Ming Li, PhD

Professor of Research Population and Public Health Sciences

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Overview

Dr. Ming Li is a Professor in the Division of Biostatistics of the Department of Preventive Medicine starting January 2020. Dr. Li now serves as the Director for Data Science Core at Norris Comprehensive Cancer Center.

Prior to joining USC, Dr. Li was an Associate Professor in the Department of Population and Quantitative Health Sciences and a faculty biostatistician at Center for Proteomics and Bioinformatics at Case Western Reserve University (CWRU) since 2014. During year 2014 to 2019, she was the Director for Biostatistics and Bioinformatics Shared Resource at Case Comprehensive Cancer Center (Case CCC) and served as a full member on the Case CCC Protocol Review and Monitoring Committee. Dr. Li was also the Director for Biostatistics Core in Department of Population and Quantitative Health Sciences. Dr. Li was the primary statistician for CWRU Center for Multimodal Evaluation of Engineered Cartilage.

Dr. Li’s research interests include proteomic data analysis, cancer biostatistics, statistical and bioinformatics methods for high dimensional data and statistical education and consulting. With more than 18 years working in biostatistics field, Dr. Li has devoted her efforts to two major areas: (1) collaborative research with principle investigators, during the collaboration, Dr. Li played a key role in multiple aspects, including designing experiments, analyzing data, supervising staff statisticians, interpreting results, drafting manuscripts, and writing statistical sections for grants; and (2) high dimensional data analysis, especially methods and software development for proteomics data.

Publications

  • A survey of cancer patients, caregivers, and providers regarding familiarity, importance, and utilization of supportive and integrative oncology services Support Care Cancer. 2021 Oct; 29(10):5777-5785. . View in PubMed
  • Evidence for racial/ethnic disparities in emergency department visits following breast cancer surgery among women in California: a population-based study Breast Cancer Res Treat. 2021 Jun; 187(3):831-841. . View in PubMed
  • Interest and Willingness to Pay for Integrative Therapies of Patients With Cancer and Caregivers JCO Oncol Pract. 2021 11; 17(11):e1622-e1630. . View in PubMed
  • Clinical Research in Hepatology in the COVID-19 Pandemic and Post-Pandemic Era: Challenges and the Need for Innovation Hepatology. 2020 11; 72(5):1819-1837. . View in PubMed
  • The nonlinear relationship between speed of sound and compression in articular cartilage: Measurements and modeling J Mech Behav Biomed Mater. 2020 10; 110. . View in PubMed
  • Effects of the 2013 American College of Cardiology/American Heart Association guidelines on racial and ethnic disparities in statin treatment among diabetics Res Social Adm Pharm. 2020 04; 16(4):544-552. . View in PubMed
  • CoPhosK: A method for comprehensive kinase substrate annotation using co-phosphorylation analysis PLoS Comput Biol. 2019 02; 15(2):e1006678. . View in PubMed
  • Analysis of -5p and -3p Strands of miR-145 and miR-140 During Mesenchymal Stem Cell Chondrogenic Differentiation Tissue Eng Part A. 2019 01; 25(1-2):80-90. . View in PubMed
  • Dynamic, Simultaneous Concentration Mapping of Multiple MRI Contrast Agents with Dual Contrast – Magnetic Resonance Fingerprinting Sci Rep. 2019 12 27; 9(1):19888. . View in PubMed
  • Global phosphoproteomics of CCR5-tropic HIV-1 signaling reveals reprogramming of cellular protein production pathways and identifies p70-S6K1 and MK2 as HIV-responsive kinases required for optimal infection of CD4+ T cells Retrovirology. 2018 07 03; 15(1):44. . View in PubMed
  • Proteomics and Network Analyses Reveal Inhibition of Akt-mTOR Signaling in CD4+ T Cells by Mycobacterium tuberculosis Mannose-Capped Lipoarabinomannan Proteomics. 2017 Nov; 17(22). . View in PubMed
  • CRABP-II enhances pancreatic cancer cell migration and invasion by stabilizing interleukin 8 expression Oncotarget. 2017 Aug 08; 8(32):52432-52444. . View in PubMed
  • Notch2 blockade enhances hematopoietic stem cell mobilization and homing Haematologica. 2017 10; 102(10):1785-1795. . View in PubMed
  • Quantitative Profiling of Protein Tyrosine Kinases in Human Cancer Cell Lines by Multiplexed Parallel Reaction Monitoring Assays Mol Cell Proteomics. 2016 Feb; 15(2):682-91. . View in PubMed
  • Causal relationship between obesity-related traits and TLR4-driven responses at the maternal-fetal interface Diabetologia. 2016 11; 59(11):2459-2466. . View in PubMed
  • Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer Mol Cell Proteomics. 2016 09; 15(9):2924-38. . View in PubMed
  • The airway epithelium undergoes metabolic reprogramming in individuals at high risk for lung cancer JCI Insight. 2016 11 17; 1(19):e88814. . View in PubMed
  • Risk factors for abandonment of Wilms tumor therapy in Kenya Pediatr Blood Cancer. 2015 02; 62(2):252-256. . View in PubMed
  • Reproducibility of Volumetric Computed Tomography of Stable Small Pulmonary Nodules with Implications on Estimated Growth Rate and Optimal Scan Interval PLoS One. 2015; 10(9):e0138144. . View in PubMed
  • Sequence design and evaluation of the reproducibility of water-selective diffusion-weighted imaging of the breast at 3? T. NMR Biomed. 2014 Sep; 27(9):1030-6.. View in PubMed
  • Toward rapid, high-sensitivity, volume-constrained biomarker quantification and validation using backscattering interferometry Anal Chem. 2014 Aug 05; 86(15):7566-74. . View in PubMed
  • Race disparities in peptide profiles of North American and Kenyan Wilms tumor specimens J Am Coll Surg. 2014 Apr; 218(4):707-20. . View in PubMed
  • Proteogenomic analysis reveals unanticipated adaptations of colorectal tumor cells to deficiencies in DNA mismatch repair Cancer Res. 2014 Jan 01; 74(1):387-97. . View in PubMed
  • IDPQuantify: combining precursor intensity with spectral counts for protein and peptide quantification J Proteome Res. 2013 Sep 06; 12(9):4111-21. . View in PubMed
  • Wilms tumor survival in Kenya J Pediatr Surg. 2013 Jun; 48(6):1254-62. . View in PubMed
  • Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS Mol Cell Proteomics. 2013 Feb; 12(2):343-55. . View in PubMed
  • Early detection of NSCLC with scFv selected against IgM autoantibody PLoS One. 2013; 8(4):e60934. . View in PubMed
  • Co-expression network analysis identifies Spleen Tyrosine Kinase (SYK) as a candidate oncogenic driver in a subset of small-cell lung cancer BMC Syst Biol. 2013; 7 Suppl 5:S1. . View in PubMed
  • Proteomic profiling of paraffin-embedded samples identifies metaplasia-specific and early-stage gastric cancer biomarkers Am J Pathol. 2012 Nov; 181(5):1560-72. . View in PubMed
  • In-depth proteomic analysis of nonsmall cell lung cancer to discover molecular targets and candidate biomarkers Mol Cell Proteomics. 2012 Oct; 11(10):916-32. . View in PubMed
  • Refining comparative proteomics by spectral counting to account for shared peptides and multiple search engines Anal Bioanal Chem. 2012 Sep; 404(4):1115-25. . View in PubMed
  • Label-free quantitation of protein modifications by pseudo selected reaction monitoring with internal reference peptides J Proteome Res. 2012 Jun 01; 11(6):3467-79. . View in PubMed
  • Global stability of plasma proteomes for mass spectrometry-based analysesMol Cell Proteomics. 2012 Jun; 11(6):M111. 014340. . View in PubMed
  • Added value of a serum proteomic signature in the diagnostic evaluation of lung nodules Cancer Epidemiol Biomarkers Prev. 2012 May; 21(5):786-92. . View in PubMed
  • Analysis of microsatellite mutations in buccal cells from a case-control study for lung cancer Cancer Epidemiol. 2012 Feb; 36(1):e33-9. . View in PubMed
  • Natural language processing improves identification of colorectal cancer testing in the electronic medical record Med Decis Making. 2012 Jan-Feb; 32(1):188-97. . View in PubMed
  • Lung cancer diagnosis from proteomic analysis of preinvasive lesions Cancer Res. 2011 Apr 15; 71(8):3009-17. . View in PubMed
  • Wave-spec: a preprocessing package for mass spectrometry data Bioinformatics. 2011 Mar 01; 27(5):739-40. . View in PubMed
  • Comparative shotgun proteomics using spectral count data and quasi-likelihood modeling J Proteome Res. 2010 Aug 06; 9(8):4295-305. . View in PubMed
  • Delay in diagnostic testing after abnormal mammography in low-income women Oncol Nurs Forum. 2009 Nov; 36(6):709-15. . View in PubMed
  • Equivalence of protein inventories obtained from formalin-fixed paraffin-embedded and frozen tissue in multidimensional liquid chromatography-tandem mass spectrometry shotgun proteomic analysis Mol Cell Proteomics. 2009 Aug; 8(8):1988-98. . View in PubMed
  • Identification of early intestinal neoplasia protein biomarkers using laser capture microdissection and MALDI MS Mol Cell Proteomics. 2009 May; 8(5):936-45. . View in PubMed
  • A novel comprehensive wave-form MS data processing method Bioinformatics. 2009 Mar 15; 25(6):808-14. . View in PubMed
  • Fruit and vegetable intakes are associated with lower risk of colorectal adenomas J Nutr. 2009 Feb; 139(2):340-4. . View in PubMed
  • Evaluation of strong cation exchange versus isoelectric focusing of peptides for multidimensional liquid chromatography-tandem mass spectrometry J Proteome Res. 2008 Dec; 7(12):5286-94. . View in PubMed
  • Global impact of oncogenic Src on a phosphotyrosine proteome J Proteome Res. 2008 Aug; 7(8):3447-60. . View in PubMed
  • Microsatellite mutations in buccal cells are associated with aging and head and neck carcinoma Br J Cancer. 2008 Feb 12; 98(3):619-26. . View in PubMed
  • Diagnostic accuracy of MALDI mass spectrometric analysis of unfractionated serum in lung cancer J Thorac Oncol. 2007 Oct; 2(10):893-901. . View in PubMed
  • The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk Am J Clin Nutr. 2007 Sep; 86(3):743-51. . View in PubMed
  • Acetylcholine and choline dynamics provide early and late markers of traumatic brain injury Brain Res. 2006 Dec 08; 1124(1):155-66. . View in PubMed
  • Mutagenic effect of cadmium on tetranucleotide repeats in human cells Mutat Res. 2006 Dec 01; 602(1-2):92-9. . View in PubMed
  • Nuclear survivin predicts recurrence and poor survival in patients with resected nonsmall cell lung carcinoma Cancer. 2005 Apr 15; 103(8):1685-92. . View in PubMed