubMed
  • Identification of tuftelin- and amelogenin-interacting proteins using the yeast two-hybrid system. Connect Tissue Res. 1998; 38(1-4):257-67.. View in PubMed
  • Transgene animal model for protein expression and accumulation into forming enamel. Connect Tissue Res. 1998; 38(1-4):279-86.. View in PubMed
  • Fluoride use in periodontal therapy: a review of the literature. J Am Dent Assoc. 1998 Jan; 129(1):69-77.. View in PubMed
  • Problem-based learning at the University of Southern California School of Dentistry. J Dent Educ. 1997 May; 61(5):417-25.. View in PubMed
  • Protein interactions during assembly of the enamel organic extracellular matrix. J Bone Miner Res. 1997 Feb; 12(2):221-7.. View in PubMed
  • Crystallization and preliminary X-ray diffraction studies of human cytochrome P450 reductase. J Struct Biol. 1996 Mar-Apr; 116(2):320-5.. View in PubMed
  • Carboxyl-region of tuftelin mediates self-assembly. Connect Tissue Res. 1996; 35(1-4):157-61.. View in PubMed
  • The murine amelogenin promoter: developmentally regulated expression in transgenic animals. Connect Tissue Res. 1996; 35(1-4):41-7.. View in PubMed
  • Intranuclear post-transcriptional down-regulation responsible for loss of a keratin differentiation marker in tumour progression. Anticancer Res. 1995 Sep-Oct; 15(5B):2145-54.. View in PubMed
  • Loss of keratin expression in anaplastic carcinoma cells due to posttranscriptional down-regulation acting in trans. Cancer Res. 1992 Dec 01; 52(23):6603-11.. View in PubMed

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